{"id":"https://openalex.org/W3013138938","doi":"https://doi.org/10.20944/preprints202003.0415.v1","title":"How to Further Reduce the Risk of Serious COVID-19 Infections: Exploiting the Fragile Viral Envelope and the Self-Cleaning Mechanisms of Our Respiratory System","display_name":"How to Further Reduce the Risk of Serious COVID-19 Infections: Exploiting the Fragile Viral Envelope and the Self-Cleaning Mechanisms of Our Respiratory System","publication_year":2020,"publication_date":"2020-03-29","ids":{"openalex":"https://openalex.org/W3013138938","doi":"https://doi.org/10.20944/preprints202003.0415.v1","mag":"3013138938"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202003.0415.v1","doi":"https://doi.org/10.20944/preprints202003.0415.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202003.0415.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202003.0415.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040449994","display_name":"Viola Vogel B","orcid":"https://orcid.org/0000-0003-2898-7671","observed_orcids":["https://orcid.org/0000-0003-2898-7671"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405256713","display_name":"Institute of Translational Medicine","ror":"https://ror.org/04f7jrb21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405256713"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Viola Vogel","raw_affiliation_strings":["Laboratory of Applied Mechanobiology, Institute of Translational Medicine, Department for Health Sciences and Technology (D-HEST), ETH Zurich, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Mechanobiology, Institute of Translational Medicine, Department for Health Sciences and Technology (D-HEST), ETH Zurich, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405256713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040449994"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405256713"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10990","display_name":"Infection Control and Ventilation","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-envelope","display_name":"viral envelope","score":0.7960000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5370000004768372},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.42500001192092896},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6759706139564514},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5356115698814392},{"id":"https://openalex.org/C2778363899","wikidata":"https://www.wikidata.org/wiki/Q23900955","display_name":"Window of opportunity","level":2,"score":0.5279991626739502},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.5248615741729736},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5175661444664001},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5159397721290588},{"id":"https://openalex.org/C172656115","wikidata":"https://www.wikidata.org/wiki/Q2142613","display_name":"Social distance","level":5,"score":0.4888395667076111},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.48596370220184326},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4406871497631073},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.38837921619415283},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.387039452791214},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.37951627373695374},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3685029149055481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3581767678260803},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3489276170730591},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33412718772888184},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2527601420879364},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23601067066192627},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.20323166251182556},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202003.0415.v1","doi":"https://doi.org/10.20944/preprints202003.0415.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202003.0415.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202003.0415.v1","doi":"https://doi.org/10.20944/preprints202003.0415.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202003.0415.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1024036315","https://openalex.org/W1974694396","https://openalex.org/W1986524556","https://openalex.org/W1998154164","https://openalex.org/W1998560561","https://openalex.org/W2155118487","https://openalex.org/W2415596211","https://openalex.org/W2560886679","https://openalex.org/W2577718450","https://openalex.org/W2612506904","https://openalex.org/W2901214720","https://openalex.org/W3006703916","https://openalex.org/W3009932851","https://openalex.org/W4246977553"],"related_works":["https://openalex.org/W3107819105","https://openalex.org/W7162753119","https://openalex.org/W4391182351","https://openalex.org/W4377294093","https://openalex.org/W3126427392","https://openalex.org/W3080662884","https://openalex.org/W3049726565","https://openalex.org/W3111501632","https://openalex.org/W4225304244","https://openalex.org/W4286888695"],"abstract_inverted_index":{"Social":[0],"distancing,":[1],"washing":[2],"hands":[3],"and":[4,9,70,98,129,143,173],"good":[5],"hygiene":[6],"are":[7,52],"essential":[8],"currently":[10],"the":[11,19,24,30,41,66,71,74,78,126,136,140,144,148,166],"most":[12],"potent":[13],"methods":[14],"available":[15],"to":[16,38,62,89,101,113,130,152,159],"curb":[17],"down":[18],"unprecedented":[20],"speed":[21],"by":[22,48],"which":[23,35,123],"new":[25],"coronavirus":[26,141],"is":[27,36,112,158],"spreading":[28],"across":[29],"globe.":[31],"Even":[32],"under":[33],"lockdown,":[34],"necessary":[37],"significantly":[39],"reduce":[40,65],"number":[42],"of":[43,58,68,73,80,109,117,139,147],"people":[44],"that":[45,56,83,96],"get":[46],"infected":[47],"an":[49,175],"ill":[50],"person,":[51],"there":[53],"additional":[54,92],"measures":[55,164],"each":[57],"us":[59],"can":[60,134],"embrace":[61],"even":[63],"further":[64],"risk":[67],"infection":[69],"severity":[72],"COVID-19":[75],"disease?":[76],"Given":[77],"lack":[79],"licensed":[81],"drugs":[82],"target":[84],"SARS-CoV-2":[85],"specifically,":[86],"we":[87,133],"have":[88],"look":[90],"into":[91],"non-specific":[93,119],"defense":[94,120],"mechanisms":[95,121],"animals":[97],"humans":[99],"evolved":[100],"protect":[102],"themselves":[103],"from":[104],"pathogen":[105],"invasions.":[106],"The":[107,156],"goal":[108],"this":[110],"article":[111],"describe":[114],"how":[115],"various":[116],"our":[118,154],"work,":[122],"actually":[124],"precede":[125],"inflammatory":[127,176],"response,":[128],"discuss":[131],"whether":[132],"exploit":[135],"unique":[137],"features":[138],"envelope":[142],"self-cleaning":[145],"machinery":[146],"human":[149],"respiratory":[150],"tract":[151],"strengthen":[153],"self-defense.":[155],"challenge":[157],"actively":[160],"interfere":[161],"with":[162],"supportive":[163],"during":[165],"short":[167],"time":[168],"window":[169],"between":[170],"getting":[171],"exposed":[172],"before":[174],"response":[177],"gets":[178],"initiated.":[179]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2020-04-03T00:00:00"}