{"id":"https://openalex.org/W3015583380","doi":"https://doi.org/10.1208/s12249-020-01656-6","title":"Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema","display_name":"Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3015583380","doi":"https://doi.org/10.1208/s12249-020-01656-6","mag":"3015583380","pmid":"https://pubmed.ncbi.nlm.nih.gov/32291553"},"language":"en","primary_location":{"id":"doi:10.1208/s12249-020-01656-6","doi":"https://doi.org/10.1208/s12249-020-01656-6","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-020-01656-6","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049521775","display_name":"Heba Farouk Salem","orcid":"https://orcid.org/0000-0002-4711-8511","observed_orcids":["https://orcid.org/0000-0002-4711-8511","https://orcid.org/0000-0002-4507-413X"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Heba F. Salem","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt. hebasalem858@yahoo.com","Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt. hebasalem858@yahoo.com","institution_ids":["https://openalex.org/I113643904"]},{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064879787","display_name":"Mohamed M. Nafady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed M. Nafady","raw_affiliation_strings":["Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt","institution_ids":["https://openalex.org/I2799409690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028331711","display_name":"Rasha M. Kharshoum","orcid":"https://orcid.org/0000-0003-0742-4028","observed_orcids":["https://orcid.org/0000-0003-0742-4028"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rasha M. Kharshoum","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104021449","display_name":"Omnia A. M. Abd El\u2010Ghafar","orcid":"https://orcid.org/0000-0002-0349-7193","observed_orcids":["https://orcid.org/0000-0002-0349-7193","https://orcid.org/0000-0001-7594-7459"]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Omnia A. Abd el-Ghafar","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt","institution_ids":["https://openalex.org/I2799409690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069821684","display_name":"Hanan Osman Farouk","orcid":"https://orcid.org/0000-0001-8272-3189","observed_orcids":["https://orcid.org/0000-0001-8272-3189"]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hanan O. Farouk","raw_affiliation_strings":["Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt","institution_ids":["https://openalex.org/I2799409690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049521775"],"corresponding_institution_ids":["https://openalex.org/I113643904"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":null,"fwci":1.5656,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.77697058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"113","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapoxetine-hydrochloride","display_name":"dapoxetine hydrochloride","score":0.9490000009536743},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nanogels","display_name":"nanogels","score":0.7239999771118164},{"id":"https://openalex.org/keywords/carbopol-971p","display_name":"Carbopol 971P","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.765999972820282},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/in-vivo-pharmacokinetics","display_name":"in vivo pharmacokinetics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.9024538993835449},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.6863047480583191},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5726730823516846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.557879626750946},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.44014492630958557},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.43308961391448975},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.41439008712768555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26833677291870117},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14699849486351013},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1457568109035492},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08354341983795166},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.04469352960586548},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1208/s12249-020-01656-6","doi":"https://doi.org/10.1208/s12249-020-01656-6","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-020-01656-6","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},{"id":"pmid:32291553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32291553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W967207246","https://openalex.org/W1554533455","https://openalex.org/W1928078716","https://openalex.org/W1972165921","https://openalex.org/W1974007378","https://openalex.org/W1980370496","https://openalex.org/W1981164474","https://openalex.org/W1994620235","https://openalex.org/W2003360832","https://openalex.org/W2006821165","https://openalex.org/W2008067040","https://openalex.org/W2010039501","https://openalex.org/W2011819473","https://openalex.org/W2028359946","https://openalex.org/W2030784829","https://openalex.org/W2034590270","https://openalex.org/W2046821342","https://openalex.org/W2051292995","https://openalex.org/W2057096079","https://openalex.org/W2059118067","https://openalex.org/W2060198845","https://openalex.org/W2062474373","https://openalex.org/W2067407703","https://openalex.org/W2069295596","https://openalex.org/W2072790660","https://openalex.org/W2075657946","https://openalex.org/W2076378379","https://openalex.org/W2102279441","https://openalex.org/W2103622241","https://openalex.org/W2122710372","https://openalex.org/W2175851332","https://openalex.org/W2221872019","https://openalex.org/W2262538191","https://openalex.org/W2299031941","https://openalex.org/W2317241847","https://openalex.org/W2337492846","https://openalex.org/W2400425349","https://openalex.org/W2470630503","https://openalex.org/W2558522085","https://openalex.org/W2561985937","https://openalex.org/W2593626546","https://openalex.org/W2596705401","https://openalex.org/W2603978658","https://openalex.org/W2610305759","https://openalex.org/W2734929607","https://openalex.org/W2749482157","https://openalex.org/W2774977654","https://openalex.org/W2805779846","https://openalex.org/W2886354371","https://openalex.org/W2888191993","https://openalex.org/W2892506986","https://openalex.org/W2967691925","https://openalex.org/W2995843861","https://openalex.org/W4285719527","https://openalex.org/W4367483734"],"related_works":["https://openalex.org/W2057559499","https://openalex.org/W2157916773","https://openalex.org/W3009481919","https://openalex.org/W2857701072","https://openalex.org/W2028359946","https://openalex.org/W2811192144","https://openalex.org/W2955692754","https://openalex.org/W2098296223","https://openalex.org/W2328912079","https://openalex.org/W4319595164"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-04-17T00:00:00"}