{"id":"https://openalex.org/W3012963243","doi":null,"title":"Dissection of the factors involved in chromatin remodelling and dna damage response pathway in hypoxic conditions","display_name":"Dissection of the factors involved in chromatin remodelling and dna damage response pathway in hypoxic conditions","publication_year":2018,"publication_date":"2018-11-30","ids":{"openalex":"https://openalex.org/W3012963243","mag":"3012963243"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/1844dcb6-1820-4328-83d8-5f3ce7cee010","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/1844dcb6-1820-4328-83d8-5f3ce7cee010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"parent_works":[],"lineage":["https://openalex.org/W3012963243"],"child_works_count":0,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061051872","display_name":"Mar\u00eda Likhatcheva","orcid":"https://orcid.org/0000-0002-5341-2063","observed_orcids":["https://orcid.org/0000-0002-5341-2063"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mar\u00eda Likhatcheva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5341-2063","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061051872"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.2354000061750412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.21580000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/h3k9me3","display_name":"H3K9me3","score":0.8930000066757202},{"id":"https://openalex.org/keywords/suv39h1","display_name":"SUV39H1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/h3k9-trimethylation","display_name":"H3K9 trimethylation","score":0.746999979019165},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.4650000035762787},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ku55933","display_name":"KU55933","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":0.5479999780654907},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ku-heterodimer","display_name":"Ku heterodimer","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7735376358032227},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6609992384910583},{"id":"https://openalex.org/C2778506107","wikidata":"https://www.wikidata.org/wiki/Q3272916","display_name":"MG132","level":4,"score":0.5878428220748901},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5792133212089539},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.5483447313308716},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5370755195617676},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4692245423793793},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46343666315078735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41103309392929077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39135846495628357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38574135303497314},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.300787091255188},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.23249471187591553},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21839448809623718},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16243505477905273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1248646080493927},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.09270605444908142},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09034666419029236},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/1844dcb6-1820-4328-83d8-5f3ce7cee010","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/1844dcb6-1820-4328-83d8-5f3ce7cee010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},{"id":"mag:3012963243","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799315","pdf_url":null,"source":{"id":"https://openalex.org/S4306532722","display_name":"[Thesis]. Manchester, UK: The University of Manchester; 2018.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2018.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3201139538","https://openalex.org/W7116793743","https://openalex.org/W7213347984","https://openalex.org/W2024243863","https://openalex.org/W4391469721","https://openalex.org/W1912093430","https://openalex.org/W2145092931","https://openalex.org/W2122969498","https://openalex.org/W2565900718","https://openalex.org/W6990359728"],"abstract_inverted_index":{"Hypoxia,":[0],"a":[1,12,73,110,292,339,358,397],"common":[2],"feature":[3],"of":[4,30,39,46,79,85,104,144,151,176,217,248,264,288,305,346,379,384,400,407,413,427,447],"solid":[5],"tumours,":[6],"is":[7,160,167,197,254,325,451,465,475],"associated":[8],"with":[9,28,43,131,235,371],"poor":[10],"prognosis,":[11],"more":[13],"aggressive":[14],"tumour":[15,493],"phenotype":[16],"and":[17,54,81,127,181,203,219,242,258,366,376,391,429],"therapeutic":[18],"resistance.":[19],"Tumour":[20],"hypoxia":[21,108,137,202,297,343,404,416],"induces":[22],"changes":[23,100],"in":[24,50,101,107,135,148,154,199,208,221,225,274,278,295,314,327,330,341,402,415,442,467],"the":[25,31,47,76,82,92,102,121,142,145,149,170,174,215,227,296,302,322,342,377,380,403,411,423,469],"chromatin":[26,276],"structure,":[27],"induction":[29],"heterochromatin":[32],"mark":[33],"H3K9me3":[34,40,126],"frequently":[35],"observed.":[36],"The":[37,262,393,436],"upregulation":[38,45],"was":[41,68,72,88,232,308,363],"observed":[42,251],"co-incidental":[44],"methyltransferase":[48],"Suv39H1":[49,71,105,139,152,159,223,249],"three":[51],"(FTC133,":[52],"U87":[53],"HCT116)":[55],"different":[56],"cancer":[57,457],"cell":[58,424,458],"lines":[59],"exposed":[60],"to":[61,124,201,210,280,332,351,355,420,453],"hypoxic":[62,117,188,374,492],"conditions":[63,118,158,241,375],"(0.1%":[64],"O2).":[65],"Thus,":[66,483],"it":[67],"hypothesised":[69],"that":[70,195,271,321,439,463],"candidate":[74],"for":[75,456,480],"tri-":[77],"methylation":[78],"H3K9":[80],"first":[83],"part":[84,304],"this":[86,265,306,357,485],"study":[87,266,307,461],"focused":[89,309],"on":[90,310],"investigating":[91],"potential":[93],"regulatory":[94],"mechanisms.":[95],"RT-qPCR":[96],"analysis":[97],"showed":[98,396,438],"no":[99],"levels":[103,175,184,224,247,378],"mRNA":[106],"suggesting":[109,141],"post":[111],"transcriptional":[112],"regulation":[113,150,287],"mechanism.":[114],"In":[115,353],"mild":[116,136],"(O2":[119],"\ufffd\u0089\ufffd1%)":[120],"cells":[122,368,431,444],"failed":[123],"induce":[125],"Suv39H1.":[128],"However,":[129,173,335],"treatment":[130],"proteasome":[132],"inhibitor":[133,230],"MG132":[134],"induced":[138,298,344,405],"upregulation,":[140],"involvement":[143,216,399],"proteasomal":[146],"pathway":[147],"stability":[153],"hypoxia.\nUnder":[155],"normal":[156,239],"oxygen":[157,240],"degraded":[161],"via":[162],"MDM2":[163,182,206,220,236,259],"dependent":[164],"ubiquitination,":[165],"which":[166],"blocked":[168],"by":[169,388,434],"protein":[171,183],"Sirt1.":[172],"Sirt1":[177],"were":[178,185,250,369,386,432],"highly":[179],"downregulated":[180],"maintained":[186],"following":[187],"exposure.":[189],"It":[190,316],"has":[191,273,317,417],"been":[192,318,349,418],"previously":[193,319],"reported":[194,320],"ATM":[196,218,228,253,272,290,312,328,347,385,414,440,464,474],"activated":[198],"response":[200,209,279,331],"negatively":[204],"regulates":[205],"activity":[207],"DNA":[211,299,333],"damage.":[212,334],"To":[213],"test":[214],"regulating":[222,275],"hypoxia,":[226,285],"specific":[229,360],"(Ku55933)":[231],"used":[233],"together":[234],"knockdown":[237],"under":[238,373,472],"hypoxia.":[243,315,473],"As":[244],"predicted,":[245],"highest":[246],"when":[252],"catalytically":[255,381],"active":[256,382],"(hypoxia)":[257],"inactive":[260],"(knockdown).":[261],"results":[263,395],"indicate":[267],"an":[268,476],"important":[269,455],"role":[270,294,340],"structure":[277],"stress":[281],"conditions,":[282],"such":[283],"as":[284,410],"through":[286],"MDM2.\nAs":[289],"plays":[291,338],"crucial":[293],"damage":[300],"response,":[301],"second":[303],"uncovering":[311,484],"activation":[313,329,345,406,412,441],"acetyltransferase":[323],"Tip60":[324,337,359,401],"involved":[326,466],"if":[336],"hasn\ufffd\u0080\u0099t":[348],"tested":[350],"date.":[352],"order":[354],"do":[356],"inhibitor,":[361],"TH1834,":[362],"used.":[364],"FTC133":[365,428,443],"HCT116":[367,430],"treated":[370],"TH1834":[372],"form":[383],"assessed":[387],"Western":[389],"blot":[390],"IF.":[392],"obtained":[394],"clear":[398],"ATM.":[408],"Finally,":[409],"related":[419],"S-phase":[421,448],"arrest,":[422],"cycle":[425],"distribution":[426],"analysed":[433],"FACS.":[435],"result":[437],"seems":[445],"independent":[446],"arrest.":[449],"\nHeterochromatin":[450],"suggested":[452],"be":[454],"survival.":[459],"This":[460],"proposes":[462],"maintaining":[468],"heterochromatic":[470],"state":[471],"extensively":[477],"researched":[478],"target":[479],"anticancer":[481],"therapy.":[482],"mechanism":[486],"enables":[487],"new":[488],"insight":[489],"into":[490],"targeting":[491],"cells.":[494]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2020-04-03T00:00:00"}
