{"id":"https://openalex.org/W3013385643","doi":"https://doi.org/10.1111/fcp.12557","title":"Cannabidiol alleviates hemorrhagic shock\u2010induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway","display_name":"Cannabidiol alleviates hemorrhagic shock\u2010induced neural apoptosis in rats by inducing autophagy through activation of the PI3K/AKT pathway","publication_year":2020,"publication_date":"2020-03-26","ids":{"openalex":"https://openalex.org/W3013385643","doi":"https://doi.org/10.1111/fcp.12557","mag":"3013385643","pmid":"https://pubmed.ncbi.nlm.nih.gov/32215966"},"language":"en","primary_location":{"id":"doi:10.1111/fcp.12557","doi":"https://doi.org/10.1111/fcp.12557","is_oa":false,"landing_page_url":"https://doi.org/10.1111/fcp.12557","pdf_url":null,"source":{"id":"https://openalex.org/S35226884","display_name":"Fundamental and Clinical Pharmacology","issn_l":"0767-3981","issn":["0767-3981","1472-8206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100657433","display_name":"Bo Lin","orcid":"https://orcid.org/0000-0001-5732-9438","observed_orcids":["https://orcid.org/0000-0001-5732-9438"]},"institutions":[{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Lin","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China"],"raw_orcid":"https://orcid.org/0000-0001-5732-9438","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China","institution_ids":["https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423310","display_name":"Youguang Gao","orcid":"https://orcid.org/0000-0001-7108-3825","observed_orcids":["https://orcid.org/0000-0001-7108-3825","https://orcid.org/0000-0002-4861-8825"]},"institutions":[{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youguang Gao","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China","institution_ids":["https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014724989","display_name":"Zhi\u2010Wang Li","orcid":"https://orcid.org/0000-0003-1623-8059","observed_orcids":["https://orcid.org/0000-0003-1623-8059"]},"institutions":[{"id":"https://openalex.org/I4210150657","display_name":"Chenzhou First People's Hospital","ror":"https://ror.org/04y2bwa40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150657"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiwang Li","raw_affiliation_strings":["Department of Anesthesiology, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China","institution_ids":["https://openalex.org/I4210150657","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570895","display_name":"Zhiming Zhang","orcid":"https://orcid.org/0000-0002-7020-0839","observed_orcids":["https://orcid.org/0000-0002-7020-0839"]},"institutions":[{"id":"https://openalex.org/I4210150657","display_name":"Chenzhou First People's Hospital","ror":"https://ror.org/04y2bwa40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150657"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Zhang","raw_affiliation_strings":["Department of Anesthesiology, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China"],"raw_orcid":"https://orcid.org/0000-0002-7020-0839","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China","institution_ids":["https://openalex.org/I4210150657","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102360892","display_name":"Xianzhong Lin","orcid":"https://orcid.org/0000-0003-1838-8018","observed_orcids":["https://orcid.org/0000-0003-1838-8018"]},"institutions":[{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianzhong Lin","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005 China","institution_ids":["https://openalex.org/I4210121761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050358141","display_name":"Jinpeng Gao","orcid":"https://orcid.org/0000-0002-6201-7268","observed_orcids":["https://orcid.org/0000-0002-6201-7268"]},"institutions":[{"id":"https://openalex.org/I4210150657","display_name":"Chenzhou First People's Hospital","ror":"https://ror.org/04y2bwa40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150657"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinpeng Gao","raw_affiliation_strings":["Department of Neurosurgery, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China"],"raw_orcid":"https://orcid.org/0000-0002-6201-7268","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First People's Hospital of Chenzhou/Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, 423000 China","institution_ids":["https://openalex.org/I4210150657","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050358141"],"corresponding_institution_ids":["https://openalex.org/I4210150657","https://openalex.org/I58200834"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.6348,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80154269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"34","issue":"6","first_page":"640","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":1.0},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.5960000157356262},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mitochondrial-dependent-apoptosis","display_name":"mitochondrial-dependent apoptosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cerebral-injury","display_name":"cerebral injury","score":0.6190000176429749},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.675000011920929},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.765999972820282},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.8009999990463257},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9376529455184937},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7986423373222351},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.6896381974220276},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6549971103668213},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6124871373176575},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5950148701667786},{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.5074047446250916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49471041560173035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46075019240379333},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4348594546318054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38550570607185364},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3640550374984741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3572302460670471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20709362626075745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11612218618392944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/fcp.12557","doi":"https://doi.org/10.1111/fcp.12557","is_oa":false,"landing_page_url":"https://doi.org/10.1111/fcp.12557","pdf_url":null,"source":{"id":"https://openalex.org/S35226884","display_name":"Fundamental and Clinical Pharmacology","issn_l":"0767-3981","issn":["0767-3981","1472-8206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:32215966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32215966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental & clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"},{"id":"https://openalex.org/F4320328318","display_name":"Fujian Provincial Health Commission","ror":"https://ror.org/0136mc929"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1606789163","https://openalex.org/W1964591640","https://openalex.org/W1978886339","https://openalex.org/W1986478574","https://openalex.org/W2025372996","https://openalex.org/W2032578573","https://openalex.org/W2042804612","https://openalex.org/W2144770302","https://openalex.org/W2229165600","https://openalex.org/W2283995152","https://openalex.org/W2398707808","https://openalex.org/W2464905193","https://openalex.org/W2552770931","https://openalex.org/W2554501591","https://openalex.org/W2562322488","https://openalex.org/W2578205996","https://openalex.org/W2610239927","https://openalex.org/W2619979905","https://openalex.org/W2740179055","https://openalex.org/W2749964253","https://openalex.org/W2752484758","https://openalex.org/W2752617071","https://openalex.org/W2758162576","https://openalex.org/W2758318500","https://openalex.org/W2762532466","https://openalex.org/W2767501955","https://openalex.org/W2773805181","https://openalex.org/W2774198194","https://openalex.org/W2775686590","https://openalex.org/W2780310467","https://openalex.org/W2784532114","https://openalex.org/W2791550326","https://openalex.org/W2792776858","https://openalex.org/W2802891428","https://openalex.org/W2806498105","https://openalex.org/W2886504687","https://openalex.org/W2886683772","https://openalex.org/W2888814179","https://openalex.org/W2901333595","https://openalex.org/W2905038803","https://openalex.org/W2915796707","https://openalex.org/W2932638633","https://openalex.org/W2959240401"],"related_works":["https://openalex.org/W2889368871","https://openalex.org/W2505024819","https://openalex.org/W1591598900","https://openalex.org/W2981192711","https://openalex.org/W3134399426","https://openalex.org/W3150599016","https://openalex.org/W4206173043","https://openalex.org/W4231020677","https://openalex.org/W2529624922","https://openalex.org/W2340891898"],"abstract_inverted_index":{"Recently,":[0],"several":[1],"studies":[2],"have":[3],"reported":[4],"that":[5,24,133,151,165,179],"the":[6,17,33,52,57,92,118,134,157,193],"pharmacological":[7],"effects":[8,59,123,136],"exerted":[9],"by":[10,96,100,126,187,191],"cannabidiol":[11],"(CBD)":[12],"are":[13],"partially":[14],"related":[15],"to":[16,197],"regulation":[18,159],"of":[19,36,60,70,87,105,115,137,160],"autophagy.":[20,88,141,161,199],"Increasing":[21],"evidence":[22],"indicates":[23],"autophagy":[25,130],"provides":[26],"protection":[27],"against":[28,38,62,183],"ischemia-induced":[29],"brain":[30,45],"injury.":[31],"However,":[32],"protective":[34,58,122,135],"effect":[35],"CBD":[37,61,74,89,138,166,180],"mitochondrial-dependent":[39,64,189],"apoptosis":[40,65,94,190],"in":[41,66,117,156],"hemorrhagic":[42],"shock":[43],"(HS)-induced":[44],"injury":[46,185],"has":[47],"not":[48],"been":[49],"studied.":[50],"In":[51,72],"present":[53],"study,":[54],"we":[55,163],"observed":[56],"neural":[63,93],"a":[67,128,143],"rat":[68],"model":[69],"HS.":[71],"addition,":[73],"increased":[75],"Beclin-1":[76],"and":[77,80,109,113],"LC3II":[78],"expression":[79],"reduced":[81],"P62":[82],"expression,":[83],"which":[84],"were":[85,124],"indicative":[86],"treatment":[90,139,167,181],"attenuated":[91],"induced":[95,186],"HS,":[97],"as":[98],"reflected":[99],"restoring":[101],"mitochondrial":[102],"dysfunction,":[103],"downregulation":[104],"BAX,":[106],"neuro-apoptosis":[107],"ratio":[108],"NF-\u03baB":[110],"signaling":[111,153,170,195],"activation,":[112],"upregulation":[114],"BCL2":[116],"cerebral":[119,184],"cortex.":[120],"Such":[121],"reversed":[125],"3-Methyladenine,":[127],"specific":[129],"inhibitor,":[131,145],"indicating":[132],"involved":[140,155],"LY294002,":[142],"PI3K":[144],"significantly":[146],"inhibited":[147],"CBD-induced":[148],"autophagy,":[149],"demonstrating":[150],"PI3K/AKT":[152,169,194],"is":[154],"CBD's":[158],"Furthermore,":[162],"found":[164],"upregulated":[168],"via":[171],"cannabinoid":[172],"receptor":[173],"1.":[174],"Therefore,":[175],"these":[176],"findings":[177],"suggested":[178],"protects":[182],"HS-mediated":[188],"activating":[192],"pathway":[196],"reinforce":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-03T00:00:00"}