{"id":"https://openalex.org/W3015963902","doi":"https://doi.org/10.35621/23587490.v7.n1.p577-593","title":"A RESIST\u00caNCIA AOS ANTIMONIAIS PODE LEVAR AO AUMENTO DA VIRUL\u00caNCIA EM LEISHMANIA SPP.?","display_name":"A RESIST\u00caNCIA AOS ANTIMONIAIS PODE LEVAR AO AUMENTO DA VIRUL\u00caNCIA EM LEISHMANIA SPP.?","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3015963902","doi":"https://doi.org/10.35621/23587490.v7.n1.p577-593","mag":"3015963902"},"language":"pt","primary_location":{"id":"doi:10.35621/23587490.v7.n1.p577-593","doi":"https://doi.org/10.35621/23587490.v7.n1.p577-593","is_oa":true,"landing_page_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","pdf_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","source":{"id":"https://openalex.org/S4210202475","display_name":"Revista interdisciplinar em sa\u00fade","issn_l":"2358-7490","issn":["2358-7490"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista interdisciplinar em sa\u00fade","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089012474","display_name":"La\u00edsa Vilar Cordeiro","orcid":"https://orcid.org/0000-0002-8884-7331","observed_orcids":["https://orcid.org/0000-0002-8884-7331"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"La\u00edsa Vilar Cordeiro","raw_affiliation_strings":["Doutorandos em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba (UFPB);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutorandos em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba (UFPB);","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071046145","display_name":"Pedro Thiago Ramalho de Figueiredo","orcid":"https://orcid.org/0000-0001-6132-6248","observed_orcids":["https://orcid.org/0000-0001-6132-6248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Thiago Ramalho de Figueiredo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017608905","display_name":"Thamara Rodrigues de Melo","orcid":"https://orcid.org/0000-0001-6540-9585","observed_orcids":["https://orcid.org/0000-0001-6540-9585"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thamara Rodrigues de Melo","raw_affiliation_strings":["Doutorandos em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba (UFPB);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutorandos em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba (UFPB);","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028798960","display_name":"Giulian C\u00e9sar da Silva S\u00e1","orcid":"https://orcid.org/0000-0002-4734-4228","observed_orcids":["https://orcid.org/0000-0002-4734-4228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulian C\u00e9sar da Silva S\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039016883","display_name":"Aleson Pereira de Sousa","orcid":"https://orcid.org/0000-0002-3430-477X","observed_orcids":["https://orcid.org/0000-0002-3430-477X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aleson Pereira de Sousa","raw_affiliation_strings":["Doutorando em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba (UFPB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutorando em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba (UFPB)","institution_ids":["https://openalex.org/I169045520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"\u00danico","first_page":"577","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.9570000171661377},{"id":"https://openalex.org/keywords/leishmaniasis","display_name":"leishmaniasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antimonial-resistance","display_name":"antimonial resistance","score":0.8579999804496765},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.8529999852180481},{"id":"https://openalex.org/keywords/parasite-fitness","display_name":"parasite fitness","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antimonials","display_name":"antimonial drugs","score":0.6129999756813049},{"id":"https://openalex.org/keywords/neglected-tropical-diseases","display_name":"neglected tropical diseases","score":0.781000018119812},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5914896130561829},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.47935372591018677},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3920542597770691},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.17220744490623474}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35621/23587490.v7.n1.p577-593","doi":"https://doi.org/10.35621/23587490.v7.n1.p577-593","is_oa":true,"landing_page_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","pdf_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","source":{"id":"https://openalex.org/S4210202475","display_name":"Revista interdisciplinar em sa\u00fade","issn_l":"2358-7490","issn":["2358-7490"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista interdisciplinar em sa\u00fade","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35621/23587490.v7.n1.p577-593","doi":"https://doi.org/10.35621/23587490.v7.n1.p577-593","is_oa":true,"landing_page_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","pdf_url":"https://doi.org/10.35621/23587490.v7.n1.p577-593","source":{"id":"https://openalex.org/S4210202475","display_name":"Revista interdisciplinar em sa\u00fade","issn_l":"2358-7490","issn":["2358-7490"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista interdisciplinar em sa\u00fade","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015963902.pdf","grobid_xml":"https://content.openalex.org/works/W3015963902.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W31119580","https://openalex.org/W1903629244","https://openalex.org/W1931541776","https://openalex.org/W1970594670","https://openalex.org/W1971178554","https://openalex.org/W1976235047","https://openalex.org/W1977685479","https://openalex.org/W1980270838","https://openalex.org/W1982360364","https://openalex.org/W1990509955","https://openalex.org/W2019945911","https://openalex.org/W2020902855","https://openalex.org/W2030222827","https://openalex.org/W2039344845","https://openalex.org/W2045821535","https://openalex.org/W2060864551","https://openalex.org/W2065143819","https://openalex.org/W2069807174","https://openalex.org/W2071729689","https://openalex.org/W2077373460","https://openalex.org/W2080706515","https://openalex.org/W2085354751","https://openalex.org/W2089430367","https://openalex.org/W2100030863","https://openalex.org/W2100453762","https://openalex.org/W2107609023","https://openalex.org/W2151444479","https://openalex.org/W2152855843","https://openalex.org/W2170956456","https://openalex.org/W2281232311","https://openalex.org/W2555473081","https://openalex.org/W2573547936","https://openalex.org/W2618705397","https://openalex.org/W2769660038","https://openalex.org/W2780932379","https://openalex.org/W2802791576","https://openalex.org/W2810773687","https://openalex.org/W2906875746","https://openalex.org/W4211078476","https://openalex.org/W4255607993"],"related_works":["https://openalex.org/W4416557776","https://openalex.org/W4413283389","https://openalex.org/W2006576505","https://openalex.org/W2060067663","https://openalex.org/W2168408102","https://openalex.org/W7096677589","https://openalex.org/W4406728348","https://openalex.org/W108047091","https://openalex.org/W7123872093","https://openalex.org/W2963005910"],"abstract_inverted_index":{"Leishmanioses":[0],"s\u00e3o":[1,57,212],"doen\u00e7as":[2],"negligenciadas,":[3],"que":[4,83,109,125,194],"acometem":[5],"principalmente":[6],"pa\u00edses":[7],"tropicais":[8],"e":[9,60,80,104,132,171,206,236],"popula\u00e7\u00f5es":[10],"de":[11,46,71,155,161,186,190,202,226],"baixa":[12],"condi\u00e7\u00e3o":[13],"socioecon\u00f4mica.":[14],"Na":[15,37],"pr\u00e1tica":[16,246],"cl\u00ednica,":[17],"a":[18,28,74,84,86,90,130,144,166,175,188,219,228,239],"principal":[19],"ferramenta":[20],"para":[21,49,173],"o":[22,31,50,61,68,120,151],"combate":[23],"da":[24,117,153],"leishmaniose":[25],"ainda":[26,211],"\u00e9":[27,34,97,123],"farmacoterapia.":[29],"Contudo,":[30],"arsenal":[32],"terap\u00eautico":[33],"bastante":[35],"limitado.":[36],"maioria":[38],"dos":[39,94],"pa\u00edses,":[40],"como":[41],"no":[42,92,101,115],"Brasil,":[43],"as":[44,230],"drogas":[45,87,131],"primeira":[47],"escolha":[48],"tratamento":[51,62],"das":[52,168],"infec\u00e7\u00f5es":[53],"por":[54],"Leishmania":[55,250],"sp.":[56],"os":[58,184],"antimoniais":[59,147,198],"possui":[63],"v\u00e1rias":[64],"limita\u00e7\u00f5es,":[65],"dentre":[66],"elas":[67],"crescente":[69],"surgimento":[70],"parasitos":[72,156,195],"resistentes":[73,196],"estas":[75],"drogas.":[76],"Estudos":[77,192],"em":[78],"procariotos":[79],"eucariotos":[81],"demonstram":[82],"resist\u00eancia":[85,129,145],"est\u00e1":[88,148],"relacionada":[89],"altera\u00e7\u00f5es":[91,111,231],"fitness":[93],"micro-organismos,":[95],"onde":[96],"poss\u00edvel":[98],"observar":[99],"modifica\u00e7\u00f5es":[100],"crescimento,":[102],"virul\u00eancia":[103,154,203],"transmissibilidade":[105],"entre":[106,128,183],"hospedeiros.":[107],"Visto":[108],"tais":[110],"podem":[112],"influenciar":[113],"diretamente":[114,244],"curso":[116],"infec\u00e7\u00e3o,":[118],"alterando":[119],"progn\u00f3stico":[121],"cl\u00ednico,":[122],"relevante":[124],"essa":[126],"associa\u00e7\u00e3o":[127],"virul\u00eancia/fitness":[133],"parasit\u00e1rio":[134],"seja":[135],"melhor":[136,224],"estudada.":[137],"Esta":[138],"revis\u00e3o":[139],"bibliogr\u00e1fica":[140],"objetivou":[141],"avaliar":[142],"se":[143],"aos":[146,197],"correlacionada":[149],"com":[150],"aumento":[152],"do":[157,177],"g\u00eanero":[158],"Leishmania.":[159],"Trata-se":[160],"um":[162],"estudo":[163],"descritivo,":[164],"realizado":[165],"partir":[167],"pesquisas":[169],"bibliogr\u00e1ficas":[170],"documentais":[172],"subsidiar":[174],"discuss\u00e3o":[176],"tema.":[178],"A":[179],"pesquisa":[180],"foi":[181],"realizada":[182],"meses":[185],"dezembro":[187],"fevereiro":[189],"2020.":[191],"apontam":[193,218],"apresentam":[199],"maiores":[200],"par\u00e2metros":[201],"in":[204,207],"vitro":[205],"vivo.":[208],"Tais":[209],"estudos":[210],"escassamente":[213],"encontrados":[214],"na":[215,245],"literatura,":[216],"mas":[217],"necessidade":[220],"dessa":[221],"correla\u00e7\u00e3o":[222],"ser":[223],"estudada,":[225],"modo":[227],"esclarecer":[229],"moleculares":[232],"envolvidas":[233],"nesses":[234],"processos":[235],"poder":[237],"otimizar":[238],"farmacoterapia":[240],"dessas":[241],"infec\u00e7\u00f5es,":[242],"impactando":[243],"cl\u00ednica.":[247],"Palavras":[248],"chave:":[249],"spp.;":[251],"leishmaniose;":[252],"resist\u00eancia;":[253],"virul\u00eancia.":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-07T09:17:50.787605","created_date":"2020-04-17T00:00:00"}