{"id":"https://openalex.org/W3015494074","doi":"https://doi.org/10.3390/cells9040899","title":"Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling","display_name":"Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling","publication_year":2020,"publication_date":"2020-04-07","ids":{"openalex":"https://openalex.org/W3015494074","doi":"https://doi.org/10.3390/cells9040899","mag":"3015494074","pmid":"https://pubmed.ncbi.nlm.nih.gov/32272626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7226784"},"language":"en","primary_location":{"id":"doi:10.3390/cells9040899","doi":"https://doi.org/10.3390/cells9040899","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells9040899","pdf_url":"https://www.mdpi.com/2073-4409/9/4/899/pdf?version=1586420632","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/9/4/899/pdf?version=1586420632","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063382999","display_name":"Justin A. Roby","orcid":"https://orcid.org/0000-0003-2434-4273","observed_orcids":["https://orcid.org/0000-0003-2434-4273"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin A. Roby","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080217914","display_name":"Katharina Esser\u2010Nobis","orcid":"https://orcid.org/0000-0002-9027-0391","observed_orcids":["https://orcid.org/0000-0002-9027-0391"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharina Esser-Nobis","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060971075","display_name":"Elyse C Dewey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elyse C. Dewey-Verstelle","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008636012","display_name":"Marian R. Fairgrieve","orcid":"https://orcid.org/0000-0002-6911-3391","observed_orcids":["https://orcid.org/0000-0002-6911-3391"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian R. Fairgrieve","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085163852","display_name":"Johannes Schwerk","orcid":"https://orcid.org/0000-0002-5964-7162","observed_orcids":["https://orcid.org/0000-0002-5964-7162"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johannes Schwerk","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041107267","display_name":"Amy Y. Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Y. Lu","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","Departments of Global Health and Microbiology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Departments of Global Health and Microbiology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021768841","display_name":"Frank W. Soveg","orcid":"https://orcid.org/0000-0002-3403-0190","observed_orcids":["https://orcid.org/0000-0002-3403-0190"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank W. Soveg","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005537326","display_name":"Emily A. Hemann","orcid":"https://orcid.org/0000-0002-6398-3492","observed_orcids":["https://orcid.org/0000-0002-6398-3492"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily A. Hemann","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002594374","display_name":"Lauren D. Hatfield","orcid":"https://orcid.org/0000-0003-0095-9863","observed_orcids":["https://orcid.org/0000-0003-0095-9863"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren D. Hatfield","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065697337","display_name":"Brian C. Keller","orcid":"https://orcid.org/0000-0003-2997-6712","observed_orcids":["https://orcid.org/0000-0003-2997-6712"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Keller","raw_affiliation_strings":["Division of Pulmonary, Critical Care & Sleep Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Critical Care & Sleep Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110676380","display_name":"Alexander Shapiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Shapiro","raw_affiliation_strings":["Shorewood High School, Shoreline, WA 98133, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shorewood High School, Shoreline, WA 98133, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022895534","display_name":"Adriana Forero","orcid":"https://orcid.org/0000-0002-2698-658X","observed_orcids":["https://orcid.org/0000-0002-2698-658X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Forero","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006025965","display_name":"Jennifer Stencel-Baerenwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Stencel-Baerenwald","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033518970","display_name":"Ram Savan","orcid":"https://orcid.org/0000-0002-3087-1355","observed_orcids":["https://orcid.org/0000-0002-3087-1355"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Savan","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031994519","display_name":"Michael Gale","orcid":"https://orcid.org/0000-0002-6332-7436","observed_orcids":["https://orcid.org/0000-0002-6332-7436"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Gale","raw_affiliation_strings":["Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","Departments of Global Health and Microbiology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Departments of Global Health and Microbiology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031994519","https://openalex.org/A5063382999"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":5.2416,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.96385682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"899","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavivirus","display_name":"flavivirus","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ns5-protein","display_name":"NS5 protein","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9629999995231628},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.6600000262260437},{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":1.0},{"id":"https://openalex.org/keywords/japanese-encephalitis-virus","display_name":"Japanese encephalitis virus","score":1.0},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7170000076293945},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.7082304954528809},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.6040953397750854},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.5190213918685913},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.5143481492996216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40628767013549805},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3652280569076538},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.34043872356414795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3332257866859436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2927730083465576},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2345360815525055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1719059944152832},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.13346216082572937},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0781853199005127},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.07357430458068848},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005416","descriptor_name":"Flavivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/cells9040899","doi":"https://doi.org/10.3390/cells9040899","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells9040899","pdf_url":"https://www.mdpi.com/2073-4409/9/4/899/pdf?version=1586420632","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7226784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7226784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:32272626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32272626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/e4e6562e-7641-4d53-b0f8-8208e9414346","doi":null,"is_oa":true,"landing_page_url":"https://researchoutput.csu.edu.au/en/publications/e4e6562e-7641-4d53-b0f8-8208e9414346","pdf_url":null,"source":{"id":"https://openalex.org/S7407055442","display_name":"Charles Sturt University Research Output (CRO)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Roby, J, Esser-Nobis, K, Dewey-Verstelle, E C, Fairgrieve, M R, Schwerk, J, Lu, A Y, Soveg, F W, Hemann, E A, Hatfield, L D, Keller, B C, Shapiro, A, Forero, A, Stencel-Baerenwald, J E, Savan, R & Gale Jr, M 2020, 'Flavivirus nonstructural protein NS5 Dysregulates HSP90 to broadly inhibit JAK/STAT signaling', Cells, vol. 9, no. 4, 899. https://doi.org/10.3390/cells9040899","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7543d266fff34f83bec7f5bdfb8814df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7543d266fff34f83bec7f5bdfb8814df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 9, Iss 4, p 899 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells9040899","doi":"https://doi.org/10.3390/cells9040899","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells9040899","pdf_url":"https://www.mdpi.com/2073-4409/9/4/899/pdf?version=1586420632","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2550824027","display_name":"Mechanisms of hepatic innate immune activation by HCV","funder_award_id":"R01AI127463","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3932161418","display_name":"Diseases of Public Health Importance Training Grant","funder_award_id":"T32AI007509","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5042967494","display_name":"Innate Immune Regulation of Zika Virus Infection","funder_award_id":"R01AI145296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G515833432","display_name":"Systems Immunogenetics of Biodefense and Emerging Pathogens in the Collaborative Cross","funder_award_id":"U19AI100625","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5635967129","display_name":"Innate Immune Control of West Nile Virus","funder_award_id":"R01AI104002","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5765432358","display_name":"Training in Cellular and Molecular Biology","funder_award_id":"T32GM007270","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7800275620","display_name":"Regulation of dendritic cell function and protective respiratory immunity by interferon-lambda","funder_award_id":"17POST33660907","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G7970403308","display_name":null,"funder_award_id":"T32AI106667","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G875107404","display_name":"JAK-STAT Control of Zika Virus-Induced Fetal Injury","funder_award_id":"R01AI143265","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000141081","display_name":null,"funder_award_id":"AI100625","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3015494074.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1511651354","https://openalex.org/W1966626624","https://openalex.org/W1970308473","https://openalex.org/W1971598496","https://openalex.org/W1973646620","https://openalex.org/W1976308168","https://openalex.org/W1984150038","https://openalex.org/W1991407510","https://openalex.org/W2000177767","https://openalex.org/W2014480740","https://openalex.org/W2028190215","https://openalex.org/W2040191194","https://openalex.org/W2042876447","https://openalex.org/W2055972388","https://openalex.org/W2067487872","https://openalex.org/W2071467437","https://openalex.org/W2074324320","https://openalex.org/W2078998316","https://openalex.org/W2095801529","https://openalex.org/W2097088780","https://openalex.org/W2097212976","https://openalex.org/W2108394487","https://openalex.org/W2111907482","https://openalex.org/W2126573043","https://openalex.org/W2135103913","https://openalex.org/W2137630130","https://openalex.org/W2141267333","https://openalex.org/W2150409982","https://openalex.org/W2160633018","https://openalex.org/W2163739062","https://openalex.org/W2167300249","https://openalex.org/W2169456871","https://openalex.org/W2294983505","https://openalex.org/W2307185071","https://openalex.org/W2472922462","https://openalex.org/W2519646798","https://openalex.org/W2528733278","https://openalex.org/W2538612363","https://openalex.org/W2554758214","https://openalex.org/W2606824156","https://openalex.org/W2611036348","https://openalex.org/W2759977828","https://openalex.org/W2786279130","https://openalex.org/W2807413300","https://openalex.org/W2889179923","https://openalex.org/W2909387480","https://openalex.org/W2912833486","https://openalex.org/W2951376956","https://openalex.org/W2967347210","https://openalex.org/W4211002680"],"related_works":["https://openalex.org/W2395416726","https://openalex.org/W2554758214","https://openalex.org/W3111508870","https://openalex.org/W2042876447","https://openalex.org/W2085114433","https://openalex.org/W6901992766","https://openalex.org/W2169072742","https://openalex.org/W2602603511","https://openalex.org/W4387798834","https://openalex.org/W2903838789"],"abstract_inverted_index":{"Pathogenic":[0],"flaviviruses":[1,22],"antagonize":[2],"host":[3],"cell":[4],"Janus":[5,59],"kinase/signal":[6],"transducer":[7],"and":[8,62,82,93],"activator":[9],"of":[10,15,31,65,72,91,101],"transcription":[11],"(JAK/STAT)":[12],"signaling":[13,25,103],"downstream":[14],"interferons":[16],"\u03b1/\u03b2.":[17],"Here,":[18],"we":[19],"show":[20],"that":[21],"inhibit":[23],"JAK/STAT":[24,95],"induced":[26],"by":[27,76],"a":[28,98],"wide":[29],"range":[30],"cytokines":[32],"beyond":[33],"interferon,":[34],"including":[35],"interleukins.":[36],"This":[37],"broad":[38],"inhibition":[39],"was":[40],"mapped":[41],"to":[42,49],"viral":[43,89],"nonstructural":[44],"protein":[45,53],"5":[46],"(NS5)":[47],"binding":[48],"cellular":[50],"heat":[51],"shock":[52],"90":[54],"(HSP90),":[55],"resulting":[56],"in":[57],"reduced":[58],"kinase\u2013HSP90":[60],"interaction":[61],"thus":[63],"destabilization":[64],"unchaperoned":[66],"JAKs":[67],"(and":[68],"other":[69],"kinase":[70],"clients)":[71],"HSP90":[73,92],"during":[74,105],"infection":[75],"Zika":[77],"virus,":[78,81],"West":[79],"Nile":[80],"Japanese":[83],"encephalitis":[84],"virus.":[85],"Our":[86],"studies":[87],"implicate":[88],"dysregulation":[90],"the":[94],"pathway":[96],"as":[97],"critical":[99],"determinant":[100],"cytokine":[102],"control":[104],"flavivirus":[106],"infection.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}
