{"id":"https://openalex.org/W3013665859","doi":"https://doi.org/10.1007/s12561-020-09272-5","title":"A Curve-Free Bayesian Decision-Theoretic Design for Phase Ia/Ib Trials Considering Both Safety and Efficacy Outcomes","display_name":"A Curve-Free Bayesian Decision-Theoretic Design for Phase Ia/Ib Trials Considering Both Safety and Efficacy Outcomes","publication_year":2020,"publication_date":"2020-03-26","ids":{"openalex":"https://openalex.org/W3013665859","doi":"https://doi.org/10.1007/s12561-020-09272-5","mag":"3013665859","pmid":"https://pubmed.ncbi.nlm.nih.gov/33815623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014959"},"language":"en","primary_location":{"id":"doi:10.1007/s12561-020-09272-5","doi":"https://doi.org/10.1007/s12561-020-09272-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12561-020-09272-5","pdf_url":null,"source":{"id":"https://openalex.org/S89613883","display_name":"Statistics in Biosciences","issn_l":"1867-1764","issn":["1867-1764","1867-1772"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014959","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048396130","display_name":"Shenghua Kelly Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184813773","display_name":"California State University, East Bay","ror":"https://ror.org/04jaeba88","country_code":"US","type":"education","lineage":["https://openalex.org/I184813773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shenghua Fan","raw_affiliation_strings":["Department of Statistics and Biostatistics, California State University, East Bay, Hayward, 94542, CA, USA","Department of Statistics and Biostatistics, California State University, East Bay, Hayward, CA, 94542, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Biostatistics, California State University, East Bay, Hayward, 94542, CA, USA","institution_ids":["https://openalex.org/I184813773"]},{"raw_affiliation_string":"Department of Statistics and Biostatistics, California State University, East Bay, Hayward, CA, 94542, USA","institution_ids":["https://openalex.org/I184813773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090134776","display_name":"Bee Leng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bee Leng Lee","raw_affiliation_strings":["Department of Mathematics and Statistics, San Jose State University, San Jose, 95192, CA, USA","Department of Mathematics and Statistics, San Jose State University, San Jose, CA, 95192, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, San Jose State University, San Jose, 95192, CA, USA","institution_ids":["https://openalex.org/I51504820"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, San Jose State University, San Jose, CA, 95192, USA","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057666375","display_name":"Ying L\u00fc","orcid":"https://orcid.org/0000-0002-7698-8962","observed_orcids":["https://orcid.org/0000-0002-7698-8962","https://orcid.org/0000-0001-7420-0206"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying Lu","raw_affiliation_strings":["Department of Biomedical Data Science, Center for Innovative Study Designs and the Biostatistics Core, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, 94305, CA, USA","Department of Biomedical Data Science, School of Medicine, Center for Innovative Study Designs and the Biostatistics Core, Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-7698-8962","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Center for Innovative Study Designs and the Biostatistics Core, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, 94305, CA, USA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biomedical Data Science, School of Medicine, Center for Innovative Study Designs and the Biostatistics Core, Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057666375"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":null,"fwci":0.5289,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66206627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"2","first_page":"146","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/two-stage-design","display_name":"two-stage design","score":0.6499999761581421},{"id":"https://openalex.org/keywords/bayesian-decision-theory","display_name":"Bayesian decision theory","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.5690000057220459},{"id":"https://openalex.org/keywords/dose-toxicity-relationship","display_name":"dose-toxicity relationship","score":0.7580000162124634},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8169999718666077},{"id":"https://openalex.org/keywords/goodness-of-fit","display_name":"goodness of fit","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C72169020","wikidata":"https://www.wikidata.org/wiki/Q194404","display_name":"Monotonic function","level":2,"score":0.5745784640312195},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.569670557975769},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5083736777305603},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.43264642357826233},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4140762984752655},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3972424268722534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33599162101745605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17341279983520508},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12561-020-09272-5","doi":"https://doi.org/10.1007/s12561-020-09272-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12561-020-09272-5","pdf_url":null,"source":{"id":"https://openalex.org/S89613883","display_name":"Statistics in Biosciences","issn_l":"1867-1764","issn":["1867-1764","1867-1772"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Biosciences","raw_type":"journal-article"},{"id":"pmid:33815623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33815623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in biosciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8014959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stat Biosci","raw_type":"Text"},{"id":"pmh:oai:RePEc:spr:stabio:v:12:y:2020:i:2:d:10.1007_s12561-020-09272-5","doi":null,"is_oa":false,"landing_page_url":"http://link.springer.com/10.1007/s12561-020-09272-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8014959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stat Biosci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000859589","display_name":"Stanford Cancer Institute","funder_award_id":"P30CA124435","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W74630330","https://openalex.org/W1896894019","https://openalex.org/W1971685703","https://openalex.org/W1974473197","https://openalex.org/W1998123344","https://openalex.org/W2041098432","https://openalex.org/W2059221883","https://openalex.org/W2092211240","https://openalex.org/W2093423617","https://openalex.org/W2115499099","https://openalex.org/W2125594974","https://openalex.org/W2128905862","https://openalex.org/W2129546350","https://openalex.org/W2173235643","https://openalex.org/W2274054852","https://openalex.org/W2509620695","https://openalex.org/W2587637943","https://openalex.org/W2736865832","https://openalex.org/W4236759481","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2277432382","https://openalex.org/W2509620695","https://openalex.org/W3108294897","https://openalex.org/W3186606527","https://openalex.org/W2108441636","https://openalex.org/W2744742277","https://openalex.org/W2274054852","https://openalex.org/W4403841423","https://openalex.org/W2801395530","https://openalex.org/W3046269351"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-04-03T00:00:00"}
