{"id":"https://openalex.org/W3014565409","doi":"https://doi.org/10.2217/nnm-2019-0428","title":"Chemotherapeutic Potential of L-Carnosine From Stimuli-Responsive Magnetic Nanoparticles Against Breast Cancer Model","display_name":"Chemotherapeutic Potential of L-Carnosine From Stimuli-Responsive Magnetic Nanoparticles Against Breast Cancer Model","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3014565409","doi":"https://doi.org/10.2217/nnm-2019-0428","mag":"3014565409","pmid":"https://pubmed.ncbi.nlm.nih.gov/32238029"},"language":"en","primary_location":{"id":"doi:10.2217/nnm-2019-0428","doi":"https://doi.org/10.2217/nnm-2019-0428","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nnm-2019-0428","pdf_url":null,"source":{"id":"https://openalex.org/S4210216406","display_name":"Nanomedicine","issn_l":"1743-5889","issn":["1743-5889","1748-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011297225","display_name":"Ragwa Mohamed Farid","orcid":"https://orcid.org/0000-0001-6308-9207","observed_orcids":["https://orcid.org/0000-0001-6308-9207"]},"institutions":[{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ragwa M Farid","raw_affiliation_strings":["Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt","institution_ids":["https://openalex.org/I146977602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087989818","display_name":"Passent M.E. Gaafar","orcid":"https://orcid.org/0000-0003-3399-9597","observed_orcids":["https://orcid.org/0000-0003-3399-9597"]},"institutions":[{"id":"https://openalex.org/I59272784","display_name":"Arab Academy for Science, Technology, and Maritime Transport","ror":"https://ror.org/0004vyj87","country_code":"EG","type":"education","lineage":["https://openalex.org/I59272784"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Passent M\u00a0E Gaafar","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport, Alexandria, Egypt","institution_ids":["https://openalex.org/I59272784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040498370","display_name":"Heba A. Hazzah","orcid":"https://orcid.org/0000-0002-4325-1649","observed_orcids":["https://orcid.org/0000-0002-4325-1649"]},"institutions":[{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Heba A Hazzah","raw_affiliation_strings":["Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt","institution_ids":["https://openalex.org/I146977602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090469369","display_name":"Maged W. Helmy","orcid":"https://orcid.org/0000-0003-0375-6762","observed_orcids":["https://orcid.org/0000-0003-0375-6762"]},"institutions":[{"id":"https://openalex.org/I169744251","display_name":"Damanhour University","ror":"https://ror.org/03svthf85","country_code":"EG","type":"education","lineage":["https://openalex.org/I169744251"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Maged W Helmy","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt","institution_ids":["https://openalex.org/I169744251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054821696","display_name":"Ossama Y. Abdallah","orcid":"https://orcid.org/0000-0003-3547-5404","observed_orcids":["https://orcid.org/0000-0003-3547-5404"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ossama Y Abdallah","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0291,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.67962309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"9","first_page":"891","last_page":"911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-carnosine","display_name":"L-carnosine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.8600000143051147},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-delivery","display_name":"stimuli-responsive drug delivery","score":0.9269999861717224},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ehrlich-ascites-carcinoma","display_name":"Ehrlich ascites carcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8029999732971191},{"id":"https://openalex.org/keywords/carnosine","display_name":"carnosine","score":0.4950000047683716},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2780687331","wikidata":"https://www.wikidata.org/wiki/Q413822","display_name":"Carnosine","level":2,"score":0.7646033763885498},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6245136260986328},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.4902094006538391},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4505239427089691},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.438823938369751},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.40061241388320923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37635403871536255},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3449772596359253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34416183829307556},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3239467144012451},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26607710123062134},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23159387707710266}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002336","descriptor_name":"Carnosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058185","descriptor_name":"Magnetite Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/nnm-2019-0428","doi":"https://doi.org/10.2217/nnm-2019-0428","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nnm-2019-0428","pdf_url":null,"source":{"id":"https://openalex.org/S4210216406","display_name":"Nanomedicine","issn_l":"1743-5889","issn":["1743-5889","1748-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine","raw_type":"journal-article"},{"id":"pmid:32238029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32238029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W146926882","https://openalex.org/W1263395533","https://openalex.org/W1546539693","https://openalex.org/W1583600800","https://openalex.org/W1890430830","https://openalex.org/W1968242916","https://openalex.org/W1970067538","https://openalex.org/W1980122435","https://openalex.org/W1981920137","https://openalex.org/W1987791720","https://openalex.org/W2000254862","https://openalex.org/W2001071466","https://openalex.org/W2008216183","https://openalex.org/W2008310888","https://openalex.org/W2010925000","https://openalex.org/W2013363967","https://openalex.org/W2017139362","https://openalex.org/W2019392121","https://openalex.org/W2024873760","https://openalex.org/W2025051061","https://openalex.org/W2026351725","https://openalex.org/W2027555238","https://openalex.org/W2028352081","https://openalex.org/W2033007989","https://openalex.org/W2035408744","https://openalex.org/W2039030515","https://openalex.org/W2041134714","https://openalex.org/W2045337840","https://openalex.org/W2047718984","https://openalex.org/W2050603121","https://openalex.org/W2052420621","https://openalex.org/W2053237060","https://openalex.org/W2062705764","https://openalex.org/W2064981718","https://openalex.org/W2068634762","https://openalex.org/W2068871092","https://openalex.org/W2070550561","https://openalex.org/W2072238968","https://openalex.org/W2072244823","https://openalex.org/W2074118721","https://openalex.org/W2077203523","https://openalex.org/W2077454707","https://openalex.org/W2079142824","https://openalex.org/W2086171977","https://openalex.org/W2087031474","https://openalex.org/W2087268698","https://openalex.org/W2093664485","https://openalex.org/W2094066733","https://openalex.org/W2094816534","https://openalex.org/W2095227474","https://openalex.org/W2097570123","https://openalex.org/W2097777266","https://openalex.org/W2116810900","https://openalex.org/W2122873513","https://openalex.org/W2132005699","https://openalex.org/W2137634849","https://openalex.org/W2139451172","https://openalex.org/W2144514205","https://openalex.org/W2157475701","https://openalex.org/W2164483701","https://openalex.org/W2165586946","https://openalex.org/W2170584001","https://openalex.org/W2185959842","https://openalex.org/W2334560101","https://openalex.org/W2402194152","https://openalex.org/W2432113050","https://openalex.org/W2516868059","https://openalex.org/W2543405117","https://openalex.org/W2611363212","https://openalex.org/W2637889902","https://openalex.org/W2760090338","https://openalex.org/W2765629531","https://openalex.org/W2766487611","https://openalex.org/W2766914562","https://openalex.org/W2771954391","https://openalex.org/W2781676508","https://openalex.org/W2888568396","https://openalex.org/W2902965611","https://openalex.org/W2917806671","https://openalex.org/W2944577037","https://openalex.org/W2955504961","https://openalex.org/W2968943106","https://openalex.org/W3000126971"],"related_works":["https://openalex.org/W4392868873","https://openalex.org/W4392292706","https://openalex.org/W4401893990","https://openalex.org/W2912304724","https://openalex.org/W4402032773","https://openalex.org/W2370624763","https://openalex.org/W4403220520","https://openalex.org/W4376140776","https://openalex.org/W3183532377","https://openalex.org/W2464316808"],"abstract_inverted_index":{"Aim:":[0],"L-carnosine-coated":[1],"magnetic":[2],"nanoparticles":[3],"(CCMNPs)":[4],"were":[5,96,119],"developed":[6,123],"to":[7,128],"enhance":[8],"chemotherapeutic":[9,48],"activity":[10,49],"of":[11,18],"carnosine-dipeptide.":[12],"Materials":[13],"&":[14],"methods:":[15],"Surface":[16],"grafting":[17],"MNPs":[19],"with":[20,77,88,107,126],"carnosine":[21,89,141],"was":[22,43,52],"contended":[23],"by":[24,54],"differential":[25],"scanning":[26],"calorimetry,":[27],"infrared":[28],"spectroscopy":[29],"and":[30,35,50,73,115],"x-ray":[31],"diffraction.":[32],"Physicochemical":[33],"characterization":[34],"in":[36,99,104,113],"vitro":[37],"cytotoxicity":[38],"on":[39],"MCF-7":[40],"cell":[41],"line":[42],"carried":[44],"out.":[45],"In":[46],"vivo":[47],"toxicity":[51],"assessed":[53],"an":[55,129],"Ehrlich":[56],"Ascites":[57],"tumor":[58,100,105],"model.":[59],"Results:":[60],"CCMNPs":[61,81,95],"possessed":[62],"monodispersed":[63],"size":[64,106],"(120":[65],"nm),":[66],"\u03b6":[67],"(-27.3":[68],"mV),":[69],"magnetization":[70],"(51.52":[71],"emu/g)":[72],"entrapment":[74],"efficiency":[75],"(88.3%)":[76],"sustained":[78],"release":[79],"rate.":[80],"showed":[82],"2.3-folds":[83],"lower":[84],"IC50":[85],"values":[86],"compared":[87],"solution":[90],"after":[91],"48":[92],"h.":[93],"Targeted":[94],"specifically":[97],"accumulated":[98],"showing":[101],"significant":[102],"reduction":[103,112],"no":[108],"systemic":[109],"toxicity.":[110],"Significant":[111],"VEGF":[114],"cyclin":[116],"D1":[117],"levels":[118],"observed.":[120],"Conclusion:":[121],"The":[122],"system":[124,139],"endowed":[125],"responsiveness":[127],"external":[130],"stimulus":[131],"can":[132],"represent":[133],"a":[134],"promising":[135],"magnetically":[136],"targeted":[137],"delivery":[138],"for":[140],"site":[142],"specific":[143],"delivery.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-04-10T00:00:00"}