{"id":"https://openalex.org/W3013145557","doi":"https://doi.org/10.2131/fts.7.97","title":"5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes","display_name":"5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3013145557","doi":"https://doi.org/10.2131/fts.7.97","mag":"3013145557"},"language":"en","primary_location":{"id":"doi:10.2131/fts.7.97","doi":"https://doi.org/10.2131/fts.7.97","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.7.97","pdf_url":"https://www.jstage.jst.go.jp/article/fts/7/2/7_97/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/fts/7/2/7_97/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058556297","display_name":"Takayuki Kumamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30181195","display_name":"Ohu University","ror":"https://ror.org/01fe6f215","country_code":"JP","type":"education","lineage":["https://openalex.org/I30181195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Kumamoto","raw_affiliation_strings":["School of Pharmaceutical Sciences, Ohu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Ohu University","institution_ids":["https://openalex.org/I30181195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071488712","display_name":"Mika Senuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122431","display_name":"Food and Drug Safety Center","ror":"https://ror.org/02rmwfb84","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210122431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mika Senuma","raw_affiliation_strings":["Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center","institution_ids":["https://openalex.org/I4210122431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044072714","display_name":"Mai Todoroki","orcid":"https://orcid.org/0009-0003-9584-5275","observed_orcids":["https://orcid.org/0009-0003-9584-5275"]},"institutions":[{"id":"https://openalex.org/I4210122431","display_name":"Food and Drug Safety Center","ror":"https://ror.org/02rmwfb84","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210122431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Todoroki","raw_affiliation_strings":["Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center","institution_ids":["https://openalex.org/I4210122431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011026779","display_name":"Fumiaki Kumagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122431","display_name":"Food and Drug Safety Center","ror":"https://ror.org/02rmwfb84","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210122431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Kumagai","raw_affiliation_strings":["Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center","institution_ids":["https://openalex.org/I4210122431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084036579","display_name":"Hajime Imai","orcid":"https://orcid.org/0009-0002-6714-2778","observed_orcids":["https://orcid.org/0009-0002-6714-2778"]},"institutions":[{"id":"https://openalex.org/I30181195","display_name":"Ohu University","ror":"https://ror.org/01fe6f215","country_code":"JP","type":"education","lineage":["https://openalex.org/I30181195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Imai","raw_affiliation_strings":["School of Dentistry, Ohu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, Ohu University","institution_ids":["https://openalex.org/I30181195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101691688","display_name":"Reiko Suzuki","orcid":"https://orcid.org/0000-0001-8670-3679","observed_orcids":["https://orcid.org/0000-0001-8670-3679"]},"institutions":[{"id":"https://openalex.org/I30181195","display_name":"Ohu University","ror":"https://ror.org/01fe6f215","country_code":"JP","type":"education","lineage":["https://openalex.org/I30181195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Suzuki","raw_affiliation_strings":["School of Dentistry, Ohu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, Ohu University","institution_ids":["https://openalex.org/I30181195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042709412","display_name":"Tetsuo Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Ogawa","raw_affiliation_strings":["Faculty of Medicine, Saitama Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Saitama Medical University","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068519388","display_name":"Makiko Kuwagata","orcid":"https://orcid.org/0000-0003-2801-444X","observed_orcids":["https://orcid.org/0000-0003-2801-444X"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Kuwagata","raw_affiliation_strings":["Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science","institution_ids":["https://openalex.org/I4210151964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3933,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59159566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"2","first_page":"97","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorocytosine","display_name":"5-fluorocytosine","score":1.0},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fetal-skeletal-malformations","display_name":"fetal skeletal malformations","score":0.8930000066757202},{"id":"https://openalex.org/keywords/supernumerary-ribs","display_name":"supernumerary ribs","score":0.8119999766349792},{"id":"https://openalex.org/keywords/homeobox-genes","display_name":"homeobox genes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hox-genes","display_name":"Hox genes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hoxa10","display_name":"HOXA10","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hoxa11","display_name":"HOXA11","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hoxd13","display_name":"HOXD13","score":1.0},{"id":"https://openalex.org/keywords/anteroposterior-axis","display_name":"anterior-posterior axis","score":0.878000020980835},{"id":"https://openalex.org/keywords/limb-development","display_name":"limb development","score":0.7829999923706055},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.9201473593711853},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.556921124458313},{"id":"https://openalex.org/C103652617","wikidata":"https://www.wikidata.org/wiki/Q18027119","display_name":"Homeobox A1","level":5,"score":0.5216708183288574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48852360248565674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4566759765148163},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4117738902568817},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4091765284538269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35032132267951965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26987752318382263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25508391857147217},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23449531197547913}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2131/fts.7.97","doi":"https://doi.org/10.2131/fts.7.97","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.7.97","pdf_url":"https://www.jstage.jst.go.jp/article/fts/7/2/7_97/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2131/fts.7.97","doi":"https://doi.org/10.2131/fts.7.97","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.7.97","pdf_url":"https://www.jstage.jst.go.jp/article/fts/7/2/7_97/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8096907723","display_name":"The origin of supernumerary ribs focused on rat strains","funder_award_id":"19K17339","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320321474","display_name":"Cabinet Office, Government of Japan","ror":"https://ror.org/007f5s288"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013145557.pdf","grobid_xml":"https://content.openalex.org/works/W3013145557.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1494381630","https://openalex.org/W1510764314","https://openalex.org/W1574722884","https://openalex.org/W1969025265","https://openalex.org/W1977021269","https://openalex.org/W1996561275","https://openalex.org/W2000173207","https://openalex.org/W2008069292","https://openalex.org/W2009266347","https://openalex.org/W2010836638","https://openalex.org/W2045937790","https://openalex.org/W2048822092","https://openalex.org/W2054141235","https://openalex.org/W2064954292","https://openalex.org/W2072785474","https://openalex.org/W2075639475","https://openalex.org/W2103945066","https://openalex.org/W2108675611","https://openalex.org/W2124800909","https://openalex.org/W2136159267","https://openalex.org/W2168062252","https://openalex.org/W2179286984","https://openalex.org/W2799771762","https://openalex.org/W2903502786","https://openalex.org/W2969814010"],"related_works":["https://openalex.org/W1880048097","https://openalex.org/W2115738159","https://openalex.org/W2027932745","https://openalex.org/W2094435140","https://openalex.org/W2002807285","https://openalex.org/W2068051474","https://openalex.org/W2086507965","https://openalex.org/W2045330378","https://openalex.org/W1969923829","https://openalex.org/W2001128146"],"abstract_inverted_index":{"5-Fluorocytosine":[0],"(5-FC)":[1],"is":[2],"an":[3],"antimycotic":[4],"and":[5,20,32,60,62,67,93,116,130],"teratogenic":[6],"compound.":[7],"Oral":[8],"administration":[9,77,106],"of":[10,43,70,82,84,90,101,113,144],"5-FC":[11,44,52,76,149],"to":[12,24,128,134,148],"pregnant":[13],"rats":[14],"on":[15,45,58,78,107],"gestation":[16],"days":[17],"(GD)":[18],"9":[19],"13":[21],"was":[22,55],"shown":[23],"induce":[25],"thoracolumbar":[26],"supernumerary":[27],"ribs":[28],"(TSR,":[29],"14th":[30],"rib)":[31],"abnormal":[33],"digits,":[34],"respectively,":[35],"in":[36,111],"fetuses.":[37],"This":[38],"study":[39],"investigated":[40],"the":[41,50,80,88,91,118,126,132],"effects":[42],"homeobox":[46],"genes,":[47],"which":[48,86],"control":[49],"anterior-posterior-axis.":[51],"(75":[53],"mg/kg)":[54],"administered":[56],"orally":[57],"GD9":[59],"GD13,":[61],"tissues":[63],"collected":[64],"from":[65,125,131],"cranial":[66],"caudal":[68],"regions":[69],"TSR":[71],"sites":[72],"were":[73,96],"analyzed.":[74],"Following":[75],"GD9,":[79],"levels":[81],"expression":[83,112,143],"Hoxa10,":[85],"determine":[87],"position":[89],"thoracic":[92],"lumbar":[94],"vertebrae,":[95],"decreased":[97],"at":[98],"GD13.":[99],"Analysis":[100],"hindlimbs":[102],"6":[103],"hours":[104],"after":[105],"GD13":[108],"showed":[109,140],"decreases":[110],"Hoxa11,":[114],"Hoxd12,":[115],"Hoxd13,":[117],"Hox":[119,145],"genes":[120,146],"responsible":[121],"for":[122],"limb":[123],"formation":[124],"proximal":[127],"distal,":[129],"anterior":[133],"posterior":[135],"directions.":[136],"The":[137],"present":[138],"findings":[139],"that":[141],"altered":[142],"contributes":[147],"teratogenicity.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-04-03T00:00:00"}