{"id":"https://openalex.org/W3014290835","doi":"https://doi.org/10.1088/1758-5090/ab8707","title":"Machine learning-based design strategy for 3D printable bioink: elastic modulus and yield stress determine printability","display_name":"Machine learning-based design strategy for 3D printable bioink: elastic modulus and yield stress determine printability","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3014290835","doi":"https://doi.org/10.1088/1758-5090/ab8707","mag":"3014290835","pmid":"https://pubmed.ncbi.nlm.nih.gov/32252038"},"language":"en","primary_location":{"id":"doi:10.1088/1758-5090/ab8707","doi":"https://doi.org/10.1088/1758-5090/ab8707","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1758-5090/ab8707","pdf_url":null,"source":{"id":"https://openalex.org/S26035906","display_name":"Biofabrication","issn_l":"1758-5082","issn":["1758-5082","1758-5090"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100401544","display_name":"Joo\u2010Young Lee","orcid":"https://orcid.org/0000-0002-5208-0941","observed_orcids":["https://orcid.org/0000-0002-5208-0941","https://orcid.org/0009-0000-3083-5357","https://orcid.org/0000-0002-6020-3040"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jooyoung Lee","raw_affiliation_strings":["Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002494133","display_name":"Seung Ja Oh","orcid":"https://orcid.org/0000-0002-4572-0656","observed_orcids":["https://orcid.org/0000-0002-4572-0656"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Ja Oh","raw_affiliation_strings":["Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030249194","display_name":"Sang\u2010Hyun An","orcid":"https://orcid.org/0000-0001-7986-778X","observed_orcids":["https://orcid.org/0000-0001-7986-778X"]},"institutions":[{"id":"https://openalex.org/I4210111434","display_name":"Korea Institute of Machinery & Materials","ror":"https://ror.org/01qcq9d74","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210111434","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Hyun An","raw_affiliation_strings":["Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea","institution_ids":["https://openalex.org/I4210111434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005902604","display_name":"Wan-Doo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111434","display_name":"Korea Institute of Machinery & Materials","ror":"https://ror.org/01qcq9d74","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210111434","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Wan-Doo Kim","raw_affiliation_strings":["Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea","institution_ids":["https://openalex.org/I4210111434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101931762","display_name":"Sang\u2010Heon Kim","orcid":"https://orcid.org/0000-0002-6128-8218","observed_orcids":["https://orcid.org/0000-0002-6128-8218"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang-Heon Kim","raw_affiliation_strings":["Author to whom any correspondence should be addressed","Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","Division of Bio-Med, Korea University of Science and Technology, Daejeon 34113, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6128-8218","affiliations":[{"raw_affiliation_string":"Author to whom any correspondence should be addressed","institution_ids":[]},{"raw_affiliation_string":"Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","institution_ids":["https://openalex.org/I58716616"]},{"raw_affiliation_string":"Division of Bio-Med, Korea University of Science and Technology, Daejeon 34113, Republic of Korea","institution_ids":["https://openalex.org/I88761825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002494133","https://openalex.org/A5005902604","https://openalex.org/A5030249194","https://openalex.org/A5100401544","https://openalex.org/A5101931762"],"corresponding_institution_ids":["https://openalex.org/I4210111434","https://openalex.org/I58716616","https://openalex.org/I88761825"],"apc_list":{"value":3895,"currency":"USD","value_usd":3895},"apc_paid":null,"fwci":5.4775,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.97238079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"035018","last_page":"035018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-bioprinting","display_name":"3D bioprinting","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atelocollagen","display_name":"atelocollagen","score":0.921999990940094},{"id":"https://openalex.org/keywords/native-collagen","display_name":"native collagen","score":0.7710000276565552},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/yield-stress","display_name":"yield stress","score":1.0},{"id":"https://openalex.org/keywords/printability","display_name":"printability","score":0.9710000157356262},{"id":"https://openalex.org/keywords/shape-fidelity","display_name":"shape fidelity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/extrusion","display_name":"extrusion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/thermosensitive-hydrogel","display_name":"thermosensitive hydrogel","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-laden-hydrogels","display_name":"cell-laden hydrogels","score":0.7919999957084656},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.515999972820282},{"id":"https://openalex.org/keywords/natural-biomaterials","display_name":"natural biomaterials","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7352516055107117},{"id":"https://openalex.org/C2779718196","wikidata":"https://www.wikidata.org/wiki/Q17018741","display_name":"3D bioprinting","level":3,"score":0.6518419981002808},{"id":"https://openalex.org/C43486711","wikidata":"https://www.wikidata.org/wiki/Q192005","display_name":"Elastic modulus","level":2,"score":0.6420947909355164},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5263306498527527},{"id":"https://openalex.org/C524769229","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3D printing","level":2,"score":0.512337327003479},{"id":"https://openalex.org/C136478896","wikidata":"https://www.wikidata.org/wiki/Q898288","display_name":"Brittleness","level":2,"score":0.4836079180240631},{"id":"https://openalex.org/C193867417","wikidata":"https://www.wikidata.org/wiki/Q6889814","display_name":"Modulus","level":2,"score":0.44906795024871826},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.4235919117927551},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.38110417127609253},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3750680685043335},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3226529061794281},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2952471971511841},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.067008376121521}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007281","descriptor_name":"Ink","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062028","descriptor_name":"Bioprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1088/1758-5090/ab8707","doi":"https://doi.org/10.1088/1758-5090/ab8707","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1758-5090/ab8707","pdf_url":null,"source":{"id":"https://openalex.org/S26035906","display_name":"Biofabrication","issn_l":"1758-5082","issn":["1758-5082","1758-5090"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"journal-article"},{"id":"pmid:32252038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32252038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"Journal Article"},{"id":"mag:3047060130","doi":null,"is_oa":false,"landing_page_url":"http://pubs.kist.re.kr/handle/201004/63511","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4116091758","display_name":null,"funder_award_id":"#2E29340","funder_id":"https://openalex.org/F4320322091","funder_display_name":"Korea Institute of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1481145212","https://openalex.org/W1504463291","https://openalex.org/W1781763918","https://openalex.org/W1967616618","https://openalex.org/W1999139561","https://openalex.org/W2027023682","https://openalex.org/W2029903083","https://openalex.org/W2030794029","https://openalex.org/W2043570602","https://openalex.org/W2048644480","https://openalex.org/W2053413775","https://openalex.org/W2055846825","https://openalex.org/W2075749768","https://openalex.org/W2078332350","https://openalex.org/W2091482871","https://openalex.org/W2092184020","https://openalex.org/W2100837269","https://openalex.org/W2111801168","https://openalex.org/W2118305071","https://openalex.org/W2122180971","https://openalex.org/W2130227698","https://openalex.org/W2133683725","https://openalex.org/W2163091503","https://openalex.org/W2163920091","https://openalex.org/W2171492615","https://openalex.org/W2172143926","https://openalex.org/W2188096331","https://openalex.org/W2197557991","https://openalex.org/W2324924698","https://openalex.org/W2394524191","https://openalex.org/W2488863215","https://openalex.org/W2519742913","https://openalex.org/W2521121173","https://openalex.org/W2552637162","https://openalex.org/W2589223642","https://openalex.org/W2647062254","https://openalex.org/W2802504186","https://openalex.org/W2807264928","https://openalex.org/W2808779459","https://openalex.org/W2884430236","https://openalex.org/W2892221324","https://openalex.org/W2898258147","https://openalex.org/W2898592867","https://openalex.org/W2919134469","https://openalex.org/W4246239401"],"related_works":["https://openalex.org/W4400412282","https://openalex.org/W4414369572","https://openalex.org/W3082213210","https://openalex.org/W3111470525","https://openalex.org/W4403233928","https://openalex.org/W2755965525","https://openalex.org/W4413419581","https://openalex.org/W4403502754","https://openalex.org/W3101442123","https://openalex.org/W3008990289"],"abstract_inverted_index":{"Although":[0],"three-dimensional":[1],"(3D)":[2],"bioprinting":[3],"technology":[4],"is":[5,106,120,128],"rapidly":[6],"developing,":[7],"the":[8,98,123,181],"design":[9,28],"strategies":[10],"for":[11,49],"biocompatible":[12],"3D-printable":[13,29],"bioinks":[14,144],"remain":[15],"a":[16,23,32,66,94,111,157,161,165],"challenge.":[17],"In":[18],"this":[19,127,135],"study,":[20],"we":[21,40,92,137,155],"developed":[22],"machine":[24,109,131],"learning-based":[25],"method":[26],"to":[27,52],"bioink":[30],"using":[31,150],"model":[33],"system":[34],"with":[35,70,164],"naturally":[36,142],"derived":[37,138,143],"biomaterials.":[38],"First,":[39],"demonstrated":[41],"that":[42,105,145,173],"atelocollagen":[43],"(AC)":[44],"has":[45],"desirable":[46],"physical":[47],"properties":[48,100],"printing":[50],"compared":[51],"native":[53],"collagen":[54],"(NC).":[55],"AC":[56],"gel":[57,76],"exhibited":[58],"weakly":[59],"elastic":[60,113],"and":[61,80,87,103,118,178],"temperature-responsive":[62,81],"reversible":[63],"behavior":[64,83],"forming":[65],"soft":[67],"cream-like":[68],"structure":[69],"low":[71],"yield":[72,89,125],"stress,":[73],"whereas":[74],"NC":[75],"showed":[77],"highly":[78,176],"crosslinked":[79],"irreversible":[82],"resulting":[84],"in":[85,180],"brittleness":[86],"high":[88,112,147,168],"stress.":[90],"Next,":[91],"discovered":[93],"universal":[95],"relationship":[96],"between":[97],"mechanical":[99],"of":[101,141,160,167],"ink":[102],"printability":[104],"supported":[107,129],"by":[108,130],"learning:":[110],"modulus":[114],"improves":[115],"shape":[116,148,169],"fidelity":[117,149,170],"extrusion":[119],"possible":[121],"below":[122],"critical":[124],"stress;":[126],"learning.":[132],"Based":[133],"on":[134],"relationship,":[136],"various":[139],"formulations":[140],"provide":[146],"multiple":[151],"regression":[152],"analysis.":[153],"Finally,":[154],"produced":[156],"3D":[158,182],"construct":[159],"cell-laden":[162],"hydrogel":[163],"framework":[166],"bioink,":[171],"confirming":[172],"cells":[174],"are":[175],"viable":[177],"proliferative":[179],"constructs.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":46},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-04-10T00:00:00"}
