{"id":"https://openalex.org/W3013077950","doi":null,"title":"Neoangiogenesis and Blood-brain Barrier Dysfunction in Human TSC Brain Lesions","display_name":"Neoangiogenesis and Blood-brain Barrier Dysfunction in Human TSC Brain Lesions","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3013077950","mag":"3013077950"},"language":"en","primary_location":{"id":"pmh:oai:jdc.jefferson.edu:si_ctr_2022_phase1-1086","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/si_ctr_2022_phase1/17","pdf_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1086&context=si_ctr_2022_phase1","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phase 1","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1086&context=si_ctr_2022_phase1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008463588","display_name":"Kimberly Sansalone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly Sansalone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087601453","display_name":"Pelin Dilsiz","orcid":"https://orcid.org/0000-0001-9192-5014","observed_orcids":["https://orcid.org/0000-0001-9192-5014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pelin Dilsiz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9192-5014","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081875906","display_name":"Howard L. Weiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Weiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001041177","display_name":"Orrin Devinsky","orcid":"https://orcid.org/0000-0003-0044-4632","observed_orcids":["https://orcid.org/0000-0003-0044-4632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Orrin Devinsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0044-4632","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039143967","display_name":"Delia M. Talos","orcid":"https://orcid.org/0009-0009-5346-8954","observed_orcids":["https://orcid.org/0009-0009-5346-8954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delia M. Talos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5346-8954","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04237572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":1.0},{"id":"https://openalex.org/keywords/neoangiogenesis","display_name":"neoangiogenesis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/blood-brain-barrier-dysfunction","display_name":"blood-brain barrier dysfunction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/brain-lesions","display_name":"brain lesions","score":0.6179999709129333},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/refractory-seizures","display_name":"refractory seizures","score":0.7049999833106995},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9490000009536743},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":1.0},{"id":"https://openalex.org/keywords/cerebral-vasculature","display_name":"cerebral vasculature","score":0.5860000252723694},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6452646255493164},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5635566711425781},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4186767339706421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4047275483608246},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3883896768093109},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.29467105865478516}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jdc.jefferson.edu:si_ctr_2022_phase1-1086","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/si_ctr_2022_phase1/17","pdf_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1086&context=si_ctr_2022_phase1","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phase 1","raw_type":"text"},{"id":"mag:3013077950","doi":null,"is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1086&context=si_ctr_2022_phase1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jdc.jefferson.edu:si_ctr_2022_phase1-1086","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/si_ctr_2022_phase1/17","pdf_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1086&context=si_ctr_2022_phase1","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phase 1","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3013077950.pdf","grobid_xml":"https://content.openalex.org/works/W3013077950.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398312771","https://openalex.org/W4389343815","https://openalex.org/W2109644106","https://openalex.org/W3048992810","https://openalex.org/W4398253468","https://openalex.org/W2056084345","https://openalex.org/W2069671270","https://openalex.org/W2906160249","https://openalex.org/W3172947898","https://openalex.org/W2045645547"],"abstract_inverted_index":{"Introduction:":[0],"Tuberous":[1],"sclerosis":[2],"complex":[3],"(TSC)":[4],"is":[5],"a":[6,270],"genetic":[7],"disorder":[8],"characterized":[9],"by":[10,146],"the":[11,18,49,58,65,97,101,107,140,160,199,265],"presence":[12],"of":[13,48,54,67,133,155,163,181,198,248],"multiple":[14],"benign":[15],"tumors":[16],"throughout":[17],"body":[19],"and":[20,29,39,52,91,106,129,136,159,174,183,207,234,251],"brain.":[21],"Patients":[22],"with":[23,36,83,88,220,278],"TSC":[24,81,170,189,206,255],"experience":[25],"severe":[26],"cognitive":[27],"dysfunction":[28,217],"therapy-resistant":[30,89],"seizures,":[31,85],"which":[32],"can":[33],"be":[34],"associated":[35],"refractory":[37],"epilepsy":[38,173],"poor":[40],"developmental":[41],"outcomes.":[42],"We":[43],"hypothesize":[44],"that":[45,261],"neoangiogenesis,":[46],"disruption":[47],"blood-brain":[50,74,215,231,266],"barrier,":[51],"leakage":[53],"serum":[55,98],"proteins":[56],"into":[57],"brain":[59],"parenchyma":[60],"play":[61],"vital":[62],"roles":[63],"in":[64,169,188,204,218,224,238,254,276],"pathogenesis":[66],"TSC.":[68,225,239,279],"Methods:":[69],"In":[70,193],"order":[71],"to":[72,115,122,139,172,191,245,273],"assess":[73,123],"barrier":[75,216,232,267],"integrity,":[76],"cortical":[77,256],"tissue":[78],"samples":[79],"from":[80],"patients":[82,87,277],"intractable":[84],"non-TSC":[86],"epilepsy,":[90],"control":[92],"subjects":[93],"were":[94,166],"immunolabeled":[95],"for":[96],"protein":[99,104,110],"fibrinogen,":[100],"adherens":[102,252],"junction":[103,109],"V-cadherin,":[105],"tight":[108,249],"occludin.":[111],"Lectin":[112],"was":[113,120,148,185,202],"used":[114],"visualize":[116],"blood":[117,125,141,156,200],"vessels.":[118],"Quantification":[119],"performed":[121],"average":[124,153,161,177],"vessel":[126,142,157],"segment":[127],"length":[128,154],"branching.":[130],"The":[131,152,176],"fraction":[132,180],"membrane-associated":[134],"V-cadherin":[135,182],"occludin,":[137],"relative":[138],"surface":[143,178],"area":[144,179],"represented":[145],"lectin,":[147],"also":[149],"analyzed.":[150],"Results:":[151],"segments":[158],"number":[162],"branch":[164],"nodes":[165],"significantly":[167,186],"increased":[168,230,235],"compared":[171,190],"control.":[175,192],"occludin":[184],"decreased":[187,246],"addition,":[194],"fibrinogen":[195],"staining":[196],"outside":[197],"vessels":[201],"extensive":[203],"both":[205],"epilepsy.":[208],"These":[209,240,258],"results":[210,228,259],"confirm":[211],"our":[212],"hypothesis,":[213],"suggesting":[214],"TSC,":[219],"disease-specific":[221],"neoangiogenic":[222],"mechanisms":[223],"Discussion:":[226],"Our":[227],"show":[229],"permeability":[233],"vascular":[236],"proliferation":[237],"findings":[241],"are":[242],"likely":[243],"due":[244],"expression":[247],"junctions":[250,253],"tissue.":[257],"suggest":[260],"antiangiogenic":[262],"therapies":[263],"targeting":[264],"may":[268],"offer":[269],"novel":[271],"approach":[272],"preventing":[274],"epileptogenesis":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-03T00:00:00"}
