{"id":"https://openalex.org/W3013480673","doi":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","title":"Abstract PD5-01: Prospective multi-institutional evaluation of pathologist assessment of PD-L1 assays in triple negative breast cancer","display_name":"Abstract PD5-01: Prospective multi-institutional evaluation of pathologist assessment of PD-L1 assays in triple negative breast cancer","publication_year":2020,"publication_date":"2020-02-15","ids":{"openalex":"https://openalex.org/W3013480673","doi":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","mag":"3013480673"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs19-pd5-01","doi":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042454182","display_name":"Emily Reisenbichler","orcid":"https://orcid.org/0000-0002-1570-6538","observed_orcids":["https://orcid.org/0000-0002-1570-6538"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Suzanne Reisenbichler","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070602177","display_name":"Gang Han","orcid":"https://orcid.org/0000-0002-5781-5169","observed_orcids":["https://orcid.org/0000-0002-5781-5169"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Han","raw_affiliation_strings":["2Texas A&M University, College Station, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Texas A&M University, College Station, TX;","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091087835","display_name":"Vasiliki Pelekanou","orcid":"https://orcid.org/0000-0002-8431-1927","observed_orcids":["https://orcid.org/0000-0002-8431-1927"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasiliki Pelekanou","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080145","display_name":"Vesal Yaghoobi","orcid":"https://orcid.org/0000-0001-6534-1293","observed_orcids":["https://orcid.org/0000-0001-6534-1293"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vesal Yaghoobi","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030441817","display_name":"Fahad Shabbir Ahmed","orcid":"https://orcid.org/0000-0002-5857-5478","observed_orcids":["https://orcid.org/0000-0002-5857-5478"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahad S Ahmed","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049947325","display_name":"Andrew M. Bellizzi","orcid":"https://orcid.org/0000-0002-8264-6379","observed_orcids":["https://orcid.org/0000-0002-8264-6379"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Bellizzi","raw_affiliation_strings":["3University of Iowa, Iowa City, IA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Iowa, Iowa City, IA;","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011363732","display_name":"Veerle Bossuyt","orcid":"https://orcid.org/0000-0003-0403-6791","observed_orcids":["https://orcid.org/0000-0003-0403-6791"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veerle Bossuyt","raw_affiliation_strings":["4Massachusetts General Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103889267","display_name":"Jane E. Brock","orcid":"https://orcid.org/0000-0003-3358-0534","observed_orcids":["https://orcid.org/0000-0003-3358-0534"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Brock","raw_affiliation_strings":["5Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046097954","display_name":"Kimberly S. Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Cole","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043669779","display_name":"Oluwole Fadare","orcid":"https://orcid.org/0000-0001-8017-2854","observed_orcids":["https://orcid.org/0000-0001-8017-2854"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwole Fadare","raw_affiliation_strings":["6University of California San Diego, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6University of California San Diego, San Diego, CA;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018745309","display_name":"Omar Hameed","orcid":"https://orcid.org/0000-0001-8725-705X","observed_orcids":["https://orcid.org/0000-0001-8725-705X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Hameed","raw_affiliation_strings":["7Forward Pathology Solutions and Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Forward Pathology Solutions and Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038852703","display_name":"Krisztina Z. Hanley","orcid":"https://orcid.org/0000-0002-7841-4700","observed_orcids":["https://orcid.org/0000-0002-7841-4700"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krisztina Hanley","raw_affiliation_strings":["8Emory University, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Emory University, Atlanta, GA;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028426531","display_name":"Beth T. Harrison","orcid":"https://orcid.org/0000-0002-8341-2961","observed_orcids":["https://orcid.org/0000-0002-8341-2961"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth T Harrison","raw_affiliation_strings":["5Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006317694","display_name":"Mar\u00eda Gabriela Kuba","orcid":"https://orcid.org/0000-0001-5431-3035","observed_orcids":["https://orcid.org/0000-0001-5431-3035"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M G Kuba","raw_affiliation_strings":["9Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103139446","display_name":"Amy Ly","orcid":"https://orcid.org/0000-0002-4888-5026","observed_orcids":["https://orcid.org/0000-0002-4888-5026"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Ly","raw_affiliation_strings":["4Massachusetts General Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053434461","display_name":"Dylan V. Miller","orcid":"https://orcid.org/0000-0003-3129-5748","observed_orcids":["https://orcid.org/0000-0003-3129-5748"]},"institutions":[{"id":"https://openalex.org/I108785884","display_name":"Intermountain Healthcare","ror":"https://ror.org/04mvr1r74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan Miller","raw_affiliation_strings":["10Intermountain Healthcare & University of Utah, Salt Lake City, UT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Intermountain Healthcare & University of Utah, Salt Lake City, UT;","institution_ids":["https://openalex.org/I108785884","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075414964","display_name":"Mirna Podoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirna Podoll","raw_affiliation_strings":["11Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034226178","display_name":"Anja Christiane Roden","orcid":"https://orcid.org/0000-0001-8948-4758","observed_orcids":["https://orcid.org/0000-0001-8948-4758"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anja C Roden","raw_affiliation_strings":["12Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003087","display_name":"Mary Ann Sanders","orcid":"https://orcid.org/0000-0002-1243-7950","observed_orcids":["https://orcid.org/0000-0002-1243-7950"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A Sanders","raw_affiliation_strings":["13University of Louisville, Louisville, KY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13University of Louisville, Louisville, KY;","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025387041","display_name":"Kamaljeet Singh","orcid":"https://orcid.org/0000-0002-2506-5703","observed_orcids":["https://orcid.org/0000-0002-2506-5703","https://orcid.org/0009-0004-7735-3856"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamaljeet Singh","raw_affiliation_strings":["14Brown University, Providence, RI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Brown University, Providence, RI;","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062372552","display_name":"Shi Wei","orcid":"https://orcid.org/0000-0003-4417-593X","observed_orcids":["https://orcid.org/0000-0003-4417-593X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shi Wei","raw_affiliation_strings":["15University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075884518","display_name":"Hannah Yong Wen","orcid":"https://orcid.org/0000-0001-6794-5234","observed_orcids":["https://orcid.org/0000-0001-6794-5234"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Wen","raw_affiliation_strings":["9Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021113979","display_name":"Lajos Pusztai","orcid":"https://orcid.org/0000-0001-9632-6686","observed_orcids":["https://orcid.org/0000-0001-9632-6686"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lajos Pusztai","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L Rimm","raw_affiliation_strings":["1Yale School of Medicine, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale School of Medicine, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"4_Supplement","first_page":"PD5","last_page":"01"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9089999794960022},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sp142","display_name":"SP142","score":0.7200000286102295},{"id":"https://openalex.org/keywords/sp263","display_name":"SP263","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interobserver-concordance","display_name":"interobserver concordance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.8360000252723694},{"id":"https://openalex.org/keywords/companion-diagnostics","display_name":"companion diagnostics","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.9281312823295593},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.717861533164978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6989693641662598},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6810770630836487},{"id":"https://openalex.org/C2780416959","wikidata":"https://www.wikidata.org/wiki/Q22907415","display_name":"Companion diagnostic","level":3,"score":0.5852768421173096},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5477426052093506},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4604611396789551},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44592487812042236},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42472514510154724},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.42388230562210083},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42149463295936584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4142901301383972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4018526077270508},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.3549925684928894},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.18380698561668396}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs19-pd5-01","doi":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs19-pd5-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3017266548","https://openalex.org/W3169461145","https://openalex.org/W2977786333","https://openalex.org/W3138068317","https://openalex.org/W3212602671","https://openalex.org/W2997305322","https://openalex.org/W3087288186","https://openalex.org/W4391188667","https://openalex.org/W3006058260","https://openalex.org/W3119079619"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,53,90,138,408,495,520,536],"IMpassion130":[3,484],"study":[4,142],"demonstrated":[5],"prolonged":[6],"overall":[7,104,289,329],"survival":[8],"when":[9,585,595],"atezolizumab,":[10,584],"a":[11,37,63,82,123,172,266,307,436,446,473,540,577],"PD-L1":[12,19,34,87,126,148,218,346,477,528,663],"inhibitor,":[13],"was":[14,143,347,394,421],"added":[15],"to":[16,66,144,175,183,235,273,306,361,509,515,576,589],"nab-paclitaxel":[17],"in":[18,75,85,120,122,135,147,193,353,396,438,482,564,665],"positive":[20,249,262,350,369,478,499],"patients":[21,581],"with":[22,46,101,163,213,331,351,363,400,406,491,502,517,526,542],"advanced":[23],"triple":[24,666],"negative":[25,243,667],"breast":[26,129,668],"cancer":[27,77,130,669],"(TNBC).":[28],"Approximately":[29],"40%":[30],"of":[31,39,115,140,189,258,281,288,294,309,312,317,327,342,356,358,417,442,449,476,498,522,549,561,580,659,662,673],"tumors":[32,479],"were":[33,201,224,229],"positive,":[35],"utilizing":[36],"cutoff":[38],"\u2265":[40],"1%":[41,245,251],"immune":[42,524,552],"cell":[43,553],"(IC)":[44],"staining":[45,260],"the":[47,157,164,177,207,210,214,256,286,292,315,324,328,332,343,364,466,483,492,507,562,674],"Ventana":[48,211],"SP142":[49,96,165,215,365,420,469],"immunohistochemical":[50],"(IHC)":[51],"assay.":[52,494],"Food":[54],"and":[55,166,216,221,231,254,322,376,381,402,419,423,457],"Drug":[56],"Administration":[57],"(FDA)":[58],"approved":[59,468],"this":[60,141],"assay":[61,366,431,514],"as":[62,191,204,241,314,349,440],"companion":[64,92],"test":[65,93],"determine":[67,176],"patient":[68,570],"eligibility":[69],"for":[70,95,111,128,180,261,379,413,429,432,455,462,512,551],"atezolizumab":[71,594],"therapy.":[72],"However,":[73],"literature":[74],"lung":[76],"shows":[78,97],"that":[79,268,557],"pathologists":[80,152,236,301,318,434,563],"have":[81],"high":[83,98,578],"discordance":[84],"assessing":[86],"on":[88,206,209],"IC.":[89],"FDA":[91,467],"documentation":[94],"inter-laboratory":[99],"reproducibility":[100,532],"nearly":[102],"95%":[103,333],"percent":[105],"agreement":[106,290,313,330],"(OPA)":[107],"between":[108,150,186],"2":[109,112,384,414],"readers":[110,190],"category":[113,385,415],"scoring":[114,149,389,416,523],"IC":[116,246,252,259,368,571],"(positive":[117,386],"versus":[118],"negative)":[119,388],"TNBC":[121,160],"central":[124],"laboratory.":[125],"testing":[127],"is":[131],"now":[132],"becoming":[133],"widespread":[134],"pathology":[136],"laboratories.":[137],"goal":[139],"assess":[145],"concordance":[146,185,390],"19":[151,433],"from":[153,337,373],"14":[154],"institutions":[155],"examining":[156],"same":[158],"86":[159],"tissues":[161],"stained":[162,202],"SP263":[167,217,352,380,401,418,456,493],"antibodies.":[168],"We":[169,264,320],"also":[170],"present":[171],"new":[173],"method":[174,267],"minimum":[178],"number":[179,316,441],"evaluators":[181],"needed":[182],"estimate":[184,326],"large":[187],"numbers":[188],"occurs":[192],"real":[194,565],"life":[195],"setting.":[196],"Methods:":[197],"Full":[198],"tissue":[199,295],"sections":[200],"exactly":[203],"prescribed":[205],"label":[208],"Benchmark":[212],"assays.":[219],"Sixty-eight":[220],"76":[222],"cases":[223,240,359,398,404,500],"evaluable":[225],"respectively.":[226,425],"Stained":[227],"slides":[228],"scanned":[230],"digital":[232],"files":[233],"distributed":[234],"who":[237],"independently":[238],"scored":[239],"either":[242,582],"(<":[244],"staining)":[247,253],"or":[248,591],"(\u2265":[250],"estimated":[255],"%":[257],"cases.":[263],"applied":[265],"we":[269,283,471],"call":[270],"Observers":[271],"Needed":[272],"Evaluate":[274],"Subjective":[275],"Tests":[276],"(ONEST).":[277],"For":[278],"any":[279],"combination":[280],"pathologists,":[282,544],"can":[284,304],"quantify":[285],"degree":[287],"using":[291],"proportion":[293,497],"samples":[296],"upon":[297],"which":[298,303],"all":[299,392],"selected":[300,340],"agreed,":[302],"lead":[305,575],"plot":[308],"non-increasing":[310],"trajectory":[311],"increases.":[319],"computed":[321],"plotted":[323],"empirical":[325],"confidence":[334],"interval":[335],"(CI)":[336],"1000":[338],"randomly":[339],"permutations":[341],"pathologists.":[344,535],"Results:":[345],"interpreted":[348],"an":[354,547],"average":[355],"78%":[357],"compared":[360],"58%":[362],"(p<.0001).":[367],"continuous":[370],"scores":[371],"ranged":[372],"1-95%":[374],"(mean=20%)":[375],"1-90%":[377],"(mean=10%)":[378],"SP142.":[382,407,463],"Complete":[383],"vs":[387],"across":[391,533],"observers":[393,443,454,461],"achieved":[395],"38":[397],"(50%)":[399],"26":[403],"(38%)":[405],"intraclass":[409],"correlation":[410],"coefficient":[411],"(ICC)":[412],"0.513":[422],"0.560":[424],"ONEST":[426,537],"plots":[427],"made":[428],"each":[430,513],"showed":[435,530],"decrease":[437],"OPA":[439,548],"increased,":[444],"reaching":[445,546],"low":[447],"plateau":[448,541],"approximately":[450],"0.46":[451],"at":[452,459],"10":[453,543],"0.42":[458],"8":[460],"Conclusions:":[464],"Utilizing":[465],"assay,":[470],"found":[472],"higher":[474],"prevalence":[475,488],"than":[480,489,559],"published":[481],"trial":[485],"but":[486],"lower":[487],"seen":[490,501],"different":[496,504],"two":[503],"assays":[505,529,664],"highlights":[506],"need":[508],"establish":[510],"cutoffs":[511],"correspond":[516],"clinical":[518],"benefit.":[519,598],"ICC":[521],"cells":[525],"both":[527],"poor":[531],"multiple":[534],"analysis":[538],"finds":[539],"only":[545],"0.4":[550],"assessment.":[554],"This":[555,573],"suggests":[556],"more":[558],"half":[560],"world":[566],"situations":[567],"may":[568,597],"mis-assign":[569],"scores.":[572],"could":[574],"percentage":[579],"receiving":[583,593],"they":[586,596],"are":[587],"unlikely":[588],"benefit":[590],"not":[592],"Citation":[599],"Format:":[600],"Emily":[601],"Suzanne":[602],"Reisenbichler,":[603],"Gang":[604],"Han,":[605],"Vasiliki":[606],"Pelekanou,":[607],"Vesal":[608],"Yaghoobi,":[609],"Fahad":[610],"S":[611],"Ahmed,":[612],"Andrew":[613],"Bellizzi,":[614],"Veerle":[615],"Bossuyt,":[616],"Jane":[617],"Brock,":[618],"Kimberly":[619],"Cole,":[620],"Oluwole":[621],"Fadare,":[622],"Omar":[623],"Hameed,":[624],"Krisztina":[625],"Hanley,":[626],"Beth":[627],"T":[628],"Harrison,":[629],"M":[630],"G":[631],"Kuba,":[632],"Amy":[633],"Ly,":[634],"Dylan":[635],"Miller,":[636],"Mirna":[637],"Podoll,":[638],"Anja":[639],"C":[640],"Roden,":[641],"Mary":[642],"A":[643],"Sanders,":[644],"Kamaljeet":[645],"Singh,":[646],"Shi":[647],"Wei,":[648],"Hannah":[649],"Wen,":[650],"Lajos":[651],"Pusztai,":[652],"David":[653],"L":[654],"Rimm.":[655],"Prospective":[656],"multi-institutional":[657],"evaluation":[658],"pathologist":[660],"assessment":[661],"[abstract].":[670],"In:":[671],"Proceedings":[672],"2019":[675,681],"San":[676,684],"Antonio":[677],"Breast":[678],"Cancer":[679,690],"Symposium;":[680],"Dec":[682],"10-14;":[683],"Antonio,":[685],"TX.":[686],"Philadelphia":[687],"(PA):":[688],"AACR;":[689],"Res":[691],"2020;80(4":[692],"Suppl):Abstract":[693],"nr":[694],"PD5-01.":[695]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-04-03T00:00:00"}