{"id":"https://openalex.org/W3015167659","doi":"https://doi.org/10.1158/1078-0432.ccr-19-3809","title":"Improvements in Clinical Outcomes for BRAFV600E-Mutant Metastatic Colorectal Cancer","display_name":"Improvements in Clinical Outcomes for BRAFV600E-Mutant Metastatic Colorectal Cancer","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3015167659","doi":"https://doi.org/10.1158/1078-0432.ccr-19-3809","mag":"3015167659","pmid":"https://pubmed.ncbi.nlm.nih.gov/32253230"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-19-3809","doi":"https://doi.org/10.1158/1078-0432.ccr-19-3809","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-3809","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010668711","display_name":"Van Karlyle Morris","orcid":"https://orcid.org/0000-0002-4911-2252","observed_orcids":["https://orcid.org/0000-0002-4911-2252"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Van K. Morris","raw_affiliation_strings":["1University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-4911-2252","affiliations":[{"raw_affiliation_string":"1University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074891676","display_name":"Tanios Bekaii\u2010Saab","orcid":"https://orcid.org/0000-0001-7721-1699","observed_orcids":["https://orcid.org/0000-0001-7721-1699","https://orcid.org/0000-0003-4653-4537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanios Bekaii-Saab","raw_affiliation_strings":["2Mayo Clinic College of Medicine and Science, Phoenix, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic College of Medicine and Science, Phoenix, Arizona","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4437,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83674533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"17","first_page":"4435","last_page":"4441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7200000286102295},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.9053370952606201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7851971387863159},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6478689312934875},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6168249249458313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5238406658172607},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4480401575565338},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.43941420316696167},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4390886425971985}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-19-3809","doi":"https://doi.org/10.1158/1078-0432.ccr-19-3809","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-3809","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:32253230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32253230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1481372545","https://openalex.org/W1597604324","https://openalex.org/W1922733886","https://openalex.org/W1975946874","https://openalex.org/W1977775137","https://openalex.org/W1981335909","https://openalex.org/W1985645498","https://openalex.org/W1990376228","https://openalex.org/W1993780950","https://openalex.org/W2007420407","https://openalex.org/W2014881369","https://openalex.org/W2017177890","https://openalex.org/W2032648482","https://openalex.org/W2034820917","https://openalex.org/W2058142370","https://openalex.org/W2072599380","https://openalex.org/W2077428590","https://openalex.org/W2085633477","https://openalex.org/W2106494998","https://openalex.org/W2110682589","https://openalex.org/W2111404068","https://openalex.org/W2121545342","https://openalex.org/W2128542677","https://openalex.org/W2128794616","https://openalex.org/W2129998117","https://openalex.org/W2130443348","https://openalex.org/W2133523341","https://openalex.org/W2134519717","https://openalex.org/W2134817224","https://openalex.org/W2135454464","https://openalex.org/W2152454229","https://openalex.org/W2152490158","https://openalex.org/W2159064822","https://openalex.org/W2160766792","https://openalex.org/W2163188200","https://openalex.org/W2166262263","https://openalex.org/W2218134618","https://openalex.org/W2275877493","https://openalex.org/W2292603426","https://openalex.org/W2335671095","https://openalex.org/W2463198458","https://openalex.org/W2491982852","https://openalex.org/W2503674037","https://openalex.org/W2514466499","https://openalex.org/W2561667833","https://openalex.org/W2598954950","https://openalex.org/W2603299281","https://openalex.org/W2613375073","https://openalex.org/W2622749234","https://openalex.org/W2623231600","https://openalex.org/W2624834472","https://openalex.org/W2739132742","https://openalex.org/W2756209926","https://openalex.org/W2756233510","https://openalex.org/W2760461398","https://openalex.org/W2763245454","https://openalex.org/W2766421017","https://openalex.org/W2770795622","https://openalex.org/W2784868445","https://openalex.org/W2787132267","https://openalex.org/W2791410762","https://openalex.org/W2792898835","https://openalex.org/W2793069904","https://openalex.org/W2793725491","https://openalex.org/W2793817570","https://openalex.org/W2795700260","https://openalex.org/W2801525089","https://openalex.org/W2804813777","https://openalex.org/W2805710821","https://openalex.org/W2885095257","https://openalex.org/W2891205725","https://openalex.org/W2909618481","https://openalex.org/W2911637802","https://openalex.org/W2938280489","https://openalex.org/W2947369329","https://openalex.org/W2952596923","https://openalex.org/W2969704902","https://openalex.org/W2977895282","https://openalex.org/W2978780646","https://openalex.org/W2983284890","https://openalex.org/W3005234029","https://openalex.org/W3217485783","https://openalex.org/W4247602120","https://openalex.org/W4248090744","https://openalex.org/W7000187168"],"related_works":["https://openalex.org/W2374019147","https://openalex.org/W2370262613","https://openalex.org/W4362606997","https://openalex.org/W4361825250","https://openalex.org/W4377092742","https://openalex.org/W2015369371","https://openalex.org/W4229447658","https://openalex.org/W4386462333","https://openalex.org/W2375232943","https://openalex.org/W2363531932"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"the":[2,18,36,42,154],"last":[3],"two":[4],"decades":[5],"have":[6],"seen":[7],"a":[8],"broad":[9],"improvement":[10],"in":[11,73,122],"overall":[12,104],"survival,":[13,105],"colorectal":[14,47,55,77,96,140,160],"cancer":[15,23,78],"is":[16,162],"still":[17],"second":[19],"leading":[20],"cause":[21],"of":[22,38,76,112,138,147,158],"deaths":[24],"worldwide.":[25],"Patient":[26],"populations":[27],"continue":[28],"to":[29,35,91],"face":[30],"poor":[31,106],"disease":[32],"prognoses":[33],"due":[34],"challenges":[37],"early":[39],"detection":[40],"and":[41,61,80,89,109,150],"molecular":[43],"subtypes":[44],"driving":[45],"their":[46],"cancer.":[48,141],"Consequently,":[49,142],"many":[50],"patients":[51],"present":[52,72],"with":[53,83,102,116,118,127,145],"metastatic":[54,113,139],"cancer,":[56,97,161],"which":[57,152],"often":[58],"limits":[59],"options":[60],"shifts":[62],"treatment":[63,107,137,166],"focus":[64],"away":[65],"from":[66],"curative":[67],"interventions.":[68],"BRAFV600E":[69,98],"mutations":[70,99],"are":[71,81,100],"approximately":[74],"10%":[75],"tumors":[79,117],"associated":[82,101],"uninhibited":[84],"cell":[85],"proliferation,":[86],"reduced":[87],"apoptosis,":[88],"resistance":[90],"standard":[92],"therapeutic":[93],"options.":[94],"In":[95],"decreased":[103],"responses,":[108],"different":[110],"patterns":[111],"spread":[114],"compared":[115],"wild-type":[119],"BRAF.":[120],"Success":[121],"treating":[123],"other":[124],"BRAFV600E-mutant":[125,159],"cancers":[126],"BRAF":[128],"inhibitors":[129,146],"as":[130],"monotherapy":[131],"has":[132],"not":[133],"translated":[134],"into":[135],"efficacious":[136],"combination":[143],"therapy":[144],"BRAF,":[148],"MEK,":[149],"EGFR,":[151],"overcomes":[153],"innate":[155],"treatment-resistant":[156],"characteristics":[157],"now":[163],"recommended":[164],"by":[165],"guidelines.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-04-10T00:00:00"}
