{"id":"https://openalex.org/W3014098568","doi":"https://doi.org/10.3390/md18040192","title":"A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation","display_name":"A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation","publication_year":2020,"publication_date":"2020-04-05","ids":{"openalex":"https://openalex.org/W3014098568","doi":"https://doi.org/10.3390/md18040192","mag":"3014098568","pmid":"https://pubmed.ncbi.nlm.nih.gov/32260516","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7230868"},"language":"en","primary_location":{"id":"doi:10.3390/md18040192","doi":"https://doi.org/10.3390/md18040192","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md18040192","pdf_url":"https://www.mdpi.com/1660-3397/18/4/192/pdf?version=1586348937","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/18/4/192/pdf?version=1586348937","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039036414","display_name":"Pietro Marchese","orcid":"https://orcid.org/0000-0002-1492-4189","observed_orcids":["https://orcid.org/0000-0002-1492-4189"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Pietro Marchese","raw_affiliation_strings":["Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-1492-4189","affiliations":[{"raw_affiliation_string":"Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085007696","display_name":"Nipun Mahajan","orcid":"https://orcid.org/0000-0001-8237-1582","observed_orcids":["https://orcid.org/0000-0001-8237-1582"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Nipun Mahajan","raw_affiliation_strings":["Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-8237-1582","affiliations":[{"raw_affiliation_string":"Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070372117","display_name":"Enda O\u2019Connell","orcid":"https://orcid.org/0000-0001-7441-0262","observed_orcids":["https://orcid.org/0000-0001-7441-0262"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Enda O\u2019Connell","raw_affiliation_strings":["Genomics and Screening Core, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Screening Core, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003954107","display_name":"Howard O. Fearnhead","orcid":"https://orcid.org/0000-0002-8054-9794","observed_orcids":["https://orcid.org/0000-0002-8054-9794"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Howard Fearnhead","raw_affiliation_strings":["Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020243914","display_name":"Maria G. Tuohy","orcid":"https://orcid.org/0000-0003-0004-0523","observed_orcids":["https://orcid.org/0000-0003-0004-0523"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maria Tuohy","raw_affiliation_strings":["Molecular Glycobiotechnology, School of Natural Sciences, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-0004-0523","affiliations":[{"raw_affiliation_string":"Molecular Glycobiotechnology, School of Natural Sciences, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027541051","display_name":"Janusz Krawczyk","orcid":"https://orcid.org/0000-0003-0631-103X","observed_orcids":["https://orcid.org/0000-0003-0631-103X"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I2802635630","display_name":"University Hospital Galway","ror":"https://ror.org/04scgfz75","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802635630","https://openalex.org/I37076085","https://openalex.org/I4210128306","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Janusz Krawczyk","raw_affiliation_strings":["Galway University Hospital, National University of Ireland Galway, School of Medicine, H91YR71 Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galway University Hospital, National University of Ireland Galway, School of Medicine, H91YR71 Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I2802635630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103635174","display_name":"OP Thomas","orcid":"https://orcid.org/0000-0002-5708-1409","observed_orcids":["https://orcid.org/0000-0002-5708-1409"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Olivier P. Thomas","raw_affiliation_strings":["Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5708-1409","affiliations":[{"raw_affiliation_string":"Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030012610","display_name":"Frank Barry","orcid":"https://orcid.org/0000-0002-5535-002X","observed_orcids":["https://orcid.org/0000-0002-5535-002X"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Frank Barry","raw_affiliation_strings":["Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013508407","display_name":"Mary J. Murphy","orcid":"https://orcid.org/0000-0003-0971-7684","observed_orcids":["https://orcid.org/0000-0003-0971-7684"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Mary J. Murphy","raw_affiliation_strings":["Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013508407"],"corresponding_institution_ids":["https://openalex.org/I188760350"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":1.2417,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.71720733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"4","first_page":"192","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itaconic-acid-derivatives","display_name":"itaconic acid derivatives","score":0.8840000033378601},{"id":"https://openalex.org/keywords/marine-fungi","display_name":"marine fungi","score":0.625},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":1.0},{"id":"https://openalex.org/keywords/ectopic-calcification","display_name":"ectopic calcification","score":0.968999981880188},{"id":"https://openalex.org/keywords/calcium-deposition","display_name":"calcium deposition","score":0.3880000114440918},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tissue-calcification","display_name":"tissue calcification","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.7589330673217773},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.693741500377655},{"id":"https://openalex.org/C2780814755","wikidata":"https://www.wikidata.org/wiki/Q5334289","display_name":"Ectopic calcification","level":3,"score":0.6720446348190308},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5396596789360046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5126103758811951},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.49405840039253235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4845239520072937},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4633631408214569},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.44939759373664856},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4336666464805603},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.4160378873348236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3560978174209595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34279322624206543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12737473845481873},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08678394556045532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010407","descriptor_name":"Penicillium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3390/md18040192","doi":"https://doi.org/10.3390/md18040192","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md18040192","pdf_url":"https://www.mdpi.com/1660-3397/18/4/192/pdf?version=1586348937","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmid:32260516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32260516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7230868","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7230868/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmh:oai:https://researchrepository.universityofgalway.ie:10379/15998","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/15998","pdf_url":"http://hdl.handle.net/10379/15998","source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:http://www.rian.ie/188337/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10379/15998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:aran.library.nuigalway.ie/:10379/15998","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/15998","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:62a0dc43ff464241b8c233b47446f517","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/62a0dc43ff464241b8c233b47446f517","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 18, Iss 4, p 192 (2020)","raw_type":"article"},{"id":"pmh:oai:researchrepository.universityofgalway.ie:10379/15998","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/15998","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/md18040192","doi":"https://doi.org/10.3390/md18040192","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md18040192","pdf_url":"https://www.mdpi.com/1660-3397/18/4/192/pdf?version=1586348937","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3655855683","display_name":null,"funder_award_id":"B1794","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G4393122106","display_name":"SRC REMEDI:  REMEDI-2: From Research to Human Therapy","funder_award_id":"09/SRC/B1794","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G5758561050","display_name":null,"funder_award_id":"PBA/MB/16/01","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G5762888200","display_name":null,"funder_award_id":"PBA/MB/16/01","funder_id":"https://openalex.org/F4320320854","funder_display_name":"Marine Institute"},{"id":"https://openalex.org/G6703067035","display_name":null,"funder_award_id":"GOIPG/2016/1113","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G7712668395","display_name":null,"funder_award_id":"PBA/MB/16/01","funder_id":"https://openalex.org/F4320320861","funder_display_name":"University of Galway"}],"funders":[{"id":"https://openalex.org/F4320311521","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320854","display_name":"Marine Institute","ror":"https://ror.org/05581wm82"},{"id":"https://openalex.org/F4320320861","display_name":"University of Galway","ror":"https://ror.org/03bea9k73"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014098568.pdf","grobid_xml":"https://content.openalex.org/works/W3014098568.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1544751778","https://openalex.org/W1641723798","https://openalex.org/W1727650677","https://openalex.org/W1964564104","https://openalex.org/W1972067639","https://openalex.org/W1972455205","https://openalex.org/W1974757380","https://openalex.org/W1976025636","https://openalex.org/W1977950302","https://openalex.org/W1978041642","https://openalex.org/W1978079041","https://openalex.org/W1988721981","https://openalex.org/W1989402713","https://openalex.org/W1990777048","https://openalex.org/W1991001144","https://openalex.org/W1992185691","https://openalex.org/W1998706191","https://openalex.org/W2008935687","https://openalex.org/W2009693550","https://openalex.org/W2014673628","https://openalex.org/W2020425602","https://openalex.org/W2022390680","https://openalex.org/W2038157992","https://openalex.org/W2040645421","https://openalex.org/W2046233476","https://openalex.org/W2050287285","https://openalex.org/W2058231261","https://openalex.org/W2066050937","https://openalex.org/W2068709374","https://openalex.org/W2073569767","https://openalex.org/W2078852165","https://openalex.org/W2089788551","https://openalex.org/W2092186339","https://openalex.org/W2096267401","https://openalex.org/W2114721006","https://openalex.org/W2139857335","https://openalex.org/W2141916150","https://openalex.org/W2143466110","https://openalex.org/W2144268541","https://openalex.org/W2145632027","https://openalex.org/W2159999899","https://openalex.org/W2254090001","https://openalex.org/W2322824973","https://openalex.org/W2604556059","https://openalex.org/W2781952526","https://openalex.org/W2806865485","https://openalex.org/W2891875808","https://openalex.org/W2939300210","https://openalex.org/W2949368627","https://openalex.org/W2997882817","https://openalex.org/W3000473592","https://openalex.org/W4252108671"],"related_works":["https://openalex.org/W3180512405","https://openalex.org/W2589215089","https://openalex.org/W6960040604","https://openalex.org/W2920189358","https://openalex.org/W2356355782","https://openalex.org/W2802316992","https://openalex.org/W2988544485","https://openalex.org/W2387023664","https://openalex.org/W3010648903","https://openalex.org/W3110538348"],"abstract_inverted_index":{"Worldwide":[0],"diffused":[1],"diseases":[2],"such":[3,30],"as":[4,139],"osteoarthritis,":[5],"atherosclerosis":[6],"or":[7],"chronic":[8],"kidney":[9],"disease":[10],"are":[11,33,82],"associated":[12],"with":[13,75],"a":[14,70,115,191],"tissue":[15,64,173],"calcification":[16,174],"process":[17],"which":[18],"may":[19],"involve":[20],"unexpected":[21],"local":[22],"stem":[23],"cell":[24,59],"differentiation.":[25],"Current":[26],"pharmacological":[27],"treatments":[28],"for":[29],"musculoskeletal":[31],"conditions":[32],"weakly":[34],"effective,":[35],"sometimes":[36],"extremely":[37],"expensive":[38],"and":[39,78,86,103,151,175],"often":[40],"absent.":[41],"The":[42,66,89],"potential":[43,77,90],"to":[44,61,99,160,170,182,196],"develop":[45],"new":[46],"therapies":[47],"is":[48,69,168],"represented":[49],"by":[50,95,123],"the":[51,101,124,132,145,176],"discovery":[52,167],"of":[53,73,91,106,141,147,178],"small":[54,92,165],"molecules":[55,81,93],"modulating":[56],"resident":[57],"progenitor":[58],"differentiation":[60,105],"prevent":[62],"aberrant":[63],"calcification.":[65,163],"marine":[67,96,188],"environment":[68],"rich":[71],"reserve":[72],"compounds":[74],"pharmaceutical":[76],"many":[79],"novel":[80],"isolated":[83],"from":[84,187],"macro":[85],"microorganisms":[87],"annually.":[88],"synthetized":[94,122],"filamentous":[97],"fungi":[98],"influence":[100],"osteogenic":[102],"chondrogenic":[104,155],"human":[107],"mesenchymal":[108],"stem/stromal":[109],"cells":[110],"(hMSCs)":[111],"was":[112],"investigated":[113],"using":[114],"novel,":[116],"high-throughput":[117],"automated":[118],"screening":[119],"platform.":[120,133],"Metabolites":[121],"marine-derived":[125],"fungus":[126],"Penicillium":[127],"antarcticum":[128],"were":[129,137],"evaluated":[130],"on":[131],"Itaconic":[134],"acid":[135],"derivatives":[136],"identified":[138],"inhibitors":[140],"calcium":[142],"elaboration":[143],"into":[144],"matrix":[146],"osteogenically":[148],"differentiated":[149],"hMSCs":[150],"also":[152],"inhibited":[153],"hMSC":[154],"differentiation,":[156],"highlighting":[157],"their":[158],"capacity":[159],"impair":[161],"ectopic":[162,172],"Bioactive":[164],"molecule":[166],"critical":[169],"address":[171],"use":[177],"biologically":[179],"relevant":[180],"assays":[181],"identify":[183],"naturally":[184],"occurring":[185],"metabolites":[186],"sources":[189],"represents":[190],"strategy":[192],"that":[193],"can":[194],"contribute":[195],"this":[197],"effort.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-04-10T00:00:00"}