{"id":"https://openalex.org/W3015404173","doi":"https://doi.org/10.1136/neurintsurg-2020-015871","title":"Early neurologic decline in acute ischemic stroke patients receiving thrombolysis with large vessel occlusion and mild deficits","display_name":"Early neurologic decline in acute ischemic stroke patients receiving thrombolysis with large vessel occlusion and mild deficits","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3015404173","doi":"https://doi.org/10.1136/neurintsurg-2020-015871","mag":"3015404173","pmid":"https://pubmed.ncbi.nlm.nih.gov/32277039"},"language":"en","primary_location":{"id":"doi:10.1136/neurintsurg-2020-015871","doi":"https://doi.org/10.1136/neurintsurg-2020-015871","is_oa":false,"landing_page_url":"https://doi.org/10.1136/neurintsurg-2020-015871","pdf_url":null,"source":{"id":"https://openalex.org/S66405466","display_name":"Journal of NeuroInterventional Surgery","issn_l":"1759-8478","issn":["1759-8478","1759-8486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of NeuroInterventional Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063953856","display_name":"Vivien H Lee","orcid":"https://orcid.org/0000-0002-8615-198X","observed_orcids":["https://orcid.org/0000-0002-8615-198X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivien H Lee","raw_affiliation_strings":["Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007876349","display_name":"Gaurav Thakur","orcid":"https://orcid.org/0000-0002-1734-880X","observed_orcids":["https://orcid.org/0000-0002-1734-880X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Thakur","raw_affiliation_strings":["Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016424099","display_name":"Shahid Mehdi Nimjee","orcid":"https://orcid.org/0000-0002-0317-8731","observed_orcids":["https://orcid.org/0000-0002-0317-8731"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahid M Nimjee","raw_affiliation_strings":["Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074375389","display_name":"Patrick P. Youssef","orcid":"https://orcid.org/0000-0001-9740-2388","observed_orcids":["https://orcid.org/0000-0001-9740-2388"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick P Youssef","raw_affiliation_strings":["Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108675091","display_name":"Sushil Lakhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushil Lakhani","raw_affiliation_strings":["Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112737965","display_name":"Sharon Heaton","orcid":"https://orcid.org/0009-0006-9616-0456","observed_orcids":["https://orcid.org/0009-0006-9616-0456"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Heaton","raw_affiliation_strings":["Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070106030","display_name":"Ciaran James Powers","orcid":"https://orcid.org/0000-0001-7339-0001","observed_orcids":["https://orcid.org/0000-0001-7339-0001"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciaran J Powers","raw_affiliation_strings":["Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063953856"],"corresponding_institution_ids":["https://openalex.org/I2802841970"],"apc_list":null,"apc_paid":null,"fwci":2.8666,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.91191676,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"1085","last_page":"1087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9589999914169312},{"id":"https://openalex.org/keywords/large-vessel-occlusion","display_name":"large vessel occlusion","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nihss-score","display_name":"NIHSS score","score":0.6539999842643738},{"id":"https://openalex.org/keywords/m2-occlusion","display_name":"M2 occlusion","score":0.5260000228881836},{"id":"https://openalex.org/keywords/carotid-occlusion","display_name":"carotid artery occlusion","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.952721357345581},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.7718310356140137},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.6103772521018982},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5914690494537354},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.4575064182281494},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.42197558283805847},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38801276683807373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36370849609375},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35176020860671997},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.07219186425209045},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/neurintsurg-2020-015871","doi":"https://doi.org/10.1136/neurintsurg-2020-015871","is_oa":false,"landing_page_url":"https://doi.org/10.1136/neurintsurg-2020-015871","pdf_url":null,"source":{"id":"https://openalex.org/S66405466","display_name":"Journal of NeuroInterventional Surgery","issn_l":"1759-8478","issn":["1759-8478","1759-8486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of NeuroInterventional Surgery","raw_type":"journal-article"},{"id":"pmid:32277039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32277039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurointerventional surgery","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:neurintsurg:12/11/1085","doi":null,"is_oa":false,"landing_page_url":"http://jnis.bmj.com/cgi/content/short/12/11/1085","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1970289689","https://openalex.org/W2054456211","https://openalex.org/W2118367509","https://openalex.org/W2158681717","https://openalex.org/W2162496460","https://openalex.org/W2171165037","https://openalex.org/W2511847235","https://openalex.org/W2765850639","https://openalex.org/W2894396335","https://openalex.org/W2974862198","https://openalex.org/W4255683973"],"related_works":["https://openalex.org/W2914109571","https://openalex.org/W3016212883","https://openalex.org/W4405877421","https://openalex.org/W4402023401","https://openalex.org/W7131133154","https://openalex.org/W4323539615","https://openalex.org/W2801635281","https://openalex.org/W3179104214","https://openalex.org/W2913380254","https://openalex.org/W3136256685"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"sought":[2],"to":[3,47,115,183],"determine":[4],"the":[5,100,143,225,246],"rate":[6],"of":[7,55,63,84,210,228],"early":[8],"neurologic":[9],"decline":[10],"(END)":[11],"in":[12,163,169,208,245],"patients":[13,39,71,93,152,193,212,239],"with":[14,19,26,40,53,60,94,171,178,194,202,213,230],"acute":[15],"ischemic":[16],"stroke":[17],"(AIS)":[18],"large":[20],"vessel":[21],"occlusion":[22],"(LVO)":[23],"who":[24,42,197],"presented":[25,59,201],"mild":[27,204,215,232],"deficits":[28,216,233],"and":[29,96,108,137,150,237],"received":[30,43,198],"intravenous":[31],"tissue":[32],"plasminogen":[33],"activator":[34],"(IVtPA).":[35],"METHODS:":[36],"Among":[37,91,142,192],"1022":[38],"AIS":[41,196],"IVtPA":[44,116],"from":[45,117],"2014":[46],"2019,":[48],"we":[49],"identified":[50],"313":[51],"(30.6%)":[52],"LVO,":[54],"which":[56],"94":[57],"(30%)":[58],"National":[61],"Institute":[62],"Health":[64],"Stroke":[65],"Scale":[66],"(NIHSS)":[67],"score":[68,165],"\u22647.":[69],"Thirteen":[70],"were":[72,110,128,153,180],"excluded,":[73],"leaving":[74],"81":[75,92,144],"for":[76,242],"analysis.":[77],"END":[78,172,179,206],"was":[79,103,121,173],"defined":[80],"as":[81,129],"NIHSS":[82,98,164],"worsening":[83],"\u22654":[85],"points":[86],"within":[87],"24":[88,167],"hours.":[89],"RESULTS:":[90],"LVO":[95,126,195,211,229],"low":[97],"score,":[99],"mean":[101,113,161],"age":[102],"65.8":[104],"years":[105],"(range":[106,124,175],"25-93)":[107],"41%":[109],"female.":[111],"The":[112,160],"time":[114],"last":[118],"known":[119],"well":[120],"2.5":[122],"hours":[123,168],"0.8-7).":[125],"sites":[127],"follows:":[130],"5":[131],"(6%)":[132],"carotid,":[133],"23":[134],"(28%)":[135],"M1,":[136],"53":[138],"(65%)":[139],"M2":[140],"occlusions.":[141],"patients,":[145],"28":[146],"(34.6%)":[147],"had":[148],"END,":[149],"these":[151,238],"older":[154],"(70.8":[155],"vs":[156,188],"63.2":[157],"years,":[158],"p=0.036).":[159],"change":[162],"at":[166],"those":[170],"10.4":[174],"4-22).":[176],"Patients":[177],"less":[181],"likely":[182],"be":[184,222],"discharged":[185],"home":[186],"(25%":[187],"66%,":[189],"p=0.004).":[190],"CONCLUSIONS:":[191],"IVtPA,":[199],"30%":[200],"initial":[203,214,231],"deficits.":[205],"occurred":[207],"one-third":[209],"despite":[217],"receiving":[218],"IVtPA.":[219],"Clinicians":[220],"should":[221],"aware":[223],"that":[224],"natural":[226],"history":[227],"is":[234],"not":[235],"benign":[236],"are":[240],"eligible":[241],"rescue":[243],"thrombectomy":[244],"24-hour":[247],"window":[248],"if":[249],"they":[250],"deteriorate.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-17T00:00:00"}