{"id":"https://openalex.org/W3014749569","doi":"https://doi.org/10.1038/s41374-020-0424-5","title":"Digital quantitative assessment of PD-L1 using digital spatial profiling","display_name":"Digital quantitative assessment of PD-L1 using digital spatial profiling","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3014749569","doi":"https://doi.org/10.1038/s41374-020-0424-5","mag":"3014749569","pmid":"https://pubmed.ncbi.nlm.nih.gov/32249818","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7502436"},"language":"en","primary_location":{"id":"doi:10.1038/s41374-020-0424-5","doi":"https://doi.org/10.1038/s41374-020-0424-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41374-020-0424-5","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/s41374-020-0424-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066336838","display_name":"Swati Gupta","orcid":"https://orcid.org/0000-0001-6406-0035","observed_orcids":["https://orcid.org/0000-0001-6406-0035"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati Gupta","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, US","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063439924","display_name":"Jon Zugazagoitia","orcid":"https://orcid.org/0000-0001-9352-5882","observed_orcids":["https://orcid.org/0000-0001-9352-5882"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Zugazagoitia","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, US","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069463643","display_name":"Sandra Mart\u00ednez-Morilla","orcid":"https://orcid.org/0000-0003-0931-4906","observed_orcids":["https://orcid.org/0000-0003-0931-4906"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Martinez-Morilla","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, US","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070396842","display_name":"Kit A. Fuhrman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099129","display_name":"Nanostring Technologies (United States)","ror":"https://ror.org/00xzdzk88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210099129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kit Fuhrman","raw_affiliation_strings":["Nanostring Technologies\u00ae, Seattle, WA, USA","Nanostring Technologies\u00ae, Seattle, WA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanostring Technologies\u00ae, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210099129"]},{"raw_affiliation_string":"Nanostring Technologies\u00ae, Seattle, WA, US","institution_ids":["https://openalex.org/I4210099129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Rimm","raw_affiliation_strings":["Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu","Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu","Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, US","Department of Pathology, Yale University School of Medicine, New Haven, CT, US"],"raw_orcid":"https://orcid.org/0000-0001-5820-4397","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, US","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, US","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027326018"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":2.0758,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89246214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"100","issue":"10","first_page":"1311","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/digital-spatial-profiling","display_name":"digital spatial profiling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pd-l1-immunohistochemistry","display_name":"PD-L1 immunohistochemistry","score":0.796999990940094},{"id":"https://openalex.org/keywords/quantitative-fluorescence","display_name":"quantitative fluorescence","score":0.4869999885559082},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.8859999775886536},{"id":"https://openalex.org/keywords/companion-diagnostics","display_name":"companion diagnostics","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tissue-microarray","display_name":"tissue microarray","score":0.5950000286102295},{"id":"https://openalex.org/keywords/isogenic-cell-lines","display_name":"isogenic cell lines","score":0.7360000014305115},{"id":"https://openalex.org/keywords/assay-standardization","display_name":"assay standardization","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.726249098777771},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4669215679168701},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40487048029899597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3389586806297302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2175702452659607},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41374-020-0424-5","doi":"https://doi.org/10.1038/s41374-020-0424-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41374-020-0424-5","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:32249818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32249818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7502436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7502436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lab Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41374-020-0424-5","doi":"https://doi.org/10.1038/s41374-020-0424-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41374-020-0424-5","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2694659828","display_name":null,"funder_award_id":"BCRF-19-138","funder_id":"https://openalex.org/F4320306260","funder_display_name":"Breast Cancer Research Foundation"},{"id":"https://openalex.org/G9000888329","display_name":"Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer","funder_award_id":"P50CA196530","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000916849","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016359","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2036905020","https://openalex.org/W2060070314","https://openalex.org/W2101653483","https://openalex.org/W2136859769","https://openalex.org/W2198093519","https://openalex.org/W2233818050","https://openalex.org/W2509467148","https://openalex.org/W2557730509","https://openalex.org/W2560367415","https://openalex.org/W2569740680","https://openalex.org/W2572174216","https://openalex.org/W2594102731","https://openalex.org/W2725050414","https://openalex.org/W2753065806","https://openalex.org/W2762777471","https://openalex.org/W2769300445","https://openalex.org/W2775098059","https://openalex.org/W2781147042","https://openalex.org/W2804957255","https://openalex.org/W2892835911","https://openalex.org/W2916942367","https://openalex.org/W2949315168","https://openalex.org/W2952481429","https://openalex.org/W3023701177"],"related_works":["https://openalex.org/W2968867518","https://openalex.org/W2908844974","https://openalex.org/W4380078610","https://openalex.org/W3025100294","https://openalex.org/W4416953579","https://openalex.org/W2794354355","https://openalex.org/W4282591082","https://openalex.org/W2804957255","https://openalex.org/W2398309632","https://openalex.org/W2542773270"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-10T00:00:00"}
