{"id":"https://openalex.org/W3015654091","doi":"https://doi.org/10.1111/jdv.16431","title":"Characteristics and outcomes of patients treated with apremilast in the real world: results from the APPRECIATE study","display_name":"Characteristics and outcomes of patients treated with apremilast in the real world: results from the APPRECIATE study","publication_year":2020,"publication_date":"2020-04-12","ids":{"openalex":"https://openalex.org/W3015654091","doi":"https://doi.org/10.1111/jdv.16431","mag":"3015654091","pmid":"https://pubmed.ncbi.nlm.nih.gov/32279378"},"language":"en","primary_location":{"id":"doi:10.1111/jdv.16431","doi":"https://doi.org/10.1111/jdv.16431","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdv.16431","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdv.16431","source":{"id":"https://openalex.org/S137740113","display_name":"Journal of the European Academy of Dermatology and Venereology","issn_l":"0926-9959","issn":["0926-9959","1468-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdv.16431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013763025","display_name":"Matthias Augustin","orcid":"https://orcid.org/0000-0002-4026-8728","observed_orcids":["https://orcid.org/0000-0002-4026-8728"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M. Augustin","raw_affiliation_strings":["Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4026-8728","affiliations":[{"raw_affiliation_string":"Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059093024","display_name":"C. Elise Kleyn","orcid":"https://orcid.org/0000-0003-4038-5833","observed_orcids":["https://orcid.org/0000-0003-4038-5833"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210159460","display_name":"NIHR Manchester Biomedical Research Centre","ror":"https://ror.org/05njkjr15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210159460"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.E. Kleyn","raw_affiliation_strings":["The Dermatology Centre, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dermatology Centre, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210159460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051830286","display_name":"Curdin Conrad","orcid":"https://orcid.org/0000-0002-2547-3440","observed_orcids":["https://orcid.org/0000-0002-2547-3440"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Conrad","raw_affiliation_strings":["Service of Dermatology and Venereology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Dermatology and Venereology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109396869","display_name":"Paul G. Sator","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089076","display_name":"Klinik Hietzing","ror":"https://ror.org/00621wh10","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210089076","https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"P.G. Sator","raw_affiliation_strings":["Department of Dermatology, Hietzing Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Hietzing Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210089076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019510030","display_name":"Mona St\u00e5hle","orcid":"https://orcid.org/0000-0002-3916-9343","observed_orcids":["https://orcid.org/0000-0002-3916-9343"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. St\u00e5hle","raw_affiliation_strings":["Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090247994","display_name":"Kilian Eyerich","orcid":"https://orcid.org/0000-0003-0094-2674","observed_orcids":["https://orcid.org/0000-0003-0094-2674"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Eyerich","raw_affiliation_strings":["Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077643212","display_name":"M.A. Radtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151227","display_name":"Dermatologikum Hamburg","ror":"https://ror.org/04whsde46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210151227"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.A. Radtke","raw_affiliation_strings":["Dermatologikum Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatologikum Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I4210151227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045713458","display_name":"Christine Bundy","orcid":"https://orcid.org/0000-0002-5981-3984","observed_orcids":["https://orcid.org/0000-0002-5981-3984"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Bundy","raw_affiliation_strings":["College of Biomedical and Health Sciences Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical and Health Sciences Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056008981","display_name":"L. Mellars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155837","display_name":"Celgene (United States)","ror":"https://ror.org/0527yg379","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387155837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Mellars","raw_affiliation_strings":["Celgene Corporation, Summit, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Summit, NJ, USA","institution_ids":["https://openalex.org/I4387155837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007298628","display_name":"Chiara Greggio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154805","display_name":"Celgene (Switzerland)","ror":"https://ror.org/055503602","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387154805"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Greggio","raw_affiliation_strings":["Celgene International, Boudry, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene International, Boudry, Switzerland","institution_ids":["https://openalex.org/I4387154805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018138915","display_name":"Myriam Cordey","orcid":"https://orcid.org/0009-0004-1797-0510","observed_orcids":["https://orcid.org/0009-0004-1797-0510"]},"institutions":[{"id":"https://openalex.org/I4210139000","display_name":"Amgen (Switzerland)","ror":"https://ror.org/045wjte67","country_code":"CH","type":"company","lineage":["https://openalex.org/I1320553840","https://openalex.org/I4210139000"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Cordey","raw_affiliation_strings":["Amgen Europe GmbH, Rotkreuz, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Europe GmbH, Rotkreuz, Switzerland","institution_ids":["https://openalex.org/I4210139000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072760779","display_name":"V. Koscielny","orcid":"https://orcid.org/0009-0004-3314-880X","observed_orcids":["https://orcid.org/0009-0004-3314-880X"]},"institutions":[{"id":"https://openalex.org/I4387154805","display_name":"Celgene (Switzerland)","ror":"https://ror.org/055503602","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387154805"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"V. Koscielny","raw_affiliation_strings":["Celgene International, Boudry, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene International, Boudry, Switzerland","institution_ids":["https://openalex.org/I4387154805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078821076","display_name":"Christopher E.M. Griffiths","orcid":"https://orcid.org/0000-0001-5371-4427","observed_orcids":["https://orcid.org/0000-0001-5371-4427"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210159460","display_name":"NIHR Manchester Biomedical Research Centre","ror":"https://ror.org/05njkjr15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210159460"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.E.M. Griffiths","raw_affiliation_strings":["The Dermatology Centre, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dermatology Centre, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210159460"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5013763025"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":2.054,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8820949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"35","issue":"1","first_page":"123","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apremilast","display_name":"apremilast","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phosphodiesterase-4-inhibitors","display_name":"phosphodiesterase-4 inhibitors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.6460000276565552},{"id":"https://openalex.org/keywords/pasi-improvement","display_name":"PASI improvement","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dermatology-life-quality-index","display_name":"Dermatology Life Quality Index","score":0.9120000004768372},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.6179999709129333},{"id":"https://openalex.org/keywords/physicians-perceptions","display_name":"physician perceptions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8849999904632568},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6890000104904175},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/patient-benefit-index","display_name":"Patient Benefit Index","score":0.5339999794960022},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.628000020980835},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.609000027179718},{"id":"https://openalex.org/keywords/headache","display_name":"headache","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2781427535","wikidata":"https://www.wikidata.org/wiki/Q2858961","display_name":"Apremilast","level":4,"score":0.9917631149291992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9278495907783508},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7715558409690857},{"id":"https://openalex.org/C2776173921","wikidata":"https://www.wikidata.org/wiki/Q25326609","display_name":"Dermatology Life Quality Index","level":3,"score":0.6760357618331909},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5689208507537842},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5536184310913086},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5397899746894836},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5151647329330444},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.48906785249710083},{"id":"https://openalex.org/C2777011040","wikidata":"https://www.wikidata.org/wiki/Q390643","display_name":"Psoriasis Area and Severity Index","level":3,"score":0.46308833360671997},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3459170162677765},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.11689490079879761},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0767446756362915}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013792","descriptor_name":"Thalidomide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1111/jdv.16431","doi":"https://doi.org/10.1111/jdv.16431","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdv.16431","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdv.16431","source":{"id":"https://openalex.org/S137740113","display_name":"Journal of the European Academy of Dermatology and Venereology","issn_l":"0926-9959","issn":["0926-9959","1468-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology","raw_type":"journal-article"},{"id":"pmid:32279378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32279378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology : JEADV","raw_type":"Journal Article"},{"id":"pmh:oai:serval.unil.ch:BIB_114D6CF8D47F","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_114D6CF8D47F","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology, vol. 35, no. 1, pp. 123-134","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:134671","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/134671/1/Augustin%20et%20al%202020.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/134671/1/Augustin%20et%20al%202020.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:iris.unil.ch:iris/68679","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/68679","pdf_url":"https://iris.unil.ch/bitstreams/ab4e9462-d7ba-40a0-85e0-6be36838d054/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1575434","doi":null,"is_oa":true,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1575434","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1589178","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1589178","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/jdv.16431","doi":"https://doi.org/10.1111/jdv.16431","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdv.16431","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdv.16431","source":{"id":"https://openalex.org/S137740113","display_name":"Journal of the European Academy of Dermatology and Venereology","issn_l":"0926-9959","issn":["0926-9959","1468-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332071","display_name":"LEO Pharma","ror":"https://ror.org/05tzrdd39"},{"id":"https://openalex.org/F4320333687","display_name":"Manchester Biomedical Research Centre","ror":"https://ror.org/05njkjr15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015654091.pdf","grobid_xml":"https://content.openalex.org/works/W3015654091.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1816336914","https://openalex.org/W1838428535","https://openalex.org/W1919283206","https://openalex.org/W1959946112","https://openalex.org/W1971301895","https://openalex.org/W1981437024","https://openalex.org/W2012964711","https://openalex.org/W2021018799","https://openalex.org/W2033988686","https://openalex.org/W2034350610","https://openalex.org/W2056468769","https://openalex.org/W2058547807","https://openalex.org/W2063512593","https://openalex.org/W2074399987","https://openalex.org/W2075361812","https://openalex.org/W2083026728","https://openalex.org/W2107730744","https://openalex.org/W2114677349","https://openalex.org/W2118781739","https://openalex.org/W2131727392","https://openalex.org/W2143003624","https://openalex.org/W2152262899","https://openalex.org/W2156148414","https://openalex.org/W2532238474","https://openalex.org/W2537338210","https://openalex.org/W2558385573","https://openalex.org/W2572142419","https://openalex.org/W2587566772","https://openalex.org/W2742484040","https://openalex.org/W2754038113","https://openalex.org/W2755210722","https://openalex.org/W2763303699","https://openalex.org/W2765883502","https://openalex.org/W2784794631","https://openalex.org/W2791244279","https://openalex.org/W2794352131","https://openalex.org/W2799955280","https://openalex.org/W2888954316","https://openalex.org/W2896346672","https://openalex.org/W2906030029","https://openalex.org/W2912787118","https://openalex.org/W2990796526"],"related_works":["https://openalex.org/W3164649164","https://openalex.org/W4319349905","https://openalex.org/W4254264677","https://openalex.org/W4322758819","https://openalex.org/W4205225795","https://openalex.org/W2753469281","https://openalex.org/W3210439600","https://openalex.org/W2791244279","https://openalex.org/W4386818334","https://openalex.org/W2920448452"],"abstract_inverted_index":{"BACKGROUND:":[0],"APPRECIATE":[1,234,255],"is":[2],"a":[3,166],"multinational,":[4],"observational,":[5],"retrospective,":[6],"cross-sectional":[7],"study":[8],"in":[9,33,70,169,194,205,233,248,276],"patients":[10,27,53,64,115,144,161,269],"treated":[11,30,69],"for":[12,262],"psoriasis":[13,29,42,68,263],"with":[14,28,31,44,65,209],"apremilast,":[15],"an":[16],"oral":[17],"phosphodiesterase":[18],"4":[19],"inhibitor.":[20],"OBJECTIVES:":[21],"To":[22],"describe":[23],"the":[24,34,50,257],"characteristics":[25],"of":[26,41,52,143,153,196,203,212,224,251,260,267,281],"apremilast":[32,45,81,149,204,261,287],"clinical":[35,71,192,249],"setting,":[36],"to":[37,47],"evaluate":[38],"real-world":[39,258],"outcomes":[40],"treatment":[43,57,117,150,213],"and":[46,54,92,95,126,133,180,229,272,279],"better":[48],"understand":[49],"perspectives":[51],"physicians":[55],"on":[56,200],"outcomes.":[58],"METHODS:":[59],"In":[60,113,160],"six":[61],"European":[62],"countries,":[63],"chronic":[66],"plaque":[67],"practice":[72],"who":[73,246],"could":[74],"be":[75],"contacted":[76],"6":[77,139,283],"(\u00b11)":[78,140,284],"months":[79,285],"after":[80,286],"initiation":[82],"were":[83,99,107,129,226],"enrolled.":[84],"Patient":[85,183],"characteristics,":[86],"Dermatology":[87],"Life":[88],"Quality":[89],"Index":[90,97,185],"(DLQI)":[91],"Psoriasis":[93],"Area":[94],"Severity":[96],"(PASI)":[98],"obtained":[100],"from":[101,254],"medical":[102],"records":[103],"when":[104],"available.":[105],"Outcomes":[106],"evaluated":[108],"using":[109],"patient/physician":[110],"questionnaires.":[111],"RESULTS:":[112],"480":[114],"at":[116],"initiation,":[118],"mean":[119,172,181],"[median;":[120],"95%":[121],"confidence":[122],"interval":[123],"(CI)]":[124],"PASI":[125,170],"DLQI":[127,175],"scores":[128],"12.5":[130],"(10.7;":[131],"11.6-13.4)":[132],"13.4":[134],"(13.0;":[135],"11.4-14.2),":[136],"respectively.":[137],"At":[138],"months,":[141],"72.3%":[142],"(n":[145],"=":[146,216],"347)":[147],"continued":[148,270],"[discontinuations:":[151],"lack":[152],"efficacy":[154],"(13.5%),":[155],"safety":[156],"(11.7%),":[157],"other":[158],"(2.5%)].":[159],"continuing":[162],"treatment,":[163,264],"48.6%":[164],"achieved":[165],"\u226575%":[167],"reduction":[168],"score;":[171],"(95%":[173],"CI)":[174],"score":[176,186],"was":[177,187],"5.7":[178],"(4.5-6.9),":[179],"(SD)":[182],"Benefit":[184],"2.8":[188],"(1.2).":[189],"Physicians":[190],"perceived":[191],"improvement":[193,275],"75.6%":[195],"patients.":[197],"Physicians'":[198],"perspective":[199],"overall":[201],"success":[202],"meeting":[206],"expectations":[207],"correlated":[208],"patients'":[210],"perception":[211],"benefit":[214],"(r":[215],"0.691).":[217],"Most":[218],"commonly":[219],"reported":[220,235],"adverse":[221],"events":[222],"(>5%":[223],"patients)":[225],"diarrhoea,":[227],"nausea":[228],"headache.":[230],"CONCLUSIONS:":[231],"Patients":[232],"high":[236],"disease":[237,277],"burden":[238],"despite":[239],"more":[240],"moderate":[241],"skin":[242],"involvement":[243],"than":[244],"those":[245],"enrolled":[247],"trials":[250],"apremilast.":[252],"Findings":[253],"demonstrate":[256],"value":[259],"as":[265],"7":[266],"10":[268],"therapy":[271],"showed":[273],"notable":[274],"severity":[278],"quality":[280],"life":[282],"initiation.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-04-17T00:00:00"}