{"id":"https://openalex.org/W3015740705","doi":"https://doi.org/10.1002/ijc.33009","title":"Development and validation of a stromal immune phenotype classifier for predicting immune activity and prognosis in triple\u2010negative breast cancer","display_name":"Development and validation of a stromal immune phenotype classifier for predicting immune activity and prognosis in triple\u2010negative breast cancer","publication_year":2020,"publication_date":"2020-04-14","ids":{"openalex":"https://openalex.org/W3015740705","doi":"https://doi.org/10.1002/ijc.33009","mag":"3015740705","pmid":"https://pubmed.ncbi.nlm.nih.gov/32285442"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.33009","doi":"https://doi.org/10.1002/ijc.33009","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.33009","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026279705","display_name":"Shaoquan Zheng","orcid":"https://orcid.org/0000-0003-1912-0216","observed_orcids":["https://orcid.org/0000-0003-1912-0216"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoquan Zheng","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048093999","display_name":"Yutian Zou","orcid":"https://orcid.org/0000-0002-5205-9923","observed_orcids":["https://orcid.org/0000-0002-5205-9923"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutian Zou","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059349758","display_name":"Xinhua Xie","orcid":"https://orcid.org/0000-0002-2775-0990","observed_orcids":["https://orcid.org/0000-0002-2775-0990"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhua Xie","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-2775-0990","affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041823322","display_name":"Jie\u2010Ying Liang","orcid":"https://orcid.org/0000-0002-9829-294X","observed_orcids":["https://orcid.org/0000-0002-9829-294X"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie\u2010ying Liang","raw_affiliation_strings":["Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029796589","display_name":"Anli Yang","orcid":"https://orcid.org/0000-0003-0966-7285","observed_orcids":["https://orcid.org/0000-0003-0966-7285"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anli Yang","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692622","display_name":"Kai Yu","orcid":"https://orcid.org/0000-0003-3343-2902","observed_orcids":["https://orcid.org/0000-0003-3343-2902"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Yu","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370386","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0001-9952-0898","observed_orcids":["https://orcid.org/0000-0001-9952-0898"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Department of Neurosurgery, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057676647","display_name":"Hailin Tang","orcid":"https://orcid.org/0000-0002-3206-782X","observed_orcids":["https://orcid.org/0000-0002-3206-782X"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hailin Tang","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3206-782X","affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xiaoming Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoming Xie","raw_affiliation_strings":["Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057676647","https://openalex.org/A5100370386"],"corresponding_institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.8488,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93497062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"147","issue":"2","first_page":"542","last_page":"553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6539999842643738},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8009999990463257},{"id":"https://openalex.org/keywords/stromal-immune-cells","display_name":"stromal immune cells","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/m1-m2-macrophages","display_name":"M1/M2 macrophages","score":0.8050000071525574},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/immune-checkpoint-proteins","display_name":"immune checkpoint molecules","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8209999799728394},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lasso-cox-regression","display_name":"LASSO Cox regression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cibersort-deconvolution","display_name":"CIBERSORT deconvolution","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6933879852294922},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5931391716003418},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5511309504508972},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5502212643623352},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.4802963435649872},{"id":"https://openalex.org/C2992734768","wikidata":"https://www.wikidata.org/wiki/Q48964","display_name":"Triple negative","level":4,"score":0.4169856011867523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3870390057563782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3711199462413788},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3673957288265228},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36632248759269714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3435380756855011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2929726541042328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2376488745212555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09932759404182434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07629403471946716}],"mesh":[{"descriptor_ui":"D000075942","descriptor_name":"Intraepithelial Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.33009","doi":"https://doi.org/10.1002/ijc.33009","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.33009","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:32285442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32285442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8077371020","display_name":null,"funder_award_id":"81772961","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8377840795","display_name":null,"funder_award_id":"81872152","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G903231573","display_name":null,"funder_award_id":"81672598","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1896351481","https://openalex.org/W1985987855","https://openalex.org/W2005895632","https://openalex.org/W2021560851","https://openalex.org/W2071462987","https://openalex.org/W2105133921","https://openalex.org/W2150024391","https://openalex.org/W2178133357","https://openalex.org/W2338576144","https://openalex.org/W2402636472","https://openalex.org/W2533508881","https://openalex.org/W2584855552","https://openalex.org/W2789798089","https://openalex.org/W2794165001","https://openalex.org/W2805124128","https://openalex.org/W2884633299","https://openalex.org/W2889746019","https://openalex.org/W2892170876","https://openalex.org/W2896872272","https://openalex.org/W2897422388","https://openalex.org/W2897523860","https://openalex.org/W2911188335","https://openalex.org/W2912993657","https://openalex.org/W2914282788","https://openalex.org/W2919182022","https://openalex.org/W2939212581","https://openalex.org/W2942793545","https://openalex.org/W2943298986","https://openalex.org/W2944687997","https://openalex.org/W2946550606","https://openalex.org/W2949746977","https://openalex.org/W2950563001","https://openalex.org/W2971220345","https://openalex.org/W2978614136","https://openalex.org/W2982501627","https://openalex.org/W2982542437","https://openalex.org/W2990398119","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W3209372426","https://openalex.org/W4398188978","https://openalex.org/W3176778065","https://openalex.org/W3209378804","https://openalex.org/W4388289558","https://openalex.org/W7208739758","https://openalex.org/W7166644240","https://openalex.org/W2907190362","https://openalex.org/W4380291621","https://openalex.org/W4396231432"],"abstract_inverted_index":{"Our":[0],"study":[1],"aims":[2],"to":[3,76,108,165],"construct":[4],"a":[5,57,201,231],"prognosis-related":[6,65],"immune":[7,15,51,66,78,102,205,217,235],"phenotype":[8,218],"classifier":[9],"for":[10,168,225,234],"predicting":[11],"clinical":[12],"prognosis":[13],"and":[14,36,73,105,122,133,146,180,200,211,227],"activity":[16,236],"in":[17,46,84,94,139,161],"triple-negative":[18],"breast":[19],"cancer":[20],"(TNBC).":[21],"A":[22,49,89,104,126,163],"total":[23,90],"of":[24,91,111,143,150,204],"237":[25],"patients":[26,38,93,145],"with":[27,39,56],"TNBC":[28,40,226],"from":[29,41],"Sun":[30],"Yat-sen":[31],"University":[32],"Cancer":[33],"Center":[34],"(SYSUCC)":[35],"533":[37,151],"public":[42],"datasets":[43],"were":[44,82,99,159,197],"included":[45],"our":[47],"study.":[48],"stromal":[50,112],"quantified":[52],"index":[53],"was":[54,74,136,220],"generated":[55],"LASSO":[58],"Cox":[59],"regression":[60],"model":[61],"based":[62],"on":[63],"five":[64],"cells":[67],"evaluated":[68,83],"by":[69],"CIBERSORT":[70],"or":[71],"IHC":[72],"used":[75],"determine":[77],"phenotypes.":[79],"Immune":[80],"features":[81],"the":[85,95,109,134,140,147,154,169,181,238],"samples":[86],"before":[87],"chemotherapy.":[88],"119":[92],"SYSUCC":[96],"training":[97],"cohort":[98,142,149],"classified":[100],"into":[101],"Phenotypes":[103],"B":[106,167],"according":[107],"density":[110],"CD4+":[113],"T":[114,117],"cells,":[115,118],"\u03b3\u03b4":[116],"monocytes,":[119],"M1":[120],"macrophages":[121],"M2":[123],"macrophages.":[124],"Phenotype":[125,131,162,166,193],"predicted":[127],"better":[128],"survival":[129,172,184],"than":[130],"B,":[132],"classification":[135,219],"further":[137],"validated":[138],"testing":[141],"118":[144],"validation":[148],"patients.":[152],"In":[153,192],"combined":[155],"cohort,":[156],"significant":[157],"differences":[158],"found":[160],"compared":[164],"5-year":[170,182],"overall":[171],"(83.5%":[173],"vs":[174,186],"65.8%,":[175],"respectively,":[176,188],"P":[177,189],"<":[178,190],".01)":[179],"disease-free":[183],"(87.3%":[185],"76.0%,":[187],".01).":[191],"A,":[194],"immune-related":[195],"pathways":[196],"significantly":[198],"enriched,":[199],"higher":[202],"level":[203],"checkpoint":[206],"molecules,":[207],"including":[208],"PD-L1,":[209],"PD-1":[210],"CTLA-4,":[212],"could":[213],"be":[214],"observed.":[215],"The":[216],"an":[221],"independent":[222],"prognostic":[223],"indicator":[224],"might":[228],"serve":[229],"as":[230],"potential":[232],"predictor":[233],"within":[237],"tumor":[239],"microenvironment.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-04-17T00:00:00"}
