{"id":"https://openalex.org/W3014956775","doi":"https://doi.org/10.4314/eajph.v12i1.126695","title":"Newborn screening for hemoglobinopathies at Muhimbili National Hospital, Dar es Salaam \u2013 Tanzania","display_name":"Newborn screening for hemoglobinopathies at Muhimbili National Hospital, Dar es Salaam \u2013 Tanzania","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W3014956775","doi":"https://doi.org/10.4314/eajph.v12i1.126695","mag":"3014956775"},"language":"en","primary_location":{"id":"doi:10.4314/eajph.v12i1.126695","doi":"https://doi.org/10.4314/eajph.v12i1.126695","is_oa":true,"landing_page_url":"https://doi.org/10.4314/eajph.v12i1.126695","pdf_url":null,"source":{"id":"https://openalex.org/S2764487253","display_name":"East African Journal of Public Health","issn_l":"0856-8960","issn":["0856-8960","2799-2128"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"East African Journal of Public Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4314/eajph.v12i1.126695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060572477","display_name":"Stella Samson Rwezaula","orcid":"https://orcid.org/0000-0003-1595-0749","observed_orcids":["https://orcid.org/0000-0003-1595-0749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SS Rwezaula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091151441","display_name":"Pius Magesa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PM Magesa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053240700","display_name":"Josephine Mgaya","orcid":"https://orcid.org/0000-0002-6234-5931","observed_orcids":["https://orcid.org/0000-0002-6234-5931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mgaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109270808","display_name":"Augustine Massawe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Massawe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014291864","display_name":"Charles R. J. C. Newton","orcid":"https://orcid.org/0000-0002-6999-5507","observed_orcids":["https://orcid.org/0000-0002-6999-5507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CR Newton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019430578","display_name":"Troy J. Marlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Marlow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008075671","display_name":"Sharon Elizabeth Cox","orcid":"https://orcid.org/0000-0002-9908-2936","observed_orcids":["https://orcid.org/0000-0002-9908-2936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SE Cox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072419484","display_name":"Monica V.E. Gallivan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gallivan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082767897","display_name":"Brett S Lowe","orcid":"https://orcid.org/0000-0002-4422-8627","observed_orcids":["https://orcid.org/0000-0002-4422-8627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Lowe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103384436","display_name":"DJ Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DJ Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050401653","display_name":"Julie Makani","orcid":"https://orcid.org/0000-0002-4801-6250","observed_orcids":["https://orcid.org/0000-0002-4801-6250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Makani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5738,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71798365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"948","last_page":"955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/newborn-screening","display_name":"newborn screening","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.996999979019165},{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.925000011920929},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.7200000286102295},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.6449999809265137},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.8679999709129333},{"id":"https://openalex.org/keywords/low-gestational-age","display_name":"low gestational age","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tanzania","display_name":"Tanzania","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dar-es-salaam","display_name":"Dar es Salaam","score":0.8080000281333923},{"id":"https://openalex.org/keywords/muhimbili-national-hospital","display_name":"Muhimbili National Hospital","score":0.8109999895095825},{"id":"https://openalex.org/keywords/high-performance-liquid-chromatography","display_name":"HPLC","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8698737025260925},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.582160234451294},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5501037240028381},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5235990285873413},{"id":"https://openalex.org/C2776169613","wikidata":"https://www.wikidata.org/wiki/Q2305910","display_name":"Newborn screening","level":2,"score":0.5100806355476379},{"id":"https://openalex.org/C2777216359","wikidata":"https://www.wikidata.org/wiki/Q426738","display_name":"Hemoglobin A2","level":3,"score":0.5053858757019043},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.4672144949436188},{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.4652147591114044},{"id":"https://openalex.org/C3019135560","wikidata":"https://www.wikidata.org/wiki/Q1960","display_name":"Dar es salaam","level":3,"score":0.4360882043838501},{"id":"https://openalex.org/C2779357621","wikidata":"https://www.wikidata.org/wiki/Q655495","display_name":"Tanzania","level":2,"score":0.41227248311042786},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.33513492345809937},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.321002334356308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31552380323410034},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.27592962980270386},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.11671274900436401},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.09734183549880981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.083812415599823},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C91375879","wikidata":"https://www.wikidata.org/wiki/Q15473274","display_name":"Environmental planning","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4314/eajph.v12i1.126695","doi":"https://doi.org/10.4314/eajph.v12i1.126695","is_oa":true,"landing_page_url":"https://doi.org/10.4314/eajph.v12i1.126695","pdf_url":null,"source":{"id":"https://openalex.org/S2764487253","display_name":"East African Journal of Public Health","issn_l":"0856-8960","issn":["0856-8960","2799-2128"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"East African Journal of Public Health","raw_type":"journal-article"},{"id":"mag:3014956775","doi":null,"is_oa":true,"landing_page_url":"https://www.ajol.info/index.php/eajph/article/view/126695","pdf_url":null,"source":{"id":"https://openalex.org/S2764487253","display_name":"East African Journal of Public Health","issn_l":"0856-8960","issn":["0856-8960","2799-2128"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"East African Journal of Public Health","raw_type":null}],"best_oa_location":{"id":"doi:10.4314/eajph.v12i1.126695","doi":"https://doi.org/10.4314/eajph.v12i1.126695","is_oa":true,"landing_page_url":"https://doi.org/10.4314/eajph.v12i1.126695","pdf_url":null,"source":{"id":"https://openalex.org/S2764487253","display_name":"East African Journal of Public Health","issn_l":"0856-8960","issn":["0856-8960","2799-2128"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"East African Journal of Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396938987","https://openalex.org/W2740415207","https://openalex.org/W4416212388","https://openalex.org/W2984834187","https://openalex.org/W2557807262","https://openalex.org/W3122985534","https://openalex.org/W4406021713","https://openalex.org/W4210643496","https://openalex.org/W2416521503","https://openalex.org/W7120820161"],"abstract_inverted_index":{"Background:":[0],"Newborn":[1,281],"screening":[2,256],"(NBS)":[3],"for":[4,8],"hemoglobinopathies":[5,101,111],"is":[6,237,258],"important":[7],"the":[9,20,73,98,182,188,205,241,267,270],"early":[10],"detection":[11],"and":[12,26,67,75,148,175,239,269],"effective":[13],"management":[14],"of":[15,22,77,94,100,107,158,160,185,191,207,232,234,247,250,266,278,289],"affected":[16],"children.Objectives:":[17],"To":[18],"determine":[19,72],"frequency":[21,157,190,231,288],"occurrence,":[23,192,290],"types":[24],"of,":[25],"factors":[27],"associated":[28,275],"with":[29,109,115,151,276],"abnormal":[30,161,202,226,235,279,285],"haemoglobins":[31,162,203,227,286],"in":[32,56,261],"newborns":[33,51,208,222],"at":[34,52,211],"Muhimbili":[35,53],"National":[36,54],"Hospital":[37,55],"(MNH),":[38],"Dar":[39],"es":[40],"Salaam.Methods:":[41],"A":[42],"hospital-based,":[43],"descriptive":[44],"cross-sectional":[45],"design":[46],"was":[47,102],"used":[48],"to":[49,71,221],"recruit":[50],"2009.":[57],"Blood":[58],"specimens":[59],"were":[60,87,163,170,273],"analyzed":[61],"by":[62,89,216],"High":[63,291],"Performance":[64,292],"Liquid":[65,293],"Chromatography":[66,294],"alkaline":[68],"Hb":[69,128,139,145],"electrophoresis":[70],"type":[74],"proportion":[76],"hemoglobin":[78,236],"variants.":[79],"Complete":[80],"blood":[81],"counts":[82],"including":[83],"red":[84],"cell":[85,117,125],"indices":[86],"done":[88],"automated":[90],"hematology":[91],"analyzer.Results:":[92],"Out":[93],"2,053":[95],"samples":[96],"analyzed,":[97],"prevalence":[99],"18.2%":[103],"(n=374).":[104],"The":[105,156,230,263],"percentages":[106],"children":[108],"defined":[110],"included":[112],"12.6%":[113],"(n=258)":[114],"sickle":[116,124],"trait":[118],"(Hb":[119,132,142,154],"FAS);":[120],"0.9%":[121],"(n=19)":[122],"as":[123,219],"carrier":[126],"or":[127,138],"S":[129,140],"Beta+":[130],"-thalassemia":[131],"FSA);":[133],"0.54%":[134],"(n=11)":[135],"had":[136,187],"SCA":[137],"Beta0-thalassemia":[141],"FS);":[143],"one":[144],"FA-D":[146],"variant":[147],"5.3%":[149],"(n=109)":[150],"possibly":[152],"\u03b1-thalassemia":[153],"Bart\u2019s).":[155],"occurrence":[159,233,277],"highest":[164],"among":[165],"participants":[166],"whose":[167],"parental":[168],"origin":[169,265],"Costal":[171],"Regions,":[172],"35.6%":[173],"(n=133)":[174],"Lake":[176],"Zone,":[177],"10.2%":[178],"(n=38).":[179],"Participants":[180],"from":[181],"Northern":[183],"Region":[184],"Tanzania":[186],"lowest":[189],"6.7%":[193],"(n=25)":[194],"(X2":[195],"=":[196],"37.7,":[197],"p":[198],"<":[199],"0.01).":[200],"Having":[201],"increased":[204],"likelihood":[206],"being":[209],"born":[210,224],"low":[212],"gestational":[213,271],"age":[214,272],"(23.8%)":[215],"1.5":[217],"fold":[218],"compared":[220],"(16.3%)":[223],"without":[225],"(X2=11.7,":[228],"p=0.001).Conclusions:":[229],"high":[238],"fulfills":[240],"World":[242],"Health":[243],"Organization":[244],"(WHO)":[245],"criteria":[246],"a":[248],"disorder":[249],"public":[251],"health":[252],"significance.":[253],"Therefore,":[254],"newborn":[255],"programme":[257],"highly":[259],"recommended":[260],"Tanzania.":[262],"ethnic":[264],"parents":[268],"significantly":[274],"haemoglobins.Keywords:":[280],"screening,":[282],"neonates":[283],",":[284],"(Hemoglobinopathies),":[287]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}