{"id":"https://openalex.org/W3013129707","doi":null,"title":"Optogenetic Manipulation of Posterior Caudatoputamen Indirect Pathway Neurons Causes Auditory Cortical Activation in Rats","display_name":"Optogenetic Manipulation of Posterior Caudatoputamen Indirect Pathway Neurons Causes Auditory Cortical Activation in Rats","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3013129707","mag":"3013129707"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/636933","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/636933","pdf_url":"http://hdl.handle.net/10150/636933","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10150/636933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031582380","display_name":"Zachary George Yellowman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zachary George Yellowman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031582380"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13397","display_name":"Hallucinations in medical conditions","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13397","display_name":"Hallucinations in medical conditions","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.15770000219345093,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auditory-hallucinations","display_name":"auditory hallucinations","score":0.9929999709129333},{"id":"https://openalex.org/keywords/auditory-cortex-activation","display_name":"auditory cortex activation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/indirect-pathway","display_name":"indirect pathway","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.7369999885559082},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.6830000281333923},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7559999823570251},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chr2","display_name":"channelrhodopsin-2","score":0.8270000219345093},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anterograde-and-retrograde-tracing","display_name":"anterograde and retrograde tracing","score":0.6980000138282776},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.9489980340003967},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7676321864128113},{"id":"https://openalex.org/C162536842","wikidata":"https://www.wikidata.org/wiki/Q6025117","display_name":"Indirect pathway of movement","level":4,"score":0.47777259349823},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35264667868614197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3215232491493225},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22268792986869812},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.1522882878780365}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/636933","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/636933","pdf_url":"http://hdl.handle.net/10150/636933","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},{"id":"mag:3013129707","doi":null,"is_oa":false,"landing_page_url":"https://repository.arizona.edu/bitstream/10150/636933/1/azu_etd_17748_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.arizona.edu:10150/636933","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/636933","pdf_url":"http://hdl.handle.net/10150/636933","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013129707.pdf","grobid_xml":"https://content.openalex.org/works/W3013129707.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1570757432","https://openalex.org/W1847846307","https://openalex.org/W1980637152","https://openalex.org/W1987953899","https://openalex.org/W1995045083","https://openalex.org/W2000073412","https://openalex.org/W2000694574","https://openalex.org/W2009134620","https://openalex.org/W2022503841","https://openalex.org/W2034064942","https://openalex.org/W2052785307","https://openalex.org/W2078655059","https://openalex.org/W2082343911","https://openalex.org/W2085031619","https://openalex.org/W2087200563","https://openalex.org/W2099002565","https://openalex.org/W2104996004","https://openalex.org/W2107394985","https://openalex.org/W2109814284","https://openalex.org/W2116386279","https://openalex.org/W2118830830","https://openalex.org/W2145602532","https://openalex.org/W2147390052","https://openalex.org/W2158137297","https://openalex.org/W2162881100","https://openalex.org/W2163815564","https://openalex.org/W2464787744","https://openalex.org/W2513722234","https://openalex.org/W2548871860","https://openalex.org/W2554656236","https://openalex.org/W2558788280","https://openalex.org/W2571197310","https://openalex.org/W2577807948","https://openalex.org/W2738227413","https://openalex.org/W2786199213","https://openalex.org/W2951234647"],"related_works":["https://openalex.org/W7027653290","https://openalex.org/W6981379995","https://openalex.org/W4403844630","https://openalex.org/W3096333932","https://openalex.org/W2057944324","https://openalex.org/W3165463416","https://openalex.org/W1175043046","https://openalex.org/W7161266628","https://openalex.org/W7139987384","https://openalex.org/W3142502035"],"abstract_inverted_index":{"Auditory":[0],"hallucinations":[1,23,209],"are":[2,9],"prevalent":[3],"in":[4,49,96,135,159,187,210],"many":[5],"neuropsychiatric":[6,211],"disorders":[7],"and":[8,38,44],"also":[10],"a":[11,139,198],"cardinal":[12],"symptom":[13],"of":[14,21,29,67,90,104,123,149,162,171,180,193,207],"schizophrenia.":[15],"Most":[16],"research":[17,34],"on":[18,26,121],"the":[19,30,42,45,58,62,68,74,91,100,105,111,124,136,145,150,163,205],"mechanism":[20,203],"auditory":[22,31,70,92,164,188,208],"has":[24,35],"focused":[25],"functional":[27,39],"imaging":[28],"cortex.":[32,71],"Recent":[33],"revealed":[36],"structural":[37],"interaction":[40],"between":[41],"striatum":[43,93],"neocortex.":[46],"Previous":[47],"studies":[48,195],"our":[50],"laboratory":[51],"have":[52],"shown":[53],"that":[54],"dopamine":[55,119],"infusion":[56,112],"into":[57,87],"posterior":[59],"caudatoputamen":[60],"(CPu),":[61],"\u201cauditory":[63],"striatum,\u201d":[64],"produce":[65],"activation":[66,161,170],"rat":[69],"To":[72],"establish":[73],"next":[75],"projection":[76],"site":[77],"from":[78],"these":[79,172,194],"neurons,":[80],"we":[81,132],"virally":[82],"infused":[83],"an":[84],"anterograde":[85],"AAV-GFP":[86],"this":[88],"region":[89],"which":[94],"resulted":[95,158],"expression":[97],"mainly":[98],"at":[99],"same":[101,173],"rostral-caudal":[102],"level":[103],"lateral":[106],"globus":[107],"pallidus":[108],"(LGP)":[109],"as":[110],"site.":[113],"Since":[114],"antipsychotic":[115],"drugs":[116],"target":[117],"D2":[118],"receptors":[120],"neurons":[122,154,177],"indirect":[125,146,152,175],"pathway":[126,153,176],"(CPu-LGP)":[127],"to":[128,142],"alleviate":[129],"psychotic":[130],"symptoms,":[131],"transfected":[133],"terminals":[134],"LGP":[137],"with":[138,155,178],"retrograde":[140],"AAV-Jaws-GFP":[141],"neuroanatomically":[143],"discriminate":[144],"pathway.":[147],"Inactivation":[148],"striatal":[151,174],"Jaws":[156],"stimulation":[157,179],"significant":[160,185],"cortex":[165,189],"via":[166],"c-Fos":[167],"expression.":[168],"Conversely,":[169],"ChannelRhodopsin-2":[181],"(ChR2)":[182],"showed":[183],"no":[184],"change":[186],"activation.":[190],"The":[191],"results":[192],"will":[196],"elucidate":[197],"potential":[199],"alternative":[200],"neural":[201],"circuit":[202],"underlying":[204],"pathophysiology":[206],"disorders.":[212]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-04-03T00:00:00"}