{"id":"https://openalex.org/W3014292227","doi":"https://doi.org/10.3897/folmed.62.e47762","title":"Various Aspects of Tiagabine Effectiveness as Add-on Therapy in Patients with Refractory Epilepsy","display_name":"Various Aspects of Tiagabine Effectiveness as Add-on Therapy in Patients with Refractory Epilepsy","publication_year":2020,"publication_date":"2020-03-31","ids":{"openalex":"https://openalex.org/W3014292227","doi":"https://doi.org/10.3897/folmed.62.e47762","mag":"3014292227","pmid":"https://pubmed.ncbi.nlm.nih.gov/32337898"},"language":"en","primary_location":{"id":"doi:10.3897/folmed.62.e47762","doi":"https://doi.org/10.3897/folmed.62.e47762","is_oa":true,"landing_page_url":"https://doi.org/10.3897/folmed.62.e47762","pdf_url":"https://foliamedica.bg/article/47762/download/pdf/","source":{"id":"https://openalex.org/S2736716135","display_name":"Folia Medica","issn_l":"0204-8043","issn":["0204-8043","1314-2143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Medica","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3014292227"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://foliamedica.bg/article/47762/download/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048794080","display_name":"Ekaterina Viteva","orcid":"https://orcid.org/0000-0001-6553-444X","observed_orcids":["https://orcid.org/0000-0001-6553-444X"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Ekaterina Viteva","raw_affiliation_strings":["Medical University of Plovdiv, Plovdiv, Bulgaria","Medical University of Plovdiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Medical University of Plovdiv","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060745675","display_name":"Zahari Zahariev","orcid":"https://orcid.org/0009-0007-5558-0320","observed_orcids":["https://orcid.org/0009-0007-5558-0320"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Zahari Zahariev","raw_affiliation_strings":["Medical University of Plovdiv, Plovdiv, Bulgaria","Medical University of Plovdiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Plovdiv, Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Medical University of Plovdiv","institution_ids":["https://openalex.org/I2801117330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048794080"],"corresponding_institution_ids":["https://openalex.org/I2801117330"],"apc_list":null,"apc_paid":null,"fwci":0.1269,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40841287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"1","first_page":"59","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiagabine","display_name":"tiagabine","score":1.0},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/seizure-frequency","display_name":"seizure frequency","score":0.7639999985694885},{"id":"https://openalex.org/keywords/seizure-severity","display_name":"seizure severity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8529999852180481},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.8740000128746033},{"id":"https://openalex.org/keywords/myoclonic-seizures","display_name":"myoclonic seizures","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bulgarian-patients","display_name":"Bulgarian patients","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.756192684173584},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.65512615442276},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5764532685279846},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5631285905838013},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5191171169281006},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.48437604308128357},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.45446908473968506},{"id":"https://openalex.org/C2776749334","wikidata":"https://www.wikidata.org/wiki/Q907219","display_name":"Tiagabine","level":4,"score":0.43322286009788513},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4226621985435486},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.3823355734348297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2223152220249176},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18959739804267883}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000078308","descriptor_name":"Tiagabine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003221","descriptor_name":"Confusion","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004244","descriptor_name":"Dizziness","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011605","descriptor_name":"Psychoses, Substance-Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013035","descriptor_name":"Spasm","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014717","descriptor_name":"Vertigo","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3897/folmed.62.e47762","doi":"https://doi.org/10.3897/folmed.62.e47762","is_oa":true,"landing_page_url":"https://doi.org/10.3897/folmed.62.e47762","pdf_url":"https://foliamedica.bg/article/47762/download/pdf/","source":{"id":"https://openalex.org/S2736716135","display_name":"Folia Medica","issn_l":"0204-8043","issn":["0204-8043","1314-2143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Medica","raw_type":"journal-article"},{"id":"pmid:32337898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32337898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia medica","raw_type":"Journal Article"},{"id":"pmh:10.3897/folmed.62.e47762","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3897/folmed.62.e47762","pdf_url":null,"source":{"id":"https://openalex.org/S199213172","display_name":"ZooKeys","issn_l":"1313-2970","issn":["1313-2970","1313-2989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Medica 62(1): 59-64","raw_type":"Original Article"},{"id":"pmh:oai:doaj.org/article:be8387ab69f644d6a6946ade8b07af98","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be8387ab69f644d6a6946ade8b07af98","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Medica, Vol 62, Iss 1, Pp 59-64 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3897/folmed.62.e47762","doi":"https://doi.org/10.3897/folmed.62.e47762","is_oa":true,"landing_page_url":"https://doi.org/10.3897/folmed.62.e47762","pdf_url":"https://foliamedica.bg/article/47762/download/pdf/","source":{"id":"https://openalex.org/S2736716135","display_name":"Folia Medica","issn_l":"0204-8043","issn":["0204-8043","1314-2143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Medica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014292227.pdf","grobid_xml":"https://content.openalex.org/works/W3014292227.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409150568","https://openalex.org/W1979402597","https://openalex.org/W179835007","https://openalex.org/W1968217355","https://openalex.org/W2170734360","https://openalex.org/W2044673072","https://openalex.org/W2169178526","https://openalex.org/W2780481816","https://openalex.org/W4252787122","https://openalex.org/W2096201943"],"abstract_inverted_index":{"The":[0,42,158],"aim":[1],"of":[2,11,33,39,68,83,116,125,178,193,205,218,225,230,235],"the":[3,26,31,36,47,65,146],"present":[4],"study":[5,24],"was":[6,93,109,162],"to":[7,136],"investigate":[8],"various":[9],"aspects":[10],"tiagabine":[12],"(TGB)":[13],"effectiveness":[14],"in":[15,99,123,155,164,203],"Bulgarian":[16],"patients":[17,27,43,101,165],"with":[18,28,70,80,166,213],"drug-resistant":[19],"epilepsy.":[20],"This":[21],"open,":[22],"prospective":[23],"recruited":[25],"epilepsy":[29],"attending":[30],"Clinic":[32],"Neurology":[34],"at":[35,59,73],"University":[37],"Hospital":[38],"Plovdiv,":[40],"Bulgaria.":[41],"completed":[44],"diaries":[45],"about":[46],"seizure":[48,84,117,120,129,150,219,226,231,237],"frequency,":[49,85,227],"severity,":[50,86,118,220],"and":[51,72,89,112,139,180,215,222,239,242],"adverse":[52,87,171],"events.":[53],"There":[54,108,169],"were":[55,170],"regular":[56],"documented":[57],"visits":[58],"3":[60],"or":[61,76],"6":[62,74,135],"months":[63,75],"during":[64,145],"first":[66],"year":[67,78],"treatment":[69,98,210],"TGB":[71,92,209],"1":[77],"afterwards,":[79],"dynamic":[81,114],"assessment":[82],"events,":[88],"EEG":[90],"recordings.":[91],"applied":[94],"as":[95],"an":[96],"add-on":[97],"43":[100],"(24":[102],"males,":[103],"mean":[104,128],"age":[105],"39":[106],"years).":[107],"relatively":[110],"mild":[111],"transient":[113,185,216],"improvement":[115,217,224],"satisfactory":[119],"frequency":[121,130],"reduction":[122,131],"32.6%":[124],"participants,":[126],"stable":[127,141,223],"(40-50%)":[132],"from":[133],"month":[134,137],"24":[138],"a":[140],"response":[142],"rate":[143],"(52.3-50%)":[144],"same":[147],"period.":[148],"New":[149],"types":[151],"(myoclonic,":[152],"myoclonic-atonic)":[153],"occurred":[154],"2":[156],"patients.":[157,206],"final":[159],"clinical":[160],"efficacy":[161],"higher":[163],"initial":[167],"monotherapy.":[168],"events":[172],"(dizziness/vertigo,":[173],"sedation,":[174],"memory":[175],"impairment,":[176],"loss":[177],"appetite":[179],"weight,":[181],"confusion,":[182],"psychosis,":[183],"insomnia,":[184],"diplopia,":[186],"lymphadenomegaly,":[187],"rash,":[188],"nausea,":[189],"depression,":[190],"anxiety,":[191],"tremor":[192],"hands,":[194],"unstable":[195],"gait,":[196],"legs":[197],"edema,":[198],"thrombocytopenia,":[199],"cervical":[200],"muscles":[201],"tightening)":[202],"26.19%":[204],"In":[207],"conclusion,":[208],"is":[211],"associated":[212],"low":[214],"good":[221],"possible":[228,233],"worsening":[229],"control,":[232],"appearance":[234],"new":[236],"types,":[238],"acceptable":[240],"safety":[241],"tolerability.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}
