{"id":"https://openalex.org/W3013254652","doi":"https://doi.org/10.1039/c9ay02778e","title":"Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements","display_name":"Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3013254652","doi":"https://doi.org/10.1039/c9ay02778e","mag":"3013254652"},"language":"en","primary_location":{"id":"doi:10.1039/c9ay02778e","doi":"https://doi.org/10.1039/c9ay02778e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9ay02778e","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069786537","display_name":"Kornelija Lasi\u0107","orcid":"https://orcid.org/0000-0002-7199-3973","observed_orcids":["https://orcid.org/0000-0002-7199-3973"]},"institutions":[{"id":"https://openalex.org/I2802433978","display_name":"Pliva (Croatia)","ror":"https://ror.org/02cthxa95","country_code":"HR","type":"company","lineage":["https://openalex.org/I2802433978"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Kornelija Lasi\u0107","raw_affiliation_strings":["10000 Zagreb","Croatia","PLIVA Croatia Ltd","R&D","TEVA Group Member"],"raw_orcid":"https://orcid.org/0000-0002-7199-3973","affiliations":[{"raw_affiliation_string":"10000 Zagreb","institution_ids":[]},{"raw_affiliation_string":"Croatia","institution_ids":[]},{"raw_affiliation_string":"PLIVA Croatia Ltd","institution_ids":["https://openalex.org/I2802433978"]},{"raw_affiliation_string":"R&D","institution_ids":[]},{"raw_affiliation_string":"TEVA Group Member","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002025835","display_name":"Ana Mornar","orcid":"https://orcid.org/0000-0002-3944-697X","observed_orcids":["https://orcid.org/0000-0002-3944-697X"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ana Mornar","raw_affiliation_strings":["10000 Zagreb","Croatia","Department of Pharmaceutical Analysis","Faculty of Pharmacy and Biochemistry","University of Zagreb"],"raw_orcid":"https://orcid.org/0000-0002-3944-697X","affiliations":[{"raw_affiliation_string":"10000 Zagreb","institution_ids":[]},{"raw_affiliation_string":"Croatia","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis","institution_ids":[]},{"raw_affiliation_string":"Faculty of Pharmacy and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of Zagreb","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018321615","display_name":"Biljana Nigovi\u0107","orcid":"https://orcid.org/0000-0001-8249-5921","observed_orcids":["https://orcid.org/0000-0001-8249-5921"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Biljana Nigovi\u0107","raw_affiliation_strings":["10000 Zagreb","Croatia","Department of Pharmaceutical Analysis","Faculty of Pharmacy and Biochemistry","University of Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10000 Zagreb","institution_ids":[]},{"raw_affiliation_string":"Croatia","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis","institution_ids":[]},{"raw_affiliation_string":"Faculty of Pharmacy and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"University of Zagreb","institution_ids":["https://openalex.org/I181343428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018321615"],"corresponding_institution_ids":["https://openalex.org/I181343428"],"apc_list":null,"apc_paid":null,"fwci":0.1953,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34600912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":"16","first_page":"2082","last_page":"2092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.9319999814033508},{"id":"https://openalex.org/keywords/uhplc-method-development","display_name":"UHPLC method development","score":0.9160000085830688},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.9710000157356262},{"id":"https://openalex.org/keywords/isoflavone-aglycones","display_name":"isoflavone aglycones","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.7919999957084656},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/daidzein","display_name":"daidzein","score":0.996999979019165},{"id":"https://openalex.org/keywords/biochanin-a","display_name":"biochanin A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/formononetin","display_name":"formononetin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genistin","display_name":"genistin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/daidzin","display_name":"daidzin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ononin","display_name":"ononin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C2777452348","wikidata":"https://www.wikidata.org/wiki/Q3814656","display_name":"Daidzin","level":4,"score":0.941281795501709},{"id":"https://openalex.org/C2779396346","wikidata":"https://www.wikidata.org/wiki/Q394316","display_name":"Aglycone","level":3,"score":0.910274088382721},{"id":"https://openalex.org/C2777504804","wikidata":"https://www.wikidata.org/wiki/Q5533221","display_name":"Genistin","level":4,"score":0.9100650548934937},{"id":"https://openalex.org/C2776578907","wikidata":"https://www.wikidata.org/wiki/Q408859","display_name":"Formononetin","level":4,"score":0.8615697622299194},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.8417407274246216},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.7390692234039307},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.7308565974235535},{"id":"https://openalex.org/C2778821405","wikidata":"https://www.wikidata.org/wiki/Q864222","display_name":"Biochanin A","level":4,"score":0.7074443697929382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6394634246826172},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.5912849307060242},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.49799394607543945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15457066893577576},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15185406804084778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0654284656047821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/c9ay02778e","doi":"https://doi.org/10.1039/c9ay02778e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9ay02778e","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1505346453","https://openalex.org/W1770284292","https://openalex.org/W1967150479","https://openalex.org/W1968599011","https://openalex.org/W1977235571","https://openalex.org/W1993959888","https://openalex.org/W1997066929","https://openalex.org/W1999950893","https://openalex.org/W2002206418","https://openalex.org/W2013506154","https://openalex.org/W2013877930","https://openalex.org/W2020606060","https://openalex.org/W2024828220","https://openalex.org/W2026298927","https://openalex.org/W2042260312","https://openalex.org/W2046478868","https://openalex.org/W2060884519","https://openalex.org/W2065896910","https://openalex.org/W2068527879","https://openalex.org/W2084989480","https://openalex.org/W2085181981","https://openalex.org/W2088946926","https://openalex.org/W2104038999","https://openalex.org/W2125938962","https://openalex.org/W2160224176","https://openalex.org/W2742968451","https://openalex.org/W2887976219","https://openalex.org/W2940352465","https://openalex.org/W3135571977","https://openalex.org/W4239378174"],"related_works":["https://openalex.org/W7100765118","https://openalex.org/W2373370332","https://openalex.org/W363330407","https://openalex.org/W2182835231","https://openalex.org/W2018706878","https://openalex.org/W3134926164","https://openalex.org/W3024913451","https://openalex.org/W7099880788","https://openalex.org/W3107981690","https://openalex.org/W2013506154"],"abstract_inverted_index":{"Systematic":[0],"development":[1],"of":[2,14,29],"a":[3],"UHPLC":[4],"method":[5],"by":[6],"QbD":[7],"approach":[8],"as":[9],"performed":[10],"for":[11],"simultaneous":[12],"determination":[13],"aglycone":[15],"(genistein,":[16],"daidzein,":[17],"biochanin":[18],"A":[19],"and":[20,22],"formononetin)":[21],"glycoside":[23],"(genistin,":[24],"daidzin,":[25],"sissotrin,":[26],"ononin)":[27],"forms":[28],"isoflavones.":[30]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-04-03T00:00:00"}
