{"id":"https://openalex.org/W3013757166","doi":"https://doi.org/10.1016/j.molmed.2020.02.006","title":"Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective","display_name":"Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective","publication_year":2020,"publication_date":"2020-03-26","ids":{"openalex":"https://openalex.org/W3013757166","doi":"https://doi.org/10.1016/j.molmed.2020.02.006","mag":"3013757166","pmid":"https://pubmed.ncbi.nlm.nih.gov/32589937"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmed.2020.02.006","doi":"https://doi.org/10.1016/j.molmed.2020.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2020.02.006","pdf_url":"http://www.cell.com/article/S1471491420300629/pdf","source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1471491420300629/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042139580","display_name":"Christopher Benjamin Jackson","orcid":"https://orcid.org/0000-0003-1035-6417","observed_orcids":["https://orcid.org/0000-0003-1035-6417"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Christopher B. Jackson","raw_affiliation_strings":["Stem Cells and Metabolism, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cells and Metabolism, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050697713","display_name":"Douglass M. Turnbull","orcid":"https://orcid.org/0000-0002-8878-9901","observed_orcids":["https://orcid.org/0000-0002-8878-9901"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Doug M. Turnbull","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035679168","display_name":"Michal A. Minczuk","orcid":"https://orcid.org/0000-0001-8242-1420","observed_orcids":["https://orcid.org/0000-0001-8242-1420"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michal Minczuk","raw_affiliation_strings":["MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I79266365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087819610","display_name":"Payam A. Gammage","orcid":"https://orcid.org/0000-0003-1968-1726","observed_orcids":["https://orcid.org/0000-0003-1968-1726"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Payam A. Gammage","raw_affiliation_strings":["CRUK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address: payam.gammage@glasgow.ac.uk","CRUK Beatson Institute, Glasgow, UK","Institute of Cancer Sciences, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRUK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address: payam.gammage@glasgow.ac.uk","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]},{"raw_affiliation_string":"CRUK Beatson Institute, Glasgow, UK","institution_ids":["https://openalex.org/I4210143228"]},{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5087819610"],"corresponding_institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":1.1246,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.76222767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"26","issue":"7","first_page":"698","last_page":"709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.17190000414848328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mitochondrial-heteroplasmy","display_name":"mitochondrial heteroplasmy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/mitochondrial-genome-editing","display_name":"mitochondrial genome editing","score":0.4009999930858612},{"id":"https://openalex.org/keywords/mitochondrial-transformation","display_name":"mitochondrial transformation","score":0.375},{"id":"https://openalex.org/keywords/inborn-errors-of-metabolism","display_name":"inborn errors of metabolism","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C181561989","wikidata":"https://www.wikidata.org/wiki/Q2581905","display_name":"Heteroplasmy","level":4,"score":0.9827179908752441},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.9326356053352356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.746117115020752},{"id":"https://openalex.org/C151994961","wikidata":"https://www.wikidata.org/wiki/Q715263","display_name":"Human mitochondrial genetics","level":4,"score":0.7002474069595337},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.6932103633880615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6202608942985535},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48698553442955017},{"id":"https://openalex.org/C2776287708","wikidata":"https://www.wikidata.org/wiki/Q2666433","display_name":"MELAS syndrome","level":5,"score":0.43271970748901367},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4221475124359131},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.41270768642425537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3404470682144165},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3205890357494354},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.28182852268218994}],"mesh":[{"descriptor_ui":"D000081942","descriptor_name":"Heteroplasmy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000081942","descriptor_name":"Heteroplasmy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000081942","descriptor_name":"Heteroplasmy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.molmed.2020.02.006","doi":"https://doi.org/10.1016/j.molmed.2020.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2020.02.006","pdf_url":"http://www.cell.com/article/S1471491420300629/pdf","source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:32589937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32589937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:helda.helsinki.fi:10138/318204","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/318204","pdf_url":"http://hdl.handle.net/10138/318204","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review Article"},{"id":"doi:10.25405/ncl.34402014","doi":"https://doi.org/10.25405/ncl.34402014","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34402014","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34402014.v1","doi":"https://doi.org/10.25405/ncl.34402014.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34402014.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.molmed.2020.02.006","doi":"https://doi.org/10.1016/j.molmed.2020.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2020.02.006","pdf_url":"http://www.cell.com/article/S1471491420300629/pdf","source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8685385623","display_name":null,"funder_award_id":"A_BICR_1920_Gammage","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013757166.pdf"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1521947818","https://openalex.org/W1937825562","https://openalex.org/W1939279832","https://openalex.org/W1964789697","https://openalex.org/W1968016095","https://openalex.org/W1974029377","https://openalex.org/W1976393409","https://openalex.org/W1977539185","https://openalex.org/W1980621619","https://openalex.org/W1995146753","https://openalex.org/W1996773289","https://openalex.org/W2007997420","https://openalex.org/W2008784634","https://openalex.org/W2011376878","https://openalex.org/W2014401528","https://openalex.org/W2018217184","https://openalex.org/W2039816767","https://openalex.org/W2050871996","https://openalex.org/W2054355568","https://openalex.org/W2066354939","https://openalex.org/W2080272457","https://openalex.org/W2083582836","https://openalex.org/W2092505434","https://openalex.org/W2095421831","https://openalex.org/W2107923677","https://openalex.org/W2112444085","https://openalex.org/W2116565356","https://openalex.org/W2129237258","https://openalex.org/W2129593212","https://openalex.org/W2130872480","https://openalex.org/W2135816734","https://openalex.org/W2136609330","https://openalex.org/W2153832849","https://openalex.org/W2162839691","https://openalex.org/W2215582843","https://openalex.org/W2268456576","https://openalex.org/W2342398525","https://openalex.org/W2360183543","https://openalex.org/W2495541981","https://openalex.org/W2512479156","https://openalex.org/W2518810695","https://openalex.org/W2556590524","https://openalex.org/W2575465356","https://openalex.org/W2603828830","https://openalex.org/W2607644287","https://openalex.org/W2742984768","https://openalex.org/W2767388250","https://openalex.org/W2770597671","https://openalex.org/W2774274736","https://openalex.org/W2783396730","https://openalex.org/W2784751183","https://openalex.org/W2786752277","https://openalex.org/W2806941167","https://openalex.org/W2809681489","https://openalex.org/W2883621329","https://openalex.org/W2890423003","https://openalex.org/W2890448051","https://openalex.org/W2891993984","https://openalex.org/W2913212173","https://openalex.org/W2922340124","https://openalex.org/W2940430745","https://openalex.org/W2953890395","https://openalex.org/W2954312670","https://openalex.org/W2960339132","https://openalex.org/W2964595602","https://openalex.org/W2965638168","https://openalex.org/W2970978182","https://openalex.org/W2980622391","https://openalex.org/W4210476933"],"related_works":["https://openalex.org/W3007098184","https://openalex.org/W2970978182","https://openalex.org/W2971170302","https://openalex.org/W4292953605","https://openalex.org/W3001134453","https://openalex.org/W2891993984","https://openalex.org/W2932897559","https://openalex.org/W3043838858","https://openalex.org/W3216425243","https://openalex.org/W2547539639"],"abstract_inverted_index":{"Mutations":[0],"of":[1,10,20,28,46,63,74,82,113],"mitochondrial":[2,7,23,115],"DNA":[3],"(mtDNA)":[4],"often":[5],"underlie":[6],"disease,":[8],"one":[9],"the":[11,18,21,26,61,88,108],"most":[12],"common":[13],"inherited":[14],"metabolic":[15],"disorders.":[16,94],"Since":[17],"sequencing":[19],"human":[22],"genome":[24],"and":[25,55,99,107],"discovery":[27],"pathogenic":[29],"mutations":[30],"in":[31,60,102],"mtDNA":[32,47,65,83],"more":[33],"than":[34],"30":[35],"years":[36],"ago,":[37],"a":[38],"movement":[39],"towards":[40],"generating":[41],"methods":[42],"for":[43,69,90,111],"robust":[44],"manipulation":[45,81],"has":[48],"ensued,":[49],"although":[50],"with":[51],"relatively":[52],"few":[53],"advances":[54],"some":[56,70],"controversy.":[57],"While":[58],"developments":[59,101],"transformation":[62],"mammalian":[64],"have":[66],"stood":[67],"still":[68],"time,":[71],"recent":[72,100],"demonstrations":[73],"programmable":[75],"nuclease-based":[76],"technology":[77,106],"suggest":[78],"that":[79],"clinical":[80,109],"heteroplasmy":[84],"may":[85],"be":[86],"on":[87],"horizon":[89],"these":[91],"largely":[92],"untreatable":[93],"Here":[95],"we":[96],"review":[97],"historical":[98],"mitochondrially":[103],"targeted":[104],"nuclease":[105],"outlook":[110],"treatment":[112],"hereditary":[114],"disease.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2020-04-03T00:00:00"}