{"id":"https://openalex.org/W3015764040","doi":"https://doi.org/10.1096/fj.201903011r","title":"The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage\u2010associated M2 macrophage polarization in vivo and in vitro","display_name":"The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage\u2010associated M2 macrophage polarization in vivo and in vitro","publication_year":2020,"publication_date":"2020-04-13","ids":{"openalex":"https://openalex.org/W3015764040","doi":"https://doi.org/10.1096/fj.201903011r","mag":"3015764040","pmid":"https://pubmed.ncbi.nlm.nih.gov/32283574"},"language":"en","primary_location":{"id":"doi:10.1096/fj.201903011r","doi":"https://doi.org/10.1096/fj.201903011r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.201903011r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002897023","display_name":"Hua Xiu Sui","orcid":"https://orcid.org/0000-0001-7255-4254","observed_orcids":["https://orcid.org/0000-0001-7255-4254"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210149132","display_name":"Shuguang Hospital","ror":"https://ror.org/03n35e656","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Sui","raw_affiliation_strings":["Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210149132"]},{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001761828","display_name":"Hongsheng Tan","orcid":"https://orcid.org/0000-0003-0921-5481","observed_orcids":["https://orcid.org/0000-0003-0921-5481"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongsheng Tan","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606551","display_name":"Jie Fu","orcid":"https://orcid.org/0000-0002-3183-453X","observed_orcids":["https://orcid.org/0000-0002-3183-453X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Fu","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qing Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210149132","display_name":"Shuguang Hospital","ror":"https://ror.org/03n35e656","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Song","raw_affiliation_strings":["Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210149132"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ru Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210149132","display_name":"Shuguang Hospital","ror":"https://ror.org/03n35e656","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Jia","raw_affiliation_strings":["Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210149132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784710","display_name":"Li Han","orcid":"https://orcid.org/0000-0002-6842-7620","observed_orcids":["https://orcid.org/0000-0002-6842-7620"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Han","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091582667","display_name":"Yue Lv","orcid":"https://orcid.org/0009-0005-8443-0925","observed_orcids":["https://orcid.org/0009-0005-8443-0925","https://orcid.org/0000-0001-8043-9651"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Lv","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430306","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0002-6191-0046","observed_orcids":["https://orcid.org/0000-0002-6191-0046","https://orcid.org/0000-0003-3176-3994","https://orcid.org/0000-0002-1000-3462","https://orcid.org/0000-0002-1481-4086"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031245030","display_name":"Dan Zheng","orcid":"https://orcid.org/0009-0007-6377-8177","observed_orcids":["https://orcid.org/0009-0007-6377-8177"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Zheng","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102203503","display_name":"Liping Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Dong","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037901154","display_name":"Songpo Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songpo Wang","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350268","display_name":"Qi Li","orcid":"https://orcid.org/0000-0001-8776-8730","observed_orcids":["https://orcid.org/0000-0001-8776-8730","https://orcid.org/0000-0002-7724-1289","https://orcid.org/0009-0007-5623-3320","https://orcid.org/0000-0001-5538-7511","https://orcid.org/0000-0001-7105-2818","https://orcid.org/0000-0001-7129-1456","https://orcid.org/0000-0002-1073-7810","https://orcid.org/0000-0002-1303-2621","https://orcid.org/0000-0002-2481-7168","https://orcid.org/0000-0002-5146-5831","https://orcid.org/0000-0002-6013-1921","https://orcid.org/0000-0002-7905-2860","https://orcid.org/0000-0003-4928-334X","https://orcid.org/0009-0005-3755-0297","https://orcid.org/0009-0006-9298-8854","https://orcid.org/0009-0007-3925-5456","https://orcid.org/0009-0008-5463-4910","https://orcid.org/0009-0009-5490-771X","https://orcid.org/0000-0003-2004-6885","https://orcid.org/0000-0001-6823-3546","https://orcid.org/0000-0001-7181-9919","https://orcid.org/0000-0001-7658-4370","https://orcid.org/0000-0001-7716-0481","https://orcid.org/0000-0001-8765-5437","https://orcid.org/0000-0001-9468-0390","https://orcid.org/0000-0002-0169-8098","https://orcid.org/0000-0002-1154-3719","https://orcid.org/0000-0002-2334-5824","https://orcid.org/0000-0002-2978-2339","https://orcid.org/0000-0002-3694-8237","https://orcid.org/0000-0002-4934-9196","https://orcid.org/0000-0002-5993-0312","https://orcid.org/0000-0002-6240-3396","https://orcid.org/0000-0002-6795-8956","https://orcid.org/0000-0002-7567-9615","https://orcid.org/0000-0002-8940-9966","https://orcid.org/0000-0002-9514-3340","https://orcid.org/0000-0003-0587-1748","https://orcid.org/0000-0003-0679-4385","https://orcid.org/0000-0003-1139-3068","https://orcid.org/0000-0003-1440-6469","https://orcid.org/0000-0003-1922-5894","https://orcid.org/0000-0003-2893-3120","https://orcid.org/0000-0003-3574-2584","https://orcid.org/0000-0003-4522-3067","https://orcid.org/0000-0003-4661-3681","https://orcid.org/0000-0003-4807-030X","https://orcid.org/0009-0000-1969-272X","https://orcid.org/0009-0000-4647-0575","https://orcid.org/0009-0000-5318-5991","https://orcid.org/0009-0000-8617-4420","https://orcid.org/0009-0001-6495-8686","https://orcid.org/0009-0002-0552-0278","https://orcid.org/0009-0002-4295-3937","https://orcid.org/0009-0002-4364-2188","https://orcid.org/0009-0002-4487-1214","https://orcid.org/0009-0002-5658-6074","https://orcid.org/0009-0002-6058-8697","https://orcid.org/0009-0002-6797-4515","https://orcid.org/0009-0003-0310-1544","https://orcid.org/0009-0003-3523-419X","https://orcid.org/0009-0003-6774-4039","https://orcid.org/0009-0003-9406-264X","https://orcid.org/0009-0003-9940-3423","https://orcid.org/0009-0004-1742-9898","https://orcid.org/0009-0004-5298-247X","https://orcid.org/0009-0004-5723-7508","https://orcid.org/0009-0004-5732-2526","https://orcid.org/0009-0004-7264-6350","https://orcid.org/0009-0005-2666-6999","https://orcid.org/0009-0005-5131-9286","https://orcid.org/0009-0005-5350-6827","https://orcid.org/0009-0005-8425-7712","https://orcid.org/0009-0005-9327-6456","https://orcid.org/0009-0005-9936-9506","https://orcid.org/0009-0006-0036-640X","https://orcid.org/0009-0006-0348-6562","https://orcid.org/0009-0006-1230-2243","https://orcid.org/0009-0006-1949-1673","https://orcid.org/0009-0006-2019-3112","https://orcid.org/0009-0006-6434-4656","https://orcid.org/0009-0006-7442-8087","https://orcid.org/0009-0006-8306-3948","https://orcid.org/0009-0006-8886-0268","https://orcid.org/0009-0007-0046-0401","https://orcid.org/0009-0007-3916-5231","https://orcid.org/0009-0007-7317-3948","https://orcid.org/0009-0007-7362-1771","https://orcid.org/0009-0008-2655-5027","https://orcid.org/0009-0008-6211-8182","https://orcid.org/0009-0008-7222-8000","https://orcid.org/0009-0008-8240-2762","https://orcid.org/0009-0008-8481-8753","https://orcid.org/0000-0001-6226-2776","https://orcid.org/0000-0003-3233-0998"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210149132","display_name":"Shuguang Hospital","ror":"https://ror.org/03n35e656","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149132"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Li","raw_affiliation_strings":["Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210149132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034735808","display_name":"Hong\u2010Xi Xu","orcid":"https://orcid.org/0000-0001-6238-4511","observed_orcids":["https://orcid.org/0000-0001-6238-4511","https://orcid.org/0009-0000-7270-2149","https://orcid.org/0000-0002-1772-4844"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongxi Xu","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034735808","https://openalex.org/A5100350268"],"corresponding_institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210149132"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.5736,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83600406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"34","issue":"6","first_page":"7387","last_page":"7403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9229999780654907},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.8259999752044678},{"id":"https://openalex.org/keywords/arg1","display_name":"Arg1","score":0.7839999794960022},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9520000219345093},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.5600000023841858},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.8579986095428467},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6126996278762817},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6060442924499512},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.569719135761261},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5606477856636047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5175630450248718},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5076466798782349},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.495724081993103},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.46496444940567017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40460002422332764},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3753117620944977},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3597677946090698},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35582125186920166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34556084871292114},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2840297818183899},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2129274308681488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20843559503555298},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09010240435600281},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001397","descriptor_name":"Azoxymethane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029760","descriptor_name":"Garcinia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.201903011r","doi":"https://doi.org/10.1096/fj.201903011r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.201903011r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:32283574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32283574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2297866529","display_name":null,"funder_award_id":"81973438","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4276700451","display_name":null,"funder_award_id":"81573749","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4277035465","display_name":null,"funder_award_id":"81703893","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5025318701","display_name":null,"funder_award_id":"81874399","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5647460602","display_name":null,"funder_award_id":"81573805","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8137172189","display_name":"\u5927\u80a0\u764c\u6e7f\u70ed\u8bc1\u80a0\u9053\u5fae\u751f\u6001\u7684\u751f\u7269\u5b66\u57fa\u7840\u53ca\u6548\u5e94\u673a\u5236","funder_award_id":"81830120","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W350013814","https://openalex.org/W806146145","https://openalex.org/W1540420432","https://openalex.org/W1757407923","https://openalex.org/W1805865584","https://openalex.org/W1861001175","https://openalex.org/W1896735974","https://openalex.org/W1956258286","https://openalex.org/W1970602197","https://openalex.org/W1974301643","https://openalex.org/W1985082045","https://openalex.org/W1986329127","https://openalex.org/W2011075508","https://openalex.org/W2011859476","https://openalex.org/W2029908111","https://openalex.org/W2033209163","https://openalex.org/W2039202048","https://openalex.org/W2040695321","https://openalex.org/W2061476761","https://openalex.org/W2065721692","https://openalex.org/W2077482066","https://openalex.org/W2093293871","https://openalex.org/W2102144390","https://openalex.org/W2113029107","https://openalex.org/W2120045074","https://openalex.org/W2123105952","https://openalex.org/W2399466007","https://openalex.org/W2412592840","https://openalex.org/W2468064173","https://openalex.org/W2556538176","https://openalex.org/W2578724964","https://openalex.org/W2624252845","https://openalex.org/W2744250815","https://openalex.org/W2747229058","https://openalex.org/W2758369229","https://openalex.org/W2760802858","https://openalex.org/W2761393612","https://openalex.org/W2763922502","https://openalex.org/W2796740739","https://openalex.org/W2797071790","https://openalex.org/W2797311158","https://openalex.org/W2802075967","https://openalex.org/W2805301164","https://openalex.org/W2883654953","https://openalex.org/W2885509002","https://openalex.org/W2897946537","https://openalex.org/W2899378876","https://openalex.org/W2916150159","https://openalex.org/W2923465599","https://openalex.org/W2923910254","https://openalex.org/W2939843823","https://openalex.org/W2947142752","https://openalex.org/W2959497269","https://openalex.org/W2961187239"],"related_works":["https://openalex.org/W4389138128","https://openalex.org/W7167416039","https://openalex.org/W3161028736","https://openalex.org/W7167378172","https://openalex.org/W7117766191","https://openalex.org/W4210397971","https://openalex.org/W4388845165","https://openalex.org/W2950428931","https://openalex.org/W4200498311","https://openalex.org/W3115749720"],"abstract_inverted_index":{"Abstract":[0],"Colorectal":[1],"cancer":[2,79],"(CRC)":[3],"is":[4,25,68],"the":[5,38,57,64,73,88,106,120,154,166,180,185,197,205,215,229,234,251],"third":[6],"most":[7],"common":[8],"solid":[9],"tumor":[10,107,109,136,167,171,206,221],"worldwide":[11],"and":[12,59,96,112,138,141,151,169,208,211,217,236,241],"has":[13],"shown":[14],"resistance":[15],"to":[16,118,233],"several":[17],"immunotherapies,":[18],"particularly":[19],"immune":[20],"checkpoint":[21],"blockade":[22],"therapy,":[23],"which":[24,173],"effective":[26],"in":[27,63,81,164,179,192,196,214,228],"many":[28],"other":[29],"types":[30],"of":[31,41,61,66,75,122,127,199,238,253],"cancer.":[32],"Our":[33],"previous":[34],"studies":[35],"indicated":[36],"that":[37,226],"active":[39],"fraction":[40],"Garcinia":[42],"yunnanensis":[43],"(YTE\u201017),":[44],"had":[45],"potent":[46],"anticancer":[47],"activities":[48],"by":[49,83,157,177],"regulating":[50],"multiple":[51],"signaling":[52],"pathways.":[53],"However,":[54],"knowledge":[55],"regarding":[56],"mechanism":[58],"effect":[60,121],"YTE\u201017":[62,76,128,178,186,202,243],"prevention":[65],"CRC":[67,94,134,189,239],"limited.":[69],"This":[70],"study":[71],"tested":[72],"effects":[74],"on":[77],"colon":[78,220],"development":[80,235],"vivo":[82],"using":[84,101],"two":[85],"murine":[86],"models:":[87],"carcigenic":[89],"azoxymethane/dextran":[90],"sulfate":[91],"sodium":[92],"(AOM/DSS)\u2010induced":[93],"model":[95,100],"a":[97,162,193,245],"genetically":[98],"induced":[99],"Apc":[102,181,218],"Min/+":[103,182,219],"mice.":[104,183],"Here,":[105],"load,":[108],"number,":[110],"histology,":[111],"even":[113],"some":[114,142],"oncogenes":[115],"were":[116,174],"used":[117],"evaluate":[119],"YTE\u201017.":[123],"The":[124],"intragastric":[125],"administration":[126],"for":[129,250],"12":[130],"weeks":[131],"significantly":[132],"decreased":[133],"incidence,":[135],"number":[137],"size,":[139],"immunity,":[140],"tumor\u2010associated":[143],"macrophage":[144,209],"(TAM)":[145],"markers,":[146],"including":[147],"CD206,":[148],"Arg\u20101,":[149],"IL\u201010,":[150],"TGF\u2010\u03b2.":[152],"Importantly,":[153],"macrophages":[155,227],"depletion":[156],"clodronate":[158],"(CEL)":[159],"also":[160],"played":[161],"role":[163],"reducing":[165],"burden":[168,207],"inhibiting":[170],"development,":[172],"not":[175],"affected":[176],"Moreover,":[184],"treatment":[187,252],"attenuated":[188],"cell":[190],"growth":[191],"co\u2010culture":[194],"system":[195],"presence":[198],"macrophages.":[200],"Consistently,":[201],"effectively":[203],"reduced":[204],"infiltration":[210],"enhanced":[212],"immunity":[213],"AOM/DSS":[216],"models.":[222],"Altogether,":[223],"we":[224],"demonstrate":[225],"microenvironment":[230],"may":[231],"contribute":[232],"progression":[237],"cells":[240],"propose":[242],"as":[244],"new":[246],"potential":[247],"drug":[248],"option":[249],"CRC.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}
