{"id":"https://openalex.org/W3014628403","doi":"https://doi.org/10.1161/circulationaha.119.045010","title":"Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019","display_name":"Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3014628403","doi":"https://doi.org/10.1161/circulationaha.119.045010","mag":"3014628403","pmid":"https://pubmed.ncbi.nlm.nih.gov/32233663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7217722"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.119.045010","doi":"https://doi.org/10.1161/circulationaha.119.045010","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.119.045010","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.045010","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.045010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072450097","display_name":"Miguel Cainzos\u2010Achirica","orcid":"https://orcid.org/0000-0002-8073-2337","observed_orcids":["https://orcid.org/0000-0002-8073-2337","https://orcid.org/0000-0002-3805-9089"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Cainzos-Achirica","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":"https://orcid.org/0000-0002-8073-2337","affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044318410","display_name":"Michael D. Miedema","orcid":"https://orcid.org/0000-0003-0499-5810","observed_orcids":["https://orcid.org/0000-0003-0499-5810"]},"institutions":[{"id":"https://openalex.org/I4210134111","display_name":"Minneapolis Heart Institute Foundation","ror":"https://ror.org/03mhcky17","country_code":"US","type":"other","lineage":["https://openalex.org/I4210134111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Miedema","raw_affiliation_strings":["Minneapolis Heart Institute and Foundation, MN (M.D.M.)","Michael D. Miedema Minneapolis Heart Institute and Foundation, MN (M.D.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minneapolis Heart Institute and Foundation, MN (M.D.M.)","institution_ids":["https://openalex.org/I4210134111"]},{"raw_affiliation_string":"Michael D. Miedema Minneapolis Heart Institute and Foundation, MN (M.D.M.)","institution_ids":["https://openalex.org/I4210134111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080567374","display_name":"John William McEvoy","orcid":"https://orcid.org/0000-0001-6530-5479","observed_orcids":["https://orcid.org/0000-0001-6530-5479"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I2802635630","display_name":"University Hospital Galway","ror":"https://ror.org/04scgfz75","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802635630","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]},{"id":"https://openalex.org/I4210128306","display_name":"Saolta University Health Care Group","ror":"https://ror.org/03w2xw870","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"John W. McEvoy","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","National Institute for Prevention and Cardiovascular Health, Galway, Ireland (J.W.M.)","National University of Ireland, Galway (J.W.M.)","Saolta University Healthcare Group, University College Hospital Galway, Ireland (J.W.M.)","John W. McEvoy Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.). National Institute for Prevention and Cardiovascular Health, Galway, Ireland (J.W.M.). National University of Ireland, Galway (J.W.M.). Saolta University Healthcare Group, University College Hospital Galway, Ireland (J.W.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"National Institute for Prevention and Cardiovascular Health, Galway, Ireland (J.W.M.)","institution_ids":[]},{"raw_affiliation_string":"National University of Ireland, Galway (J.W.M.)","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Saolta University Healthcare Group, University College Hospital Galway, Ireland (J.W.M.)","institution_ids":["https://openalex.org/I2802635630","https://openalex.org/I4210128306"]},{"raw_affiliation_string":"John W. McEvoy Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.). National Institute for Prevention and Cardiovascular Health, Galway, Ireland (J.W.M.). National University of Ireland, Galway (J.W.M.). Saolta University Healthcare Group, University College Hospital Galway, Ireland (J.W.M.)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I188760350","https://openalex.org/I2802635630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069046885","display_name":"Mahmoud Al Rifai","orcid":"https://orcid.org/0000-0002-6933-790X","observed_orcids":["https://orcid.org/0000-0002-6933-790X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud Al Rifai","raw_affiliation_strings":["Baylor College of Medicine, Houston, TX (M.A.R.)","Mahmoud Al Rifai Baylor College of Medicine, Houston, TX (M.A.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, TX (M.A.R.)","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Mahmoud Al Rifai Baylor College of Medicine, Houston, TX (M.A.R.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005650203","display_name":"Philip Greenland","orcid":"https://orcid.org/0000-0002-6327-2439","observed_orcids":["https://orcid.org/0000-0002-6327-2439"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Greenland","raw_affiliation_strings":["Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.)","Philip Greenland Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.)","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Philip Greenland Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.)","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028530208","display_name":"Zeina Dardari","orcid":"https://orcid.org/0000-0001-6026-3329","observed_orcids":["https://orcid.org/0000-0001-6026-3329"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeina Dardari","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","Zeina Dardari Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Zeina Dardari Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079665496","display_name":"Matthew Jay Budoff","orcid":"https://orcid.org/0000-0002-9616-1946","observed_orcids":["https://orcid.org/0000-0002-9616-1946"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Budoff","raw_affiliation_strings":["Harbor\u2013University of California Medical Center, Los Angeles (M.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbor\u2013University of California Medical Center, Los Angeles (M.B.)","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087095202","display_name":"Roger Scott Blumenthal","orcid":"https://orcid.org/0000-0003-1910-3168","observed_orcids":["https://orcid.org/0000-0003-1910-3168"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger S. Blumenthal","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","Roger S. Blumenthal Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Roger S. Blumenthal Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068380422","display_name":"Joseph Yeboah","orcid":"https://orcid.org/0000-0001-6274-5882","observed_orcids":["https://orcid.org/0000-0001-6274-5882"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Yeboah","raw_affiliation_strings":["Wake Forest Baptist Health, Winston-Salem, NC (J.Y.)","Joseph Yeboah Wake Forest Baptist Health, Winston-Salem, NC (J.Y.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Health, Winston-Salem, NC (J.Y.)","institution_ids":["https://openalex.org/I1282516798"]},{"raw_affiliation_string":"Joseph Yeboah Wake Forest Baptist Health, Winston-Salem, NC (J.Y.)","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075267063","display_name":"Daniel A. Duprez","orcid":"https://orcid.org/0000-0002-0993-6839","observed_orcids":["https://orcid.org/0000-0002-0993-6839"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Duprez","raw_affiliation_strings":["Cardiovascular Division, University of Minnesota, Minneapolis (D.A.D.)","Daniel A. Duprez Cardiovascular Division, University of Minnesota, Minneapolis (D.A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, University of Minnesota, Minneapolis (D.A.D.)","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Daniel A. Duprez Cardiovascular Division, University of Minnesota, Minneapolis (D.A.D.)","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065926842","display_name":"Martin B\u00f8dtker Mortensen","orcid":"https://orcid.org/0000-0003-2693-4154","observed_orcids":["https://orcid.org/0000-0003-2693-4154"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Martin B\u00f8dtker Mortensen","raw_affiliation_strings":["Aarhus University Hospital, Denmark (M.B.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aarhus University Hospital, Denmark (M.B.M.)","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069052759","display_name":"Omar Dildar a Dzaye","orcid":"https://orcid.org/0000-0001-9483-3510","observed_orcids":["https://orcid.org/0000-0001-9483-3510"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Dzaye","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","Omar Dzaye Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Omar Dzaye Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008335380","display_name":"Jonathan C. Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Hong","raw_affiliation_strings":["Northwestern University, Chicago, IL (J.H.)","Jonathan Hong Northwestern University, Chicago, IL (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL (J.H.)","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jonathan Hong Northwestern University, Chicago, IL (J.H.)","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072663918","display_name":"Khurram Nasir","orcid":"https://orcid.org/0000-0001-5376-2269","observed_orcids":["https://orcid.org/0000-0001-5376-2269","https://orcid.org/0000-0002-2632-1318"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khurram Nasir","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","Khurram Nasir Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Khurram Nasir Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008531984","display_name":"Michael Joseph Blaha","orcid":"https://orcid.org/0000-0001-5138-9683","observed_orcids":["https://orcid.org/0000-0001-5138-9683"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Blaha","raw_affiliation_strings":["Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","Michael J. Blaha Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Michael J. Blaha Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, The Johns Hopkins University, Baltimore, MD (M.C.-A., J.W.M., Z.D., R.S.B., O.D., K.N., M.J.B.)","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.1814,"has_fulltext":true,"cited_by_count":201,"citation_normalized_percentile":{"value":0.99474627,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"141","issue":"19","first_page":"1541","last_page":"1553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-calcium","display_name":"coronary artery calcium","score":0.9610000252723694},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.652999997138977},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7329999804496765},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease-risk","display_name":"atherosclerotic cardiovascular disease risk","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.6100000143051147},{"id":"https://openalex.org/keywords/number-needed-to-treat","display_name":"number needed to treat","score":0.8519999980926514},{"id":"https://openalex.org/keywords/number-needed-to-harm","display_name":"number needed to harm","score":0.9950000047683716},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5960000157356262},{"id":"https://openalex.org/keywords/pooled-cohort-equations","display_name":"Pooled Cohort Equations","score":0.6899999976158142},{"id":"https://openalex.org/keywords/benefit-harm-assessment","display_name":"benefit-harm assessment","score":0.5590000152587891},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9561781287193298},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8655291795730591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5717763900756836},{"id":"https://openalex.org/C67774102","wikidata":"https://www.wikidata.org/wiki/Q614132","display_name":"Number needed to treat","level":4,"score":0.5500971078872681},{"id":"https://openalex.org/C142454548","wikidata":"https://www.wikidata.org/wiki/Q7069573","display_name":"Number needed to harm","level":5,"score":0.5453873872756958},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.5276381373405457},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5234543681144714},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5176199674606323},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4903602600097656},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.4880289137363434},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4670490324497223},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46098336577415466},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.44775906205177307},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.42421165108680725},{"id":"https://openalex.org/C2993857929","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Primary prevention","level":3,"score":0.41295480728149414},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39223816990852356},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.26023319363594055},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072226","descriptor_name":"Computed Tomography Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082742","descriptor_name":"Heart Disease Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/circulationaha.119.045010","doi":"https://doi.org/10.1161/circulationaha.119.045010","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.119.045010","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.045010","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:32233663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32233663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/b2328429-7974-42c9-a40b-c3bf1782f51d","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7217722","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7217722/pdf/nihms-1581973.pdf","source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cainzos-Achirica, M, Miedema, M D, McEvoy, J W, Al Rifai, M, Greenland, P, Dardari, Z, Budoff, M, Blumenthal, R S, Yeboah, J, Duprez, D A, Mortensen, M B, Dzaye, O, Hong, J, Nasir, K & Blaha, M J 2020, 'Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019 : The MESA Study (Multi-Ethnic Study of Atherosclerosis)', Circulation, vol. 141, no. 19, pp. 1541-1553. https://doi.org/10.1161/CIRCULATIONAHA.119.045010","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7217722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7217722","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8w696162","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8w696162","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Circulation, vol 141, iss 19","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.119.045010","doi":"https://doi.org/10.1161/circulationaha.119.045010","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.119.045010","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.045010","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1261793039","display_name":null,"funder_award_id":"N01 HC-95159","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1263205516","display_name":"MESA","funder_award_id":"n01hc95164-17-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1409423729","display_name":null,"funder_award_id":"N01-HC095169","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1686417863","display_name":null,"funder_award_id":"N01-HC-095165","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1849232265","display_name":"Wake Forest Clinical and Translational Science Award","funder_award_id":"UL1TR001420","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2095596736","display_name":null,"funder_award_id":"UL1-TR-000040, UL1-TR-001079","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2095942735","display_name":null,"funder_award_id":"UL1-TR","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2424056273","display_name":"MESA","funder_award_id":"n01hc95165-34-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G282574681","display_name":"MESA","funder_award_id":"n01hc95161-24-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2920032576","display_name":"SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING","funder_award_id":"n01hc095169-003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3581052147","display_name":null,"funder_award_id":"UL1-TR-","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3595232572","display_name":null,"funder_award_id":"N01-HC-95159","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G3647016462","display_name":null,"funder_award_id":"N01-HC-095159","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3687594596","display_name":null,"funder_award_id":"N01 HC095168","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G382391581","display_name":"MESA","funder_award_id":"n01hc95166-21-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G399481048","display_name":null,"funder_award_id":"N01-HC-095162","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G430578851","display_name":"TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)","funder_award_id":"n01hc95162-31-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4512137732","display_name":null,"funder_award_id":"N01-HC-095161","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4590187187","display_name":null,"funder_award_id":"HHSN268201500003I","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G486926878","display_name":"OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI","funder_award_id":"n01hc95168-27-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4949915199","display_name":"MESA","funder_award_id":"n01hc95160-18-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5075046117","display_name":null,"funder_award_id":"N01-HC-95169","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G5088122703","display_name":null,"funder_award_id":"HHSN268201500003C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5108002584","display_name":null,"funder_award_id":"HHSN26820150 0003I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G521967098","display_name":"SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND","funder_award_id":"n01hc095167-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5787256936","display_name":null,"funder_award_id":"N01 HC095167","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6095866717","display_name":null,"funder_award_id":"N01-HC-095160","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6359107525","display_name":null,"funder_award_id":"N01 HC095166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6405609260","display_name":"Institute for Clinical and Translational Research","funder_award_id":"UL1TR001079","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6514094751","display_name":null,"funder_award_id":"N01 HC095164","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6541715359","display_name":null,"funder_award_id":"UL1-TR-000040, UL1-TR-001079, UL1-TR-001420","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7249398899","display_name":null,"funder_award_id":"UL1-TR-000040, UL1-TR-001079, UL1-TR-001420","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G734627383","display_name":"MESA","funder_award_id":"n01hc95159-40-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7838448616","display_name":"Johns Hopkins Institute for Clinical and Translational Research","funder_award_id":"UL1TR003098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8079444471","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR000040","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000915209","display_name":"UCLA Clinical and Translational Science Institute","funder_award_id":"UL1TR001881","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G991334795","display_name":null,"funder_award_id":"N01 HC95169","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014628403.pdf","grobid_xml":"https://content.openalex.org/works/W3014628403.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1480729244","https://openalex.org/W1810855509","https://openalex.org/W1821026158","https://openalex.org/W1969678022","https://openalex.org/W1996606690","https://openalex.org/W2033209427","https://openalex.org/W2034942998","https://openalex.org/W2048943621","https://openalex.org/W2053760965","https://openalex.org/W2087242360","https://openalex.org/W2100089051","https://openalex.org/W2109960851","https://openalex.org/W2153785016","https://openalex.org/W2154988791","https://openalex.org/W2156097706","https://openalex.org/W2311450563","https://openalex.org/W2331422116","https://openalex.org/W2546545402","https://openalex.org/W2589983177","https://openalex.org/W2762510852","https://openalex.org/W2888108651","https://openalex.org/W2891412296","https://openalex.org/W2899755710","https://openalex.org/W2900034165","https://openalex.org/W2904205413","https://openalex.org/W2914972362","https://openalex.org/W2921012991","https://openalex.org/W2942638642","https://openalex.org/W2944839418","https://openalex.org/W2945570808","https://openalex.org/W2954143312","https://openalex.org/W2976528928"],"related_works":["https://openalex.org/W4389952785","https://openalex.org/W2234506975","https://openalex.org/W2109960851","https://openalex.org/W7006558470","https://openalex.org/W4393204869","https://openalex.org/W3097756563","https://openalex.org/W4308493598","https://openalex.org/W2027162040","https://openalex.org/W7172212725","https://openalex.org/W4384945139"],"abstract_inverted_index":{"Background:":[0],"Recent":[1],"American":[2,202,357],"College":[3,203,358],"of":[4,23,39,59,98,188,204,228,234,348,354,359,369,383,389],"Cardiology/American":[5,205,360],"Heart":[6,206,361],"Association":[7,207,362],"Primary":[8],"Prevention":[9],"Guidelines":[10],"recommended":[11],"considering":[12],"low-dose":[13],"aspirin":[14,66,74,194,242,349,384],"therapy":[15],"only":[16],"among":[17,270],"adults":[18],"40":[19],"to":[20,55,116,135,156,179,200,215,223,243,266,339,344],"70":[21],"years":[22,227],"age":[24,229],"who":[25],"are":[26,48],"at":[27,36,125,231],"higher":[28,217,321],"atherosclerotic":[29],"cardiovascular":[30,78,146,246],"disease":[31,79,147,247],"(ASCVD)":[32],"risk":[33,38,81,101,143,166,214,233,273,308,373],"but":[34],"not":[35,230],"high":[37,232],"bleeding.":[40],"However,":[41],"it":[42],"remains":[43],"unclear":[44],"how":[45],"these":[46,390],"patients":[47],"best":[49],"identified.":[50],"The":[51,87,237,257],"present":[52],"study":[53,88],"aimed":[54],"assess":[56],"the":[57,93,105,152,175,201,252,267,316,323,340,346,367],"value":[58],"coronary":[60],"artery":[61],"calcium":[62],"(CAC)":[63],"for":[64,68,151,174,193,196,371],"guiding":[65],"allocation":[67,347,382],"primary":[69,197,351,386],"prevention":[70,198],"by":[71],"using":[72,104,210],"2019":[73,356],"meta-analysis":[75],"data":[76],"on":[77],"relative":[80,142,165],"reduction":[82,144],"and":[83,109,118,127,138,162,209,251,277,305],"bleeding":[84,170,235],"risk.":[85,218],"Methods:":[86],"included":[89],"6470":[90],"participants":[91,121,190,225],"from":[92],"MESA":[94,189],"Study":[95,97],"(Multi-Ethnic":[96],"Atherosclerosis).":[99],"ASCVD":[100,213,272,307],"was":[102,149,172,249,255,260,285,292,319],"estimated":[103,212,271],"pooled":[106,341],"cohort":[107,342],"equations,":[108],"3":[110],"strata":[111],"were":[112,130,221],"defined:":[113],"<5%,":[114],"5%":[115,187],"20%,":[117],">20%.":[119],"All":[120],"underwent":[122],"CAC":[123,128,335,370],"scoring":[124],"baseline,":[126],"scores":[129],"stratified":[131],"as":[132],"=0,":[133],"1":[134,245],"99,":[136],"\u2265100,":[137],"\u2265400.":[139],"A":[140],"12%":[141],"in":[145,168,281,314,350,377,385,392],"events":[148,171],"used":[150,173],"5-year":[153,176],"number":[154,177],"needed":[155,178],"treat":[157],"(NNT":[158],"5":[159,182,240,254,259,269,284,289,299,303,318,325,328,332],")":[160,183],"calculations,":[161],"a":[163,378],"42%":[164],"increase":[167],"major":[169],"harm":[180],"(NNH":[181],"estimations.":[184],"Results:":[185],"Only":[186],"would":[191],"qualify":[192],"consideration":[195],"according":[199],"guidelines":[208],">20%":[211],"define":[216],"Benefit/harm":[219],"calculations":[220],"restricted":[222],"aspirin-naive":[224],"<70":[226],"(n=3540).":[236],"overall":[238,295],"NNT":[239,258,283,298,317,327],"with":[241,366],"prevent":[244],"event":[248],"476":[250],"NNH":[253,268,288,302,324,331],"355.":[256],"also":[261],"greater":[262],"than":[263,287,322],"or":[264],"similar":[265],"strata.":[274,309],"Conversely,":[275],"CAC\u2265100":[276],"CAC\u2265400":[278],"identified":[279,312],"subgroups":[280,313],"which":[282,315],"lower":[286],".":[290],"This":[291],"true":[293],"both":[294],"(for":[296],"CAC\u2265100,":[297],"=140":[300],"versus":[301,330],"=518)":[304],"within":[306],"Also,":[310],"CAC=0":[311],"much":[320],"(overall,":[326],"=1190":[329],"=567).":[333],"Conclusions:":[334],"may":[336,375],"be":[337],"superior":[338],"equations":[343],"inform":[345],"prevention.":[352,387],"Implementation":[353],"current":[355],"guideline":[363],"recommendations":[364],"together":[365],"use":[368],"further":[372],"assessment":[374],"result":[376],"more":[379],"personalized,":[380],"safer":[381],"Confirmation":[388],"findings":[391],"experimental":[393],"settings":[394],"is":[395],"needed.":[396]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-10T00:00:00"}