{"id":"https://openalex.org/W3015069998","doi":"https://doi.org/10.2147/bctt.s224758","title":"Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data","display_name":"Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3015069998","doi":"https://doi.org/10.2147/bctt.s224758","mag":"3015069998","pmid":"https://pubmed.ncbi.nlm.nih.gov/32308474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7138626"},"language":"en","primary_location":{"id":"doi:10.2147/bctt.s224758","doi":"https://doi.org/10.2147/bctt.s224758","is_oa":true,"landing_page_url":"https://doi.org/10.2147/bctt.s224758","pdf_url":"https://www.dovepress.com/getfile.php?fileID=57231","source":{"id":"https://openalex.org/S4210232997","display_name":"Breast Cancer Targets and Therapy","issn_l":"1179-1314","issn":["1179-1314"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer: Targets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=57231","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072458181","display_name":"Patrick Michael Dillon","orcid":"https://orcid.org/0000-0003-0622-725X","observed_orcids":["https://orcid.org/0000-0003-0622-725X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick M Dillon","raw_affiliation_strings":["University of Virginia, Division of Hematology/Oncology, Charlottesville, VA 22908, USA"],"raw_orcid":"https://orcid.org/0000-0003-0622-725X","affiliations":[{"raw_affiliation_string":"University of Virginia, Division of Hematology/Oncology, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062167342","display_name":"Christiana M. Brenin","orcid":"https://orcid.org/0000-0002-1606-0177","observed_orcids":["https://orcid.org/0000-0002-1606-0177"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christiana M Brenin","raw_affiliation_strings":["University of Virginia, Division of Hematology/Oncology, Charlottesville, VA 22908, USA"],"raw_orcid":"https://orcid.org/0000-0002-1606-0177","affiliations":[{"raw_affiliation_string":"University of Virginia, Division of Hematology/Oncology, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090865977","display_name":"Craig Lee Slingluff","orcid":"https://orcid.org/0000-0002-6664-4373","observed_orcids":["https://orcid.org/0000-0002-6664-4373"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig L Slingluff Jr","raw_affiliation_strings":["University of Virginia, Department of Surgery, Charlottesville, VA 22908, USA"],"raw_orcid":"https://orcid.org/0000-0002-6664-4373","affiliations":[{"raw_affiliation_string":"University of Virginia, Department of Surgery, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072458181"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.9585,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.72108454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"Volume 12","issue":null,"first_page":"69","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.515999972820282},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.824999988079071},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9030720591545105},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7468547224998474},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.7318655848503113},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5747808218002319},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.5671197175979614},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5320896506309509},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.5099962949752808},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4897730350494385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47303077578544617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.360318660736084},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.27031785249710083},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2138303518295288},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2147/bctt.s224758","doi":"https://doi.org/10.2147/bctt.s224758","is_oa":true,"landing_page_url":"https://doi.org/10.2147/bctt.s224758","pdf_url":"https://www.dovepress.com/getfile.php?fileID=57231","source":{"id":"https://openalex.org/S4210232997","display_name":"Breast Cancer Targets and Therapy","issn_l":"1179-1314","issn":["1179-1314"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer: Targets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7138626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7138626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer (Dove Med Press)","raw_type":"Text"},{"id":"pmid:32308474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32308474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer (Dove Medical Press)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8f13b704edc548b7967b873fe2665815","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f13b704edc548b7967b873fe2665815","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breast Cancer: Targets and Therapy, Vol Volume 12, Pp 69-75 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/bctt.s224758","doi":"https://doi.org/10.2147/bctt.s224758","is_oa":true,"landing_page_url":"https://doi.org/10.2147/bctt.s224758","pdf_url":"https://www.dovepress.com/getfile.php?fileID=57231","source":{"id":"https://openalex.org/S4210232997","display_name":"Breast Cancer Targets and Therapy","issn_l":"1179-1314","issn":["1179-1314"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer: Targets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000901327","display_name":"University of Virginia Cancer Center Support Grant","funder_award_id":"P30CA044579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320317351","display_name":"UVA Cancer Center","ror":"https://ror.org/04w75nz84"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015069998.pdf","grobid_xml":"https://content.openalex.org/works/W3015069998.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1587782817","https://openalex.org/W1699177402","https://openalex.org/W1980575358","https://openalex.org/W2023519138","https://openalex.org/W2023685040","https://openalex.org/W2060163140","https://openalex.org/W2063236751","https://openalex.org/W2095575390","https://openalex.org/W2096833042","https://openalex.org/W2101030466","https://openalex.org/W2105584714","https://openalex.org/W2109601337","https://openalex.org/W2110250476","https://openalex.org/W2112607009","https://openalex.org/W2115439647","https://openalex.org/W2141935247","https://openalex.org/W2145136557","https://openalex.org/W2155240407","https://openalex.org/W2171515055","https://openalex.org/W2330055582","https://openalex.org/W2565898883","https://openalex.org/W2763544029","https://openalex.org/W2767308092","https://openalex.org/W2799689622","https://openalex.org/W2942554478","https://openalex.org/W3007421866","https://openalex.org/W4232529261"],"related_works":["https://openalex.org/W2330055582","https://openalex.org/W2167129525","https://openalex.org/W2316742355","https://openalex.org/W4289731414","https://openalex.org/W2807255957","https://openalex.org/W4206723637","https://openalex.org/W4322770350","https://openalex.org/W2180645599","https://openalex.org/W2061943395","https://openalex.org/W2264296375"],"abstract_inverted_index":{"Vaccine":[0],"therapies":[1],"for":[2,28,42,53,85],"treatment":[3],"and":[4,25,68,89],"prevention":[5],"of":[6,12,34,80],"cancer":[7,44],"have":[8,45],"seen":[9],"modest":[10],"degrees":[11],"efficacy":[13],"with":[14],"wide":[15],"variation":[16],"related":[17],"to":[18],"the":[19,32,35,78],"tumor":[20],"type,":[21,23],"vaccine":[22,52,59,84],"adjuvants":[24],"clinical":[26,70],"setting":[27],"their":[29],"study.":[30],"Over":[31],"course":[33],"last":[36],"two":[37],"decades,":[38],"various":[39],"peptide":[40,51,83],"vaccines":[41],"breast":[43,91],"been":[46],"studied.":[47],"The":[48],"current":[49],"leading":[50],"human":[54],"application":[55],"is":[56],"a":[57],"HER2-based":[58],"known":[60],"as":[61],"Nelipepimut-S,":[62],"which":[63],"has":[64],"demonstrated":[65],"immune":[66],"activity":[67,71],"promising":[69],"in":[72],"some":[73],"settings.":[74],"This":[75],"review":[76],"covers":[77],"development":[79],"this":[81],"newer":[82],"both":[86],"HER2":[87],"amplified":[88],"non-amplified":[90],"cancer.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}