{"id":"https://openalex.org/W3013081676","doi":null,"title":"Mechanisms of Endogenous Alpha-Glycosylceramide Generation for Development and Activation of NKT Cells","display_name":"Mechanisms of Endogenous Alpha-Glycosylceramide Generation for Development and Activation of NKT Cells","publication_year":2017,"publication_date":"2017-05-12","ids":{"openalex":"https://openalex.org/W3013081676","mag":"3013081676"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/40046428","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101721936","display_name":"Jessica Kim","orcid":"https://orcid.org/0000-0001-9795-2275","observed_orcids":["https://orcid.org/0000-0001-9795-2275"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9795-2275","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101721936"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.15080000460147858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inkt-cells","display_name":"invariant natural killer T cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alpha-galactosylceramide","display_name":"alpha-galactosylceramide","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ugcg","display_name":"UGCG","score":0.7850000262260437},{"id":"https://openalex.org/keywords/inkt-cell-development","display_name":"iNKT cell development","score":0.9120000004768372},{"id":"https://openalex.org/keywords/inkt-cell-activation","display_name":"iNKT cell activation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/galactose-metabolism","display_name":"galactose metabolism","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6766338348388672},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5947243571281433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36175838112831116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30071312189102173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2723272144794464},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.20393922924995422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13235008716583252},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0836920440196991},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/40046428","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:3013081676","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/40046428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/40046428","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:40046428","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013081676.pdf","grobid_xml":"https://content.openalex.org/works/W3013081676.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W23696427","https://openalex.org/W64458079","https://openalex.org/W151461208","https://openalex.org/W861789265","https://openalex.org/W1487732284","https://openalex.org/W1508427423","https://openalex.org/W1522913832","https://openalex.org/W1537951595","https://openalex.org/W1538716250","https://openalex.org/W1539628793","https://openalex.org/W1551389252","https://openalex.org/W1579320766","https://openalex.org/W1638302066","https://openalex.org/W1768853402","https://openalex.org/W1963713163","https://openalex.org/W1968518932","https://openalex.org/W1970777915","https://openalex.org/W1976710853","https://openalex.org/W1982720299","https://openalex.org/W1982727887","https://openalex.org/W1984510622","https://openalex.org/W1987471913","https://openalex.org/W1989478912","https://openalex.org/W1990286006","https://openalex.org/W1992523113","https://openalex.org/W1995529916","https://openalex.org/W1996424780","https://openalex.org/W2000041926","https://openalex.org/W2000653530","https://openalex.org/W2004736287","https://openalex.org/W2005283688","https://openalex.org/W2007348345","https://openalex.org/W2008920151","https://openalex.org/W2011932510","https://openalex.org/W2013255473","https://openalex.org/W2015194963","https://openalex.org/W2015557434","https://openalex.org/W2022273281","https://openalex.org/W2023554646","https://openalex.org/W2024192918","https://openalex.org/W2024436717","https://openalex.org/W2026802569","https://openalex.org/W2027679419","https://openalex.org/W2028123014","https://openalex.org/W2029542530","https://openalex.org/W2029933983","https://openalex.org/W2030126827","https://openalex.org/W2032406291","https://openalex.org/W2038057643","https://openalex.org/W2039096244","https://openalex.org/W2046746241","https://openalex.org/W2050917357","https://openalex.org/W2050925766","https://openalex.org/W2056861635","https://openalex.org/W2059254962","https://openalex.org/W2062058925","https://openalex.org/W2062211895","https://openalex.org/W2063540835","https://openalex.org/W2064096355","https://openalex.org/W2064107742","https://openalex.org/W2064794064","https://openalex.org/W2065202184","https://openalex.org/W2069556438","https://openalex.org/W2071530096","https://openalex.org/W2073232640","https://openalex.org/W2073343574","https://openalex.org/W2074612105","https://openalex.org/W2075364390","https://openalex.org/W2076024275","https://openalex.org/W2080898127","https://openalex.org/W2080934862","https://openalex.org/W2081254732","https://openalex.org/W2082862556","https://openalex.org/W2085116778","https://openalex.org/W2089940031","https://openalex.org/W2091013032","https://openalex.org/W2095035085","https://openalex.org/W2095967285","https://openalex.org/W2096142215","https://openalex.org/W2098344073","https://openalex.org/W2098405100","https://openalex.org/W2099465341","https://openalex.org/W2102355478","https://openalex.org/W2102785691","https://openalex.org/W2103768147","https://openalex.org/W2103794578","https://openalex.org/W2104585015","https://openalex.org/W2106322659","https://openalex.org/W2109381821","https://openalex.org/W2111699832","https://openalex.org/W2115462848","https://openalex.org/W2121095247","https://openalex.org/W2121477549","https://openalex.org/W2121784695","https://openalex.org/W2122130567","https://openalex.org/W2122202268","https://openalex.org/W2126161157","https://openalex.org/W2127436129","https://openalex.org/W2127605217","https://openalex.org/W2129776856","https://openalex.org/W2129927698","https://openalex.org/W2134096822","https://openalex.org/W2135645817","https://openalex.org/W2139553339","https://openalex.org/W2139710737","https://openalex.org/W2140025019","https://openalex.org/W2140991438","https://openalex.org/W2143682488","https://openalex.org/W2143749697","https://openalex.org/W2148077170","https://openalex.org/W2151164793","https://openalex.org/W2151250349","https://openalex.org/W2152644554","https://openalex.org/W2152696606","https://openalex.org/W2152940310","https://openalex.org/W2153416566","https://openalex.org/W2154948906","https://openalex.org/W2155255799","https://openalex.org/W2156472038","https://openalex.org/W2158332761","https://openalex.org/W2159081962","https://openalex.org/W2159783205","https://openalex.org/W2161307276","https://openalex.org/W2170316367","https://openalex.org/W2171789816","https://openalex.org/W2215442559","https://openalex.org/W2512241017","https://openalex.org/W2523345159","https://openalex.org/W2566400539"],"related_works":["https://openalex.org/W2082302265","https://openalex.org/W4405621033","https://openalex.org/W783089911","https://openalex.org/W192057085","https://openalex.org/W4249737342","https://openalex.org/W2024436717","https://openalex.org/W4224011495","https://openalex.org/W2971969269","https://openalex.org/W1009184763","https://openalex.org/W2008657122"],"abstract_inverted_index":{"Invariant":[0],"natural":[1],"killer":[2],"T":[3],"(iNKT)":[4],"cells":[5,187,319],"recognize":[6],"lipid":[7,29,285],"antigens":[8,286],"loaded":[9],"on":[10,97,223,265],"CD1d":[11],"molecules":[12],"and":[13,52,89,106,151,165,178,234,245,291,303,322],"modulate":[14],"downstream":[15],"immune":[16],"responses":[17],"by":[18],"rapidly":[19],"releasing":[20],"multiple":[21],"cytokines.":[22],"Their":[23],"most":[24],"potent":[25],"antigen":[26,61],"is":[27,119,126,169,215,221],"the":[28,54,57,83,134,144,271,281,296],"\u03b1-galactosylceramide":[30],"(\u03b1-GalCer)":[31],"from":[32],"a":[33,197,277],"marine":[34],"sponge,":[35],"which":[36,220,310],"has":[37],"been":[38],"thought":[39],"not":[40],"to":[41,101,109,316],"exist":[42],"in":[43,48,78,121,133,143,163,171,188,202,231,248,260,270,287,314,320],"mammals.":[44,79],"Despite":[45],"its":[46,98,107,131],"importance":[47],"iNKT":[49,59,93,152,183,186,205,240,249,261,288,307,318],"cell":[50,60,94,153,206,250,262,289,308],"development":[51,66,290],"activation,":[53],"nature":[55],"of":[56,67,85,137,146,182,199,204,239],"endogenous":[58,86,122,200,217,284],"remained":[62],"unclear.":[63],"The":[64],"recent":[65],"antibodies":[68],"specific":[69],"for":[70,130,280,306],"\u03b1-glycosylceramides":[71],"demonstrated":[72,141,211],"that":[73,115,142,167,212,243,299],"\u03b1-linked":[74],"glycolipids":[75,254],"are":[76,155,304],"produced":[77],"Here,":[80],"we":[81,113,158,210,294],"discuss":[82],"mechanisms":[84],"\u03b1-glycosylceramide":[87],"generation":[88],"how":[90],"they":[91],"influence":[92],"biology.":[95],"Based":[96],"structural":[99],"similarity":[100],"fatty":[102],"acid":[103],"binding":[104],"protein":[105],"ability":[108],"distinguish":[110],"galactose":[111,116,138],"anomers,":[112],"hypothesized":[114],"mutarotase":[117],"(Galm)":[118],"involved":[120],"\u03b1-GalCer":[123,149,168,201,244],"synthesis.":[124],"Galm":[125,164,233],"an":[127],"enzyme":[128],"known":[129],"role":[132,198,279],"Leloir":[135],"pathway":[136],"metabolism.":[139],"We":[140],"absence":[145],"Galm,":[147],"both":[148,232],"synthesis":[150],"autoreactivity":[154],"abrogated.":[156],"Furthermore,":[157],"have":[159,179,236],"generated":[160],"mice":[161,175,190,229],"deficient":[162,230],"confirmed":[166],"lacking":[170],"these":[172,189,253,274,301],"mice.":[173],"Galm-deficient":[174],"develop":[176],"normally":[177],"normal":[180],"frequencies":[181,238],"cells.":[184],"However,":[185,252],"exhibit":[191],"increased":[192],"activation":[193],"when":[194],"challenged,":[195],"suggesting":[196],"regulation":[203],"activation.":[207,292],"In":[208],"addition,":[209],"\u03b1-glucosylceramide":[213],"(\u03b1-GluCer)":[214],"another":[216],"\u03b1-anomeric":[218],"antigen,":[219],"dependent":[222],"UDP-glucose":[224],"ceramide":[225],"glucosyltransferase":[226],"(Ugcg).":[227],"Importantly,":[228],"Ugcg":[235],"reduced":[237],"cells,":[241],"indicating":[242],"\u03b1-GluCer":[246],"cooperate":[247],"development.":[251],"may":[255],"be":[256,312],"serving":[257],"non-redundant":[258],"functions":[259],"selection":[263],"based":[264],"their":[266],"distinct":[267,278],"localization":[268],"patterns":[269],"thymus.":[272],"Together,":[273],"studies":[275],"suggest":[276],"newly":[282],"discovered":[283],"Moreover,":[293],"identified":[295],"key":[297],"enzymes":[298],"generate":[300],"ligands":[302],"vital":[305],"biology,":[309],"can":[311],"targeted":[313],"order":[315],"regulate":[317],"autoimmunity":[321],"other":[323],"disease":[324],"settings.":[325]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2020-04-03T00:00:00"}