{"id":"https://openalex.org/W3014145051","doi":null,"title":"Spatial characterization of the BT-20 triple negative breast cancer spheroidal model","display_name":"Spatial characterization of the BT-20 triple negative breast cancer spheroidal model","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3014145051","mag":"3014145051"},"language":"en","primary_location":{"id":"pmh:oai:repository.up.ac.za:2263/70368","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2263/70368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005162431","display_name":"Keith Ntokozo Ncube","orcid":"https://orcid.org/0000-0003-4693-9868","observed_orcids":["https://orcid.org/0000-0003-4693-9868"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Keith Ntokozo Ncube","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4693-9868","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005162431"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/spheroid-morphology","display_name":"spheroid morphology","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.875},{"id":"https://openalex.org/keywords/iridium-complexes","display_name":"iridium complexes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cadherins","display_name":"cadherins","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anticancer-drug-screening","display_name":"anticancer drug screening","score":0.7070000171661377},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6039165258407593},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5380235910415649},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.510884702205658},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4505791664123535},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3408561944961548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2812579274177551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26532667875289917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23161187767982483},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22874382138252258},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19077527523040771}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.up.ac.za:2263/70368","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2263/70368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:3014145051","doi":null,"is_oa":false,"landing_page_url":"https://repository.up.ac.za/handle/2263/70368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W840861454","https://openalex.org/W1512072225","https://openalex.org/W1512321076","https://openalex.org/W1517318768","https://openalex.org/W1527442973","https://openalex.org/W1543790510","https://openalex.org/W1603300429","https://openalex.org/W1757407923","https://openalex.org/W1881540319","https://openalex.org/W1892496998","https://openalex.org/W1899376386","https://openalex.org/W1956944003","https://openalex.org/W1963928942","https://openalex.org/W1965037168","https://openalex.org/W1965528165","https://openalex.org/W1965909642","https://openalex.org/W1967997862","https://openalex.org/W1968971179","https://openalex.org/W1972825083","https://openalex.org/W1973339193","https://openalex.org/W1975298162","https://openalex.org/W1978139448","https://openalex.org/W1980181948","https://openalex.org/W1981487137","https://openalex.org/W1981717673","https://openalex.org/W1981989535","https://openalex.org/W1982481909","https://openalex.org/W1983673827","https://openalex.org/W1986503899","https://openalex.org/W1987007050","https://openalex.org/W1987777080","https://openalex.org/W1988481255","https://openalex.org/W1990251632","https://openalex.org/W1990472984","https://openalex.org/W1991847152","https://openalex.org/W1993497779","https://openalex.org/W1995224853","https://openalex.org/W2003395833","https://openalex.org/W2005025207","https://openalex.org/W2006483529","https://openalex.org/W2009526752","https://openalex.org/W2009931687","https://openalex.org/W2010183849","https://openalex.org/W2010251891","https://openalex.org/W2011824328","https://openalex.org/W2021550972","https://openalex.org/W2022532929","https://openalex.org/W2024644688","https://openalex.org/W2024905084","https://openalex.org/W2027542963","https://openalex.org/W2034269086","https://openalex.org/W2035959037","https://openalex.org/W2038443758","https://openalex.org/W2040051569","https://openalex.org/W2040558370","https://openalex.org/W2041585886","https://openalex.org/W2045387133","https://openalex.org/W2046097243","https://openalex.org/W2047242615","https://openalex.org/W2048217074","https://openalex.org/W2051740336","https://openalex.org/W2054814252","https://openalex.org/W2055498672","https://openalex.org/W2056984964","https://openalex.org/W2061789450","https://openalex.org/W2063169494","https://openalex.org/W2065177893","https://openalex.org/W2065573007","https://openalex.org/W2067428007","https://openalex.org/W2071333117","https://openalex.org/W2071369430","https://openalex.org/W2072860434","https://openalex.org/W2080090304","https://openalex.org/W2080919968","https://openalex.org/W2082898208","https://openalex.org/W2084659308","https://openalex.org/W2092880308","https://openalex.org/W2094454542","https://openalex.org/W2104176186","https://openalex.org/W2105017561","https://openalex.org/W2114229735","https://openalex.org/W2116040950","https://openalex.org/W2117692326","https://openalex.org/W2121836743","https://openalex.org/W2124073148","https://openalex.org/W2125149985","https://openalex.org/W2134539328","https://openalex.org/W2135177404","https://openalex.org/W2135736714","https://openalex.org/W2136445803","https://openalex.org/W2138969252","https://openalex.org/W2141022069","https://openalex.org/W2142995639","https://openalex.org/W2145200068","https://openalex.org/W2152635438","https://openalex.org/W2153565541","https://openalex.org/W2155024834","https://openalex.org/W2155916082","https://openalex.org/W2158060338","https://openalex.org/W2159256342","https://openalex.org/W2161273389","https://openalex.org/W2165316896","https://openalex.org/W2166498422","https://openalex.org/W2167279371","https://openalex.org/W2168056522","https://openalex.org/W2170602872","https://openalex.org/W2171634093","https://openalex.org/W2221584143","https://openalex.org/W2244037166","https://openalex.org/W2254833392","https://openalex.org/W2256545339","https://openalex.org/W2275011229","https://openalex.org/W2309067861","https://openalex.org/W2309472119","https://openalex.org/W2323860656","https://openalex.org/W2332155194","https://openalex.org/W2332230038","https://openalex.org/W2332911404","https://openalex.org/W2439344486","https://openalex.org/W2463139428","https://openalex.org/W2515721699","https://openalex.org/W2530991050","https://openalex.org/W2531225026","https://openalex.org/W2551920634","https://openalex.org/W2560836545","https://openalex.org/W2562852255","https://openalex.org/W2588271989","https://openalex.org/W2591628935","https://openalex.org/W2600129852","https://openalex.org/W2649656222","https://openalex.org/W2695955856","https://openalex.org/W2721843986","https://openalex.org/W2742716572","https://openalex.org/W2747464956","https://openalex.org/W2749146004","https://openalex.org/W2763457304","https://openalex.org/W2765291098","https://openalex.org/W2768033029","https://openalex.org/W2770397194","https://openalex.org/W2782732374","https://openalex.org/W2782752739","https://openalex.org/W2789637558","https://openalex.org/W2792527037","https://openalex.org/W2793152198","https://openalex.org/W2794144380","https://openalex.org/W2802241675","https://openalex.org/W2808121706","https://openalex.org/W2811022508","https://openalex.org/W2888483008","https://openalex.org/W2888561138","https://openalex.org/W2889646458","https://openalex.org/W2891241558","https://openalex.org/W2899243612","https://openalex.org/W2987126840","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W4377116075","https://openalex.org/W2953627287","https://openalex.org/W7131329183","https://openalex.org/W7133481226","https://openalex.org/W3209298496","https://openalex.org/W3084219506","https://openalex.org/W4413027906","https://openalex.org/W7204969746","https://openalex.org/W7204874228","https://openalex.org/W7203600399"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,6,174],"is":[2,21,38,51,108],"a":[3,69,133,168,194],"commonly":[4],"diagnosed":[5],"in":[7,80,95,126,266,287],"women,":[8],"with":[9,153,175],"increasing":[10],"diagnosis":[11],"and":[12,34,49,140,148,156,166,180,186,207,224,246,252,268,271,285],"mortality":[13],"rates.":[14],"The":[15,243],"triple-negative":[16,77,172],"sub-type":[17],"of":[18,25,29,57,59,76,98,104,124,150,159,171,241,264,281],"the":[19,39,55,73,87,102,121,136,146,154,208,216,239,260,278,282],"disease":[20],"characterised":[22,31],"by":[23,110],"lack":[24,56],"hormone-receptor":[26],"overexpression,":[27],"exhibition":[28],"poorly":[30],"molecular":[32,157],"aberrations,":[33],"treatment":[35,64],"failure.":[36,65],"Chemotherapy":[37],"current":[40],"mainstay;":[41],"however,":[42],"it":[43],"fails":[44],"to":[45,54,71,82,113,135,164,177,192,237,258,276],"slow":[46],"tumor":[47],"progression,":[48],"this":[50],"partially":[52],"attributed":[53],"characterisation":[58],"biological":[60,74],"features":[61,75],"that":[62],"drive":[63],"There":[66],"is,":[67],"therefore,":[68],"need":[70],"characterise":[72,167],"breast":[78,173],"cancer,":[79],"order":[81],"develop":[83],"effective":[84,105],"therapies":[85],"against":[86],"disease.":[88],"\\nResearchers":[89],"widely":[90],"use":[91],"monolayer":[92],"cell":[93,151],"culture":[94,115,152],"pre-clinical":[96],"screening":[97],"anticancer":[99],"drugs.":[100],"However,":[101],"development":[103],"anti-cancer":[106],"drugs":[107],"hampered":[109],"limitations":[111],"inherent":[112],"these":[114],"systems,":[116],"as":[117,132,143],"they":[118,144],"insufficiently":[119],"mimic":[120],"physiological":[122],"characteristics":[123],"tumours":[125],"vivo.":[127],"Spheroids":[128],"have":[129],"been":[130],"suggested":[131],"bridge":[134],"gap":[137],"between":[138],"monolayers":[139,267],"animal":[141],"models,":[142],"combine":[145],"flexibility":[147],"cost-effectiveness":[149],"spatial":[155,279],"attributes":[158],"tissue.":[160],"This":[161],"study":[162],"aimed":[163],"grow":[165],"spheroid":[169],"model":[170],"regards":[176],"growth,":[178],"morphology,":[179],"drug":[181],"sensitivity.":[182],"\\nThe":[183],"hanging":[184],"drop":[185],"liquid":[187],"overlay":[188],"techniques":[189],"were":[190,227,256,274],"compared":[191],"select":[193],"method":[195],"for":[196,229],"growing":[197],"spheroids.":[198,269,288],"Spheroid":[199],"growth":[200],"was":[201,213,235],"assessed":[202,214],"using":[203,215],"phase":[204,253],"contrast":[205,254],"microscopy":[206,255],"bicinchoninic":[209],"acid":[210,247],"assay.":[211,222],"Viability":[212],"fluorescein":[217],"diacetate":[218],"(FDA)/propidium":[219],"iodide":[220],"(PI)":[221],"Haematoxylin":[223],"eosin":[225],"staining":[226,251],"used":[228,236,257,275],"morphological":[230],"evaluation.":[231],"An":[232],"iridium":[233],"complex":[234],"investigate":[238],"induction":[240],"hypoxia.":[242],"sulphorodamine":[244],"B":[245],"phosphatase":[248],"assays,":[249],"FDA/PI":[250],"assess":[259],"72-h":[261],"cytotoxicity":[262],"effects":[263],"doxorubicin":[265],"Immunostaining":[270],"optical":[272],"clearing":[273],"visualise":[277],"distribution":[280],"Ki-67":[283],"antigen":[284],"cadherins":[286]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-10T00:00:00"}
