{"id":"https://openalex.org/W3015437269","doi":"https://doi.org/10.1038/s41573-020-0065-9","title":"Leveraging preclinical models for the development of Alzheimer disease therapeutics","display_name":"Leveraging preclinical models for the development of Alzheimer disease therapeutics","publication_year":2020,"publication_date":"2020-04-08","ids":{"openalex":"https://openalex.org/W3015437269","doi":"https://doi.org/10.1038/s41573-020-0065-9","mag":"3015437269","pmid":"https://pubmed.ncbi.nlm.nih.gov/32612262"},"language":"en","primary_location":{"id":"doi:10.1038/s41573-020-0065-9","doi":"https://doi.org/10.1038/s41573-020-0065-9","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41573-020-0065-9","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022932542","display_name":"Kimberly A. Scearce-Levie","orcid":"https://orcid.org/0000-0003-0568-802X","observed_orcids":["https://orcid.org/0000-0003-0568-802X"]},"institutions":[{"id":"https://openalex.org/I4210097160","display_name":"Denali Therapeutics (United States)","ror":"https://ror.org/00pprn321","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberly Scearce-Levie","raw_affiliation_strings":["Denali Therapeutics, South San Francisco, CA, USA. scearce-levie@dnli.com","Denali Therapeutics, South San Francisco, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0568-802X","affiliations":[{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA. scearce-levie@dnli.com","institution_ids":["https://openalex.org/I4210097160"]},{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210097160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067119749","display_name":"Pascal E. Sanchez","orcid":"https://orcid.org/0000-0002-2620-5165","observed_orcids":["https://orcid.org/0000-0002-2620-5165"]},"institutions":[{"id":"https://openalex.org/I4210097160","display_name":"Denali Therapeutics (United States)","ror":"https://ror.org/00pprn321","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pascal E. Sanchez","raw_affiliation_strings":["Denali Therapeutics, South San Francisco, CA, USA. sanchez@dnli.com","Denali Therapeutics, South San Francisco, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2620-5165","affiliations":[{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA. sanchez@dnli.com","institution_ids":["https://openalex.org/I4210097160"]},{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210097160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073158589","display_name":"Joseph W. Lewcock","orcid":"https://orcid.org/0000-0003-3012-7881","observed_orcids":["https://orcid.org/0000-0003-3012-7881"]},"institutions":[{"id":"https://openalex.org/I4210097160","display_name":"Denali Therapeutics (United States)","ror":"https://ror.org/00pprn321","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph W. Lewcock","raw_affiliation_strings":["Denali Therapeutics, South San Francisco, CA, USA. lewcock@dnli.com","Denali Therapeutics, South San Francisco, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3012-7881","affiliations":[{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA. lewcock@dnli.com","institution_ids":["https://openalex.org/I4210097160"]},{"raw_affiliation_string":"Denali Therapeutics, South San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210097160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022932542","https://openalex.org/A5067119749","https://openalex.org/A5073158589"],"corresponding_institution_ids":["https://openalex.org/I4210097160"],"apc_list":null,"apc_paid":null,"fwci":2.3899,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.90854167,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"7","first_page":"447","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.8659999966621399},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5989999771118164},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/presenilin-mutations","display_name":"presenilin mutations","score":0.8209999799728394},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.925000011920929},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9300000071525574},{"id":"https://openalex.org/keywords/treatment-development","display_name":"treatment development","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.6999242305755615},{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.6877825856208801},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6262328624725342},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6209473609924316},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5617436170578003},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5375639200210571},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4676005244255066},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42246949672698975},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39927056431770325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3749089241027832},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3623925447463989},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3412218391895294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33483877778053284},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.16909730434417725},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10704472661018372},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10137996077537537},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41573-020-0065-9","doi":"https://doi.org/10.1038/s41573-020-0065-9","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41573-020-0065-9","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},{"id":"pmid:32612262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32612262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Drug discovery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":201,"referenced_works":["https://openalex.org/W1480745369","https://openalex.org/W1534454046","https://openalex.org/W1572225000","https://openalex.org/W1579606275","https://openalex.org/W1581476053","https://openalex.org/W1584834830","https://openalex.org/W1585083630","https://openalex.org/W1596984737","https://openalex.org/W1664338907","https://openalex.org/W1754645121","https://openalex.org/W1856941844","https://openalex.org/W1927066019","https://openalex.org/W1934117767","https://openalex.org/W1964049915","https://openalex.org/W1968781179","https://openalex.org/W1969828537","https://openalex.org/W1972229580","https://openalex.org/W1972361954","https://openalex.org/W1975975999","https://openalex.org/W1976140425","https://openalex.org/W1980181946","https://openalex.org/W1981310043","https://openalex.org/W1985359371","https://openalex.org/W1986154975","https://openalex.org/W1991457465","https://openalex.org/W1992430680","https://openalex.org/W1993858035","https://openalex.org/W1994964794","https://openalex.org/W1995344309","https://openalex.org/W2000536660","https://openalex.org/W2000809016","https://openalex.org/W2001834310","https://openalex.org/W2011041653","https://openalex.org/W2011195206","https://openalex.org/W2011347889","https://openalex.org/W2013706950","https://openalex.org/W2017079501","https://openalex.org/W2021181758","https://openalex.org/W2021620079","https://openalex.org/W2026592619","https://openalex.org/W2026938853","https://openalex.org/W2029073267","https://openalex.org/W2031700674","https://openalex.org/W2033672635","https://openalex.org/W2036362108","https://openalex.org/W2038659500","https://openalex.org/W2041173844","https://openalex.org/W2044799286","https://openalex.org/W2045311514","https://openalex.org/W2050212231","https://openalex.org/W2051532765","https://openalex.org/W2054388625","https://openalex.org/W2056101817","https://openalex.org/W2056414888","https://openalex.org/W2057815562","https://openalex.org/W2059548307","https://openalex.org/W2062214806","https://openalex.org/W2063967205","https://openalex.org/W2064044397","https://openalex.org/W2066792703","https://openalex.org/W2067833766","https://openalex.org/W2081388499","https://openalex.org/W2088714934","https://openalex.org/W2090271811","https://openalex.org/W2090620788","https://openalex.org/W2092132480","https://openalex.org/W2092356280","https://openalex.org/W2103139149","https://openalex.org/W2105824687","https://openalex.org/W2110888808","https://openalex.org/W2113759533","https://openalex.org/W2118935254","https://openalex.org/W2119874037","https://openalex.org/W2123047934","https://openalex.org/W2124726981","https://openalex.org/W2125866101","https://openalex.org/W2126231259","https://openalex.org/W2126800086","https://openalex.org/W2128216497","https://openalex.org/W2128613449","https://openalex.org/W2129267808","https://openalex.org/W2134323711","https://openalex.org/W2136902554","https://openalex.org/W2137516955","https://openalex.org/W2137527705","https://openalex.org/W2139046272","https://openalex.org/W2141210743","https://openalex.org/W2143955562","https://openalex.org/W2147328441","https://openalex.org/W2147654688","https://openalex.org/W2148898943","https://openalex.org/W2149469549","https://openalex.org/W2152652033","https://openalex.org/W2155344647","https://openalex.org/W2157203036","https://openalex.org/W2161771297","https://openalex.org/W2167179215","https://openalex.org/W2168130410","https://openalex.org/W2169308121","https://openalex.org/W2170039745","https://openalex.org/W2170644095","https://openalex.org/W2171526610","https://openalex.org/W2172839874","https://openalex.org/W2189737667","https://openalex.org/W2202164390","https://openalex.org/W2207047877","https://openalex.org/W2226896309","https://openalex.org/W2239130196","https://openalex.org/W2265799967","https://openalex.org/W2266996964","https://openalex.org/W2272900632","https://openalex.org/W2329336071","https://openalex.org/W2337275183","https://openalex.org/W2353776455","https://openalex.org/W2408084759","https://openalex.org/W2415660587","https://openalex.org/W2418840920","https://openalex.org/W2466890096","https://openalex.org/W2470345034","https://openalex.org/W2474343990","https://openalex.org/W2510806376","https://openalex.org/W2525538087","https://openalex.org/W2548224030","https://openalex.org/W2549366107","https://openalex.org/W2560062133","https://openalex.org/W2582618976","https://openalex.org/W2592518050","https://openalex.org/W2593638094","https://openalex.org/W2600914407","https://openalex.org/W2605401453","https://openalex.org/W2605473592","https://openalex.org/W2609022262","https://openalex.org/W2615586845","https://openalex.org/W2619332462","https://openalex.org/W2622807556","https://openalex.org/W2623352127","https://openalex.org/W2624657184","https://openalex.org/W2624768339","https://openalex.org/W2740213823","https://openalex.org/W2747341145","https://openalex.org/W2750718695","https://openalex.org/W2754890392","https://openalex.org/W2756959977","https://openalex.org/W2761726094","https://openalex.org/W2763928642","https://openalex.org/W2765738520","https://openalex.org/W2765888687","https://openalex.org/W2772451653","https://openalex.org/W2774947569","https://openalex.org/W2779463443","https://openalex.org/W2783582599","https://openalex.org/W2784206224","https://openalex.org/W2787981664","https://openalex.org/W2790842992","https://openalex.org/W2790983771","https://openalex.org/W2792018142","https://openalex.org/W2793872352","https://openalex.org/W2794458912","https://openalex.org/W2794553092","https://openalex.org/W2795504192","https://openalex.org/W2799995660","https://openalex.org/W2802659348","https://openalex.org/W2807252917","https://openalex.org/W2809913775","https://openalex.org/W2811459126","https://openalex.org/W2883703220","https://openalex.org/W2885552850","https://openalex.org/W2888662179","https://openalex.org/W2890074452","https://openalex.org/W2890556232","https://openalex.org/W2892210142","https://openalex.org/W2894203109","https://openalex.org/W2897658623","https://openalex.org/W2901473819","https://openalex.org/W2907318708","https://openalex.org/W2914396477","https://openalex.org/W2917810483","https://openalex.org/W2941510527","https://openalex.org/W2942678593","https://openalex.org/W2942813518","https://openalex.org/W2945865866","https://openalex.org/W2947469782","https://openalex.org/W2948955942","https://openalex.org/W2953373572","https://openalex.org/W2964755252","https://openalex.org/W2964940927","https://openalex.org/W2965260142","https://openalex.org/W2967807085","https://openalex.org/W2981166078","https://openalex.org/W2989361381","https://openalex.org/W2996729595","https://openalex.org/W3012091890","https://openalex.org/W3143527962","https://openalex.org/W3145943915","https://openalex.org/W3150015993","https://openalex.org/W3211563941","https://openalex.org/W4210821588","https://openalex.org/W4244315768","https://openalex.org/W4294214907","https://openalex.org/W6685155733","https://openalex.org/W7074145136"],"related_works":["https://openalex.org/W4281394547","https://openalex.org/W7201959178","https://openalex.org/W2740213823","https://openalex.org/W4417288175","https://openalex.org/W2091995002","https://openalex.org/W2607050832","https://openalex.org/W4402926058","https://openalex.org/W2889808182","https://openalex.org/W2207047877","https://openalex.org/W1976366652"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}