{"id":"https://openalex.org/W3015487322","doi":"https://doi.org/10.1016/j.cbi.2020.109086","title":"Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation","display_name":"Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation","publication_year":2020,"publication_date":"2020-04-07","ids":{"openalex":"https://openalex.org/W3015487322","doi":"https://doi.org/10.1016/j.cbi.2020.109086","mag":"3015487322","pmid":"https://pubmed.ncbi.nlm.nih.gov/32275923"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbi.2020.109086","doi":"https://doi.org/10.1016/j.cbi.2020.109086","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2020.109086","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078112607","display_name":"Ya-Zhi Fan","orcid":"https://orcid.org/0000-0002-9150-1470","observed_orcids":["https://orcid.org/0000-0002-9150-1470"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yazhi Fan","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China. Electronic address: fanyazhi8227@163.com","Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China. Electronic address: fanyazhi8227@163.com","institution_ids":["https://openalex.org/I4210131893"]},{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512813","display_name":"Xing Yao","orcid":"https://orcid.org/0000-0003-3673-5896","observed_orcids":["https://orcid.org/0000-0003-3673-5896"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Xing","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786846","display_name":"Lei Xiong","orcid":"https://orcid.org/0000-0002-4614-4777","observed_orcids":["https://orcid.org/0000-0002-4614-4777"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xiong","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035598952","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0003-4118-6289","observed_orcids":["https://orcid.org/0000-0003-4118-6289"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianming Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078112607"],"corresponding_institution_ids":["https://openalex.org/I4210131893"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":4.99,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96576435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"324","issue":null,"first_page":"109086","last_page":"109086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sestrin2","display_name":"Sestrin2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7149999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidant-response-element","display_name":"antioxidant response element","score":0.8539999723434448},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.925000011920929},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.8818116188049316},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.840336799621582},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8233895301818848},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6806980967521667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5907976627349854},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.567416787147522},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.497221976518631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23672881722450256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2118230164051056},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1402251422405243},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000084622","descriptor_name":"Sestrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061745","descriptor_name":"Antioxidant Response Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbi.2020.109086","doi":"https://doi.org/10.1016/j.cbi.2020.109086","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2020.109086","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:32275923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32275923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W775311174","https://openalex.org/W952491933","https://openalex.org/W1812788896","https://openalex.org/W1831319365","https://openalex.org/W1972618720","https://openalex.org/W1979350693","https://openalex.org/W1981284402","https://openalex.org/W1983422848","https://openalex.org/W1987586434","https://openalex.org/W2035676834","https://openalex.org/W2043771487","https://openalex.org/W2057762456","https://openalex.org/W2066556283","https://openalex.org/W2090215555","https://openalex.org/W2102899871","https://openalex.org/W2104106422","https://openalex.org/W2147041159","https://openalex.org/W2148593034","https://openalex.org/W2152907543","https://openalex.org/W2164726552","https://openalex.org/W2198597618","https://openalex.org/W2309057657","https://openalex.org/W2383446000","https://openalex.org/W2468097483","https://openalex.org/W2499664073","https://openalex.org/W2536186876","https://openalex.org/W2589115588","https://openalex.org/W2594385119","https://openalex.org/W2622950952","https://openalex.org/W2744988474","https://openalex.org/W2808694385","https://openalex.org/W2820862309","https://openalex.org/W2889572850","https://openalex.org/W2896036304","https://openalex.org/W2901759806","https://openalex.org/W2908223750","https://openalex.org/W2909648307","https://openalex.org/W2910229477","https://openalex.org/W2911448712","https://openalex.org/W2943104900","https://openalex.org/W2956489313","https://openalex.org/W2970295815","https://openalex.org/W6757020451","https://openalex.org/W6758721452","https://openalex.org/W6767201872"],"related_works":["https://openalex.org/W3165360967","https://openalex.org/W1981976464","https://openalex.org/W2910431910","https://openalex.org/W4284958948","https://openalex.org/W2385547055","https://openalex.org/W3128475302","https://openalex.org/W2903625960","https://openalex.org/W3033024223","https://openalex.org/W3088501489","https://openalex.org/W4376224234"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}