{"id":"https://openalex.org/W3015019101","doi":"https://doi.org/10.1016/j.eclinm.2020.100303","title":"Safety and tolerability of injectable Rilpivirine LA in HPTN 076: A phase 2 HIV pre-exposure prophylaxis study in women","display_name":"Safety and tolerability of injectable Rilpivirine LA in HPTN 076: A phase 2 HIV pre-exposure prophylaxis study in women","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3015019101","doi":"https://doi.org/10.1016/j.eclinm.2020.100303","mag":"3015019101","pmid":"https://pubmed.ncbi.nlm.nih.gov/32280940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7139112"},"language":"en","primary_location":{"id":"doi:10.1016/j.eclinm.2020.100303","doi":"https://doi.org/10.1016/j.eclinm.2020.100303","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2020.100303","pdf_url":"http://www.thelancet.com/article/S258953702030047X/pdf","source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thelancet.com/article/S258953702030047X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039983859","display_name":"Linda\u2010Gail Bekker","orcid":"https://orcid.org/0000-0002-0755-4386","observed_orcids":["https://orcid.org/0000-0002-0755-4386"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"L.G. Bekker","raw_affiliation_strings":["The Desmond Tutu HIV Centre, University of Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Desmond Tutu HIV Centre, University of Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050846096","display_name":"SHUANGLING LI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Li","raw_affiliation_strings":["Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056695345","display_name":"Subash Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Pathak","raw_affiliation_strings":["Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058050986","display_name":"Elizabeth E. Tolley","orcid":"https://orcid.org/0000-0002-9823-3675","observed_orcids":["https://orcid.org/0000-0002-9823-3675"]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.E. Tolley","raw_affiliation_strings":["FHI 360, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Durham, NC, USA","institution_ids":["https://openalex.org/I1290866511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082007029","display_name":"Mark A. Marzinke","orcid":"https://orcid.org/0000-0003-1670-8786","observed_orcids":["https://orcid.org/0000-0003-1670-8786"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Marzinke","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067182786","display_name":"Jessica\u00a0E. Justman","orcid":"https://orcid.org/0000-0003-4704-3115","observed_orcids":["https://orcid.org/0000-0003-4704-3115"]},"institutions":[{"id":"https://openalex.org/I4387154024","display_name":"ICAP Global Health","ror":"https://ror.org/01f0vkh84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4387154024","https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.E. Justman","raw_affiliation_strings":["ICAP at Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICAP at Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I4387154024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004112212","display_name":"Nyaradzo Mavis Mgodi","orcid":"https://orcid.org/0000-0002-3085-5259","observed_orcids":["https://orcid.org/0000-0002-3085-5259"]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"N.M. Mgodi","raw_affiliation_strings":["University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031416879","display_name":"Michael Chirenje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153455119","display_name":"University of Zimbabwe","ror":"https://ror.org/04ze6rb18","country_code":"ZW","type":"education","lineage":["https://openalex.org/I153455119"]}],"countries":["ZW"],"is_corresponding":false,"raw_author_name":"M. Chirenje","raw_affiliation_strings":["University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe","institution_ids":["https://openalex.org/I153455119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039731539","display_name":"Shobha Swaminathan","orcid":"https://orcid.org/0000-0001-8609-3073","observed_orcids":["https://orcid.org/0000-0001-8609-3073"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Swaminathan","raw_affiliation_strings":["Rutgers New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022642666","display_name":"Adeola Adeyeye","orcid":"https://orcid.org/0000-0002-3677-6068","observed_orcids":["https://orcid.org/0000-0002-3677-6068"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Adeyeye","raw_affiliation_strings":["DAIDS/NIAID/NIH, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DAIDS/NIAID/NIH, Rockville, MD, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041162382","display_name":"Jennifer Farrior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Farrior","raw_affiliation_strings":["FHI 360, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Durham, NC, USA","institution_ids":["https://openalex.org/I1290866511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053567182","display_name":"Craig W. Hendrix","orcid":"https://orcid.org/0000-0002-5696-8665","observed_orcids":["https://orcid.org/0000-0002-5696-8665"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.W. Hendrix","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029835552","display_name":"Estelle Piwowar\u2010Manning","orcid":"https://orcid.org/0000-0002-6501-0440","observed_orcids":["https://orcid.org/0000-0002-6501-0440"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Piwowar-Manning","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Richardson","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002703624","display_name":"S.H. Eshelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.H. Eshelman","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041985430","display_name":"H. Redinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Redinger","raw_affiliation_strings":["Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Williams","raw_affiliation_strings":["Johnson and Johnson Global Public Health, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson and Johnson Global Public Health, Belgium","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053701157","display_name":"Nirupama Sista","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.D. Sista","raw_affiliation_strings":["FHI 360, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Durham, NC, USA","institution_ids":["https://openalex.org/I1290866511"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5039983859"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.5244,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80785718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"21","issue":null,"first_page":"100303","last_page":"100303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rilpivirine","display_name":"rilpivirine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/long-acting-injectable-antiretrovirals","display_name":"long-acting injectable antiretrovirals","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hiv-pre-exposure-prophylaxis","display_name":"HIV pre-exposure prophylaxis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5339999794960022},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7129999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.671999990940094},{"id":"https://openalex.org/keywords/product-acceptance","display_name":"product acceptance","score":0.5170000195503235},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.45100000500679016},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.3269999921321869},{"id":"https://openalex.org/keywords/african-women","display_name":"African women","score":0.4099999964237213},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.3930000066757202},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9457176923751831},{"id":"https://openalex.org/C2778723075","wikidata":"https://www.wikidata.org/wiki/Q421547","display_name":"Rilpivirine","level":5,"score":0.9243743419647217},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7996822595596313},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7172946929931641},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.584905743598938},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5642877221107483},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47643524408340454},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47421932220458984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3675524592399597},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.34429508447647095},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2739938497543335},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.21989324688911438},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.06756025552749634},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.eclinm.2020.100303","doi":"https://doi.org/10.1016/j.eclinm.2020.100303","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2020.100303","pdf_url":"http://www.thelancet.com/article/S258953702030047X/pdf","source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7139112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7139112","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"Text"},{"id":"pmid:32280940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32280940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:08c96beca20d4b6b84b8ac07f70f7d3c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08c96beca20d4b6b84b8ac07f70f7d3c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EClinicalMedicine, Vol 21, Iss , Pp - (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.eclinm.2020.100303","doi":"https://doi.org/10.1016/j.eclinm.2020.100303","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2020.100303","pdf_url":"http://www.thelancet.com/article/S258953702030047X/pdf","source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G6258373279","display_name":"UZ-UCSF Clinical Trials Unit","funder_award_id":"U01AI069436","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000857907","display_name":"UZ-UCSF CTU","funder_award_id":"UM1AI069436","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000860069","display_name":"HIV Prevention Trials Network Leadership and Operations Center","funder_award_id":"UM1AI068619","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000861975","display_name":"Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials Unit","funder_award_id":"UM1AI069419","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895440","display_name":"Columbia Collaborative HIV/AIDS Clinical Trials Unit","funder_award_id":"UM1AI069470","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895738","display_name":"LC: HIV PREVENTION TRIALS NETWORK","funder_award_id":"UM1AI068613","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897886","display_name":"SDMC: HIV Prevention Trials Network","funder_award_id":"UM1AI068617","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320308612","display_name":"PATH","ror":"https://ror.org/02ycvrx49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015019101.pdf","grobid_xml":"https://content.openalex.org/works/W3015019101.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1979285938","https://openalex.org/W2058499501","https://openalex.org/W2099826019","https://openalex.org/W2106408660","https://openalex.org/W2120602370","https://openalex.org/W2265390138","https://openalex.org/W2326890844","https://openalex.org/W2338216801","https://openalex.org/W2341474797","https://openalex.org/W2345950548","https://openalex.org/W2396399579","https://openalex.org/W2401613699","https://openalex.org/W2412387621","https://openalex.org/W2423803673","https://openalex.org/W2518173094","https://openalex.org/W2519933747","https://openalex.org/W2531572956","https://openalex.org/W2738541296","https://openalex.org/W2739472324","https://openalex.org/W2800724979","https://openalex.org/W2899917447","https://openalex.org/W6704575224","https://openalex.org/W6728838901"],"related_works":["https://openalex.org/W2948004532","https://openalex.org/W2519933747","https://openalex.org/W2982097452","https://openalex.org/W1866224665","https://openalex.org/W2418956875","https://openalex.org/W2396399579","https://openalex.org/W2803558969","https://openalex.org/W3179882906","https://openalex.org/W1979285938","https://openalex.org/W7128485355"],"abstract_inverted_index":{"Background":[0],"Daily":[1],"oral":[2,19,81,88,95,134,267],"TDF/FTC":[3],"is":[4,21],"protective":[5],"against":[6],"HIV":[7],"infection":[8],"when":[9],"used":[10],"for":[11,23,47,356],"pre-exposure":[12],"prophylaxis":[13],"(PrEP).":[14],"However,":[15],"daily":[16],"adherence":[17],"to":[18,73,129,169,307,314],"PrEP":[20,28,501,552],"difficult":[22],"many;":[24],"therefore,":[25],"finding":[26],"alternative":[27],"strategies":[29],"remains":[30],"a":[31,58,79,146,500],"priority.":[32],"HPTN":[33,53],"076":[34,54],"evaluated":[35],"the":[36,66,133,159,170,180,236,243,274,285,290,294,315,336,340,348,376,409,430,437,442,460,471,504,532,537,547],"long-acting":[37],"injectable":[38,115,502,551],"form":[39],"of":[40,68,84,139,179,213,326,373,412,433,463,479,550],"rilpivirine":[41],"(RPV),":[42],"known":[43],"as":[44,339],"RPV":[45,70,89,414,464,507,535],"LA":[46,71,262,299,357,377,386,508,536],"safety,":[48,150],"pharmacokinetics":[49],"and":[50,110,152,208,225,249,263,270,300,358,440,448,493,516,521,529],"acceptability.":[51],"Methods":[52],"(NTC":[55],"02165202)":[56],"was":[57,117,183,343,420,467],"phase":[59,83,338,439],"2,":[60],"double-blind,":[61],"2:1":[62],"randomized":[63,313],"trial":[64],"comparing":[65],"safety":[67],"1200mg":[69],"(LA)":[72],"placebo":[74],"(P).":[75],"The":[76,176,324],"study":[77,244,253,268,545],"included":[78],"28-day":[80],"run-in":[82,135],"daily,":[85],"self-":[86],"administered":[87,118],"(25":[90],"mg),":[91],"with":[92,318,380,396],"directly":[93],"observed":[94],"dosing":[96],"about":[97,491],"six":[98,140,233,428],"times.":[99],"Of":[100,289],"136":[101],"enrolled":[102,181],"sexually":[103],"active,":[104],"HIV-uninfected,":[105],"low":[106],"HIV-risk":[107],"African":[108,515],"(100)":[109],"US":[111,517],"(36)":[112],"adult":[113],"women,":[114],"product":[116,254,269,278,291],"in":[119,293,298,302,371,375,382,398,503,514,531],"two":[120,286,349],"gluteal,":[121],"intramuscular":[122],"(IM)":[123],"injections":[124,510,538],"once":[125],"every":[126,511],"eight":[127,512],"weeks":[128,456,513],"122":[130,214],"participants":[131,402,424,533],"following":[132],"phase.":[136,276],"A":[137,211],"maximum":[138],"injection":[141,224,237,275,295,337,392,438,444,473,526],"time":[142],"points":[143],"occurred":[144,370],"over":[145],"48-week":[147],"period.":[148],"Acceptability,":[149],"tolerability":[151],"pharmacokinetic":[153],"(PK)":[154],"data":[155,166],"were":[156,280,305,445,519,539],"collected":[157,167],"throughout":[158],"study.":[160],"This":[161],"paper":[162],"includes":[163],"primary":[164,341],"endpoint":[165],"up":[168],"week":[171,453],"52":[172,454],"post":[173],"enrollment.":[174],"Findings":[175],"median":[177,188,195],"age":[178],"population":[182],"31":[184],"years":[185],"(IQR:":[186,192,201],"25,38),":[187],"weight":[189],"75":[190],"kg":[191],"64,":[193],"89),":[194],"body":[196],"mass":[197],"index":[198],"(BMI)":[199],"30":[200],"27,":[202],"35),":[203],"46%":[204],"married,":[205],"94%":[206],"Black":[207],"60%":[209],"unemployed.":[210],"total":[212],"(80":[215],"LA,":[216,228,246,256],"42":[217],"P)":[218,230,248,265],"women":[219,240,251,260,327,374,387,480,518],"received":[220,231,404,426],"at":[221,405],"least":[222,406],"one":[223,312],"98":[226],"(64":[227],"34":[229],"all":[232,427],"injections.":[234],"During":[235],"phase,":[238,296],"three":[239],"withdrew":[241],"from":[242,543],"(2":[245],"1":[247,407],"16":[250],"discontinued":[252,266],"(10":[255],"6":[257],"P).":[258],"Fourteen":[259],"(11":[261],"3":[264,391],"did":[271],"not":[272,281,344],"enter":[273],"Study":[277],"discontinuations":[279,292],"significantly":[282,345],"different":[283,346],"between":[284,347],"arms":[287,350],"throughout.":[288],"8%":[297],"5%":[301],"P":[303,316,383,399],"arm":[304,317,378],"due":[306],"adverse":[308],"events":[309],"(AEs),":[310],"including":[311],"prolonged":[319],"QTc":[320],"interval":[321],"on":[322],"EKG.":[323],"proportion":[325],"who":[328,403,425,481],"experienced":[329],"Grade":[330,366,390],"2":[331],"or":[332],"higher":[333],"AEs":[334],"during":[335],"outcome":[342],"[73.8%,":[351],"95%":[352,360],"CI:":[353,361],"(63.2%,":[354],"82.1%)":[355],"73.8%,":[359],"(58.9%,":[362],"84.7%),":[363],"p>0.99].":[364],"Transient":[365],"\u22652":[367],"liver":[368],"abnormalities":[369],"14%":[372],"compared":[379,395],"12%":[381],"arm.":[384,400],"Three":[385],"(4%)":[388],"developed":[389],"site":[393,527],"reactions":[394,528],"none":[397],"In":[401,423],"injection,":[408],"geometric":[410,431,461],"mean":[411,432,462],"overall":[413],"trough":[415,418,466],"concentrations":[416],"(C":[417],")":[419],"62.2":[421],"ng/mL.":[422,469],"injections,":[429],"C":[434,465],"Trough":[435],"through":[436],"after":[441,457],"last":[443,458,472],"72.8":[446],"ng/mL":[447],"100.9":[449],"ng/mL,":[450],"respectively.":[451],"At":[452,470],"(eight":[455],"injection),":[459],"75.0":[468],"visit":[474],"(Week":[475],"44),":[476],"80":[477],"%":[478],"answered":[482],"acceptability":[483],"questions":[484],"strongly":[485],"agreed":[486],"that":[487,495],"they":[488,496],"would":[489,497],"think":[490],"using-":[492],"68%":[494],"definitely":[498],"use":[499],"future.":[505],"Interpretation":[506],"IM":[509],"safe":[520],"acceptable.":[522],"Overall,":[523],"despite":[524],"more":[525],"pain":[530],"receiving":[534],"well":[540],"tolerated.":[541],"Data":[542],"this":[544],"support":[546],"further":[548],"development":[549],"agents.":[553]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-04-10T00:00:00"}
