{"id":"https://openalex.org/W3014782009","doi":null,"title":"Analiza crijevnog mikrobioma u \u0161takorskom modelu Alzheimerove bolesti","display_name":"Analiza crijevnog mikrobioma u \u0161takorskom modelu Alzheimerove bolesti","publication_year":2017,"publication_date":"2017-09-20","ids":{"openalex":"https://openalex.org/W3014782009","mag":"3014782009"},"language":"bs","primary_location":{"id":"mag:3014782009","doi":null,"is_oa":false,"landing_page_url":"https://dabar.srce.hr/en/islandora/object/pmf%3A6662","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013134818","display_name":"Maja Ledinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maja Ledinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013134818"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8009999990463257},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aluminum-chloride","display_name":"aluminum chloride","score":0.8840000033378601},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.9929999709129333},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/probiotic-bacteria","display_name":"probiotic bacteria","score":0.7789999842643738},{"id":"https://openalex.org/keywords/beta-galactosidase","display_name":"beta-galactosidase","score":0.906000018119812},{"id":"https://openalex.org/keywords/beta-glucosidase","display_name":"\u03b2-glucosidase","score":1.0},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bacterial-enzyme-activity","display_name":"bacterial enzyme activity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gut-microbiota-composition","display_name":"gut microbiota composition","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6328442692756653},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.4691399931907654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4657752215862274},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4562888741493225},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4414314925670624},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.42407795786857605},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4057161211967468},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.35733580589294434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3077678978443146},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25145289301872253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10244956612586975}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3014782009","doi":null,"is_oa":false,"landing_page_url":"https://dabar.srce.hr/en/islandora/object/pmf%3A6662","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401702325","https://openalex.org/W4211063536","https://openalex.org/W4411153105","https://openalex.org/W3031399914","https://openalex.org/W4416345548","https://openalex.org/W2944415973","https://openalex.org/W2762048636","https://openalex.org/W4405261069","https://openalex.org/W4415062856","https://openalex.org/W2981007829"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,6],"(AD)":[2],"is":[3,20],"progressive":[4],"neurodegenerative":[5],"and":[7,12,25,32,60,75,84,92,104,177,187],"leading":[8],"cause":[9],"of":[10,15,46,54,82,87,113,126,146,156,159,175,182],"cognitive":[11,33],"behaviour":[13],"impairments":[14],"industrialized":[16],"society.":[17],"Microbiome-gut-brain":[18],"axis":[19],"bidirectional":[21],"communication":[22],"between":[23],"central":[24],"enteric":[26],"nervous":[27],"system,":[28],"thus":[29],"connecting":[30],"emotional":[31],"centers":[34],"in":[35,116,131,144,196],"brain":[36],"with":[37,193],"peripheral":[38],"gut":[39],"function.":[40],"In":[41],"this":[42],"research":[43],"rat":[44,198],"model":[45,118,133],"AD":[47,117,132,197],"(n=10)":[48],"was":[49,90,99,140],"induced":[50,195],"by":[51,101],"intraperitoneal":[52],"injection":[53],"aluminium":[55],"chloride":[56],"(10":[57],"mg/kg":[58,63],"rat)":[59,64],"D-galactose":[61],"(60":[62],"during":[65],"28":[66],"days.":[67],"Dilutions":[68],"were":[69],"made":[70],"from":[71],"rat's":[72],"colon":[73],"content":[74],"streaked":[76],"on":[77,165],"selective":[78],"plates":[79],"for":[80,95],"isolation":[81],"Lactobacillus":[83,176],"Bifidobacter,":[85,178],"activity":[86,125,181],"bacterial":[88,151],"enzymes":[89],"analyzed":[91,100],"DNA":[93],"isolated":[94],"sequencing.":[96],"Sequencing":[97],"data":[98],"hierarchical":[102],"clustering":[103],"principal":[105],"component":[106],"analysis.":[107],"Results":[108],"showed:":[109],"a)":[110],"reduced":[111,173,188],"number":[112,174],"probiotic":[114],"bacteria":[115],"compared":[119,134],"to":[120,135],"control":[121,136,160],"group;":[122],"b)":[123],"increased":[124,179],"\u03b2-galactosidase,":[127,183],"\u03b2-glucosidase":[128,184],"i":[129,185],"\u03b2-glucuronidase":[130,186],"group":[137],"c)":[138],"there":[139],"no":[141],"great":[142],"changes":[143],"composition":[145],"intestine":[147,157,189],"microbiome,":[148],"but":[149],"46":[150],"species,":[152],"which":[153],"make":[154],"11,61%":[155],"microbiome":[158],"group,":[161],"significantly":[162],"changed.":[163],"Based":[164],"these":[166],"results":[167],"it":[168],"can":[169],"be":[170],"concluded":[171],"that":[172],"enzyme":[180],"biomass":[190],"are":[191],"connected":[192],"inflammation":[194],"model.":[199]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2020-04-10T00:00:00"}