{"id":"https://openalex.org/W3013604892","doi":null,"title":"Forced degradation studies of new formulation containing naltrexone","display_name":"Forced degradation studies of new formulation containing naltrexone","publication_year":2019,"publication_date":"2019-12-30","ids":{"openalex":"https://openalex.org/W3013604892","mag":"3013604892"},"language":"en","primary_location":{"id":"pmh:oai:dergipark.org.tr:article/647161","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/emujpharmsci/article/647161","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065332110","display_name":"Golnaz Yaghoubnezhadzanganeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Golnaz Yaghoubnezhadzanganeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073341192","display_name":"Emine Vildan Burgaz","orcid":"https://orcid.org/0000-0003-3245-5934","observed_orcids":["https://orcid.org/0000-0003-3245-5934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Vildan Burgaz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3245-5934","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"2","first_page":"75","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-dose-naltrexone","display_name":"low-dose naltrexone","score":0.9610000252723694},{"id":"https://openalex.org/keywords/forced-degradation","display_name":"forced degradation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.7599999904632568},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.8370000123977661},{"id":"https://openalex.org/keywords/uv-vis-spectroscopy","display_name":"UV-Vis spectroscopy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/tablet-formulation","display_name":"tablet formulation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/acidic-degradation","display_name":"acid degradation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/basic-degradation","display_name":"basic degradation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.9903281927108765},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5121729373931885},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.4918637275695801},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4413997530937195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4265303611755371},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3550805449485779},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.352343887090683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22517642378807068},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20949700474739075},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.1428433358669281},{"id":"https://openalex.org/C2775986502","wikidata":"https://www.wikidata.org/wiki/Q420466","display_name":"Ammonium formate","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dergipark.org.tr:article/647161","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/emujpharmsci/article/647161","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3013604892","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/download/article-file/910293","pdf_url":null,"source":{"id":"https://openalex.org/S4387279949","display_name":"EMU Journal of Pharmaceutical Sciences","issn_l":"2651-3587","issn":["2651-3587"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"EMU Journal of Pharmaceutical Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1774782845","https://openalex.org/W1964140127","https://openalex.org/W2029219416","https://openalex.org/W2041131094","https://openalex.org/W2185903804","https://openalex.org/W2327042539"],"related_works":["https://openalex.org/W7009541125","https://openalex.org/W4407592401","https://openalex.org/W2149213603","https://openalex.org/W2059729413","https://openalex.org/W59971345","https://openalex.org/W7160584539","https://openalex.org/W2806234223","https://openalex.org/W4205488794","https://openalex.org/W2023875144","https://openalex.org/W2062527564"],"abstract_inverted_index":{"Naltrexone":[0,138],"is":[1,26],"one":[2],"of":[3,21,34,59,69,79,93,121,135],"the":[4,60,66,102,119,133,147],"classical":[5],"opioid":[6],"antagonists.":[7],"In":[8],"substantially":[9],"lower":[10],"than":[11],"standard":[12],"doses,":[13],"they":[14],"apply":[15],"different":[16],"pharmacodynamics.":[17],"A":[18,89],"daily":[19],"dose":[20],"1":[22],"to":[23,64,84,108,141,153],"5":[24],"mg":[25],"considered":[27],"as":[28,44],"low-dose":[29],"naltrexone":[30,70,80,94],"(LDN).":[31],"Clinical":[32],"reports":[33],"LDN":[35],"have":[36],"demonstrated":[37],"its":[38,96],"possible":[39],"benefits":[40],"in":[41,95,106,146],"diseases":[42],"such":[43],"fibromyalgia,":[45],"Crohn\u2019s":[46],"disease,":[47,54],"multiple":[48],"sclerosis,":[49],"complex-regional":[50],"pain":[51],"syndrome,":[52],"Hailey-Hailey":[53],"and":[55,71,86,104,112,144,149],"cancer.":[56],"The":[57],"aim":[58],"present":[61],"study":[62,92],"was":[63,99,124,139],"establish":[65],"inherent":[67],"stability":[68,72,114],"indicating":[73,115],"assay":[74],"method":[75,117],"for":[76,118],"simultaneous":[77],"determination":[78],"after":[81],"being":[82],"subjected":[83],"acidic":[85,103,148],"basic":[87,150],"stress.":[88],"forced":[90],"degradation":[91],"tablet":[97],"form":[98],"conducted":[100],"under":[101],"basicconditions":[105],"order":[107],"develop":[109],"a":[110],"rapid":[111],"sensitive":[113],"UV-Visible":[116],"quantification":[120],"naltrexone.":[122],"Quantification":[123],"achieved":[125],"by":[126],"UV":[127],"detection":[128],"at":[129],"286.60":[130],"nm,":[131],"on":[132],"basis":[134],"peak":[136],"area.":[137],"found":[140],"be":[142],"unstable":[143],"degraded":[145],"buffer":[151],"up":[152],"3":[154],"hours.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-04-03T00:00:00"}