{"id":"https://openalex.org/W3015012380","doi":"https://doi.org/10.1161/circep.119.007607","title":"Protein Biomarkers and Risk of Atrial Fibrillation","display_name":"Protein Biomarkers and Risk of Atrial Fibrillation","publication_year":2020,"publication_date":"2020-01-16","ids":{"openalex":"https://openalex.org/W3015012380","doi":"https://doi.org/10.1161/circep.119.007607","mag":"3015012380","pmid":"https://pubmed.ncbi.nlm.nih.gov/31941368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7031024"},"language":"en","primary_location":{"id":"doi:10.1161/circep.119.007607","doi":"https://doi.org/10.1161/circep.119.007607","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circep.119.007607","pdf_url":null,"source":{"id":"https://openalex.org/S28979613","display_name":"Circulation Arrhythmia and Electrophysiology","issn_l":"1941-3084","issn":["1941-3084","1941-3149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Arrhythmia and Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7031024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038237898","display_name":"Laila St\u00e6rk","orcid":"https://orcid.org/0000-0001-8001-8240","observed_orcids":["https://orcid.org/0000-0001-8001-8240"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Laila Staerk","raw_affiliation_strings":["Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Helleup, Denmark (L.S.)","National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","Laila Staerk National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Helleup, Denmark (L.S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Helleup, Denmark (L.S.)","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Laila Staerk National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Helleup, Denmark (L.S.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044662521","display_name":"Sarah R. Preis","orcid":"https://orcid.org/0000-0002-9360-4166","observed_orcids":["https://orcid.org/0000-0002-9360-4166"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah R. Preis","raw_affiliation_strings":["Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA","Sarah R. Preis Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Sarah R. Preis Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017261731","display_name":"Honghuang Lin","orcid":"https://orcid.org/0000-0003-3043-3942","observed_orcids":["https://orcid.org/0000-0003-3043-3942"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Honghuang Lin","raw_affiliation_strings":["National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","Section of Computational Biomedicine (H.L.), Department of Medicine, Boston University School of Medicine, MA","Honghuang Lin National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Section of Computational Biomedicine (H.L.), Department of Medicine, Boston University School of Medicine, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Section of Computational Biomedicine (H.L.), Department of Medicine, Boston University School of Medicine, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Honghuang Lin National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Section of Computational Biomedicine (H.L.), Department of Medicine, Boston University School of Medicine, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042984133","display_name":"Steven A. Lubitz","orcid":"https://orcid.org/0000-0002-9599-4866","observed_orcids":["https://orcid.org/0000-0002-9599-4866"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Lubitz","raw_affiliation_strings":["Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","Steven A. Lubitz Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Steven A. Lubitz Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069822855","display_name":"Patrick T. Ellinor","orcid":"https://orcid.org/0000-0002-2067-0533","observed_orcids":["https://orcid.org/0000-0002-2067-0533"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick T. Ellinor","raw_affiliation_strings":["Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","Patrick T. Ellinor Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Patrick T. Ellinor Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.A.L., P.T.E.)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117194","display_name":"Daniel A Levy","orcid":"https://orcid.org/0000-0003-1843-8724","observed_orcids":["https://orcid.org/0000-0003-1843-8724"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Levy","raw_affiliation_strings":["National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","Daniel Levy National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Daniel Levy National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064309113","display_name":"Emelia J. Benjamin","orcid":"https://orcid.org/0000-0003-4076-2336","observed_orcids":["https://orcid.org/0000-0003-4076-2336"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emelia J. Benjamin","raw_affiliation_strings":["Cardiology and Preventive Medicine Sections (E.J.B.), Department of Medicine, Boston University School of Medicine, MA","Department of Epidemiology (E.J.B.), Boston University School of Public Health, MA","National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (E.J.B.)","Emelia J. Benjamin National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Department of Epidemiology (E.J.B.), Boston University School of Public Health, MA. Cardiology and Preventive Medicine Sections (E.J.B.), Department of Medicine, Boston University School of Medicine, MA. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (E.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology and Preventive Medicine Sections (E.J.B.), Department of Medicine, Boston University School of Medicine, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Epidemiology (E.J.B.), Boston University School of Public Health, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (E.J.B.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Emelia J. Benjamin National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.). Department of Epidemiology (E.J.B.), Boston University School of Public Health, MA. Cardiology and Preventive Medicine Sections (E.J.B.), Department of Medicine, Boston University School of Medicine, MA. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (E.J.B.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014513186","display_name":"Ludovic Trinquart","orcid":"https://orcid.org/0000-0002-3028-4900","observed_orcids":["https://orcid.org/0000-0002-3028-4900"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludovic Trinquart","raw_affiliation_strings":["Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA","National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics (S.R.P., L.T.), Boston University School of Public Health, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, MA (L.S., H.L., D.L., E.J.B., L.T.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7612,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.96443377,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"e007607","last_page":"e007607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/incident-atrial-fibrillation-risk","display_name":"incident atrial fibrillation risk","score":0.8050000071525574},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9390000104904175},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9490000009536743},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.6690000295639038},{"id":"https://openalex.org/keywords/framingham-offspring-cohort","display_name":"Framingham Offspring cohort","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8430184721946716},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7964837551116943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7049521803855896},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6278777122497559},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5817131996154785},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5719354152679443},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5225017666816711},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5030869841575623},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.49659067392349243},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48012256622314453},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45363837480545044},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.4280358552932739},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.4253404140472412},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.28250500559806824},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2771255373954773},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16929909586906433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/circep.119.007607","doi":"https://doi.org/10.1161/circep.119.007607","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circep.119.007607","pdf_url":null,"source":{"id":"https://openalex.org/S28979613","display_name":"Circulation Arrhythmia and Electrophysiology","issn_l":"1941-3084","issn":["1941-3084","1941-3149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Arrhythmia and Electrophysiology","raw_type":"journal-article"},{"id":"pmid:31941368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31941368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation. Arrhythmia and electrophysiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6755494","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7031024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7031024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7031024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Arrhythm Electrophysiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6755494","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7031024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3405256882","display_name":null,"funder_award_id":"HHSN268201500001C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3577564063","display_name":"AFGen Consortium: Atrial Fibrillation Genomics to Functional Analyses","funder_award_id":"R01HL128914","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8147749999","display_name":"Mentoring in Arrhythmia Research","funder_award_id":"K24HL105780","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000887157","display_name":"IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL","funder_award_id":"R01HL092577","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G917740572","display_name":"Genomics of Cardiac Arrhythmias","funder_award_id":"R01HL139731","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1924098982","https://openalex.org/W1965498798","https://openalex.org/W1967482036","https://openalex.org/W1978025072","https://openalex.org/W1986122868","https://openalex.org/W1988290507","https://openalex.org/W2000081470","https://openalex.org/W2006665600","https://openalex.org/W2008086028","https://openalex.org/W2011449660","https://openalex.org/W2023369573","https://openalex.org/W2027560922","https://openalex.org/W2034137026","https://openalex.org/W2036523102","https://openalex.org/W2045153334","https://openalex.org/W2057971268","https://openalex.org/W2068000772","https://openalex.org/W2069136548","https://openalex.org/W2097173178","https://openalex.org/W2110065044","https://openalex.org/W2113865982","https://openalex.org/W2118539594","https://openalex.org/W2120722598","https://openalex.org/W2120915876","https://openalex.org/W2122713183","https://openalex.org/W2133685977","https://openalex.org/W2133867913","https://openalex.org/W2138951209","https://openalex.org/W2145397058","https://openalex.org/W2149407433","https://openalex.org/W2153739619","https://openalex.org/W2155645904","https://openalex.org/W2167813229","https://openalex.org/W2168305767","https://openalex.org/W2278906856","https://openalex.org/W2512908020","https://openalex.org/W2513430955","https://openalex.org/W2528599788","https://openalex.org/W2585653915","https://openalex.org/W2596018199","https://openalex.org/W2609696371","https://openalex.org/W2621490222","https://openalex.org/W2766470675","https://openalex.org/W2767998629","https://openalex.org/W2768956134","https://openalex.org/W2789931151","https://openalex.org/W2792431841","https://openalex.org/W2803081342","https://openalex.org/W2883061610","https://openalex.org/W2891353305","https://openalex.org/W2910737182","https://openalex.org/W2924193458"],"related_works":["https://openalex.org/W3011608774","https://openalex.org/W2512908020","https://openalex.org/W3213961641","https://openalex.org/W4403816845","https://openalex.org/W7161286283","https://openalex.org/W2506083433","https://openalex.org/W7127914316","https://openalex.org/W2922347496","https://openalex.org/W4388686383","https://openalex.org/W2068000772"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identification":[1],"of":[2,15,22,44,74,143,156,163,171,193,201,230,235,244],"protein":[3,33,184,207],"biomarkers":[4,34],"associated":[5,166,196,240],"with":[6,139,167,197,241],"incident":[7,36,83,164,194,245],"atrial":[8],"fibrillation":[9],"(AF)":[10],"may":[11],"improve":[12],"the":[13,16,29,47,121],"understanding":[14],"pathophysiology,":[17],"risk":[18,243],"prediction,":[19],"and":[20,35,53,79,115,190,215,232,237],"development":[21],"new":[23],"therapeutics":[24],"for":[25,82,92,127],"AF.":[26,37,246],"We":[27,39,119,159],"examined":[28],"associations":[30],"between":[31],"85":[32,59],"METHODS:":[38],"included":[40],"participants":[41,136],"\u226550":[42],"years":[43],"age":[45,142],"from":[46],"FHS":[48],"(Framingham":[49],"Heart":[50],"Study)":[51],"Offspring":[52],"Third":[54],"Generation":[55],"cohorts,":[56],"who":[57],"had":[58],"fasting":[60],"plasma":[61],"proteins":[62],"measured":[63],"using":[64,87],"Luminex":[65],"xMAP":[66],"platform.":[67],"Hazard":[68],"ratios":[69],"(per":[70],"1":[71,180],"SD":[72,181],"increment":[73,182],"rank-normalized":[75],"biomarker":[76],"[hazard":[77],"ratio])":[78],"95%":[80],"CIs":[81],"AF":[84,151,165,195],"were":[85,239],"calculated":[86],"Cox":[88],"regression":[89],"models":[90],"adjusted":[91],"age,":[93],"sex,":[94],"height,":[95],"weight,":[96],"current":[97],"smoking,":[98],"systolic":[99],"blood":[100,103],"pressure,":[101,104],"diastolic":[102],"hypertension":[105],"treatment,":[106],"diabetes":[107],"mellitus,":[108],"valvular":[109],"heart":[110,117],"disease,":[111],"prevalent":[112,116],"myocardial":[113],"infarction,":[114],"failure.":[118],"used":[120],"false":[122],"discovery":[123],"rate":[124],"to":[125],"account":[126],"multiple":[128],"testing.":[129],"RESULTS:":[130],"The":[131],"study":[132],"sample":[133],"comprised":[134],"3378":[135],"(54%":[137],"women)":[138],"mean":[140,154,169,199],"(SD)":[141],"61.5":[144],"(8.4)":[145],"years.":[146,158],"In":[147],"total,":[148],"401":[149],"developed":[150],"over":[152],"a":[153],"follow-up":[155],"12.3\u00b13.8":[157],"observed":[160],"lower":[161],"hazard":[162,177,192,209,221],"higher":[168,191,198,242],"levels":[170,200,229,234],"IGF1":[172,231],"(insulin-like":[173,204],"growth":[174,205],"factor":[175],"1;":[176,208],"ratio":[178],"per":[179],"in":[183],"level,":[185],"0.84":[186],"[95%":[187,212,224],"CI,":[188,213,225],"0.76-0.93]),":[189],"both":[202],"IGFBP1":[203,236],"factor-binding":[206],"ratio,":[210,222],"1.24":[211],"1.1-1.39])":[214],"NT-proBNP":[216,238],"(N-terminal":[217],"pro-B-type":[218],"natriuretic":[219],"peptide;":[220],"1.73":[223],"1.52-1.96]).":[226],"CONCLUSIONS:":[227],"Decreased":[228],"increased":[233]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}