{"id":"https://openalex.org/W3013374462","doi":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","title":"Desain Turunan Senyawa Leonurine Sebagai Kandidat Obat Anti Inflamasi","display_name":"Desain Turunan Senyawa Leonurine Sebagai Kandidat Obat Anti Inflamasi","publication_year":2020,"publication_date":"2020-03-26","ids":{"openalex":"https://openalex.org/W3013374462","doi":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","mag":"3013374462"},"language":"en","primary_location":{"id":"doi:10.22487/j24428744.2020.v6.i1.15025","doi":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15025/11284","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15025/11284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068173629","display_name":"Ruslin Beny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35304288","display_name":"Universitas Halu Oleo","ror":"https://ror.org/02j4mf075","country_code":"ID","type":"education","lineage":["https://openalex.org/I35304288"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ruslin Beny","raw_affiliation_strings":["Ruslin Faculty of Pharmacy Halu Oleo University Kendari 93231 Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruslin Faculty of Pharmacy Halu Oleo University Kendari 93231 Indonesia","institution_ids":["https://openalex.org/I35304288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031351560","display_name":"Nindy Rachma Az Yana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35304288","display_name":"Universitas Halu Oleo","ror":"https://ror.org/02j4mf075","country_code":"ID","type":"education","lineage":["https://openalex.org/I35304288"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nindy Rachma Az Yana","raw_affiliation_strings":["Universitas Halu Oleo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Halu Oleo","institution_ids":["https://openalex.org/I35304288"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089031052","display_name":"Mesi Leorita","orcid":"https://orcid.org/0009-0006-2894-7054","observed_orcids":["https://orcid.org/0009-0006-2894-7054"]},"institutions":[{"id":"https://openalex.org/I35304288","display_name":"Universitas Halu Oleo","ror":"https://ror.org/02j4mf075","country_code":"ID","type":"education","lineage":["https://openalex.org/I35304288"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mesi Leorita","raw_affiliation_strings":["Universitas Halu Oleo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Halu Oleo","institution_ids":["https://openalex.org/I35304288"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I35304288"],"apc_list":{"value":500000,"currency":"IDR","value_usd":32},"apc_paid":{"value":500000,"currency":"IDR","value_usd":32},"fwci":0.3135,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.50742746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"181","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leonurine","display_name":"leonurine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.753000020980835},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.8130000233650208},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ligand-receptor-binding","display_name":"ligand-receptor binding","score":0.7279999852180481},{"id":"https://openalex.org/keywords/binding-energy","display_name":"binding energy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.8470754027366638},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.738515317440033},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.723427414894104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.609568178653717},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5230318307876587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45272165536880493},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3423980176448822},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32907557487487793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2898070514202118},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2851969599723816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26376956701278687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20347371697425842},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.1339327096939087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22487/j24428744.2020.v6.i1.15025","doi":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15025/11284","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:447d5abeb59f47feac97e348e9944301","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/447d5abeb59f47feac97e348e9944301","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), Vol 6, Iss 1, Pp 181-191 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22487/j24428744.2020.v6.i1.15025","doi":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2020.v6.i1.15025","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15025/11284","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013374462.pdf","grobid_xml":"https://content.openalex.org/works/W3013374462.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1483846144","https://openalex.org/W1996084143","https://openalex.org/W2077089041","https://openalex.org/W2563529332","https://openalex.org/W2605341116","https://openalex.org/W2786777785","https://openalex.org/W2948420913","https://openalex.org/W6781820834","https://openalex.org/W7039602964"],"related_works":["https://openalex.org/W2138341634","https://openalex.org/W4407925069","https://openalex.org/W4403606980","https://openalex.org/W3042391810","https://openalex.org/W2343478640","https://openalex.org/W2793121833","https://openalex.org/W4401523908","https://openalex.org/W4396863279","https://openalex.org/W7208799292","https://openalex.org/W7164361162"],"abstract_inverted_index":{"In":[0],"this":[1,39,121],"research,":[2,122],"there":[3],"was":[4,41],"docking":[5,64,87,100,140],"process":[6],"of":[7,38,46,75,99,120],"leonurine":[8,47,104,128],"compounds":[9,48,56,129],"and":[10,49,105,130],"their":[11,50,131],"derivatives":[12,51,107,132],"to":[13,42,110],"Cyclooxygenase-2":[14],"(COX-2)":[15],"enzyme":[16],"as":[17],"an":[18],"anti-inflammatory.":[19],"The":[20,36,63,139],"receptor":[21],"code":[22],"used":[23],"is":[24,27,66,158],"6COX":[25],"which":[26,157],"downloaded":[28],"from":[29],"the":[30,44,70,73,76,86,118,143,153],"protein":[31],"data":[32],"bank":[33],"site":[34],"(PDB).":[35],"aims":[37],"study":[40],"investigate":[43],"interaction":[45,113],"against":[52,136],"COX-2":[53,115,137],"receptors.":[54,116,138],"All":[55],"are":[57,108],"docked":[58],"using":[59],"AutoDock":[60],"4.2":[61],"software.":[62],"validation":[65,88],"performed":[67],"by":[68],"tethering":[69],"ligand-receptor":[71,148],"with":[72,114],"parameter":[74],"Root":[77],"Mean":[78],"Square":[79],"Deviation":[80],"(RMSD)":[81],"value":[82,94,147],"<2":[83],"\u00c5.":[84,97],"From":[85,117],"results,":[89],"have":[90,111,133],"been":[91],"obtained":[92],"RMSD":[93],"=":[95],"0.31":[96],"Analysis":[98],"results":[101,119,141],"indicates":[102],"that":[103,127],"its":[106],"predicted":[109],"good":[112],"it":[123],"can":[124],"be":[125],"concluded":[126],"inhibitory":[134],"activity":[135],"showed":[142],"lowest":[144],"binding":[145],"energy":[146],"(\u0394G)":[149],"best":[150],"matched":[151],"in":[152],"11th":[154],"derived":[155],"compound":[156],"-7.95":[159],"kcal/mol.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-04-03T00:00:00"}
