{"id":"https://openalex.org/W3015501020","doi":"https://doi.org/10.1096/fasebj.21.5.a136-a","title":"Life and Death of Neurons in the Aging Cerebral Cortex","display_name":"Life and Death of Neurons in the Aging Cerebral Cortex","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W3015501020","doi":"https://doi.org/10.1096/fasebj.21.5.a136-a","mag":"3015501020"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a136-a","doi":"https://doi.org/10.1096/fasebj.21.5.a136-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a136-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045886993","display_name":"John H. Morrison","orcid":"https://orcid.org/0000-0002-8292-0964","observed_orcids":["https://orcid.org/0000-0002-8292-0964"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H. Morrison","raw_affiliation_strings":["Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY, 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY, 10029","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045886993"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.2112,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64842635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-brain-aging","display_name":"normal brain aging","score":0.7239999771118164},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.49000000953674316},{"id":"https://openalex.org/keywords/synaptic-changes","display_name":"synaptic changes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6039999723434448},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8069859147071838},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6020681858062744},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5819370746612549},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.5419749021530151},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5363847613334656},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4899982511997223},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.484609454870224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4418959617614746},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4359838366508484},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4294036626815796},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.369037926197052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27375277876853943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11323943734169006},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a136-a","doi":"https://doi.org/10.1096/fasebj.21.5.a136-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a136-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986909933","https://openalex.org/W2497884452","https://openalex.org/W1584384737","https://openalex.org/W2062322562","https://openalex.org/W1578061035","https://openalex.org/W2023831571","https://openalex.org/W2019249853","https://openalex.org/W2119175433","https://openalex.org/W2114881111","https://openalex.org/W1544696258"],"abstract_inverted_index":{"The":[0,54,78],"human":[1],"brain":[2],"is":[3,34,84,171],"uniquely":[4],"powerful":[5],"with":[6,45],"respect":[7],"to":[8,25,29,36,67,95],"cognitive":[9,110,126,131,169],"abilities,":[10],"yet":[11],"the":[12,38,58,65,68,105,135,147],"hippocampal":[13],"and":[14,57,75,104,134,150],"neocortical":[15],"circuits":[16,56,151],"that":[17,61,146,152],"mediate":[18],"such":[19,49,182],"complex":[20],"functions":[21],"are":[22,64,156],"highly":[23],"vulnerable":[24,157],"aging.":[26,77],"In":[27],"order":[28],"understand":[30],"normal":[31,76,159],"aging,":[32,160],"it":[33],"instructive":[35],"review":[37],"major":[39],"elements":[40],"of":[41,81,91,98,109,113,140,196],"circuit":[42],"degeneration":[43,90],"associated":[44],"a":[46,96,128],"neurodegenerative":[47],"disorder":[48],"as":[50,118,191],"Alzheimer's":[51],"disease":[52],"(AD).":[53],"corticocortical":[55],"pyramidal":[59],"neurons":[60,83,93,149],"provide":[62],"them":[63],"key":[66],"functional":[69],"deficits":[70],"seen":[71],"in":[72,87,130,154,158,166,177],"both":[73],"AD":[74,117,155],"selective":[79],"vulnerability":[80],"these":[82],"profoundly":[85],"manifested":[86],"AD,":[88,167],"where":[89],"select":[92],"leads":[94],"disconnection":[97],"cortical":[99],"regions":[100],"from":[101],"each":[102],"other,":[103],"near":[106],"complete":[107],"loss":[108],"abilities.":[111],"Most":[112],"us":[114],"will":[115,123],"avoid":[116],"we":[119],"age.":[120],"However,":[121],"many":[122],"experience":[124],"age\u2010associated":[125,168],"impairment,":[127],"decline":[129],"status,":[132],"memory,":[133],"capacity":[136],"for":[137],"strategic":[138],"use":[139],"acquired":[141],"information.":[142],"Animal":[143],"studies":[144,195],"suggest":[145],"same":[148],"degenerate":[153],"however,":[161],"while":[162],"neuron":[163],"death":[164],"predominates":[165],"impairment":[170],"likely":[172],"mediated":[173],"by":[174,193],"synaptic":[175,184],"alterations":[176,185],"otherwise":[178],"intact":[179],"circuits.":[180],"Fortunately,":[181],"age\u2010related":[183],"may":[186],"be":[187],"preventable":[188],"or":[189],"reversible,":[190],"suggested":[192],"recent":[194],"hormone":[197],"replacement.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-17T00:00:00"}
