{"id":"https://openalex.org/W3014201892","doi":"https://doi.org/10.7554/elife.52613","title":"Cell-type diversity and regionalized gene expression in the planarian intestine","display_name":"Cell-type diversity and regionalized gene expression in the planarian intestine","publication_year":2020,"publication_date":"2020-04-02","ids":{"openalex":"https://openalex.org/W3014201892","doi":"https://doi.org/10.7554/elife.52613","mag":"3014201892","pmid":"https://pubmed.ncbi.nlm.nih.gov/32240093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7117911"},"language":"en","primary_location":{"id":"doi:10.7554/elife.52613","doi":"https://doi.org/10.7554/elife.52613","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.52613","pdf_url":"https://elifesciences.org/articles/52613.bib","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://elifesciences.org/articles/52613.bib","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028406771","display_name":"David J. Forsthoefel","orcid":"https://orcid.org/0000-0002-8583-4383","observed_orcids":["https://orcid.org/0000-0002-8583-4383"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Forsthoefel","raw_affiliation_strings":["Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA","Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States;","Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States"],"raw_orcid":"https://orcid.org/0000-0002-8583-4383","affiliations":[{"raw_affiliation_string":"Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]},{"raw_affiliation_string":"Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States;","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004550948","display_name":"Nicholas I. Cejda","orcid":"https://orcid.org/0000-0003-4518-4125","observed_orcids":["https://orcid.org/0000-0003-4518-4125"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas I. Cejda","raw_affiliation_strings":["Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA","Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States;"],"raw_orcid":"https://orcid.org/0000-0003-4518-4125","affiliations":[{"raw_affiliation_string":"Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, United States;","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055646091","display_name":"Umair W. Khan","orcid":"https://orcid.org/0000-0003-0206-0667","observed_orcids":["https://orcid.org/0000-0003-0206-0667"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umair W. Khan","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Graduate Program in Cell and Molecular Biology, University of Wisconsin-Madison, Madison, United States;","Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]},{"raw_affiliation_string":"Graduate Program in Cell and Molecular Biology, University of Wisconsin-Madison, Madison, United States;","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043948579","display_name":"Phillip A. Newmark","orcid":"https://orcid.org/0000-0003-0793-022X","observed_orcids":["https://orcid.org/0000-0003-0793-022X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phillip A. Newmark","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States","Howard Hughes Medical Institute, Morgridge Institute for Research, Department of Integrative Biology, University of Wisconsin-Madison, Madison, United States"],"raw_orcid":"https://orcid.org/0000-0003-0793-022X","affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I157725225"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Morgridge Institute for Research, Department of Integrative Biology, University of Wisconsin-Madison, Madison, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I29680605"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028406771","https://openalex.org/A5043948579"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I157725225","https://openalex.org/I29680605","https://openalex.org/I30558944"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.1888,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.88714808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14399","display_name":"Invertebrate Taxonomy and Ecology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schmidtea-mediterranea","display_name":"Schmidtea mediterranea","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intestinal-transcriptome","display_name":"intestinal transcriptome","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-diversity","display_name":"cell type diversity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intestinal-regeneration","display_name":"intestinal regeneration","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gastrointestinal-physiology","display_name":"digestive physiology","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2775935104","wikidata":"https://www.wikidata.org/wiki/Q6502673","display_name":"Planarian","level":3,"score":0.9481391906738281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6159752607345581},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5488982796669006},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5372675657272339},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.4662415385246277},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4626418650150299},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.45539018511772156},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3874841332435608},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3858755826950073},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3816570043563843},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3224930763244629},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.16767042875289917},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.52613","doi":"https://doi.org/10.7554/elife.52613","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.52613","pdf_url":"https://elifesciences.org/articles/52613.bib","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/756924","doi":"https://doi.org/10.1101/756924","is_oa":true,"landing_page_url":"https://doi.org/10.1101/756924","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/09/05/756924.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7117911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7117911","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:32240093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32240093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ff49e0917861474d8325cb12398203a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff49e0917861474d8325cb12398203a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 9 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.52613","doi":"https://doi.org/10.7554/elife.52613","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.52613","pdf_url":"https://elifesciences.org/articles/52613.bib","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.6800000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2709750837","display_name":null,"funder_award_id":"HD043403","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2834709554","display_name":null,"funder_award_id":"P20\u2010GM103636","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2867018313","display_name":"Molecular Mechanisms and Genetics of Autoimmunity COBRE","funder_award_id":"P30GM110766","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4473694703","display_name":"Mentoring Translational Cancer Research in Oklahoma","funder_award_id":"P20GM103639","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4724425049","display_name":null,"funder_award_id":"P30CA225520","funder_id":"https://openalex.org/F4320332607","funder_display_name":"University of Oklahoma Health Sciences Center"},{"id":"https://openalex.org/G501766673","display_name":null,"funder_award_id":"#P30CA225520","funder_id":"https://openalex.org/F4320333795","funder_display_name":"Stephenson Cancer Center"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6856584325","display_name":"Expanding Excellence in Developmental Biology in Oklahoma","funder_award_id":"5p20gm103636-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8310093164","display_name":null,"funder_award_id":"COBRE GM103636-Project 1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000034000","display_name":null,"funder_award_id":"COBRE P20GM103639","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000130911","display_name":null,"funder_award_id":"GM110766","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000301793","display_name":null,"funder_award_id":"GM103636","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881557","display_name":"Stephenson Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA225520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000883582","display_name":"Germ cell specification and differentiation in planarians","funder_award_id":"R01HD043403","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F3824742741","display_name":"Oklahoma Center for Adult Stem Cell Research","ror":"https://ror.org/0520gqb12"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320310851","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33"},{"id":"https://openalex.org/F4320315709","display_name":"Tobacco Settlement Endowment Trust","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320332607","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98"},{"id":"https://openalex.org/F4320333795","display_name":"Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014201892.pdf","grobid_xml":"https://content.openalex.org/works/W3014201892.grobid-xml"},"referenced_works_count":181,"referenced_works":["https://openalex.org/W145072841","https://openalex.org/W181331372","https://openalex.org/W329953562","https://openalex.org/W748778761","https://openalex.org/W1496540148","https://openalex.org/W1506515851","https://openalex.org/W1529957136","https://openalex.org/W1923231248","https://openalex.org/W1947892036","https://openalex.org/W1966740969","https://openalex.org/W1967092051","https://openalex.org/W1971615347","https://openalex.org/W1971903348","https://openalex.org/W1972752128","https://openalex.org/W1980371495","https://openalex.org/W1981287744","https://openalex.org/W1981749506","https://openalex.org/W1986685674","https://openalex.org/W1988896305","https://openalex.org/W1989844217","https://openalex.org/W1990453950","https://openalex.org/W1996933969","https://openalex.org/W1998364288","https://openalex.org/W2004101774","https://openalex.org/W2005406099","https://openalex.org/W2007734760","https://openalex.org/W2008290596","https://openalex.org/W2009273580","https://openalex.org/W2009785574","https://openalex.org/W2011337131","https://openalex.org/W2012034410","https://openalex.org/W2012811488","https://openalex.org/W2015282904","https://openalex.org/W2015621557","https://openalex.org/W2017874888","https://openalex.org/W2022281303","https://openalex.org/W2025317147","https://openalex.org/W2026300944","https://openalex.org/W2026641296","https://openalex.org/W2026753351","https://openalex.org/W2027945041","https://openalex.org/W2028626013","https://openalex.org/W2029549744","https://openalex.org/W2029916705","https://openalex.org/W2030890903","https://openalex.org/W2031402631","https://openalex.org/W2032237342","https://openalex.org/W2032605950","https://openalex.org/W2034011855","https://openalex.org/W2034132082","https://openalex.org/W2035353547","https://openalex.org/W2037798895","https://openalex.org/W2038830569","https://openalex.org/W2040056656","https://openalex.org/W2043137697","https://openalex.org/W2043351969","https://openalex.org/W2044861333","https://openalex.org/W2045097086","https://openalex.org/W2050039053","https://openalex.org/W2053496006","https://openalex.org/W2059755754","https://openalex.org/W2064851823","https://openalex.org/W2066972948","https://openalex.org/W2069336691","https://openalex.org/W2070075984","https://openalex.org/W2075708010","https://openalex.org/W2078251936","https://openalex.org/W2078843126","https://openalex.org/W2081077466","https://openalex.org/W2082644877","https://openalex.org/W2084515556","https://openalex.org/W2084586161","https://openalex.org/W2087206725","https://openalex.org/W2087801719","https://openalex.org/W2091966685","https://openalex.org/W2093162194","https://openalex.org/W2093840308","https://openalex.org/W2094774123","https://openalex.org/W2095380321","https://openalex.org/W2097702986","https://openalex.org/W2099540110","https://openalex.org/W2100787580","https://openalex.org/W2101783948","https://openalex.org/W2104008077","https://openalex.org/W2104558541","https://openalex.org/W2105312191","https://openalex.org/W2106740149","https://openalex.org/W2108234281","https://openalex.org/W2109847775","https://openalex.org/W2114104545","https://openalex.org/W2115799739","https://openalex.org/W2117499811","https://openalex.org/W2119085116","https://openalex.org/W2120231073","https://openalex.org/W2120655432","https://openalex.org/W2126804187","https://openalex.org/W2128927944","https://openalex.org/W2131433316","https://openalex.org/W2132620196","https://openalex.org/W2136399909","https://openalex.org/W2138743768","https://openalex.org/W2143721749","https://openalex.org/W2146557306","https://openalex.org/W2146887271","https://openalex.org/W2147191899","https://openalex.org/W2153544371","https://openalex.org/W2153718995","https://openalex.org/W2154139219","https://openalex.org/W2155763709","https://openalex.org/W2158487621","https://openalex.org/W2158797557","https://openalex.org/W2161017899","https://openalex.org/W2162139653","https://openalex.org/W2162744532","https://openalex.org/W2167990668","https://openalex.org/W2170551349","https://openalex.org/W2171030481","https://openalex.org/W2171897290","https://openalex.org/W2191053757","https://openalex.org/W2224056471","https://openalex.org/W2246624679","https://openalex.org/W2262790410","https://openalex.org/W2273834235","https://openalex.org/W2294426565","https://openalex.org/W2314696528","https://openalex.org/W2336319651","https://openalex.org/W2343591175","https://openalex.org/W2344511876","https://openalex.org/W2345158396","https://openalex.org/W2345621458","https://openalex.org/W2352780606","https://openalex.org/W2403046618","https://openalex.org/W2407572234","https://openalex.org/W2428872011","https://openalex.org/W2471917135","https://openalex.org/W2472063172","https://openalex.org/W2475127848","https://openalex.org/W2486651492","https://openalex.org/W2499872337","https://openalex.org/W2510925426","https://openalex.org/W2514318134","https://openalex.org/W2516927204","https://openalex.org/W2547783103","https://openalex.org/W2551884408","https://openalex.org/W2553785299","https://openalex.org/W2582175008","https://openalex.org/W2582289155","https://openalex.org/W2587163858","https://openalex.org/W2595444111","https://openalex.org/W2597312491","https://openalex.org/W2602302971","https://openalex.org/W2611036723","https://openalex.org/W2625639088","https://openalex.org/W2746575864","https://openalex.org/W2761688050","https://openalex.org/W2761961135","https://openalex.org/W2769587587","https://openalex.org/W2785060806","https://openalex.org/W2786250214","https://openalex.org/W2788066338","https://openalex.org/W2792647356","https://openalex.org/W2799796757","https://openalex.org/W2800907246","https://openalex.org/W2801443765","https://openalex.org/W2802025024","https://openalex.org/W2806840045","https://openalex.org/W2808131763","https://openalex.org/W2808909535","https://openalex.org/W2809416844","https://openalex.org/W2888139780","https://openalex.org/W2891260560","https://openalex.org/W2895635508","https://openalex.org/W2897031692","https://openalex.org/W2901254075","https://openalex.org/W2901453315","https://openalex.org/W2904735040","https://openalex.org/W2941492678","https://openalex.org/W2951092994","https://openalex.org/W2964353163","https://openalex.org/W4233120011","https://openalex.org/W4245612329"],"related_works":["https://openalex.org/W2799796757","https://openalex.org/W2888139780","https://openalex.org/W2123989509","https://openalex.org/W2129132528","https://openalex.org/W3186541564","https://openalex.org/W2108489651","https://openalex.org/W2026388645","https://openalex.org/W3130932594","https://openalex.org/W2801443765","https://openalex.org/W4389640121"],"abstract_inverted_index":{"Abstract":[0],"Organ":[1],"regeneration":[2,173],"requires":[3],"precise":[4],"coordination":[5],"of":[6,12,24,57,60,72,79,88,106,115,129,140,153,176,181,215,222],"new":[7,210],"cell":[8,28,96,109,224],"differentiation":[9],"and":[10,20,27,51,98,111,143,163,174,187,207,226],"remodeling":[11],"uninjured":[13,32],"tissue":[14],"to":[15,53,92],"faithfully":[16],"re-establish":[17],"organ":[18],"morphology":[19],"function.":[21],"An":[22],"atlas":[23],"gene":[25,141,203],"expression":[26,101,127,142,204],"types":[29],"in":[30,132,171,205],"the":[31,55,58,89,104,126,151,154,172,219],"state":[33],"is":[34,43,196],"therefore":[35],"an":[36],"essential":[37],"pre-requisite":[38],"for":[39,200,212],"understanding":[40],"how":[41],"damage":[42],"repaired.":[44],"Here,":[45],"we":[46,135,157],"use":[47],"laser-capture":[48],"microdissection":[49],"(LCM)":[50],"RNA-Seq":[52],"define":[54],"transcriptome":[56,91],"intestine":[59],"Schmidtea":[61],"mediterranea,":[62],"a":[63,197,209],"planarian":[64,185],"flatworm":[65],"with":[66,82,118],"exceptional":[67],"regenerative":[68],"capacity.":[69],"Bioinformatic":[70],"analysis":[71],"1,844":[73],"intestine-enriched":[74,160],"transcripts":[75,117,131],"suggests":[76],"extensive":[77],"conservation":[78],"digestive":[80,216],"physiology":[81],"other":[83],"animals,":[84],"including":[85],"humans.":[86],"Comparison":[87],"intestinal":[90,95,108,121,155,223],"purified":[93],"absorptive":[94],"(phagocyte)":[97],"published":[99],"single-cell":[100],"profiles":[102],"confirms":[103],"identities":[105],"known":[107],"types,":[110,225],"also":[112],"identifies":[113],"hundreds":[114],"additional":[116],"previously":[119],"undetected":[120],"enrichment.":[122],"Furthermore,":[123,179],"by":[124],"assessing":[125,201],"patterns":[128],"143":[130],"situ":[133],",":[134],"discover":[136],"unappreciated":[137],"mediolateral":[138],"regionalization":[139],"cell-type":[144],"diversity,":[145],"especially":[146],"among":[147],"goblet":[148,177,182],"cells.":[149,178],"Demonstrating":[150],"utility":[152],"transcriptome,":[156],"identify":[158],"22":[159],"transcription":[161],"factors,":[162],"find":[164],"that":[165,194],"several":[166],"have":[167],"distinct":[168],"functional":[169],"roles":[170,221],"maintenance":[175],"depletion":[180],"cells":[183],"inhibits":[184],"feeding":[186],"reduces":[188],"viability.":[189],"Altogether,":[190],"our":[191],"results":[192],"show":[193],"LCM":[195],"viable":[198],"approach":[199],"tissue-specific":[202],"planarians,":[206],"provide":[208],"resource":[211],"further":[213],"investigation":[214],"tract":[217],"regeneration,":[218],"physiological":[220],"axial":[227],"polarity.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-10T00:00:00"}