{"id":"https://openalex.org/W3015145140","doi":"https://doi.org/10.1016/j.msec.2020.110917","title":"Incorporation of lysozyme into a mucoadhesive electrospun patch for rapid protein delivery to the oral mucosa","display_name":"Incorporation of lysozyme into a mucoadhesive electrospun patch for rapid protein delivery to the oral mucosa","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3015145140","doi":"https://doi.org/10.1016/j.msec.2020.110917","mag":"3015145140","pmid":"https://pubmed.ncbi.nlm.nih.gov/32409068"},"language":"en","primary_location":{"id":"doi:10.1016/j.msec.2020.110917","doi":"https://doi.org/10.1016/j.msec.2020.110917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.msec.2020.110917","pdf_url":"https://www.sciencedirect.com/science/article/pii/S092849311934754X/pdf","source":{"id":"https://openalex.org/S43139658","display_name":"Materials Science and Engineering C","issn_l":"0928-4931","issn":["0928-4931","1873-0191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Science and Engineering: C","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S092849311934754X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058485353","display_name":"Jake G. Edmans","orcid":"https://orcid.org/0000-0002-4539-9145","observed_orcids":["https://orcid.org/0000-0002-4539-9145"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jake G. Edmans","raw_affiliation_strings":["School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK; Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK","Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK","School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK; Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066689668","display_name":"Craig Murdoch","orcid":"https://orcid.org/0000-0001-9724-122X","observed_orcids":["https://orcid.org/0000-0001-9724-122X"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Craig Murdoch","raw_affiliation_strings":["School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046392259","display_name":"Martin E. Santocildes\u2010Romero","orcid":"https://orcid.org/0000-0003-3805-3055","observed_orcids":["https://orcid.org/0000-0003-3805-3055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin E. Santocildes-Romero","raw_affiliation_strings":["AFYX Therapeutics, Lergravsej 57, 2. tv, 2300 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFYX Therapeutics, Lergravsej 57, 2. tv, 2300 Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067078089","display_name":"Paul V. Hatton","orcid":"https://orcid.org/0000-0001-5234-1104","observed_orcids":["https://orcid.org/0000-0001-5234-1104"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul V. Hatton","raw_affiliation_strings":["School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025894707","display_name":"Helen Elizabeth Colley","orcid":"https://orcid.org/0000-0003-0053-7468","observed_orcids":["https://orcid.org/0000-0003-0053-7468"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Helen E. Colley","raw_affiliation_strings":["School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK. Electronic address: h.colley@sheffield.ac.uk","School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK. Electronic address: h.colley@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"School of Clinical Dentistry, 19 Claremont Crescent, University of Sheffield, Sheffield S10 2TA, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018262535","display_name":"Sebastian G. Spain","orcid":"https://orcid.org/0000-0001-7241-5713","observed_orcids":["https://orcid.org/0000-0001-7241-5713"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastian G. Spain","raw_affiliation_strings":["Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025894707"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":2.1792,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.87648755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"112","issue":null,"first_page":"110917","last_page":"110917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.1517000049352646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mucoadhesive-patch","display_name":"mucoadhesive patch","score":0.9240000247955322},{"id":"https://openalex.org/keywords/electrospun-nanofibers","display_name":"electrospun nanofibers","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protein-delivery","display_name":"protein delivery","score":0.8519999980926514},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9449999928474426},{"id":"https://openalex.org/keywords/eudragit-rs100","display_name":"Eudragit RS100","score":0.972000002861023},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.9259999990463257},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5569999814033508},{"id":"https://openalex.org/keywords/enzyme-activity-retention","display_name":"enzyme activity retention","score":0.6269999742507935},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oral-infection","display_name":"oral infection","score":0.8309999704360962},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.8464797139167786},{"id":"https://openalex.org/C144796933","wikidata":"https://www.wikidata.org/wiki/Q1533542","display_name":"Electrospinning","level":3,"score":0.6118049025535583},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.608791708946228},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5445204377174377},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.521506130695343},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5178342461585999},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.4946283996105194},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.49074873328208923},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.4307657778263092},{"id":"https://openalex.org/C2779409057","wikidata":"https://www.wikidata.org/wiki/Q1776131","display_name":"Oral mucosa","level":2,"score":0.4226093590259552},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.4169429540634155},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37135010957717896},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.24783378839492798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2118658721446991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2094673216342926},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18302083015441895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16367807984352112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14851412177085876},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07303968071937561},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.msec.2020.110917","doi":"https://doi.org/10.1016/j.msec.2020.110917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.msec.2020.110917","pdf_url":"https://www.sciencedirect.com/science/article/pii/S092849311934754X/pdf","source":{"id":"https://openalex.org/S43139658","display_name":"Materials Science and Engineering C","issn_l":"0928-4931","issn":["0928-4931","1873-0191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Science and Engineering: C","raw_type":"journal-article"},{"id":"pmid:32409068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32409068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials science & engineering. C, Materials for biological applications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:159338","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/159338/7/1-s2.0-S092849311934754X-main.pdf","pdf_url":"http://eprints.whiterose.ac.uk/159338/7/1-s2.0-S092849311934754X-main.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.msec.2020.110917","doi":"https://doi.org/10.1016/j.msec.2020.110917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.msec.2020.110917","pdf_url":"https://www.sciencedirect.com/science/article/pii/S092849311934754X/pdf","source":{"id":"https://openalex.org/S43139658","display_name":"Materials Science and Engineering C","issn_l":"0928-4931","issn":["0928-4931","1873-0191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Science and Engineering: C","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3764639493","display_name":null,"funder_award_id":"EP/ L016281","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3947294123","display_name":"EPSRC Centre for Doctoral Training in Polymers, Soft Matter and Colloids","funder_award_id":"EP/L016281/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6869095645","display_name":null,"funder_award_id":"2128145","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015145140.pdf","grobid_xml":"https://content.openalex.org/works/W3015145140.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W60759778","https://openalex.org/W1496461131","https://openalex.org/W1532610717","https://openalex.org/W1548962750","https://openalex.org/W1559832400","https://openalex.org/W1717267491","https://openalex.org/W1972778990","https://openalex.org/W1974397513","https://openalex.org/W1979516644","https://openalex.org/W1989748817","https://openalex.org/W1993298115","https://openalex.org/W1997576911","https://openalex.org/W2004272248","https://openalex.org/W2013796894","https://openalex.org/W2017998764","https://openalex.org/W2025969146","https://openalex.org/W2027843124","https://openalex.org/W2027920506","https://openalex.org/W2029980933","https://openalex.org/W2032999290","https://openalex.org/W2048874935","https://openalex.org/W2049483740","https://openalex.org/W2065699286","https://openalex.org/W2069365129","https://openalex.org/W2077287304","https://openalex.org/W2082833445","https://openalex.org/W2083672158","https://openalex.org/W2106727463","https://openalex.org/W2112446084","https://openalex.org/W2113269648","https://openalex.org/W2121748291","https://openalex.org/W2122675955","https://openalex.org/W2127068727","https://openalex.org/W2134916694","https://openalex.org/W2138250682","https://openalex.org/W2144673413","https://openalex.org/W2157174496","https://openalex.org/W2159505559","https://openalex.org/W2167279371","https://openalex.org/W2335178464","https://openalex.org/W2597365136","https://openalex.org/W2724823461","https://openalex.org/W2727966947","https://openalex.org/W2808035335","https://openalex.org/W2966351938","https://openalex.org/W4254689880"],"related_works":["https://openalex.org/W6983580533","https://openalex.org/W4406557379","https://openalex.org/W4381550758","https://openalex.org/W2597365136","https://openalex.org/W2990089642","https://openalex.org/W4416969271","https://openalex.org/W4297982815","https://openalex.org/W4292858692","https://openalex.org/W7202301928","https://openalex.org/W2808035335"],"abstract_inverted_index":{"The":[0,87,141],"delivery":[1,61,216,223],"of":[2,11,118,128,147,156,158,186,224],"biopharmaceuticals":[3],"to":[4,17,30,62,180,227],"the":[5,63,92,116,145,148,190,205,214,222,228],"oral":[6,64,149,170,229],"mucosa":[7],"offers":[8],"a":[9,70,95,163],"range":[10],"potential":[12,164,220],"applications":[13],"including":[14],"antimicrobial":[15,72],"peptides":[16],"treat":[18],"resistant":[19],"infections,":[20],"growth":[21,146],"factors":[22],"for":[23,32,59,166,221],"tissue":[24],"regeneration,":[25],"or":[26],"as":[27,69],"an":[28,52,84,199],"alternative":[29],"injections":[31],"systemic":[33],"delivery.":[34],"Existing":[35],"formulations":[36],"targeting":[37],"this":[38],"site":[39],"are":[40],"typically":[41],"non-specific":[42],"and":[43,74,112,120,126,136,161,168,189],"provide":[44],"little":[45],"control":[46],"over":[47],"dose.":[48],"To":[49],"address":[50],"this,":[51],"electrospun":[53],"dual-layer":[54,192],"mucoadhesive":[55],"patch":[56],"was":[57,67,178],"investigated":[58],"protein":[60,73,93],"mucosa.":[65,230],"Lysozyme":[66],"used":[68],"model":[71],"incorporated":[75],"into":[76],"poly(vinylpyrrolidone)/Eudragit":[77],"RS100":[78],"polymer":[79,121],"nanofibers":[80],"using":[81,198],"electrospinning":[82],"from":[83],"ethanol/water":[85],"mixture.":[86],"resulting":[88,191],"fibrous":[89],"membranes":[90],"released":[91,142],"at":[94],"clinically":[96],"desirable":[97],"rate,":[98],"reaching":[99],"90":[100],"\u00b1":[101,134,138],"13%":[102],"cumulative":[103],"release":[104],"after":[105],"2":[106],"h.":[107],"Dual":[108],"fluorescent":[109],"fibre":[110],"labelling":[111],"confocal":[113],"microscopy":[114],"demonstrated":[115],"homogeneity":[117],"lysozyme":[119,143],"distribution.":[122],"High":[123],"encapsulation":[124],"efficiency":[125],"preservation":[127],"enzyme":[129,187],"activity":[130,160],"were":[131,208],"achieved":[132],"(93.4":[133],"7.0%":[135],"96.1":[137],"3.3%":[139],"respectively).":[140],"inhibited":[144],"bacterium":[150],"Streptococcus":[151],"ratti,":[152],"providing":[153],"further":[154],"evidence":[155],"retention":[157],"biological":[159],"illustrating":[162],"application":[165],"treating":[167],"preventing":[169],"infections.":[171],"An":[172],"additional":[173],"protective":[174],"poly(caprolactone)":[175],"backing":[176],"layer":[177],"introduced":[179],"promote":[181],"unidirectional":[182],"delivery,":[183],"without":[184],"loss":[185],"activity,":[188],"patches":[193],"displayed":[194],"long":[195],"residence":[196],"times":[197],"in":[200],"vitro":[201],"test,":[202],"showing":[203],"that":[204,213],"adhesive":[206],"properties":[207],"maintained.":[209],"This":[210],"study":[211],"demonstrates":[212],"drug":[215],"system":[217],"has":[218],"great":[219],"therapeutic":[225],"proteins":[226]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-04-10T00:00:00"}