{"id":"https://openalex.org/W3014882016","doi":"https://doi.org/10.1021/acs.jmedchem.9b02052","title":"Identification of the Clinical Development Candidate MRTX849 , a Covalent KRASG12C Inhibitor for the Treatment of Cancer","display_name":"Identification of the Clinical Development Candidate MRTX849 , a Covalent KRASG12C Inhibitor for the Treatment of Cancer","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3014882016","doi":"https://doi.org/10.1021/acs.jmedchem.9b02052","mag":"3014882016","pmid":"https://pubmed.ncbi.nlm.nih.gov/32250617"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.9b02052","doi":"https://doi.org/10.1021/acs.jmedchem.9b02052","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b02052","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jmedchem.9b02052","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041504457","display_name":"Jay B. Fell","orcid":"https://orcid.org/0000-0002-5770-1225","observed_orcids":["https://orcid.org/0000-0002-5770-1225"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay B. Fell","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":"https://orcid.org/0000-0002-5770-1225","affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John P. Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Fischer","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052279694","display_name":"Brian R. Baer","orcid":"https://orcid.org/0009-0003-7431-1266","observed_orcids":["https://orcid.org/0009-0003-7431-1266"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian R. Baer","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110904464","display_name":"James F. Blake","orcid":"https://orcid.org/0000-0001-7525-7140","observed_orcids":["https://orcid.org/0000-0001-7525-7140"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Blake","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064251187","display_name":"Karyn Bouhana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karyn Bouhana","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013889220","display_name":"David M. Briere","orcid":"https://orcid.org/0009-0006-3868-0859","observed_orcids":["https://orcid.org/0009-0006-3868-0859"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Briere","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029014694","display_name":"Karin D. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin D. Brown","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103468126","display_name":"Laurence E. Burgess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence E. Burgess","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083558388","display_name":"Aaron C. Burns","orcid":"https://orcid.org/0000-0001-9485-3781","observed_orcids":["https://orcid.org/0000-0001-9485-3781"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron C. Burns","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046487180","display_name":"Michael Burkard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Burkard","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068350117","display_name":"Harrah Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harrah Chiang","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034410111","display_name":"Mark Joseph Chicarelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Chicarelli","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027555707","display_name":"Adam W. Cook","orcid":"https://orcid.org/0009-0003-0172-1424","observed_orcids":["https://orcid.org/0009-0003-0172-1424"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam W. Cook","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081491244","display_name":"John J. Gaudino","orcid":"https://orcid.org/0009-0004-7043-2770","observed_orcids":["https://orcid.org/0009-0004-7043-2770"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Gaudino","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009869639","display_name":"Jill F. Hallin","orcid":"https://orcid.org/0000-0002-8443-7116","observed_orcids":["https://orcid.org/0000-0002-8443-7116"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Hallin","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016544434","display_name":"Lauren M. Hanson","orcid":"https://orcid.org/0000-0003-3654-9188","observed_orcids":["https://orcid.org/0000-0003-3654-9188"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Hanson","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017750917","display_name":"Dylan P. Hartley","orcid":"https://orcid.org/0009-0009-8853-5213","observed_orcids":["https://orcid.org/0009-0009-8853-5213"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan P. Hartley","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020361767","display_name":"Erik J. Hicken","orcid":"https://orcid.org/0009-0007-6426-3044","observed_orcids":["https://orcid.org/0009-0007-6426-3044"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik J. Hicken","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051720564","display_name":"Gary P. Hingorani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary P. Hingorani","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010395017","display_name":"Ronald J. Hinklin","orcid":"https://orcid.org/0000-0003-2494-5888","observed_orcids":["https://orcid.org/0000-0003-2494-5888"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Hinklin","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086754835","display_name":"Macedonio J. Mejia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Macedonio J. Mejia","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042557251","display_name":"Peter Olson","orcid":"https://orcid.org/0009-0008-5164-8102","observed_orcids":["https://orcid.org/0009-0008-5164-8102"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Olson","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059989618","display_name":"Jennifer N. Otten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer N. Otten","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085606910","display_name":"Susan P. Rhodes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan P. Rhodes","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108474669","display_name":"Martha E. Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha E. Rodriguez","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011083469","display_name":"Pavel Y. Savechenkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavel Savechenkov","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110152413","display_name":"Darin J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darin J. Smith","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062077509","display_name":"Niranjan Sudhakar","orcid":"https://orcid.org/0009-0001-3509-8429","observed_orcids":["https://orcid.org/0009-0001-3509-8429"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niranjan Sudhakar","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103877666","display_name":"Francis X. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis X. Sullivan","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069948075","display_name":"Tony P. Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony P. Tang","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057285781","display_name":"Guy P. A. Vigers","orcid":"https://orcid.org/0000-0003-4451-8453","observed_orcids":["https://orcid.org/0000-0003-4451-8453"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy P. Vigers","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036014338","display_name":"Lance A. Wollenberg","orcid":"https://orcid.org/0009-0002-4791-8655","observed_orcids":["https://orcid.org/0009-0002-4791-8655"]},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Wollenberg","raw_affiliation_strings":["Array BioPharma Inc , 3200 Walnut Street , , ,","Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Array BioPharma Inc , 3200 Walnut Street , , ,","institution_ids":["https://openalex.org/I4210101899"]},{"raw_affiliation_string":"Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074923974","display_name":"James G. Christensen","orcid":"https://orcid.org/0000-0003-1835-0335","observed_orcids":["https://orcid.org/0000-0003-1835-0335"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Christensen","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008501938","display_name":"Matthew A. Marx","orcid":"https://orcid.org/0000-0003-2351-4787","observed_orcids":["https://orcid.org/0000-0003-2351-4787"]},"institutions":[{"id":"https://openalex.org/I4210103611","display_name":"Mirati Therapeutics (United States)","ror":"https://ror.org/01by01460","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103611"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew A. Marx","raw_affiliation_strings":["Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States"],"raw_orcid":"https://orcid.org/0000-0003-2351-4787","affiliations":[{"raw_affiliation_string":"Mirati Therapeutics , 9393 Towne Centre Drive, Suite 200 , , ,","institution_ids":["https://openalex.org/I4210103611"]},{"raw_affiliation_string":"Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States","institution_ids":["https://openalex.org/I4210103611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008501938","https://openalex.org/A5041504457"],"corresponding_institution_ids":["https://openalex.org/I4210101899","https://openalex.org/I4210103611"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":19.3475,"has_fulltext":false,"cited_by_count":616,"citation_normalized_percentile":{"value":0.99766603,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"63","issue":"13","first_page":"6679","last_page":"6693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adagrasib","display_name":"adagrasib","score":0.996999979019165},{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.8989999890327454},{"id":"https://openalex.org/keywords/covalent-inhibitors","display_name":"covalent inhibitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/switch-ii-pocket","display_name":"switch-II pocket","score":0.9350000023841858},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9039999842643738},{"id":"https://openalex.org/keywords/adme-profiling","display_name":"ADME profiling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/metabolic-liability","display_name":"metabolic liability","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7762866020202637},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.7446662783622742},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5644530057907104},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5554839968681335},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5182278156280518},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5029386878013611},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4397675693035126},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.42339658737182617},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3845660984516144},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33291929960250854},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3055498003959656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28496643900871277},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17457348108291626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11030265688896179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jmedchem.9b02052","doi":"https://doi.org/10.1021/acs.jmedchem.9b02052","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b02052","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:32250617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32250617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"doi:10.7270/q2g164c5","doi":"https://doi.org/10.7270/q2g164c5","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2g164c5","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1021/acs.jmedchem.9b02052","doi":"https://doi.org/10.1021/acs.jmedchem.9b02052","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b02052","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W152943885","https://openalex.org/W307680137","https://openalex.org/W1564180078","https://openalex.org/W1977059612","https://openalex.org/W1998948060","https://openalex.org/W2004132523","https://openalex.org/W2026128118","https://openalex.org/W2052490505","https://openalex.org/W2068332174","https://openalex.org/W2128339707","https://openalex.org/W2134917212","https://openalex.org/W2159594827","https://openalex.org/W2161434860","https://openalex.org/W2233032895","https://openalex.org/W2300615341","https://openalex.org/W2501247313","https://openalex.org/W2540525654","https://openalex.org/W2560367892","https://openalex.org/W2597182072","https://openalex.org/W2611666059","https://openalex.org/W2732767128","https://openalex.org/W2785187242","https://openalex.org/W2796153225","https://openalex.org/W2800484366","https://openalex.org/W2804697234","https://openalex.org/W2900061002","https://openalex.org/W2902268901","https://openalex.org/W2951887320","https://openalex.org/W2982321167","https://openalex.org/W2982602983","https://openalex.org/W3023379891"],"related_works":["https://openalex.org/W3030972949","https://openalex.org/W4306404900","https://openalex.org/W4229832877","https://openalex.org/W3111812619","https://openalex.org/W4248366929","https://openalex.org/W2590035663","https://openalex.org/W2914997899","https://openalex.org/W4229670017","https://openalex.org/W2127264463","https://openalex.org/W3164924009"],"abstract_inverted_index":{"Abstract":[0],"Capping":[1],"off":[2],"an":[3],"era":[4],"marred":[5],"by":[6,12],"drug":[7,64],"development":[8,99],"failures":[9],"and":[10,15,25,54,76,87],"punctuated":[11],"waning":[13],"interest":[14],"presumed":[16],"intractability":[17],"toward":[18],"direct":[19],"targeting":[20],"of":[21,44,52,91,96,108],"KRAS,":[22],"new":[23],"technologies":[24],"strategies":[26],"are":[27],"aiding":[28],"in":[29,48,66,71],"the":[30,36,49,85,97],"target\u2019s":[31],"resurgence.":[32],"As":[33],"previously":[34],"reported,":[35],"tetrahydropyridopyrimidines":[37],"were":[38,81],"identified":[39],"as":[40,102],"irreversible":[41],"covalent":[42,57,106],"inhibitors":[43],"KRASG12C":[45,109],"that":[46],"bind":[47],"switch-II":[50],"pocket":[51],"KRAS":[53],"make":[55],"a":[56,69,103],"bond":[58],"to":[59,83],"cysteine":[60],"12.":[61],"Using":[62],"structure-based":[63],"design":[65],"conjunction":[67],"with":[68],"focused":[70],"vitro":[72],"absorption,":[73],"distribution,":[74],"metabolism":[75],"excretion":[77],"screening":[78],"approach,":[79],"analogues":[80],"synthesized":[82],"increase":[84],"potency":[86],"reduce":[88],"metabolic":[89],"liabilities":[90],"this":[92],"series.":[93],"The":[94],"discovery":[95],"clinical":[98],"candidate":[100],"MRTX849":[101],"potent,":[104],"selective":[105],"inhibitor":[107],"is":[110],"described.":[111]},"counts_by_year":[{"year":2026,"cited_by_count":98},{"year":2025,"cited_by_count":102},{"year":2024,"cited_by_count":136},{"year":2023,"cited_by_count":114},{"year":2022,"cited_by_count":87},{"year":2021,"cited_by_count":51},{"year":2020,"cited_by_count":28}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2020-04-10T00:00:00"}
