{"id":"https://openalex.org/W3013388971","doi":null,"title":"Targeting ROR1 inhibits epithelial to mesenchymal transition in human lung adenocarcinoma via mTOR signaling pathway.","display_name":"Targeting ROR1 inhibits epithelial to mesenchymal transition in human lung adenocarcinoma via mTOR signaling pathway.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3013388971","mag":"3013388971","pmid":"https://pubmed.ncbi.nlm.nih.gov/31949551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5916262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082303887","display_name":"Ming\u2010Peng Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Peng Long","raw_affiliation_strings":["School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui-Li Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Li Wang","raw_affiliation_strings":["School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong-Bin Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114896","display_name":"The First Hospital of Kunming","ror":"https://ror.org/01hq7pd83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-Bin Luo","raw_affiliation_strings":["Department of Clinical Laboratory, The First People's Hospital of Kunming Kunming, Yunnan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First People's Hospital of Kunming Kunming, Yunnan, PR China","institution_ids":["https://openalex.org/I4210114896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015823958","display_name":"Jiahui Yang","orcid":"https://orcid.org/0000-0002-7704-8585","observed_orcids":["https://orcid.org/0000-0002-7704-8585","https://orcid.org/0000-0001-7613-6615"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Hui Yang","raw_affiliation_strings":["School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, PR China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.078,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.39920046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"10","first_page":"4759","last_page":"4770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.902999997138977},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.8744293451309204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7432595491409302},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.726379930973053},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6454510688781738},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5697264075279236},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5090975165367126},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4797602593898773},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.47700098156929016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4394494593143463},{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.42046108841896057},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.39874136447906494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33641111850738525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27336522936820984},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22968855500221252},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20485079288482666},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16474753618240356},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.06414827704429626},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5916262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6962910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:31949551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:3013388971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5916262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962910","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1822418390","https://openalex.org/W1963195533","https://openalex.org/W1964847767","https://openalex.org/W1967394241","https://openalex.org/W1975711182","https://openalex.org/W1983054966","https://openalex.org/W1984384507","https://openalex.org/W2000110198","https://openalex.org/W2000421454","https://openalex.org/W2009811887","https://openalex.org/W2026577870","https://openalex.org/W2060157525","https://openalex.org/W2062974600","https://openalex.org/W2075752480","https://openalex.org/W2106787323","https://openalex.org/W2123811897","https://openalex.org/W2160827892","https://openalex.org/W2162585517","https://openalex.org/W2166836693","https://openalex.org/W2169396440","https://openalex.org/W2413591396","https://openalex.org/W2416824063","https://openalex.org/W2521309265","https://openalex.org/W2523524031","https://openalex.org/W2554091579","https://openalex.org/W2565961256","https://openalex.org/W2577961189","https://openalex.org/W2589848799","https://openalex.org/W2597907561","https://openalex.org/W2599874869","https://openalex.org/W2611877356","https://openalex.org/W2619135413","https://openalex.org/W2638401050","https://openalex.org/W2750880769","https://openalex.org/W2750947159","https://openalex.org/W2754396651","https://openalex.org/W2756322300","https://openalex.org/W2765949732","https://openalex.org/W2770576214","https://openalex.org/W2784254353","https://openalex.org/W2791073714","https://openalex.org/W2791598504","https://openalex.org/W2791874567","https://openalex.org/W2793727642","https://openalex.org/W2794022179","https://openalex.org/W2794633020","https://openalex.org/W2795195475","https://openalex.org/W2800001731","https://openalex.org/W2800097232","https://openalex.org/W2801167282","https://openalex.org/W2804899776","https://openalex.org/W2806677552","https://openalex.org/W2979836143"],"related_works":["https://openalex.org/W2162585517","https://openalex.org/W7098126847","https://openalex.org/W1983054966","https://openalex.org/W2742161063","https://openalex.org/W2913445208","https://openalex.org/W7208164434","https://openalex.org/W2126022920","https://openalex.org/W3032904673","https://openalex.org/W2566191767","https://openalex.org/W2196262692"],"abstract_inverted_index":{"and":[0,13,36],"also":[1],"significantly":[2],"inhibited":[3],"the":[4],"phosphorylation":[5],"of":[6,45],"Akt":[7],"(Ser473),":[8],"mTOR":[9,42],"(Ser2448),":[10],"Raptor":[11],"(Ser792)":[12],"p70S6K":[14],"(Thr389)":[15],"in":[16,33,38],"all":[17],"four":[18],"cell":[19],"lines.":[20],"This":[21],"strongly":[22],"supports":[23],"our":[24],"proposal":[25],"that":[26],"ROR1":[27],"may":[28],"play":[29],"a":[30],"central":[31],"role":[32],"tumor":[34],"progression":[35],"metastasis":[37],"lung":[39],"adenocarcinoma":[40],"through":[41],"signaling,":[43],"regardless":[44],"its":[46],"EGFR-TKI":[47],"sensitivity":[48],"status.":[49]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-04-03T00:00:00"}
