{"id":"https://openalex.org/W3015072425","doi":"https://doi.org/10.1002/jsfa.10400","title":"Nano\u2010vesicular formulation of propolis and cytotoxic effects in a 3D spheroid model of lung cancer","display_name":"Nano\u2010vesicular formulation of propolis and cytotoxic effects in a 3D spheroid model of lung cancer","publication_year":2020,"publication_date":"2020-04-02","ids":{"openalex":"https://openalex.org/W3015072425","doi":"https://doi.org/10.1002/jsfa.10400","mag":"3015072425","pmid":"https://pubmed.ncbi.nlm.nih.gov/32239766"},"language":"en","primary_location":{"id":"doi:10.1002/jsfa.10400","doi":"https://doi.org/10.1002/jsfa.10400","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.10400","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089805359","display_name":"Esra \u0130lhan-Ay\u0131\u015f\u0131\u011f\u0131","orcid":"https://orcid.org/0000-0003-1880-4261","observed_orcids":["https://orcid.org/0000-0003-1880-4261"]},"institutions":[{"id":"https://openalex.org/I204483917","display_name":"Ahi Evran University","ror":"https://ror.org/05rrfpt58","country_code":"TR","type":"education","lineage":["https://openalex.org/I204483917"]},{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esra Ilhan\u2010Ayisigi","raw_affiliation_strings":["Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","Genetic and Bioengineering Department, Faculty of Engineering and Architecture, Ahi Evran University, Kirsehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Genetic and Bioengineering Department, Faculty of Engineering and Architecture, Ahi Evran University, Kirsehir, Turkey","institution_ids":["https://openalex.org/I204483917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043536305","display_name":"Fulden Ulucan\u2010Karnak","orcid":"https://orcid.org/0000-0001-5567-0261","observed_orcids":["https://orcid.org/0000-0001-5567-0261"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fulden Ulucan","raw_affiliation_strings":["Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071651981","display_name":"Ecem Sayg\u0131l\u0131","orcid":"https://orcid.org/0000-0002-8389-9079","observed_orcids":["https://orcid.org/0000-0002-8389-9079"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ecem Saygili","raw_affiliation_strings":["Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085343254","display_name":"Pelin Saglam\u2010Metiner","orcid":"https://orcid.org/0000-0002-5726-1928","observed_orcids":["https://orcid.org/0000-0002-5726-1928"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Pelin Saglam\u2010Metiner","raw_affiliation_strings":["Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054008128","display_name":"Sultan G\u00fcl\u00e7e \u0130z","orcid":"https://orcid.org/0000-0002-9275-6272","observed_orcids":["https://orcid.org/0000-0002-9275-6272"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL","TR"],"is_corresponding":false,"raw_author_name":"Sultan Gulce\u2010Iz","raw_affiliation_strings":["Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey","Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032324154","display_name":"\u00d6zlem Ye\u015fil-\u00c7elikta\u015f","orcid":"https://orcid.org/0000-0003-4509-2212","observed_orcids":["https://orcid.org/0000-0003-4509-2212"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ozlem Yesil\u2010Celiktas","raw_affiliation_strings":["Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey","Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4509-2212","affiliations":[{"raw_affiliation_string":"Biomedical Technologies Graduate Programme, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Turkey","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032324154"],"corresponding_institution_ids":["https://openalex.org/I41641357"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":4.6828,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.95343339,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"100","issue":"8","first_page":"3525","last_page":"3535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.44749999046325684,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/niosomes","display_name":"niosomes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/galangin","display_name":"galangin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/3d-spheroid-model","display_name":"3D spheroid model","score":0.9589999914169312},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.889159083366394},{"id":"https://openalex.org/C2777302768","wikidata":"https://www.wikidata.org/wiki/Q2456591","display_name":"Galangin","level":5,"score":0.8529541492462158},{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.6707557439804077},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.6627105474472046},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.5926417112350464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5703437328338623},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5524451732635498},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4877853989601135},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.42173996567726135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21219950914382935},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1946304440498352},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.12533777952194214},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.10660725831985474},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.09961947798728943},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.07932668924331665},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jsfa.10400","doi":"https://doi.org/10.1002/jsfa.10400","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.10400","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},{"id":"pmid:32239766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32239766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the science of food and agriculture","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W653519797","https://openalex.org/W1799139420","https://openalex.org/W1972116828","https://openalex.org/W2001955647","https://openalex.org/W2007207787","https://openalex.org/W2017466143","https://openalex.org/W2030137484","https://openalex.org/W2059219385","https://openalex.org/W2082327761","https://openalex.org/W2083462231","https://openalex.org/W2085769213","https://openalex.org/W2103729271","https://openalex.org/W2106291265","https://openalex.org/W2109205889","https://openalex.org/W2111878270","https://openalex.org/W2128984725","https://openalex.org/W2136848635","https://openalex.org/W2144428994","https://openalex.org/W2145536750","https://openalex.org/W2161389630","https://openalex.org/W2184622055","https://openalex.org/W2206283449","https://openalex.org/W2431426158","https://openalex.org/W2461760632","https://openalex.org/W2488407280","https://openalex.org/W2517253057","https://openalex.org/W2523258773","https://openalex.org/W2549203378","https://openalex.org/W2586453840","https://openalex.org/W2734468281","https://openalex.org/W2750082776","https://openalex.org/W2781666028","https://openalex.org/W2792682188","https://openalex.org/W2891653767","https://openalex.org/W2896224080","https://openalex.org/W2901921442","https://openalex.org/W2922360292","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4417342986","https://openalex.org/W2980098149","https://openalex.org/W4408003857","https://openalex.org/W2794805772","https://openalex.org/W4412468303","https://openalex.org/W2609876587","https://openalex.org/W4396796000","https://openalex.org/W4221002794","https://openalex.org/W4410627494","https://openalex.org/W4322730837"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Propolis":[2],"exhibits":[3],"therapeutic":[4],"properties":[5],"due":[6],"to":[7,22,76],"the":[8,51,83,144,147],"presence":[9],"of":[10,18,62,89,113,126,133,150,180],"phenolic":[11],"acids,":[12],"esters,":[13],"and":[14,27,82,129,143,166],"flavonoids.":[15],"The":[16,94,110,138],"scope":[17],"this":[19],"study":[20],"was":[21,85,97,116,135],"develop":[23],"a":[24,29,56,90,122,162],"nano\u2010vesicular":[25],"formulation":[26],"establish":[28],"three\u2010dimensional":[30],"(3D)":[31],"spheroid":[32,80],"model":[33,81],"in":[34,140,146],"which":[35],"lung":[36,78,152],"cancer":[37,79,153],"is":[38],"recapitulated.":[39],"RESULTS":[40],"Niosome":[41],"vesicles":[42],"doped":[43],"with":[44,87,121,156],"galangin\u2010rich":[45],"propolis":[46,103],"extract":[47,104],"were":[48,74,159],"synthesized":[49],"by":[50,105],"ether":[52],"injection":[53],"method":[54],"using":[55],"cholesterol":[57],":":[58,64],"surfactant":[59],"mass":[60],"ratio":[61],"1":[63,70],"3":[65],"at":[66],"40":[67],"\u00b0C":[68],"for":[69],"h.":[71],"Formulated":[72],"niosomes":[73,158],"administered":[75],"3D":[77,148],"cytotoxicity":[84],"compared":[86],"that":[88,168],"two\u2010dimensional":[91],"(2D)":[92],"setting.":[93],"galangin":[95],"content":[96],"determined":[98],"as":[99,173],"86":[100],"\u03bcg":[101],"mg\u20131":[102],"ultra\u2010performance":[106],"liquid":[107],"chromatography":[108],"(UPLC).":[109],"particle":[111],"size":[112],"loaded":[114],"niosome":[115],"151":[117],"\u00b1":[118],"2.84":[119],"nm":[120],"polydispersity":[123],"index":[124],"(PDI)":[125],"about":[127],"0.232,":[128],"an":[130,174],"encapsulation":[131],"efficiency":[132],"70%":[134],"achieved.":[136],"CONCLUSION":[137],"decrease":[139],"cell":[141],"viability":[142],"scattering":[145],"spheroids":[149],"A549":[151],"cells":[154],"treated":[155],"propolis\u2010loaded":[157],"notable,":[160],"indicating":[161],"profound":[163],"cytotoxic":[164],"effect":[165],"suggesting":[167],"they":[169],"can":[170],"be":[171],"utilized":[172],"effective":[175],"nano\u2010vesicle.":[176],"\u00a9":[177],"2020":[178],"Society":[179],"Chemical":[181],"Industry":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}