{"id":"https://openalex.org/W3014720336","doi":"https://doi.org/10.1002/cpdd.797","title":"Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers","display_name":"Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3014720336","doi":"https://doi.org/10.1002/cpdd.797","mag":"3014720336","pmid":"https://pubmed.ncbi.nlm.nih.gov/32250057"},"language":"en","primary_location":{"id":"doi:10.1002/cpdd.797","doi":"https://doi.org/10.1002/cpdd.797","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpdd.797","pdf_url":null,"source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kun Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Hu","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062487012","display_name":"Qian Xiang","orcid":"https://orcid.org/0000-0002-8245-2611","observed_orcids":["https://orcid.org/0000-0002-8245-2611"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xiang","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407553","display_name":"Zhe Wang","orcid":"https://orcid.org/0000-0001-5407-4230","observed_orcids":["https://orcid.org/0000-0001-5407-4230"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Wang","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089116496","display_name":"Xiaoyan Sheng","orcid":"https://orcid.org/0000-0002-3385-3451","observed_orcids":["https://orcid.org/0000-0002-3385-3451"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Sheng","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016647580","display_name":"Lie Li","orcid":"https://orcid.org/0000-0003-1508-5484","observed_orcids":["https://orcid.org/0000-0003-1508-5484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li'e Li","raw_affiliation_strings":["Yichang Humanwell Pharmaceutical CO., LTD.  Hubei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yichang Humanwell Pharmaceutical CO., LTD.  Hubei China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000799847","display_name":"Yan Liang","orcid":"https://orcid.org/0000-0002-9009-3284","observed_orcids":["https://orcid.org/0000-0002-9009-3284"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Liang","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101681289","display_name":"Xia Zhao","orcid":"https://orcid.org/0000-0003-2497-3934","observed_orcids":["https://orcid.org/0000-0003-2497-3934","https://orcid.org/0009-0003-4861-1433","https://orcid.org/0000-0002-1755-6334"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Zhao","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101766101","display_name":"Xia Ye","orcid":"https://orcid.org/0000-0001-6015-1634","observed_orcids":["https://orcid.org/0000-0001-6015-1634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Ye","raw_affiliation_strings":["Yichang Humanwell Pharmaceutical CO., LTD.  Hubei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yichang Humanwell Pharmaceutical CO., LTD.  Hubei China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100377723","display_name":"Yimin Cui","orcid":"https://orcid.org/0000-0002-4186-1005","observed_orcids":["https://orcid.org/0000-0002-4186-1005"]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yimin Cui","raw_affiliation_strings":["Department of Pharmacy Peking University First Hospital  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Peking University First Hospital  Beijing China","institution_ids":["https://openalex.org/I4210130930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100377723"],"corresponding_institution_ids":["https://openalex.org/I4210130930"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.9243,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.66991525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"22","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remimazolam","display_name":"remimazolam","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.7990000247955322},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.7110000252723694},{"id":"https://openalex.org/keywords/midazolam-metabolism","display_name":"midazolam metabolism","score":0.8029999732971191},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.7960000038146973},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7962435483932495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6565260291099548},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.641061007976532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.636650562286377},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6340376138687134},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5463306903839111},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.500950813293457},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.4946450889110565},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.4521005153656006},{"id":"https://openalex.org/C50605568","wikidata":"https://www.wikidata.org/wiki/Q14912267","display_name":"CYP2B6","level":5,"score":0.4368789494037628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2791784107685089},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.22001901268959045},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21253308653831482},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.19851550459861755}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpdd.797","doi":"https://doi.org/10.1002/cpdd.797","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpdd.797","pdf_url":null,"source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},{"id":"pmid:32250057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32250057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology in drug development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4473767866","display_name":null,"funder_award_id":"81973395","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4821748471","display_name":null,"funder_award_id":"81872940","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7599122811","display_name":null,"funder_award_id":"7171012","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W645001953","https://openalex.org/W1725210601","https://openalex.org/W1862656882","https://openalex.org/W2017335874","https://openalex.org/W2017790292","https://openalex.org/W2058208264","https://openalex.org/W2059865921","https://openalex.org/W2063516288","https://openalex.org/W2097100227","https://openalex.org/W2102755313","https://openalex.org/W2124725201","https://openalex.org/W2135711647","https://openalex.org/W2162663840","https://openalex.org/W2254563264","https://openalex.org/W2325500307","https://openalex.org/W2484729923","https://openalex.org/W2507979671","https://openalex.org/W2593864915","https://openalex.org/W2731782453","https://openalex.org/W2764162165","https://openalex.org/W2805653972","https://openalex.org/W2807784181","https://openalex.org/W2811256744","https://openalex.org/W2894718719","https://openalex.org/W2901633965","https://openalex.org/W2929003467","https://openalex.org/W2970487601","https://openalex.org/W2996803040","https://openalex.org/W2998786011","https://openalex.org/W3000153718","https://openalex.org/W4295192786","https://openalex.org/W7075600336"],"related_works":["https://openalex.org/W4399224705","https://openalex.org/W4412530269","https://openalex.org/W6927267892","https://openalex.org/W4391825574","https://openalex.org/W4283016510","https://openalex.org/W3092196027","https://openalex.org/W1977462728","https://openalex.org/W4412166309","https://openalex.org/W4401401825","https://openalex.org/W2998786011"],"abstract_inverted_index":{"Abstract":[0],"Remimazolam":[1],"is":[2,19],"a":[3,69],"new":[4],"ultra\u2010short\u2010acting":[5],"benzodiazepine":[6],"used":[7,99],"to":[8,21,100],"induce":[9],"and":[10,13,36,53,90,104,120],"maintain":[11],"anesthesia":[12],"procedural":[14],"sedation.":[15],"Its":[16],"compound":[17],"structure":[18],"similar":[20],"midazolam's.":[22],"Midazolam":[23],"metabolism":[24],"might":[25,170],"be":[26],"affected":[27,131,145],"by":[28],"vitamin":[29],"D":[30],"receptor":[31],"(VDR),":[32],"cytochrome":[33,37,50,54],"P450":[34,38,51,55],"3A,":[35,52],"oxidoreductase":[39,56],"genetic":[40,57,168],"polymorphisms.":[41],"This":[42],"study":[43],"investigated":[44],"the":[45,60,132,142,146,172,177],"effects":[46],"of":[47,62,73,135,155,174],"VDR":[48,167],",":[49],"polymorphisms":[58,169],"on":[59],"pharmacokinetics":[61,173],"remimazolam":[63,74,103,116,156,175],"in":[64,161,176],"healthy":[65],"Chinese":[66,178],"volunteers":[67],"after":[68,91],"single":[70],"intravenous":[71],"injection":[72],"besylate.":[75],"Blood":[76],"samples":[77],"were":[78],"collected":[79],"from":[80],"subjects":[81],"(n":[82],"=":[83,139,159],"62)":[84],"at":[85],"scheduled":[86],"time":[87],"intervals":[88],"before":[89],"injection.":[92],"High\u2010performance":[93],"liquid":[94],"chromatography\u2013tandem":[95],"mass":[96],"spectrometry":[97],"was":[98,123],"quantify":[101],"plasma":[102,115,150],"RF7054":[105,136],"(its":[106],"inactive":[107],"carboxylic":[108],"acid":[109],"metabolite)":[110],"concentrations.":[111],"The":[112,128],"relationship":[113],"between":[114],"concentration,":[117],"pharmacokinetic":[118],"parameters,":[119],"polymorphic":[121],"alleles":[122],"assessed":[124],"for":[125],"each":[126],"subject.":[127],"rs4516035":[129],"allele":[130,144],"elimination":[133],"half\u2010life":[134],"(":[137,157],"P":[138,158],".043),":[140],"while":[141],"rs1544410":[143],"dose\u2010normalized":[147],"maximum":[148],"observed":[149],"concentration":[151],"(C":[152],"max":[153],"/D)":[154],".025)":[160],"46":[162],"volunteers.":[163],"Results":[164],"showed":[165],"that":[166],"affect":[171],"population.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-04-10T00:00:00"}