{"id":"https://openalex.org/W3014296189","doi":"https://doi.org/10.1016/j.biopsych.2020.03.013","title":"Inherited Risk for Autism Through Maternal and Paternal Lineage","display_name":"Inherited Risk for Autism Through Maternal and Paternal Lineage","publication_year":2020,"publication_date":"2020-04-02","ids":{"openalex":"https://openalex.org/W3014296189","doi":"https://doi.org/10.1016/j.biopsych.2020.03.013","mag":"3014296189","pmid":"https://pubmed.ncbi.nlm.nih.gov/32430199"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2020.03.013","doi":"https://doi.org/10.1016/j.biopsych.2020.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2020.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.biopsych.2020.03.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102725050","display_name":"Dan Bai","orcid":"https://orcid.org/0000-0003-0029-1162","observed_orcids":["https://orcid.org/0000-0003-0029-1162"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Dan Bai","raw_affiliation_strings":["Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017803091","display_name":"Natasha M. Marrus","orcid":"https://orcid.org/0000-0001-6521-0373","observed_orcids":["https://orcid.org/0000-0001-6521-0373"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Marrus","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012414832","display_name":"Benjamin Hon Kei Yip","orcid":"https://orcid.org/0000-0002-4749-7611","observed_orcids":["https://orcid.org/0000-0002-4749-7611"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["HK","SE"],"is_corresponding":false,"raw_author_name":"Benjamin Hon Kei Yip","raw_affiliation_strings":["Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-4749-7611","affiliations":[{"raw_affiliation_string":"Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086216270","display_name":"Abraham Reichenberg","orcid":"https://orcid.org/0000-0003-2729-8575","observed_orcids":["https://orcid.org/0000-0003-2729-8575"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Reichenberg","raw_affiliation_strings":["Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York","Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York","Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041301597","display_name":"John Nicholas Constantino","orcid":"https://orcid.org/0000-0001-8888-4186","observed_orcids":["https://orcid.org/0000-0001-8888-4186"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. Constantino","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004878095","display_name":"Sven Sandin","orcid":"https://orcid.org/0000-0001-6994-4884","observed_orcids":["https://orcid.org/0000-0001-6994-4884"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["HK","SE","US"],"is_corresponding":true,"raw_author_name":"Sven Sandin","raw_affiliation_strings":["Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: sven.sandin@ki.se","Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York","Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong","Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":"https://orcid.org/0000-0001-6994-4884","affiliations":[{"raw_affiliation_string":"Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: sven.sandin@ki.se","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I28166907","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004878095"],"corresponding_institution_ids":["https://openalex.org/I177725633","https://openalex.org/I28166907","https://openalex.org/I98704320"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":3.6132,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.93610487,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"88","issue":"6","first_page":"480","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11632","display_name":"Family and Disability Support Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/familial-risk","display_name":"familial risk","score":0.5830000042915344},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.574999988079071},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.737934410572052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7090002298355103},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7009983658790588},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.6923816204071045},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6523601412773132},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6489151120185852},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.6170879602432251},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5801622867584229},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5601518750190735},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4857071340084076},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47500789165496826},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4612066149711609},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.45812758803367615},{"id":"https://openalex.org/C2779425982","wikidata":"https://www.wikidata.org/wiki/Q2323264","display_name":"Generation R","level":3,"score":0.44471147656440735},{"id":"https://openalex.org/C167704817","wikidata":"https://www.wikidata.org/wiki/Q7295548","display_name":"Rate ratio","level":3,"score":0.41136878728866577},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3108694553375244},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2496313750743866},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.20191076397895813},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.16240093111991882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1284412145614624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11668762564659119},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.biopsych.2020.03.013","doi":"https://doi.org/10.1016/j.biopsych.2020.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2020.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:32430199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32430199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7329120","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7483301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7483301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7483301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biol Psychiatry","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-1504","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.biopsych.2020.03.013","doi":"https://doi.org/10.1016/j.biopsych.2020.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2020.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2754895010","display_name":null,"funder_award_id":"P50HD103525","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3693353605","display_name":null,"funder_award_id":"U54HD087011","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4150964979","display_name":"ADVANCING EARLY BEHAVIORAL AND NEURAL PHENOTYPES OF SOCIAL MOTIVATION IN ASD","funder_award_id":"K08MH112891","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6825361638","display_name":null,"funder_award_id":"PM04-2016","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7412560871","display_name":null,"funder_award_id":"HD087011","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320310295","display_name":"Autism Science Foundation","ror":"https://ror.org/03063wv95"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W144464069","https://openalex.org/W1534086060","https://openalex.org/W1545398402","https://openalex.org/W1554944419","https://openalex.org/W1713509593","https://openalex.org/W1963736913","https://openalex.org/W1963959581","https://openalex.org/W1966714873","https://openalex.org/W1978744843","https://openalex.org/W1999204296","https://openalex.org/W2010164205","https://openalex.org/W2012203722","https://openalex.org/W2019357894","https://openalex.org/W2033021653","https://openalex.org/W2035263233","https://openalex.org/W2071432550","https://openalex.org/W2078129874","https://openalex.org/W2090495936","https://openalex.org/W2095229916","https://openalex.org/W2112600232","https://openalex.org/W2128161895","https://openalex.org/W2129873641","https://openalex.org/W2145053483","https://openalex.org/W2166018731","https://openalex.org/W2169222610","https://openalex.org/W2207583083","https://openalex.org/W2316811866","https://openalex.org/W2318996262","https://openalex.org/W2604697269","https://openalex.org/W2614349964","https://openalex.org/W2757581422","https://openalex.org/W2765858400","https://openalex.org/W2805711097","https://openalex.org/W2941892929","https://openalex.org/W2955503846","https://openalex.org/W2959289532","https://openalex.org/W2991349598","https://openalex.org/W2994909664","https://openalex.org/W4244767238"],"related_works":["https://openalex.org/W2418612925","https://openalex.org/W4236540109","https://openalex.org/W3148472658","https://openalex.org/W2385924770","https://openalex.org/W2434862809","https://openalex.org/W1498065504","https://openalex.org/W2419380365","https://openalex.org/W2087734183","https://openalex.org/W2135559483","https://openalex.org/W4310936753"],"abstract_inverted_index":{"BACKGROUND:":[0],"Autism":[1],"spectrum":[2],"disorder":[3],"(ASD)":[4],"is":[5,15,33],"highly":[6],"familial,":[7],"with":[8,119,134,140,144,184,186],"a":[9,29,88,141,173,217],"positively":[10],"skewed":[11],"male-to-female":[12],"ratio":[13],"that":[14,34],"purported":[16],"to":[17,41],"arise":[18],"from":[19,77],"the":[20,78,84,102,115,152,205,211,232,245,249],"so-called":[21],"female":[22,30,241],"protective":[23,31,242],"effect.":[24],"A":[25],"serious":[26],"implication":[27],"of":[28,46,54,90,138,149,221,227],"effect":[32],"familial":[35],"ASD":[36,55,97,145,150,187,222],"liability":[37],"would":[38,50,166],"be":[39,167],"expected":[40],"aggregate":[42],"asymptomatically":[43],"in":[44,100,114,204,253],"sisters":[45],"affected":[47,70,229],"probands,":[48],"who":[49],"incur":[51],"elevated":[52],"rates":[53,67,148],"among":[56,68],"their":[57,122],"offspring.":[58],"Currently,":[59],"there":[60],"exist":[61],"no":[62],"data":[63,76],"on":[64],"second-generation":[65],"recurrence":[66],"families":[69],"by":[71,230],"ASD.":[72,120,254],"METHODS:":[73],"We":[74],"analyzed":[75],"Swedish":[79],"National":[80],"Patient":[81],"Register":[82,86],"and":[83,95,104,125,129,175,200],"Multi-Generation":[85],"for":[87,169,182,197,201,225],"cohort":[89,116],"children":[91,113],"born":[92],"between":[93],"2003":[94],"2012.":[96],"was":[98,180],"ascertained":[99],"both":[101],"child":[103],"parental":[105,206],"generations.":[106],"RESULTS:":[107],"Among":[108,121],"847,732":[109],"children,":[110],"13,103":[111],"(1.55%)":[112],"were":[117,132],"diagnosed":[118,133,143],"maternal/paternal":[123],"aunts":[124],"uncles,":[126],"1744":[127],"(0.24%)":[128],"1374":[130],"(0.18%)":[131],"ASD,":[135,231],"respectively.":[136],"Offspring":[137],"mothers":[139],"sibling(s)":[142],"had":[146],"higher":[147],"than":[151,165,179],"general":[153,219],"population":[154],"(relative":[155,188],"risk,":[156,189],"3.05;":[157],"95%":[158,191],"confidence":[159,192],"interval,":[160,193],"2.52-3.64),":[161],"but":[162],"not":[163,209,239],"more":[164,178],"predicted":[168],"second-degree":[170],"relatives":[171],"within":[172],"generation,":[174],"only":[176],"slightly":[177],"observed":[181],"fathers":[183],"siblings":[185,226],"2.08;":[190],"1.53-2.67).":[194],"Models":[195],"adjusting":[196],"temporal":[198],"trends":[199],"psychiatric":[202],"history":[203],"generation":[207],"did":[208],"alter":[210],"results.":[212],"CONCLUSIONS:":[213],"These":[214],"findings":[215,237],"establish":[216],"robust":[218],"estimate":[220],"transmission":[223],"risk":[224],"individuals":[228],"first":[233],"ever":[234],"reported.":[235],"Our":[236],"do":[238],"suggest":[240],"factors":[243],"as":[244],"principal":[246],"mechanism":[247],"underlying":[248],"male":[250],"sex":[251],"bias":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
