{"id":"https://openalex.org/W3015167693","doi":"https://doi.org/10.1101/mcs.a004820","title":"BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition","display_name":"BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3015167693","doi":"https://doi.org/10.1101/mcs.a004820","mag":"3015167693","pmid":"https://pubmed.ncbi.nlm.nih.gov/32238401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7133746"},"language":"en","primary_location":{"id":"doi:10.1101/mcs.a004820","doi":"https://doi.org/10.1101/mcs.a004820","is_oa":true,"landing_page_url":"https://doi.org/10.1101/mcs.a004820","pdf_url":"http://molecularcasestudies.cshlp.org/content/6/2/a004820.full.pdf","source":{"id":"https://openalex.org/S4210220596","display_name":"Molecular Case Studies","issn_l":"2373-2865","issn":["2373-2865","2373-2873"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Case Studies","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://molecularcasestudies.cshlp.org/content/6/2/a004820.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004971979","display_name":"Patience Odeniyide","orcid":"https://orcid.org/0000-0002-9783-1657","observed_orcids":["https://orcid.org/0000-0002-9783-1657"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patience Obasaju","raw_affiliation_strings":["Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008383242","display_name":"Shubin Shahab","orcid":"https://orcid.org/0000-0003-2323-5892","observed_orcids":["https://orcid.org/0000-0003-2323-5892"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubin Shahab","raw_affiliation_strings":["Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103188021","display_name":"Emily A. Dunn","orcid":"https://orcid.org/0000-0003-4249-4654","observed_orcids":["https://orcid.org/0000-0003-4249-4654"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Dunn","raw_affiliation_strings":["Division of Pediatric Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","2Division of Pediatric Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"2Division of Pediatric Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009179890","display_name":"Daniel S. Rhee","orcid":"https://orcid.org/0000-0003-1895-6679","observed_orcids":["https://orcid.org/0000-0003-1895-6679"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Rhee","raw_affiliation_strings":["Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","3Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"3Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054352397","display_name":"Liqun Jiang","orcid":"https://orcid.org/0000-0002-8541-7539","observed_orcids":["https://orcid.org/0000-0002-8541-7539"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiQun Jiang","raw_affiliation_strings":["The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","4The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"4The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642378","display_name":"Jeffrey S. Dome","orcid":"https://orcid.org/0000-0002-9037-369X","observed_orcids":["https://orcid.org/0000-0002-9037-369X"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Dome","raw_affiliation_strings":["Center for Cancer and Blood Disorders, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20010, USA","5Center for Cancer and Blood Disorders, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Blood Disorders, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20010, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"5Center for Cancer and Blood Disorders, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20010, USA","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002253253","display_name":"Alan D. Friedman","orcid":"https://orcid.org/0000-0002-5615-7061","observed_orcids":["https://orcid.org/0000-0002-5615-7061"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D. Friedman","raw_affiliation_strings":["Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005154278","display_name":"Pedram Argani","orcid":"https://orcid.org/0000-0001-8797-9474","observed_orcids":["https://orcid.org/0000-0001-8797-9474"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedram Argani","raw_affiliation_strings":["The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","4The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"4The Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075174884","display_name":"Christine A. Pratilas","orcid":"https://orcid.org/0000-0002-7116-0605","observed_orcids":["https://orcid.org/0000-0002-7116-0605"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine A. Pratilas","raw_affiliation_strings":["Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"1Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"2","first_page":"a004820","last_page":"a004820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pediatric-renal-malignancy","display_name":"pediatric renal malignancy","score":0.625},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dabrafenib","display_name":"dabrafenib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.726550281047821},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6246658563613892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4978020191192627},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45664000511169434},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.4437633156776428},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4272368550300598},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4190743863582611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3465544879436493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24195247888565063},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.19517996907234192},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16417750716209412},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.15419432520866394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12658828496932983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09045413136482239}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/mcs.a004820","doi":"https://doi.org/10.1101/mcs.a004820","is_oa":true,"landing_page_url":"https://doi.org/10.1101/mcs.a004820","pdf_url":"http://molecularcasestudies.cshlp.org/content/6/2/a004820.full.pdf","source":{"id":"https://openalex.org/S4210220596","display_name":"Molecular Case Studies","issn_l":"2373-2865","issn":["2373-2865","2373-2873"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Case Studies","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7133746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7133746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harb Mol Case Stud","raw_type":"Text"},{"id":"pmid:32238401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32238401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor molecular case studies","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1101/mcs.a004820","doi":"https://doi.org/10.1101/mcs.a004820","is_oa":true,"landing_page_url":"https://doi.org/10.1101/mcs.a004820","pdf_url":"http://molecularcasestudies.cshlp.org/content/6/2/a004820.full.pdf","source":{"id":"https://openalex.org/S4210220596","display_name":"Molecular Case Studies","issn_l":"2373-2865","issn":["2373-2865","2373-2873"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Case Studies","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015167693.pdf","grobid_xml":"https://content.openalex.org/works/W3015167693.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1755477811","https://openalex.org/W1764134105","https://openalex.org/W1819015028","https://openalex.org/W1846586690","https://openalex.org/W1933537883","https://openalex.org/W1940641879","https://openalex.org/W1949194567","https://openalex.org/W1982972087","https://openalex.org/W1986660874","https://openalex.org/W1989901777","https://openalex.org/W2004295816","https://openalex.org/W2025560324","https://openalex.org/W2032211985","https://openalex.org/W2043058822","https://openalex.org/W2050573392","https://openalex.org/W2051165598","https://openalex.org/W2063609798","https://openalex.org/W2070719243","https://openalex.org/W2100614336","https://openalex.org/W2105317859","https://openalex.org/W2106451155","https://openalex.org/W2106494998","https://openalex.org/W2111404068","https://openalex.org/W2124662474","https://openalex.org/W2133427336","https://openalex.org/W2149662085","https://openalex.org/W2152454229","https://openalex.org/W2155461614","https://openalex.org/W2160766792","https://openalex.org/W2163188200","https://openalex.org/W2166262263","https://openalex.org/W2299591642","https://openalex.org/W2317706749","https://openalex.org/W2335671095","https://openalex.org/W2405758572","https://openalex.org/W2406379437","https://openalex.org/W2409383155","https://openalex.org/W2559842631","https://openalex.org/W2587527610","https://openalex.org/W2620581814","https://openalex.org/W2724458594","https://openalex.org/W2746135575","https://openalex.org/W2797061397","https://openalex.org/W2806332662","https://openalex.org/W2810955429","https://openalex.org/W2889624058","https://openalex.org/W2898608732","https://openalex.org/W2904473855","https://openalex.org/W2908805720","https://openalex.org/W2921169197","https://openalex.org/W2944256711","https://openalex.org/W2949390198","https://openalex.org/W2972559932","https://openalex.org/W3164126191","https://openalex.org/W4232880663","https://openalex.org/W4237120103"],"related_works":["https://openalex.org/W7160563345","https://openalex.org/W4400664885","https://openalex.org/W3111422905","https://openalex.org/W2139850974","https://openalex.org/W2908805720","https://openalex.org/W2025560324","https://openalex.org/W4212968644","https://openalex.org/W2339077589","https://openalex.org/W2905617672","https://openalex.org/W2809504305"],"abstract_inverted_index":{"Wilms":[0,250],"tumor":[1,251],"(WT)":[2],"is":[3,34,40],"the":[4,22,44,63,140,144,168,179,211,217,233],"most":[5],"common":[6],"renal":[7],"malignancy":[8],"of":[9,15,47,69,73,114,142,201,213,239],"childhood":[10,17],"and":[11,65,96,99,133,162,205,224],"accounts":[12],"for":[13,27,43],"6%":[14],"all":[16],"malignancies.":[18],"With":[19],"current":[20],"therapies,":[21],"5-yr":[23],"overall":[24],"survival":[25],"(OS)":[26],"children":[28],"with":[29,51,58,76,126,136,147,185,203,220,242],"unilateral":[30],"favorable":[31,80,130],"histology":[32,81,131],"WT":[33,82,132],"greater":[35],"than":[36],"85%.":[37],"The":[38,88],"prognosis":[39],"worse,":[41],"however,":[42],"roughly":[45],"15%":[46],"patients":[48],"who":[49,119],"relapse,":[50],"only":[52],"50%-80%":[53],"OS":[54],"reported":[55,107],"in":[56,94,102,111,122,247],"those":[57],"recurrence.":[59],"Herein,":[60],"we":[61],"describe":[62],"extended":[64],"detailed":[66],"clinical":[67],"course":[68],"a":[70,74,84,112,173,182,221,248],"rare":[71],"case":[72],"child":[75],"recurrent,":[77],"pulmonary":[78,148,170],"metastatic,":[79],"harboring":[83],"BRAF":[85,89,174],"V600E":[86,90,175],"mutation.":[87,176],"mutation,":[91],"commonly":[92],"found":[93],"melanoma":[95],"other":[97],"cancers,":[98],"previously":[100],"undescribed":[101],"WT,":[103],"has":[104,225],"recently":[105],"been":[106],"by":[108],"our":[109,237],"group":[110],"subset":[113],"epithelial-predominant":[115],"WT.":[116],"This":[117,231],"patient,":[118],"was":[120,134,191,196],"included":[121],"that":[123,151],"series,":[124],"presented":[125],"unilateral,":[127],"stage":[128],"1,":[129],"treated":[135],"standard":[137],"chemotherapy.":[138],"Following":[139],"completion":[141],"therapy,":[143],"patient":[145,218],"relapsed":[146],"metastatic":[149,169],"disease,":[150],"then":[152],"again":[153],"recurred":[154],"despite":[155],"an":[156],"initial":[157],"response":[158,195,223],"to":[159,236],"salvage":[160],"chemotherapy":[161],"radiation.":[163],"Next-generation":[164],"sequencing":[165],"(NGS)":[166],"on":[167],"nodule":[171],"revealed":[172],"After":[177],"weighing":[178],"therapeutic":[180],"options,":[181],"novel":[183],"approach":[184],"dual":[186],"BRAF/MEK":[187,214,243],"inhibitor":[188],"combination":[189,215],"therapy":[190,202,246],"initiated.":[192],"Complete":[193],"radiographic":[194],"observed":[197],"following":[198,210],"4":[199],"months":[200,209],"dabrafenib":[204],"trametinib.":[206],"At":[207],"12":[208],"start":[212],"treatment,":[216],"continues":[219],"complete":[222],"experienced":[226],"minimal":[227],"treatment-related":[228],"side":[229],"effects.":[230],"represents":[232],"first":[234],"case,":[235],"knowledge,":[238],"effective":[240],"treatment":[241],"molecularly":[244],"targeted":[245],"pediatric":[249],"patient.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}