{"id":"https://openalex.org/W3013784705","doi":null,"title":"Erythropoietin suppresses D-galactose-induced aging of rats via the PI3K/Akt/Nrf2-ARE pathway.","display_name":"Erythropoietin suppresses D-galactose-induced aging of rats via the PI3K/Akt/Nrf2-ARE pathway.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3013784705","mag":"3013784705","pmid":"https://pubmed.ncbi.nlm.nih.gov/31938335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958193"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6958193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958193","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101410212","display_name":"Haiqin Wu","orcid":"https://orcid.org/0000-0002-8589-2727","observed_orcids":["https://orcid.org/0000-0002-8589-2727"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiqin Wu","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034864372","display_name":"Mengyi Chen","orcid":"https://orcid.org/0000-0002-9971-0787","observed_orcids":["https://orcid.org/0000-0002-9971-0787","https://orcid.org/0009-0001-8008-1976"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyi Chen","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pu Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pu Yan","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010809712","display_name":"Qingling Yao","orcid":"https://orcid.org/0000-0002-8026-801X","observed_orcids":["https://orcid.org/0000-0002-8026-801X","https://orcid.org/0000-0003-1903-1774"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingling Yao","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009336243","display_name":"Jiaxin Fan","orcid":"https://orcid.org/0000-0002-2883-9946","observed_orcids":["https://orcid.org/0000-0002-2883-9946"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin Fan","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103138985","display_name":"Zhen Gao","orcid":"https://orcid.org/0000-0002-2676-8742","observed_orcids":["https://orcid.org/0000-0002-2676-8742"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Gao","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075545837","display_name":"Huqing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huqing Wang","raw_affiliation_strings":["Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Affiliated Hospital of The Medical School, Xi'an Jiaotong University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4889,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.55958517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"2227","last_page":"2240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/d-galactose-induced-aging","display_name":"D-galactose-induced aging","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antioxidant-response-element","display_name":"antioxidant response element","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9369999766349792},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6179999709129333},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.8705419301986694},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8180952072143555},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.809407114982605},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.73089200258255},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5234046578407288},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5021457672119141},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.46853747963905334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46357280015945435},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.45205825567245483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43720555305480957},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.43694251775741577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43039655685424805},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42277437448501587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3961291015148163},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33404016494750977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2985319197177887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25192347168922424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2057032585144043},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6958193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:31938335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:3013784705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6958193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W952491933","https://openalex.org/W1487155952","https://openalex.org/W1547877665","https://openalex.org/W1550247880","https://openalex.org/W1560090495","https://openalex.org/W1594404253","https://openalex.org/W1845708584","https://openalex.org/W1967396933","https://openalex.org/W1968051733","https://openalex.org/W1972500079","https://openalex.org/W1981243676","https://openalex.org/W1995654460","https://openalex.org/W2023119443","https://openalex.org/W2027731032","https://openalex.org/W2028513193","https://openalex.org/W2057956870","https://openalex.org/W2073759014","https://openalex.org/W2080477342","https://openalex.org/W2100488949","https://openalex.org/W2103255946","https://openalex.org/W2121647621","https://openalex.org/W2125236254","https://openalex.org/W2142957408","https://openalex.org/W2150129386","https://openalex.org/W2175833749","https://openalex.org/W2180741876","https://openalex.org/W2197086939","https://openalex.org/W2207241376","https://openalex.org/W2267907650","https://openalex.org/W2268731158","https://openalex.org/W2277797200","https://openalex.org/W2410250993","https://openalex.org/W2586667951","https://openalex.org/W2613795168","https://openalex.org/W2626719895","https://openalex.org/W2640661976","https://openalex.org/W2759348220","https://openalex.org/W3149365340"],"related_works":["https://openalex.org/W2586667951","https://openalex.org/W4210982229","https://openalex.org/W1544786107","https://openalex.org/W2485254848","https://openalex.org/W4225428243","https://openalex.org/W1560090495","https://openalex.org/W4281647241","https://openalex.org/W2125236254","https://openalex.org/W2922117972","https://openalex.org/W2640661976"],"abstract_inverted_index":{"EPO":[0,37,94,124,187],"(erythropoietin)":[1],"is":[2,198],"a":[3,7,19,163],"hormone-like":[4],"substance":[5],"with":[6,145,182],"putative":[8],"role":[9],"in":[10,32,67,122,157,165,178,215],"hematopoietic":[11],"regulation.":[12],"Current":[13],"research":[14],"suggests":[15],"that":[16,36,186],"it":[17],"exerts":[18],"neuroprotective":[20],"effect":[21],"by":[22,44,76,135,170,191],"enhancing":[23],"the":[24,54,65,88,103,112,123,179,202],"activity":[25],"of":[26,41,46,72,80,102,111,115,129,148,159,167,201,208,212],"antioxidant":[27,213],"enzymes.":[28],"Our":[29],"previous":[30],"studies":[31],"vitro":[33],"have":[34],"confirmed":[35],"can":[38,188],"delay":[39],"senescence":[40],"cultured":[42],"neurons":[43],"activation":[45,211],"nuclear":[47],"factor-erythroid":[48],"2-related":[49],"factor":[50],"2":[51],"(Nrf2)":[52],"and":[53,117,138,162,205,210],"phosphoinositide-3-kinase":[55],"(PI3K)/AKT":[56],"pathway.":[57],"Thus":[58],"we":[59],"set":[60],"out":[61],"to":[62,109],"further":[63],"substantiate":[64],"mechanism":[66,197],"vivo.":[68],"A":[69],"rat":[70],"model":[71],"aging":[73,190,216],"was":[74,95,106,154],"induced":[75],"continuous":[77],"subcutaneous":[78],"injection":[79],"5%":[81],"D-galactose":[82],"for":[83],"6":[84],"weeks.":[85],"Starting":[86],"at":[87],"7th":[89],"week,":[90],"physiological":[91],"saline":[92],"or":[93],"administered":[96],"twice":[97],"daily.":[98],"LY294002,":[99],"an":[100,155,199],"inhibitor":[101],"PI3K/AKT":[104,149],"pathway,":[105],"also":[107],"given":[108],"one":[110],"groups.":[113],"Improvement":[114],"learning":[116],"memory":[118],"abilities":[119],"were":[120,133,175],"observed":[121],"intervention":[125],"group.":[126],"Raised":[127],"levels":[128],"Cu-Zn":[130],"SOD":[131],"protein":[132],"detected":[134],"immunohistochemical":[136],"staining":[137],"Western":[139],"blot":[140],"after":[141],"using":[142],"EPO,":[143],"together":[144],"increased":[146],"expression":[147,158,166,209],"pathway":[150,204],"proteins.":[151],"Concomitantly,":[152],"there":[153],"increase":[156],"Nrf2":[160],"mRNA":[161,169],"decrease":[164],"Keap1":[168],"qRT-PCR.":[171],"All":[172],"these":[173],"effects":[174],"not":[176],"found":[177],"group":[180],"injected":[181],"LY294002.":[183],"We":[184],"conclude":[185],"suppress":[189],"reducing":[192],"oxidative":[193],"stress.":[194],"The":[195],"proposed":[196],"upregulation":[200],"PI3K/Akt/Nrf2-ARE":[203],"thus":[206],"maintenance":[207],"enzymes":[214],"rats.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-04-03T00:00:00"}