{"id":"https://openalex.org/W3013453265","doi":null,"title":"Biophysical Modeling of Endolymph Transport During Inner Ear Development","display_name":"Biophysical Modeling of Endolymph Transport During Inner Ear Development","publication_year":2018,"publication_date":"2018-04-16","ids":{"openalex":"https://openalex.org/W3013453265","mag":"3013453265"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/37945119","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076398843","display_name":"Kishore R. Mosaliganti","orcid":"https://orcid.org/0000-0002-2684-600X","observed_orcids":["https://orcid.org/0000-0002-2684-600X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kishore Mosaliganti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076398843"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inner-ear-development","display_name":"inner ear development","score":0.9909999966621399},{"id":"https://openalex.org/keywords/otic-vesicle","display_name":"otic vesicle","score":0.9909999966621399},{"id":"https://openalex.org/keywords/paracellular-pathway","display_name":"paracellular pathway","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.7490000128746033},{"id":"https://openalex.org/keywords/perilymph","display_name":"perilymph","score":0.7289999723434448},{"id":"https://openalex.org/keywords/advection","display_name":"advection","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hearing-disorders","display_name":"hearing disorders","score":0.5680000185966492},{"id":"https://openalex.org/keywords/balance-disorders","display_name":"balance disorders","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2778969067","wikidata":"https://www.wikidata.org/wiki/Q1340752","display_name":"Endolymph","level":3,"score":0.9598995447158813},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.6985521912574768},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40995141863822937},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3571452796459198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22346889972686768}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/37945119","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:3013453265","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/37945119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/37945119","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37945119","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013453265.pdf","grobid_xml":"https://content.openalex.org/works/W3013453265.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2468224074","https://openalex.org/W2074926562","https://openalex.org/W3099912250","https://openalex.org/W2792694621","https://openalex.org/W2271595502","https://openalex.org/W2087404393","https://openalex.org/W2091620807","https://openalex.org/W2977318758","https://openalex.org/W4302594289","https://openalex.org/W4392642991"],"abstract_inverted_index":{"The":[0,25,49,176],"goal":[1],"of":[2,21,59,118,165,171,174,186,202,213,225],"this":[3,112],"work":[4,76],"was":[5],"to":[6,40,70,91,104,137,145,151,234,238,247],"investigate":[7],"the":[8,19,37,85,116,119,121,125,132,146,172,200,226],"biophysical":[9,126],"mechanisms":[10],"underlying":[11,128],"fluid":[12,79,93,109,141,143,248],"transport":[13,80,94,110,130,215],"across":[14,183,194],"a":[15,31,101,180],"single-cell":[16],"epithelium":[17],"in":[18,57,84],"context":[20],"inner":[22,27,147],"ear":[23,28,148],"development.":[24],"primordial":[26],"grows":[29],"as":[30,36],"fluid-filled":[32],"spherical":[33],"shell,":[34],"called":[35,52],"otic":[38],"vesicle,":[39],"form":[41],"complex":[42],"sub-organs":[43],"necessary":[44],"for":[45,220],"hearing":[46,71],"and":[47,62,66,72,95,124,193,208,222],"balance.":[48],"luminal":[50,86,133],"fluid,":[51,120,209],"endolymph,":[53],"is":[54,244],"tightly":[55],"regulated":[56],"terms":[58],"its":[60,129],"composition":[61],"volume":[63],"throughout":[64],"development":[65],"whose":[67],"dysregulation":[68],"leads":[69],"balance":[73],"disorders.":[74],"Previous":[75],"showed":[77],"that":[78,88,240],"creates":[81],"hydrostatic":[82],"pressure":[83,107],"cavity":[87],"feeds":[89],"back":[90],"inhibit":[92],"regulate":[96],"vesicle":[97],"growth":[98,223],"rates.":[99],"As":[100],"first":[102],"step":[103],"linking":[105],"how":[106],"affects":[108],"mechanisms,":[111],"study":[113],"focused":[114],"on":[115],"origin":[117],"path":[122,173],"taken,":[123],"mechanism":[127],"into":[131],"cavity.":[134],"In":[135],"order":[136],"distinguish":[138],"whether":[139],"intracellular":[140],"or":[142],"external":[144],"(perilymph)":[149],"contributes":[150],"transport,":[152],"quantitative":[153],"imaging":[154],"techniques":[155],"were":[156,216,232],"used":[157,233],"with":[158],"small":[159],"fluorescent":[160],"tracer":[161,177,241],"dyes.":[162],"3D+time":[163],"visualizations":[164],"localization":[166],"patterns":[167],"provide":[168],"direct":[169],"evidence":[170],"endolymph.":[175],"dye":[178,207,214,242],"highlighted":[179],"paracellular":[181],"pathway":[182],"basal":[184],"junctions":[185],"cells,":[187,192],"lateral":[188],"spaces":[189],"between":[190],"adjacent":[191],"apical":[195],"junctions.":[196],"To":[197],"rule":[198],"out":[199],"possibility":[201],"different":[203],"paths":[204],"taken":[205],"by":[206,218],"several":[210],"mathematical":[211],"models":[212],"evaluated":[217],"accounting":[219],"geometry":[221],"dynamics":[224],"vesicle.":[227],"Data":[228],"from":[229],"experimental":[230],"perturbations":[231],"validate":[235],"model":[236],"predictions":[237],"prove":[239],"movement":[243],"advectively":[245],"coupled":[246],"movement.":[249]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-04-03T00:00:00"}