{"id":"https://openalex.org/W3014648232","doi":"https://doi.org/10.18632/aging.102979","title":"Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer","display_name":"Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer","publication_year":2020,"publication_date":"2020-03-31","ids":{"openalex":"https://openalex.org/W3014648232","doi":"https://doi.org/10.18632/aging.102979","mag":"3014648232","pmid":"https://pubmed.ncbi.nlm.nih.gov/32235004","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7185108"},"language":"en","primary_location":{"id":"doi:10.18632/aging.102979","doi":"https://doi.org/10.18632/aging.102979","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.102979","pdf_url":"https://www.aging-us.com/article/102979/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/102979/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023857538","display_name":"Lin Kang","orcid":"https://orcid.org/0000-0002-9186-9574","observed_orcids":["https://orcid.org/0000-0002-9186-9574"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Lin","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797507","display_name":"Jun Huang","orcid":"https://orcid.org/0000-0002-6468-3715","observed_orcids":["https://orcid.org/0000-0002-6468-3715"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Huang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781240","display_name":"Hongliang Luo","orcid":"https://orcid.org/0000-0001-9522-8881","observed_orcids":["https://orcid.org/0000-0001-9522-8881"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongliang Luo","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101481371","display_name":"Chen Huan Luo","orcid":"https://orcid.org/0000-0002-2719-244X","observed_orcids":["https://orcid.org/0000-0002-2719-244X"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Luo","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102025646","display_name":"Xiaojian Zhu","orcid":"https://orcid.org/0000-0002-5112-7971","observed_orcids":["https://orcid.org/0000-0002-5112-7971"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojian Zhu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027959095","display_name":"Fanqin Bu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanqin Bu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061892970","display_name":"Han Xiao","orcid":"https://orcid.org/0000-0003-1978-9593","observed_orcids":["https://orcid.org/0000-0003-1978-9593"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Xiao","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659676","display_name":"Xiao Li","orcid":"https://orcid.org/0000-0003-4135-2275","observed_orcids":["https://orcid.org/0000-0003-4135-2275"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xiao","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100744549","display_name":"Zhengming Zhu","orcid":"https://orcid.org/0000-0002-7821-678X","observed_orcids":["https://orcid.org/0000-0002-7821-678X"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengming Zhu","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100744549"],"corresponding_institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"],"apc_list":null,"apc_paid":null,"fwci":3.5665,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.94809225,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"7","first_page":"5832","last_page":"5857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.9670000076293945},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8019999861717224},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5759999752044678},{"id":"https://openalex.org/keywords/fabp4","display_name":"FABP4","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nerve-growth-factor-receptor","display_name":"nerve growth factor receptor","score":0.722000002861023},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.6740000247955322},{"id":"https://openalex.org/keywords/vip","display_name":"VIP","score":0.652999997138977},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7161771059036255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5913347005844116},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5710400342941284},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.5422488451004028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4669405519962311},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43666285276412964},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15947726368904114},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.07589840888977051}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.102979","doi":"https://doi.org/10.18632/aging.102979","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.102979","pdf_url":"https://www.aging-us.com/article/102979/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmid:32235004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32235004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7185108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7185108/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/aging.102979","doi":"https://doi.org/10.18632/aging.102979","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.102979","pdf_url":"https://www.aging-us.com/article/102979/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326696","display_name":"Jiangxi Provincial Department of Science and Technology","ror":"https://ror.org/00t30yz20"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014648232.pdf","grobid_xml":"https://content.openalex.org/works/W3014648232.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1962460712","https://openalex.org/W1982906652","https://openalex.org/W1993412356","https://openalex.org/W2007390245","https://openalex.org/W2010121426","https://openalex.org/W2030702612","https://openalex.org/W2031681802","https://openalex.org/W2043904711","https://openalex.org/W2044967196","https://openalex.org/W2046092325","https://openalex.org/W2049801235","https://openalex.org/W2054371974","https://openalex.org/W2065383116","https://openalex.org/W2065544364","https://openalex.org/W2097995306","https://openalex.org/W2103970768","https://openalex.org/W2114843025","https://openalex.org/W2115578647","https://openalex.org/W2117692326","https://openalex.org/W2120421863","https://openalex.org/W2123363005","https://openalex.org/W2123664981","https://openalex.org/W2124427232","https://openalex.org/W2127008679","https://openalex.org/W2133075384","https://openalex.org/W2133465414","https://openalex.org/W2136850043","https://openalex.org/W2143457318","https://openalex.org/W2146512944","https://openalex.org/W2147297736","https://openalex.org/W2148360952","https://openalex.org/W2149441684","https://openalex.org/W2154458783","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2160369658","https://openalex.org/W2160834915","https://openalex.org/W2170137783","https://openalex.org/W2170564314","https://openalex.org/W2171030481","https://openalex.org/W2270038845","https://openalex.org/W2327519840","https://openalex.org/W2328653797","https://openalex.org/W2334684541","https://openalex.org/W2352793274","https://openalex.org/W2411767313","https://openalex.org/W2507880739","https://openalex.org/W2579462828","https://openalex.org/W2585253307","https://openalex.org/W2604496742","https://openalex.org/W2745821917","https://openalex.org/W2754377355","https://openalex.org/W2757235467","https://openalex.org/W2765224588","https://openalex.org/W2765480297","https://openalex.org/W2783494975","https://openalex.org/W2787775113","https://openalex.org/W2792461052","https://openalex.org/W2792468812","https://openalex.org/W2794041272","https://openalex.org/W2801037033","https://openalex.org/W2801380511","https://openalex.org/W2806265592","https://openalex.org/W2866490332","https://openalex.org/W2884754721","https://openalex.org/W2898415660","https://openalex.org/W2900569176","https://openalex.org/W2901007408","https://openalex.org/W2915761934","https://openalex.org/W2920256884","https://openalex.org/W2920863623","https://openalex.org/W2945057866","https://openalex.org/W2956024695","https://openalex.org/W2970515629","https://openalex.org/W2973337846","https://openalex.org/W2982617740","https://openalex.org/W4211199921"],"related_works":["https://openalex.org/W3089479144","https://openalex.org/W4383371271","https://openalex.org/W3047949176","https://openalex.org/W3047837989","https://openalex.org/W4290615463","https://openalex.org/W3036457781","https://openalex.org/W3135621359","https://openalex.org/W4399149013","https://openalex.org/W4213190524","https://openalex.org/W3109591414"],"abstract_inverted_index":{"BACKGROUND:":[0],"Colorectal":[1],"cancer":[2],"(CRC)":[3],"accounts":[4],"for":[5,110,134],"the":[6,26,91,147,160,175,180],"highest":[7],"fatality":[8],"rate":[9],"among":[10],"all":[11],"malignant":[12,23],"tumors.":[13],"Immunotherapy":[14],"has":[15],"shown":[16],"great":[17],"promise":[18],"in":[19,32,70,142,169,183],"management":[20],"of":[21,40,50,98,114,123,131,177,179],"many":[22],"tumors,":[24],"necessitating":[25],"need":[27],"to":[28,120,158],"explore":[29],"its":[30],"role":[31],"CRC.":[33,124],"RESULTS:":[34],"Our":[35],"analysis":[36,130,157],"revealed":[37],"a":[38,128,187],"total":[39],"71":[41],"differentially":[42,163],"expressed":[43,164],"IRGs,":[44],"that":[45],"were":[46,75],"associated":[47,77],"with":[48,78],"prognosis":[49,122],"CRC":[51,72,144,170],"patients.":[52,171],"Ten":[53],"IRGs":[54,165,181],"(FABP4,":[55],"IGKV1-33,":[56],"IGKV2D-40,":[57],"IGLV6-57,":[58],"NGF,":[59],"RETNLB,":[60],"UCN,":[61],"VIP,":[62],"NGFR,":[63],"and":[64,74,87,112,138,154,166,185],"OXTR)":[65],"showed":[66],"high":[67],"prognostic":[68,93,189],"performance":[69],"predicting":[71],"outcomes,":[73],"further":[76],"tumor":[79,82],"burden,":[80],"metastasis,":[81],"TNM":[83],"stage,":[84],"gender,":[85],"age,":[86],"pathological":[88],"stage.":[89],"Interestingly,":[90],"IRG-based":[92,117],"index":[94,190],"(IRGPI)":[95],"reflected":[96],"infiltration":[97],"multiple":[99],"immune":[100],"cell":[101],"types.":[102],"CONCLUSIONS:":[103],"This":[104],"model":[105],"provides":[106],"an":[107],"effective":[108],"approach":[109],"stratification":[111],"characterization":[113],"patients":[115,145],"using":[116],"immunolabeling":[118],"tools":[119],"monitor":[121],"METHODS:":[125],"We":[126,150],"performed":[127],"comprehensive":[129],"expression":[132],"profiles":[133],"immune-related":[135],"genes":[136],"(IRGs)":[137],"overall":[139],"survival":[140,167],"time":[141],"437":[143],"from":[146],"TCGA":[148],"database.":[149],"employed":[151],"computational":[152],"algorithms":[153],"Cox":[155,194],"regression":[156],"estimate":[159],"relationship":[161],"between":[162],"rates":[168],"Furthermore,":[172],"we":[173],"investigated":[174],"mechanisms":[176],"action":[178],"involved":[182],"CRC,":[184],"established":[186],"novel":[188],"based":[191],"on":[192],"multivariate":[193],"models.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-04-10T00:00:00"}
