{"id":"https://openalex.org/W3013062014","doi":"https://doi.org/10.1037/bne0000368","title":"Gestational exposure to a ketogenic diet increases sociability in CD-1 mice.","display_name":"Gestational exposure to a ketogenic diet increases sociability in CD-1 mice.","publication_year":2020,"publication_date":"2020-03-30","ids":{"openalex":"https://openalex.org/W3013062014","doi":"https://doi.org/10.1037/bne0000368","mag":"3013062014","pmid":"https://pubmed.ncbi.nlm.nih.gov/32223276"},"language":"en","primary_location":{"id":"doi:10.1037/bne0000368","doi":"https://doi.org/10.1037/bne0000368","is_oa":false,"landing_page_url":"https://doi.org/10.1037/bne0000368","pdf_url":null,"source":{"id":"https://openalex.org/S25269534","display_name":"Behavioral Neuroscience","issn_l":"0735-7044","issn":["0735-7044","1939-0084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320262","host_organization_name":"American Psychological Association","host_organization_lineage":["https://openalex.org/P4310320262"],"host_organization_lineage_names":["American Psychological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014722059","display_name":"Amro M. S. Arqoub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]},{"id":"https://openalex.org/I56722557","display_name":"Trinity College","ror":"https://ror.org/03j3dbz94","country_code":"US","type":"education","lineage":["https://openalex.org/I56722557"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Amro M. S. Arqoub","raw_affiliation_strings":["Neuroscience Program, Trinity College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Trinity College","institution_ids":["https://openalex.org/I204442077","https://openalex.org/I56722557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041205605","display_name":"Kiera G. Flynn","orcid":"https://orcid.org/0000-0003-0913-6193","observed_orcids":["https://orcid.org/0000-0003-0913-6193"]},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]},{"id":"https://openalex.org/I56722557","display_name":"Trinity College","ror":"https://ror.org/03j3dbz94","country_code":"US","type":"education","lineage":["https://openalex.org/I56722557"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Kiera G. Flynn","raw_affiliation_strings":["Neuroscience Program, Trinity College"],"raw_orcid":"https://orcid.org/0000-0003-0913-6193","affiliations":[{"raw_affiliation_string":"Neuroscience Program, Trinity College","institution_ids":["https://openalex.org/I204442077","https://openalex.org/I56722557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100657051","display_name":"Luis A. Martinez","orcid":"https://orcid.org/0000-0002-4073-0732","observed_orcids":["https://orcid.org/0000-0002-4073-0732"]},"institutions":[{"id":"https://openalex.org/I204442077","display_name":"Trinity College","ror":"https://ror.org/019dhar59","country_code":"CA","type":"education","lineage":["https://openalex.org/I204442077"]},{"id":"https://openalex.org/I56722557","display_name":"Trinity College","ror":"https://ror.org/03j3dbz94","country_code":"US","type":"education","lineage":["https://openalex.org/I56722557"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Luis A. Martinez","raw_affiliation_strings":["Neuroscience Program, Trinity College"],"raw_orcid":"https://orcid.org/0000-0002-4073-0732","affiliations":[{"raw_affiliation_string":"Neuroscience Program, Trinity College","institution_ids":["https://openalex.org/I204442077","https://openalex.org/I56722557"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7531,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64840786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"134","issue":"4","first_page":"358","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sociability","display_name":"sociability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/social-novelty","display_name":"social novelty","score":0.699999988079071},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cross-fostering","display_name":"cross-fostering","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cd-1-mice","display_name":"ICR mice","score":0.8050000071525574},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.5090000033378601},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/low-carbohydrate-high-fat-diet","display_name":"low-carbohydrate high-fat diet","score":0.7710000276565552},{"id":"https://openalex.org/keywords/offspring-development","display_name":"offspring development","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.6449882388114929},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5789827108383179},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5593194365501404},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5354846119880676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5189632773399353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49630385637283325},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.46238982677459717},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.337973415851593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33047014474868774},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.32060128450393677},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2564164698123932},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20295706391334534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10675689578056335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066107","descriptor_name":"Social Skills","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1037/bne0000368","doi":"https://doi.org/10.1037/bne0000368","is_oa":false,"landing_page_url":"https://doi.org/10.1037/bne0000368","pdf_url":null,"source":{"id":"https://openalex.org/S25269534","display_name":"Behavioral Neuroscience","issn_l":"0735-7044","issn":["0735-7044","1939-0084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320262","host_organization_name":"American Psychological Association","host_organization_lineage":["https://openalex.org/P4310320262"],"host_organization_lineage_names":["American Psychological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral Neuroscience","raw_type":"journal-article"},{"id":"pmid:32223276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32223276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W84246589","https://openalex.org/W120557066","https://openalex.org/W1481250329","https://openalex.org/W1614399163","https://openalex.org/W1654041858","https://openalex.org/W1926126169","https://openalex.org/W1965150061","https://openalex.org/W1987473962","https://openalex.org/W1991218188","https://openalex.org/W2002102734","https://openalex.org/W2008321290","https://openalex.org/W2009396016","https://openalex.org/W2012292223","https://openalex.org/W2027917639","https://openalex.org/W2030260775","https://openalex.org/W2035747986","https://openalex.org/W2043446856","https://openalex.org/W2045659750","https://openalex.org/W2046016307","https://openalex.org/W2048359070","https://openalex.org/W2050055596","https://openalex.org/W2065338532","https://openalex.org/W2067213832","https://openalex.org/W2071797996","https://openalex.org/W2073658789","https://openalex.org/W2085694620","https://openalex.org/W2087543582","https://openalex.org/W2095586613","https://openalex.org/W2099168883","https://openalex.org/W2104655808","https://openalex.org/W2107189849","https://openalex.org/W2119573186","https://openalex.org/W2134966855","https://openalex.org/W2141984006","https://openalex.org/W2149111020","https://openalex.org/W2152053863","https://openalex.org/W2161709076","https://openalex.org/W2166979654","https://openalex.org/W2169871810","https://openalex.org/W2174046044","https://openalex.org/W2198583220","https://openalex.org/W2264732642","https://openalex.org/W2319931466","https://openalex.org/W2460352546","https://openalex.org/W2509638174","https://openalex.org/W2549854172","https://openalex.org/W2561484251","https://openalex.org/W2565292117","https://openalex.org/W2583795843","https://openalex.org/W2586792047","https://openalex.org/W2594571195","https://openalex.org/W2597416155","https://openalex.org/W2609340709","https://openalex.org/W2612259630","https://openalex.org/W2624747585","https://openalex.org/W2777169815","https://openalex.org/W2804460705","https://openalex.org/W2900777723","https://openalex.org/W3022052974","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1991218188","https://openalex.org/W2319931466","https://openalex.org/W1983183646","https://openalex.org/W2624747585","https://openalex.org/W2482772512","https://openalex.org/W2568243372","https://openalex.org/W7098582661","https://openalex.org/W4390223897","https://openalex.org/W7124974633","https://openalex.org/W2067213832"],"abstract_inverted_index":{"Postnatal":[0],"administration":[1],"of":[2,28,31,39,76,103,162,167,205,209,239],"high-fat,":[3],"low-carbohydrate":[4],"ketogenic":[5,214],"diets":[6],"(KDs)":[7],"is":[8,83],"an":[9],"established":[10],"and":[11,33,60,96,110,132,148,153,173,181,190,244],"effective":[12],"treatment":[13],"option":[14],"for":[15,146,176,232,236],"refractory":[16],"epilepsy,":[17],"with":[18,127],"more":[19],"recently":[20],"identified":[21],"therapeutic":[22,230],"potential":[23],"across":[24],"a":[25,43,117,122,135,213],"wide":[26],"range":[27],"preclinical":[29],"models":[30,75],"neurological":[32],"psychiatric":[34],"disorders.":[35],"However,":[36],"the":[37,89,101,165,203,206],"impact":[38,208],"gestational":[40,210],"exposure":[41,57,211],"to":[42,115,212,216],"KD":[44,68,123],"(GKD)":[45],"on":[46,105,134,220],"offspring":[47,142],"development":[48],"remains":[49],"unclear.":[50],"Previous":[51],"work":[52],"has":[53],"found":[54,185],"that":[55,88,138,186,225],"GKD":[56,104,187],"reduces":[58],"depression-":[59],"anxiety-like":[61],"behaviors":[62,155],"in":[63,71,179,198],"CD-1":[64,112],"mice,":[65],"whereas":[66],"postnatal":[67],"improves":[69],"sociability":[70,82,147,189],"several":[72],"different":[73],"rodent":[74],"autism.":[77],"Here":[78],"we":[79,98],"examined":[80,100],"how":[81],"impacted":[84],"by":[85],"GKD.":[86],"Given":[87],"neuropeptide":[90],"oxytocin":[91,107,177,196],"positively":[92],"regulates":[93],"affect,":[94],"anxiety,":[95],"sociability,":[97,221],"also":[99],"effects":[102,219],"brain":[106,169],"expression.":[108],"Male":[109],"female":[111],"mice":[113],"exposed":[114],"either":[116],"standard":[118],"diet":[119,215],"(SD)":[120],"or":[121],"gestationally":[124],"were":[125,143],"cross-fostered":[126],"SD":[128,136],"dams":[129],"at":[130,159,234],"birth":[131],"remained":[133],"from":[137],"point":[139],"onward.":[140],"These":[141],"then":[144],"tested":[145],"social":[149,240],"novelty":[150],"(three-chambered":[151],"test)":[152,158],"depressive-like":[154,192],"(forced":[156],"swim":[157],"10":[160],"weeks":[161],"age.":[163],"At":[164],"conclusion":[166],"testing,":[168],"tissue":[170],"was":[171],"collected":[172],"immunohistochemically":[174],"processed":[175],"expression":[178,197],"hypothalamic":[180],"limbic":[182],"areas.":[183,200],"We":[184],"increased":[188],"reduced":[191],"symptoms,":[193],"without":[194],"affecting":[195],"quantified":[199],"By":[201],"expanding":[202],"scope":[204],"lasting":[207],"include":[217],"positive":[218],"these":[222],"results":[223],"indicate":[224],"GKDs":[226],"may":[227],"have":[228],"novel":[229],"applications":[231],"individuals":[233],"risk":[235],"developmental":[237],"disorders":[238],"behavior,":[241],"including":[242],"autism":[243],"schizophrenia.":[245],"(PsycInfo":[246],"Database":[247],"Record":[248],"(c)":[249],"2020":[250],"APA,":[251],"all":[252],"rights":[253],"reserved).":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-04-03T00:00:00"}
