{"id":"https://openalex.org/W3014176489","doi":"https://doi.org/10.1177/0333102420916751","title":"Effect of genetic liability to migraine on cognition and brain volume: A Mendelian randomization study","display_name":"Effect of genetic liability to migraine on cognition and brain volume: A Mendelian randomization study","publication_year":2020,"publication_date":"2020-04-04","ids":{"openalex":"https://openalex.org/W3014176489","doi":"https://doi.org/10.1177/0333102420916751","mag":"3014176489","pmid":"https://pubmed.ncbi.nlm.nih.gov/32249589"},"language":"en","primary_location":{"id":"doi:10.1177/0333102420916751","doi":"https://doi.org/10.1177/0333102420916751","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0333102420916751","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027876852","display_name":"Iyas Daghlas","orcid":"https://orcid.org/0000-0001-8735-284X","observed_orcids":["https://orcid.org/0000-0001-8735-284X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Iyas Daghlas","raw_affiliation_strings":["Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005759523","display_name":"Pamela M. Rist","orcid":"https://orcid.org/0000-0003-3543-045X","observed_orcids":["https://orcid.org/0000-0003-3543-045X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M Rist","raw_affiliation_strings":["Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013920089","display_name":"Daniel I. Chasman","orcid":"https://orcid.org/0000-0003-3357-0862","observed_orcids":["https://orcid.org/0000-0003-3357-0862"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I Chasman","raw_affiliation_strings":["Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3357-0862","affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027876852"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.639,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.81586436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"40","issue":"9","first_page":"998","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/g-factor","display_name":"general intelligence","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-volume","display_name":"brain volume","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intracranial-volume","display_name":"intracranial volume","score":0.9769999980926514},{"id":"https://openalex.org/keywords/subcortical-structures","display_name":"subcortical structures","score":0.8659999966621399},{"id":"https://openalex.org/keywords/causality","display_name":"causality","score":0.6549999713897705},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9606786966323853},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.6943081021308899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6038213968276978},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6010107398033142},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.587266206741333},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.44563767313957214},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.43552637100219727},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4181610643863678},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.41177183389663696},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3560234606266022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28650057315826416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2048366665840149},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1464364230632782},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12252399325370789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1028190553188324},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.08095186948776245},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.07918867468833923},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06998470425605774},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007360","descriptor_name":"Intelligence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0333102420916751","doi":"https://doi.org/10.1177/0333102420916751","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0333102420916751","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},{"id":"pmid:32249589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32249589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia : an international journal of headache","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4782689199","display_name":"Effects of Vitamin D and Omega-3 on Cerebrovascular Disease","funder_award_id":"K01HL128791","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G570081107","display_name":null,"funder_award_id":"R21NS09296","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G89988062","display_name":"Causality and/or shared physiology linking plasma lipids and blood pressure to migraine","funder_award_id":"R21NS104398","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2012579424","https://openalex.org/W2034287626","https://openalex.org/W2101851412","https://openalex.org/W2140054173","https://openalex.org/W2464448281","https://openalex.org/W2622693920","https://openalex.org/W2797906093","https://openalex.org/W2805983714","https://openalex.org/W2809193491","https://openalex.org/W2818417770","https://openalex.org/W2908002252","https://openalex.org/W2916749909","https://openalex.org/W2971642666"],"related_works":["https://openalex.org/W7125642487","https://openalex.org/W3111943281","https://openalex.org/W4399354927","https://openalex.org/W4323045255","https://openalex.org/W4396777770","https://openalex.org/W4400363982","https://openalex.org/W4226248303","https://openalex.org/W4392741931","https://openalex.org/W2982490410","https://openalex.org/W4399353498"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"potential":[3],"causality":[4],"between":[5],"genetic":[6,27],"liability":[7,89,152],"to":[8,90],"migraine":[9,31,91,130,151],"and":[10,14,62],"Alzheimer\u2019s":[11,44,96,154],"disease,":[12,155],"intelligence,":[13,156],"brain":[15,65,121,158],"volume":[16,58,122],"using":[17,83],"two-sample":[18],"Mendelian":[19,78],"randomization.":[20],"Methods":[21],"The":[22],"exposure":[23],"consisted":[24],"of":[25,51,135,150],"independent":[26],"variants":[28],"associated":[29,132],"with":[30,71,95,133],"in":[32],"the":[33,136],"largest":[34],"(59,674":[35],"cases/316,078":[36],"controls)":[37],"published":[38],"genome-wide":[39,73,139],"association":[40,74],"study.":[41],"Outcomes":[42],"included":[43],"disease":[45,97],"(71,880":[46],"cases/383,378":[47],"controls),":[48],"a":[49,147],"measure":[50],"general":[52],"intelligence":[53,108],"(n":[54,59,67],"=":[55,60,106,117],"269,867),":[56],"intracranial":[57],"11,373),":[61],"seven":[63],"subcortical":[64],"volumes":[66],"\u223c":[68],"13,000),":[69],"all":[70],"available":[72],"study":[75],"summary":[76],"statistics.":[77],"randomization":[79],"effects":[80],"were":[81],"estimated":[82],"inverse-variance":[84],"weighted":[85],"analysis.":[86],"Results":[87],"Genetic":[88],"did":[92],"not":[93,145],"associate":[94],"(odds":[98],"ratio":[99],"[95%":[100,111],"confidence":[101,112],"interval]":[102,113],"1.01":[103],"[1.00\u20131.02],":[104],"p":[105,116,125],"0.07),":[107],"(standardized":[109],"beta":[110],"0.01":[114],"[0.00\u20130.02],":[115],"0.13),":[118],"or":[119,157],"any":[120,134],"measures":[123],"(all":[124],">":[126],"0.05).":[127],"No":[128],"individual":[129],"variant":[131],"outcomes":[137],"at":[138],"significance.":[140],"Conclusions":[141],"These":[142],"data":[143],"do":[144],"support":[146],"causal":[148],"effect":[149],"on":[153],"volume.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-04-10T00:00:00"}