{"id":"https://openalex.org/W3013799485","doi":"https://doi.org/10.1182/blood.2019003358","title":"Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms","display_name":"Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms","publication_year":2020,"publication_date":"2020-03-27","ids":{"openalex":"https://openalex.org/W3013799485","doi":"https://doi.org/10.1182/blood.2019003358","mag":"3013799485","pmid":"https://pubmed.ncbi.nlm.nih.gov/32219445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7332892"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2019003358","doi":"https://doi.org/10.1182/blood.2019003358","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.2019003358","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7332892/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040331469","display_name":"Kotaro Shide","orcid":"https://orcid.org/0000-0002-0046-3254","observed_orcids":["https://orcid.org/0000-0002-0046-3254"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Shide","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030683315","display_name":"Takuro Kameda","orcid":"https://orcid.org/0000-0003-0100-1710","observed_orcids":["https://orcid.org/0000-0003-0100-1710"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuro Kameda","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020241997","display_name":"Ayako Kamiunten","orcid":"https://orcid.org/0000-0002-6347-4305","observed_orcids":["https://orcid.org/0000-0002-6347-4305"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Kamiunten","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040080787","display_name":"Yoshinori Ozono","orcid":"https://orcid.org/0000-0003-4616-5831","observed_orcids":["https://orcid.org/0000-0003-4616-5831"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Ozono","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070628001","display_name":"Yuki Tahira","orcid":"https://orcid.org/0000-0001-6640-4559","observed_orcids":["https://orcid.org/0000-0001-6640-4559"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Tahira","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Alabama, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Alabama, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001251832","display_name":"Takako Yokomizo\u2010Nakano","orcid":"https://orcid.org/0000-0003-3879-7046","observed_orcids":["https://orcid.org/0000-0003-3879-7046"]},"institutions":[{"id":"https://openalex.org/I4405286931","display_name":"International Research Center for Medical Sciences, Kumamoto University","ror":"https://ror.org/03kw3qk87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takako Yokomizo-Nakano","raw_affiliation_strings":["Kumamoto University, Kumamoto, Japan","Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008350228","display_name":"Sho Kubota","orcid":"https://orcid.org/0000-0001-6119-1259","observed_orcids":["https://orcid.org/0000-0001-6119-1259"]},"institutions":[{"id":"https://openalex.org/I4405286931","display_name":"International Research Center for Medical Sciences, Kumamoto University","ror":"https://ror.org/03kw3qk87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Kubota","raw_affiliation_strings":["Kumamoto University, Kumamoto, Japan","Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6119-1259","affiliations":[{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083808757","display_name":"Masaya Ono","orcid":"https://orcid.org/0009-0005-9717-5564","observed_orcids":["https://orcid.org/0009-0005-9717-5564"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Ono","raw_affiliation_strings":["National Cancer Center Research Institute, Tokyo, Japan","Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051244269","display_name":"Kazuhiko Ikeda","orcid":"https://orcid.org/0000-0002-5269-269X","observed_orcids":["https://orcid.org/0000-0002-5269-269X"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Ikeda","raw_affiliation_strings":["Fukushima Medical University, Fukushima, Japan","Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5269-269X","affiliations":[{"raw_affiliation_string":"Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072491642","display_name":"Masaaki Sekine","orcid":"https://orcid.org/0000-0001-5481-3451","observed_orcids":["https://orcid.org/0000-0001-5481-3451"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Sekine","raw_affiliation_strings":["miyazaki university, miyazaki, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"miyazaki university, miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014327036","display_name":"Keiichi Akizuki","orcid":"https://orcid.org/0000-0003-0031-3456","observed_orcids":["https://orcid.org/0000-0003-0031-3456"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Akizuki","raw_affiliation_strings":["University of Miyazaki","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101435028","display_name":"Kenichi Nakamura","orcid":"https://orcid.org/0000-0003-3534-8296","observed_orcids":["https://orcid.org/0000-0003-3534-8296"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Nakamura","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036728147","display_name":"Tomonori Hidaka","orcid":"https://orcid.org/0000-0002-7018-3653","observed_orcids":["https://orcid.org/0000-0002-7018-3653"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Hidaka","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031290393","display_name":"Yoko Kubuki","orcid":"https://orcid.org/0000-0002-0763-9136","observed_orcids":["https://orcid.org/0000-0002-0763-9136"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Kubuki","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084132492","display_name":"Hisayoshi Iwakiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisayoshi Iwakiri","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024916484","display_name":"Satoru Hasuike","orcid":"https://orcid.org/0000-0002-5312-5152","observed_orcids":["https://orcid.org/0000-0002-5312-5152"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Hasuike","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046779019","display_name":"Kenji Nagata","orcid":"https://orcid.org/0000-0002-9955-9431","observed_orcids":["https://orcid.org/0000-0002-9955-9431","https://orcid.org/0000-0001-7861-6372","https://orcid.org/0000-0001-9894-4461"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Nagata","raw_affiliation_strings":["University of Miyazaki, Miyazaki, Mi, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Miyazaki, Mi, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046739350","display_name":"Goro Sashida","orcid":"https://orcid.org/0000-0003-2318-5987","observed_orcids":["https://orcid.org/0000-0003-2318-5987"]},"institutions":[{"id":"https://openalex.org/I4405286931","display_name":"International Research Center for Medical Sciences, Kumamoto University","ror":"https://ror.org/03kw3qk87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Goro Sashida","raw_affiliation_strings":["Kumamoto University, IRCMS, Kumamoto, Japan","Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University, IRCMS, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I4405286931","https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079272025","display_name":"Kazuya Shimoda","orcid":"https://orcid.org/0000-0002-2555-8188","observed_orcids":["https://orcid.org/0000-0002-2555-8188"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Shimoda","raw_affiliation_strings":["University of Miyazaki, Kiyotake, Japan","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miyazaki, Kiyotake, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.1317,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88095388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"136","issue":"1","first_page":"106","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.9309999942779541},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7210000157356262},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.800000011920929},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.777999997138977},{"id":"https://openalex.org/keywords/extramedullary-hematopoiesis","display_name":"extramedullary hematopoiesis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/calr-mutation","display_name":"CALR mutation","score":0.43799999356269836},{"id":"https://openalex.org/keywords/mpn-pathogenesis","display_name":"MPN pathogenesis","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.9087321758270264},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.7387305498123169},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.6607140898704529},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6313050985336304},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6104682087898254},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5518018007278442},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.5237277150154114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127362012863159},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4862024188041687},{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.4282801151275635},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4055751860141754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4014946222305298},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.18949925899505615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14317867159843445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11943107843399048},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.08191096782684326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066673","descriptor_name":"Cell Self Renewal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006411","descriptor_name":"Hematopoiesis, Extramedullary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.2019003358","doi":"https://doi.org/10.1182/blood.2019003358","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.2019003358","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:32219445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32219445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7332892","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7332892/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7332892","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7332892/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1567973791","display_name":"Control of myelofibrosis targeting the amplification mechanism of CALR mutant stem cells and the functional motif of CALR mutant proteins","funder_award_id":"19K08819","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2805900773","display_name":"MPN research focusing on ER stress response and  tumor-derived fibrocytes","funder_award_id":"20H03713","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3541171295","display_name":"Mutual role of a driver mutation and abnormality of histone modification in progression of myeloproliferative neoplasms","funder_award_id":"18K08365","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3861989185","display_name":"Regulation of the pathogenesis of myeloproliferative neoplasms with a focus on IFNalpha signaling and the mechanism of renal dysfunction.","funder_award_id":"20K17404","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7308282470","display_name":"Myeloproliferative neoplasms research for drug discovery focusing on CALR mutation and fibrocyte","funder_award_id":"17H04210","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7667063334","display_name":"Role of Epigenomic alterations in Myeloproliferative neoplasms","funder_award_id":"19K17834","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1507809982","https://openalex.org/W1605230984","https://openalex.org/W1962949679","https://openalex.org/W1964691854","https://openalex.org/W1980568348","https://openalex.org/W1987895181","https://openalex.org/W2002782759","https://openalex.org/W2011722739","https://openalex.org/W2016825113","https://openalex.org/W2028078153","https://openalex.org/W2030716854","https://openalex.org/W2035166160","https://openalex.org/W2036055444","https://openalex.org/W2037919426","https://openalex.org/W2038970416","https://openalex.org/W2049145190","https://openalex.org/W2050676604","https://openalex.org/W2053519828","https://openalex.org/W2057360098","https://openalex.org/W2063756127","https://openalex.org/W2065726682","https://openalex.org/W2072411272","https://openalex.org/W2076600290","https://openalex.org/W2115110568","https://openalex.org/W2116205277","https://openalex.org/W2116878961","https://openalex.org/W2121709505","https://openalex.org/W2128720297","https://openalex.org/W2138709799","https://openalex.org/W2144621019","https://openalex.org/W2144664431","https://openalex.org/W2146505525","https://openalex.org/W2151017891","https://openalex.org/W2157694607","https://openalex.org/W2174217532","https://openalex.org/W2230798701","https://openalex.org/W2306779733","https://openalex.org/W2310016096","https://openalex.org/W2339658711","https://openalex.org/W2344384041","https://openalex.org/W2398816975","https://openalex.org/W2417685891","https://openalex.org/W2471203955","https://openalex.org/W2548605737","https://openalex.org/W2566136692","https://openalex.org/W2778344263","https://openalex.org/W2779262202","https://openalex.org/W2884708858","https://openalex.org/W2897600982","https://openalex.org/W2899551887","https://openalex.org/W4243372250"],"related_works":["https://openalex.org/W2915871325","https://openalex.org/W4310108983","https://openalex.org/W4389243592","https://openalex.org/W2989725576","https://openalex.org/W7214388261","https://openalex.org/W3003967832","https://openalex.org/W2979714695","https://openalex.org/W2976755053","https://openalex.org/W3081758173","https://openalex.org/W2584188940"],"abstract_inverted_index":{"Mutations":[0],"in":[1,11,19,37,62,77,85,111,131,138,201],"JAK2,":[2],"myeloproliferative":[3,26],"leukemia":[4],"virus":[5],"(MPL),":[6],"or":[7,108],"calreticulin":[8],"(CALR)":[9],"occur":[10],"hematopoietic":[12,93,119],"stem":[13],"cells":[14,130,191],"(HSCs)":[15],"and":[16,58,88,126,135,170,196],"are":[17,30],"detected":[18],"more":[20],"than":[21],"80%":[22],"of":[23,43,67,72,83,121,151,179,213],"patients":[24,169],"with":[25,159,189],"neoplasms":[27],"(MPNs).":[28],"They":[29],"thought":[31],"to":[32,51],"play":[33],"a":[34,73,163],"driver":[35],"role":[36,74,82],"MPN":[38,89,168,200],"pathogenesis":[39],"via":[40],"autosomal":[41],"activation":[42],"the":[44,81,103,132,139,148,176,211],"JAK-STAT":[45],"signaling":[46,56],"cascade.":[47],"Mutant":[48],"CALR":[49,76,84,97,183,194,206],"binds":[50],"MPL,":[52],"activates":[53],"downstream":[54],"MPL":[55],"cascades,":[57],"induces":[59],"essential":[60],"thrombocythemia":[61],"mice.":[63,96],"However,":[64,114],"embryonic":[65],"lethality":[66],"Calr-deficient":[68,95,115],"mice":[69,116,158,187],"precludes":[70],"determination":[71],"for":[75,210],"hematopoiesis.":[78],"To":[79],"clarify":[80],"normal":[86],"hematopoiesis":[87,137],"pathogenesis,":[90],"we":[91],"generated":[92,154],"cell-specific":[94],"deficiency":[98],"had":[99],"little":[100],"effect":[101],"on":[102],"leukocyte":[104],"count,":[105],"hemoglobin":[106],"levels,":[107],"platelet":[109],"count":[110],"peripheral":[112],"blood.":[113],"showed":[117],"some":[118],"properties":[120],"MPN,":[122],"including":[123],"decreased":[124],"erythropoiesis":[125],"increased":[127],"myeloid":[128],"progenitor":[129],"bone":[133],"marrow":[134],"extramedullary":[136],"spleen.":[140],"Transplantation":[141],"experiments":[142],"revealed":[143],"that":[144,165,172,205],"Calr":[145,160,173,197],"haploinsufficiency":[146,161,174,198,207],"promoted":[147],"self-renewal":[149,177],"capacity":[150,178],"HSCs.":[152],"We":[153],"CALRdel52":[155],"mutant":[156],"transgenic":[157],"as":[162],"model":[164],"mimics":[166],"human":[167],"found":[171],"restored":[175],"HSCs":[180],"damaged":[181],"by":[182],"mutations.":[184],"Only":[185],"recipient":[186],"transplanted":[188],"Lineage-Sca1+c-kit+":[190],"harboring":[192],"both":[193],"mutation":[195],"developed":[199],"competitive":[202],"conditions,":[203],"showing":[204],"was":[208],"necessary":[209],"onset":[212],"CALR-mutated":[214],"MPNs.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-04-03T00:00:00"}
